Donlin, Laura Theresa

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Rheumatoid arthritis synovial fibroblasts modulate T cell activation. JCI insight. 2025 Academic Article GET IT
Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases. 2025 GET IT
Opposing regulation of TNF responses by IFN-γ and a PGE2-cAMP axis that is apparent in rheumatoid and immune checkpoint inhibitor-induced arthritis human IL-1β+ macrophages. eLife. 2025 Academic Article GET IT
Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis. The Journal of clinical investigation. 2025 Academic Article GET IT
Times cited: 8
Deep topic modeling of spatial transcriptomics in the rheumatoid arthritis synovium identifies distinct classes of ectopic lymphoid structures. 2025 GET IT
Are There Disease Endotypes in Axial Spondyloarthritis and How Would We Define Them?. The Journal of rheumatology. 2024 Review GET IT
Times cited: 1
Disrupting the RNA polymerase II transcription cycle through CDK7 inhibition ameliorates inflammatory arthritis. Science translational medicine. 2024 Academic Article GET IT
Times cited: 3
Characterizing molecular targets in difficult-to-treat rheumatoid arthritis. Seminars in arthritis and rheumatism. 2024 Academic Article GET IT
Times cited: 1
Periprosthetic Joint Infection in Patients With Inflammatory Arthritis: Optimal Tests to Differentiate From Flares. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 2024 Academic Article GET IT
Times cited: 2
Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue. Nature communications. 2024 Academic Article GET IT
Times cited: 5
Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium. Nature communications. 2024 Academic Article GET IT
Times cited: 29
The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis. Nature communications. 2024 Academic Article GET IT
Times cited: 12
Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles. Nature genetics. 2024 Academic Article GET IT
Times cited: 18
Associations Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Types and States. Arthritis & rheumatology (Hoboken, N.J.). 2024 Academic Article GET IT
Times cited: 6
Dynamic regulatory elements in single-cell multimodal data implicate key immune cell states enriched for autoimmune disease heritability. Nature genetics. 2023 Academic Article GET IT
Times cited: 13
Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution. Nature genetics. 2023 Academic Article GET IT
Times cited: 18
Computer Vision Analysis of Rheumatoid Arthritis Synovium Reveals Lymphocytic Inflammation Is Associated With Immunoglobulin Skewing in Blood. Arthritis & rheumatology (Hoboken, N.J.). 2023 Academic Article GET IT
Times cited: 5
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes. Nature. 2023 Academic Article GET IT
Times cited: 203
Clonally expanded CD38^hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritis. Science immunology. 2023 Academic Article GET IT
Times cited: 31
Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis. 2023 GET IT
Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis. Nature immunology. 2023 Academic Article GET IT
Times cited: 96
The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis. 2023 GET IT
Times cited: 33198
Emerging synovial cell states in rheumatoid arthritis as potential therapeutic targets. Current opinion in rheumatology. 2023 Review GET IT
Times cited: 2
Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium. 2023 GET IT
Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution. 2023 GET IT
Machine learning identification of thresholds to discriminate osteoarthritis and rheumatoid arthritis synovial inflammation. Arthritis research & therapy. 2023 Academic Article GET IT
Times cited: 22
Clinical and Histological Features of Prosthetic Joint Infections May Differ in Patients With Inflammatory Arthritis and Osteoarthritis. HSS journal : the musculoskeletal journal of Hospital for Special Surgery. 2023 Academic Article GET IT
Times cited: 4
Cytotoxic CD8⁺ T cells target citrullinated antigens in rheumatoid arthritis. Nature communications. 2023 Academic Article GET IT
Times cited: 59
Inching closer to precision treatment for rheumatoid arthritis. Nature medicine. 2022 Comment GET IT
Times cited: 11
Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression. Cell reports. 2022 Academic Article GET IT
Times cited: 30
Neoplastic synovial lining cells that coexpress podoplanin and CD90 overproduce CSF-1, driving tenosynovial giant cell tumor. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2021 Academic Article GET IT
Times cited: 6
Sequencing of Circulating Microbial Cell-Free DNA Can Identify Pathogens in Periprosthetic Joint Infections. The Journal of bone and joint surgery. American volume. 2021 Academic Article GET IT
Times cited: 21
In vitro responses to platelet-rich-plasma are associated with variable clinical outcomes in patients with knee osteoarthritis. Scientific reports. 2021 Academic Article GET IT
