Nakahira, Kiichi

Publications

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selected publications

Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort. JCI insight. 2020 Academic Article GET IT
Times cited: 29
Apolipoprotein E and Periostin Are Potential Biomarkers of Nasal Mucosal Inflammation. A Parallel Approach of In Vitro and In Vivo Secretomes. American journal of respiratory cell and molecular biology. 2020 Academic Article GET IT
Times cited: 12
GLUT1-dependent glycolysis regulates exacerbation of fibrosis via AIM2 inflammasome activation. Thorax. 2019 Academic Article GET IT
Times cited: 46
Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis. JCI insight. 2019 Academic Article GET IT
Times cited: 96
Heteroplasmy concordance between mitochondrial DNA and RNA. Scientific reports. 2019 Academic Article GET IT
Times cited: 9
Mitochondrial DNA Mutation, Diseases, and Nutrient-Regulated Mitophagy. Annual review of nutrition. 2019 Review GET IT
Times cited: 5
Circulating Mitochondrial DNA as Predictor of Mortality in Critically Ill Patients: A Systematic Review of Clinical Studies. Chest. 2019 Academic Article GET IT
Times cited: 33
Association of Elevated Plasma Interleukin-18 Level With Increased Mortality in a Clinical Trial of Statin Treatment for Acute Respiratory Distress Syndrome. Critical care medicine. 2019 Academic Article GET IT
Times cited: 68
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science (New York, N.Y.). 2019 Academic Article GET IT
Times cited: 574
Diurnal Rhythms Spatially and Temporally Organize Autophagy. Cell reports. 2019 Academic Article GET IT
Times cited: 44
Plasma mitochondrial DNA and metabolomic alterations in severe critical illness. Critical care (London, England). 2018 Academic Article GET IT
Times cited: 30
A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS. JCI insight. 2018 Academic Article GET IT
Times cited: 73
RIPK3 mediates pathogenesis of experimental ventilator-induced lung injury. JCI insight. 2018 Academic Article GET IT
Times cited: 54
RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase. JCI insight. 2018 Academic Article GET IT
Times cited: 71
Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages. Biochemical and biophysical research communications. 2017 Academic Article GET IT
Times cited: 14
NLRP3 Inflammasome Deficiency Protects against Microbial Sepsis via Increased Lipoxin B₄ Synthesis. American journal of respiratory and critical care medicine. 2017 Academic Article GET IT
Times cited: 121
Mitochondrial DNA in Sepsis. Current opinion in critical care. 2017 Information Resource GET IT
Times cited: 61
Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit. Critical care (London, England). 2017 Academic Article GET IT
Times cited: 160
Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction. American journal of respiratory cell and molecular biology. 2017 Academic Article GET IT
Times cited: 35
Inflammasomes: Key Mediators of Lung Immunity. Annual review of physiology. 2017 Review GET IT
Times cited: 37
Very Short Mitochondrial DNA Fragments and Heteroplasmy in Human Plasma. Scientific reports. 2016 Academic Article GET IT
Times cited: 49
NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. Nature medicine. 2016 Academic Article GET IT
Autophagy: Friend or Foe in Lung Disease?. Annals of the American Thoracic Society. 2016 Review GET IT
Times cited: 76
Fatty acid synthesis and NLRP3-inflammasome. Oncotarget. 2015 Editorial Article GET IT
Times cited: 7
mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation. Cell reports. 2015 Academic Article GET IT
Times cited: 316
BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension. Cell metabolism. 2015 Academic Article GET IT
Times cited: 164
Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages. American journal of physiology. Lung cellular and molecular physiology. 2015 Academic Article GET IT
Times cited: 59
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. The Journal of clinical investigation. 2015 Academic Article GET IT
Times cited: 209
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD. The Journal of clinical investigation. 2014 Academic Article GET IT
Times cited: 437
Metabolomic derangements are associated with mortality in critically ill adult patients. PloS one. 2014 Academic Article GET IT
Times cited: 108
Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. PLoS medicine. 2013 Academic Article GET IT
Times cited: 325
Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis. Antioxidants & redox signaling. 2013 Academic Article GET IT
Times cited: 101
Autophagy: a crucial moderator of redox balance, inflammation, and apoptosis in lung disease. Antioxidants & redox signaling. 2013 Information Resource GET IT
Times cited: 85
Guidelines for the use and interpretation of assays for monitoring autophagy. 2012 GET IT
Times cited: 2762
Inflammasome-regulated cytokines are critical mediators of acute lung injury. American journal of respiratory and critical care medicine. 2012 Academic Article GET IT
Times cited: 450
Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. American journal of respiratory and critical care medicine. 2012 Academic Article GET IT
Times cited: 115
Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy. 2011 Academic Article GET IT
Carbon monoxide activates autophagy via mitochondrial reactive oxygen species formation. American journal of respiratory cell and molecular biology. 2011 Academic Article GET IT
Times cited: 109
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nature immunology. 2010 Academic Article GET IT
Times cited: 2325
Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 435
The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 173
Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PloS one. 2008 Academic Article GET IT
Times cited: 391
Ex vivo carbon monoxide prevents cytochrome P450 degradation and ischemia/reperfusion injury of kidney grafts. Kidney international. 2008 Academic Article GET IT
Times cited: 61
Protective functions of heme oxygenase-1 and carbon monoxide in the respiratory system. Antioxidants & redox signaling. 2007 Information Resource GET IT
Times cited: 90
Mechanisms of cell death in oxidative stress. Antioxidants & redox signaling. 2007 Information Resource GET IT
Times cited: 835
Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation. The Journal of biological chemistry. 2006 Academic Article GET IT
Times cited: 168
Highly liver-specific heme oxygenase-1 induction by interleukin-11 prevents carbon tetrachloride-induced hepatotoxicity. International journal of molecular medicine. 2006 Academic Article GET IT
Times cited: 28
Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. The Journal of experimental medicine. 2006 Academic Article GET IT
Times cited: 324
Heart allograft protection with low-dose carbon monoxide inhalation: effects on inflammatory mediators and alloreactive T-cell responses. Transplantation. 2006 Academic Article GET IT
Times cited: 61
A protective role of interleukin 11 on hepatic injury in acute endotoxemia. Shock (Augusta, Ga.). 2004 Academic Article GET IT
Times cited: 34
Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity. Biochemical pharmacology. 2003 Academic Article GET IT
Times cited: 111
Protective role of heme oxygenase-1 in the intestinal tissue injury in an experimental model of sepsis. Critical care medicine. 2003 Academic Article GET IT
Times cited: 67
Tin chloride pretreatment prevents renal injury in rats with ischemic acute renal failure. Critical care medicine. 2002 Academic Article GET IT
Times cited: 44

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Research

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Funding awarded

A Phase II Study of Inhaled CO for the Treatment of ARDS awarded by United States Department of Defense Co-Investigator 2018 - 2024

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Background

education and training

Ph.D., Okayama University (Japan) 2003
B.M., Okayama University School of Medicine (Japan) 1997

Contact

full name

Kiichi Nakahira

primary email

kin2007@med.cornell.edu

VIVO Weill Cornell Medical College

Kiichi Nakahira Adjunct Assistant Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email