Dampening insulin signaling by an NLRP3 'meta-flammasome'. uri icon

Overview

abstract

  • The inflammasome has been linked to metabolic disorders such as obesity and type 2 diabetes. Data now suggest that the crosstalk between the inflammasome and autophagy critically mediates cytoplasmic receptor NLRP3–dependent activation of the inflammasome by the saturated fatty acids contained in a high-fat diet.

publication date

  • May 1, 2011

Research

keywords

  • Autophagy
  • Carrier Proteins
  • Inflammasomes
  • Insulin

Identity

PubMed Central ID

  • PMC6240333

Scopus Document Identifier

  • 79955006431

Digital Object Identifier (DOI)

  • 10.1038/ni.2028

PubMed ID

  • 21502990

Additional Document Info

volume

  • 12

issue

  • 5