selected publications
- Origin of Osteoclasts: Osteoclast Precursor Cells. Journal of bone metabolism. 2023 Academic Article GET IT
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RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts.
Cellular & molecular immunology.
2022
Academic Article
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Times cited: 14 - Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis. 2022 GET IT
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Osteoclasts: Other functions.
Bone.
2022
Review
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Times cited: 2 - WNT-modulating gene silencers as a gene therapy for osteoporosis, bone fracture, and critical-sized bone defects. Molecular therapy : the journal of the American Society of Gene Therapy. 2022 Academic Article GET IT
- The crosstalk between MYC and mTORC1 during osteoclastogenesis. Frontiers in cell and developmental biology. 2022 Academic Article GET IT
- THOC5 regulates human osteoclastogenesis. European journal of cell biology. 2022 Academic Article GET IT
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Distinct Inflammatory Macrophage Populations Sequentially Infiltrate Bone-to-Tendon Interface Tissue After Anterior Cruciate Ligament (ACL) Reconstruction Surgery in Mice.
JBMR plus.
2022
Academic Article
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Times cited: 8 -
Role of Lysine-Specific Demethylase 1 in Metabolically Integrating Osteoclast Differentiation and Inflammatory Bone Resorption Through Hypoxia-Inducible Factor 1α and E2F1.
Arthritis & rheumatology (Hoboken, N.J.).
2022
Academic Article
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Times cited: 24 -
Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion.
Bone research.
2021
Academic Article
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Times cited: 6 - Glucocorticoid-induced osteonecrosis in systemic lupus erythematosus patients. Clinical and translational medicine. 2021 Review GET IT
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MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages.
Cell reports.
2021
Academic Article
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Times cited: 33 - Risk factors for multi-joint disease in patients with glucocorticoid-induced osteonecrosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2021 Academic Article GET IT
- Sexual Dimorphism in Differentiating Osteoclast Precursors Demonstrates Enhanced Inflammatory Pathway Activation in Female Cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2021 Academic Article GET IT
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MEF2C regulates osteoclastogenesis and pathologic bone resorption via c-FOS.
Bone research.
2021
Academic Article
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Times cited: 35 -
Regulation of Osteoclast Differentiation and Activity by Lipid Metabolism.
Cells.
2021
Review
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Times cited: 48 -
NRF2 Is an Upstream Regulator of MYC-Mediated Osteoclastogenesis and Pathological Bone Erosion.
Cells.
2020
Academic Article
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Times cited: 12 -
Alendronate enhances osseointegration in a murine implant model.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2020
Academic Article
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Times cited: 3 -
The M-CSF receptor in osteoclasts and beyond.
Experimental & molecular medicine.
2020
Review
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Times cited: 115 -
Nuclear receptors in osteoclasts.
Current opinion in pharmacology.
2020
Review
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Times cited: 4 -
Metabolic reprogramming in osteoclasts.
Seminars in immunopathology.
2019
Information Resource
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Times cited: 86 -
IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation.
Nature communications.
2019
Academic Article
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Times cited: 59 -
The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair.
Immunity.
2019
Academic Article
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Times cited: 93 -
Insights into rheumatic diseases from next-generation sequencing.
Nature reviews. Rheumatology.
2019
Information Resource
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Times cited: 27 -
Mechanisms involved in normal and pathological osteoclastogenesis.
Cellular and molecular life sciences : CMLS.
2018
Information Resource
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Times cited: 37 -
Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.
JCI insight.
2017
Academic Article
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Times cited: 35 -
Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation.
Nature immunology.
2017
Academic Article
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Times cited: 170 -
Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF.
Immunity.
2017
Academic Article
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Times cited: 123 -
Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis.
Immunity.
2017
Academic Article
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Times cited: 69 -
MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα.
The Journal of clinical investigation.
2017
Academic Article
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Times cited: 84 -
Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages.
Scientific reports.
2016
Academic Article
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Times cited: 26 -
Cutting Edge: EZH2 Promotes Osteoclastogenesis by Epigenetic Silencing of the Negative Regulator IRF8.
Journal of immunology (Baltimore, Md. : 1950).
2016
Academic Article
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Times cited: 60 -
Epigenetic regulation of bone cells.
Connective tissue research.
2016
Information Resource
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Times cited: 24 -
Intravenous Immunoglobulin (IVIG) Attenuates TNF-Induced Pathologic Bone Resorption and Suppresses Osteoclastogenesis by Inducing A20 Expression.
Journal of cellular physiology.
2016
Academic Article
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Times cited: 16 -
Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass.
Proceedings of the National Academy of Sciences of the United States of America.
2015
Academic Article
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Times cited: 30 -
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.
Nature.
2015
Academic Article
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Times cited: 441 -
Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation.
Nature communications.
2014
Academic Article
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Times cited: 108 -
Tumor necrosis factor α induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblasts.
Arthritis and rheumatism.
2013
Academic Article
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Times cited: 121 -
iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.
The Journal of clinical investigation.
2013
Academic Article
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Times cited: 143 -
Negative regulation of osteoclast precursor differentiation by CD11b and β2 integrin-B-cell lymphoma 6 signaling.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2013
Academic Article
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Times cited: 47 -
ITAM-coupled receptors inhibit IFNAR signaling and alter macrophage responses to TLR4 and Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950).
2012
Academic Article
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Times cited: 24 -
Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages.
Nature immunology.
2011
Academic Article
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Times cited: 147 -
Direct inhibition of human RANK+ osteoclast precursors identifies a homeostatic function of IL-1beta.
Journal of immunology (Baltimore, Md. : 1950).
2010
Academic Article
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Times cited: 35 -
Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins.
Immunity.
2010
Academic Article
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Times cited: 120 -
Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling.
Arthritis and rheumatism.
2010
Academic Article
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Times cited: 79 -
Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors.
Journal of immunology (Baltimore, Md. : 1950).
2009
Academic Article
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Times cited: 130 -
IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression.
Journal of immunology (Baltimore, Md. : 1950).
2009
Academic Article
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Times cited: 102 -
Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.
Human immunology.
2009
Academic Article
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Times cited: 87 -
Regulation of STAT pathways and IRF1 during human dendritic cell maturation by TNF-alpha and PGE2.
Journal of leukocyte biology.
2008
Academic Article
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Times cited: 22 -
TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes.
Nature immunology.
2008
Academic Article
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Times cited: 282 -
'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages.
Nature immunology.
2007
Academic Article
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Times cited: 63 -
Apoptotic cells inhibit LPS-induced cytokine and chemokine production and IFN responses in macrophages.
Human immunology.
2007
Academic Article
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Times cited: 45 -
FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin.
Immunity.
2007
Academic Article
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Times cited: 127 -
IFN-gamma-primed macrophages exhibit increased CCR2-dependent migration and altered IFN-gamma responses mediated by Stat1.
Journal of immunology (Baltimore, Md. : 1950).
2005
Academic Article
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Times cited: 46 -
Kinetics of IL-10-induced gene expression in human macrophages.
Immunobiology.
2005
Academic Article
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Times cited: 22 -
Regulation of macrophage phenotype by long-term exposure to IL-10.
Immunobiology.
2005
Academic Article
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Times cited: 44 -
Inhibition of interleukin 10 signaling after Fc receptor ligation and during rheumatoid arthritis.
The Journal of experimental medicine.
2003
Academic Article
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Times cited: 64