Times cited: 25
IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation. Genome medicine. 2021 Academic Article GET IT
Times cited: 158
Rheumatology in the era of precision medicine: synovial tissue molecular patterns and treatment response in rheumatoid arthritis. Current opinion in rheumatology. 2021 Review GET IT
Times cited: 5
IFN- γ and TNF- α drive a CXCL10 + CCL2 + macrophage phenotype expanded in severe COVID-19 and other diseases with tissue inflammation. 2020 GET IT
Times cited: 570
Rheumatoid Arthritis Flares After Total Hip and Total Knee Arthroplasty: Outcomes at One Year. Arthritis care & research. 2020 Academic Article GET IT
Times cited: 24
Fibroblast subtypes in tissues affected by autoimmunity: with lessons from lymph node fibroblasts. Current opinion in immunology. 2020 Review GET IT
Times cited: 4
Notch signalling drives synovial fibroblast identity and arthritis pathology. Nature. 2020 Academic Article GET IT
Times cited: 368
Advancing Rheumatoid Arthritis Synovial Biopsy Analysis: One B Cell at a Time. Arthritis & rheumatology (Hoboken, N.J.). 2020 Editorial Article GET IT
Times cited: 4
Histologic and Transcriptional Evidence of Subclinical Synovial Inflammation in Patients With Rheumatoid Arthritis in Clinical Remission. Arthritis & rheumatology (Hoboken, N.J.). 2020 Academic Article GET IT
Times cited: 26
Synovial Tissue: Cellular and Molecular Phenotyping. Current rheumatology reports. 2019 Review GET IT
Times cited: 3
Insights into rheumatic diseases from next-generation sequencing. Nature reviews. Rheumatology. 2019 Review GET IT
Times cited: 33
HBEGF⁺ macrophages in rheumatoid arthritis induce fibroblast invasiveness. Science translational medicine. 2019 Academic Article GET IT
Times cited: 185
Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nature immunology. 2019 Academic Article GET IT
Times cited: 948
Increased Staphylococcus aureus Nasal Carriage Rates in Rheumatoid Arthritis Patients on Biologic Therapy. The Journal of arthroplasty. 2019 Academic Article GET IT
Times cited: 15
Mixed-effects association of single cells identifies an expanded effector CD4⁺ T cell subset in rheumatoid arthritis. Science translational medicine. 2018 Academic Article GET IT
Times cited: 111
Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue. Arthritis research & therapy. 2018 Academic Article GET IT
Times cited: 97
Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data. Arthritis & rheumatology (Hoboken, N.J.). 2018 Academic Article GET IT
Times cited: 158
Flares in Patients with Rheumatoid Arthritis after Total Hip and Total Knee Arthroplasty: Rates, Characteristics, and Risk Factors. The Journal of rheumatology. 2018 Academic Article GET IT
Times cited: 18
iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling. The Journal of clinical investigation. 2018 Academic Article GET IT
Times cited: 78
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis. Nature communications. 2018 Academic Article GET IT
Times cited: 439
Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation. Nature communications. 2018 Academic Article GET IT
Times cited: 281
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature. 2017 Academic Article GET IT
Times cited: 876
Modulation of TNF-induced macrophage polarization by synovial fibroblasts. Journal of immunology (Baltimore, Md. : 1950). 2014 Academic Article GET IT
Times cited: 88
Regulation of type I interferon responses. Nature reviews. Immunology. 2014 Review GET IT
Times cited: 2539
Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization. Genes & development. 2012 Academic Article GET IT
Times cited: 138
Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin. The Journal of experimental medicine. 2010 Academic Article GET IT
Times cited: 22
Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation. Molecular and cellular biology. 2005 Academic Article GET IT
Times cited: 15
The adapter molecule Sin regulates T-cell-receptor-mediated signal transduction by modulating signaling substrate availability. Molecular and cellular biology. 2004 Academic Article GET IT
Times cited: 6
Sin: good or bad? A T lymphocyte perspective. Immunological reviews. 2003 Review GET IT
Times cited: 18
Defective thymocyte maturation by transgenic expression of a truncated form of the T lymphocyte adapter molecule and Fyn substrate, Sin. Journal of immunology (Baltimore, Md. : 1950). 2002 Academic Article GET IT
Times cited: 10
Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling. Proceedings of the National Academy of Sciences of the United States of America. 2000 Academic Article GET IT
Times cited: 87

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Research

keywords

- Autoimmunity
- Lymphocyte biology
- Innate immunity
- Omics

Background

education and training

Rockefeller University
M.A., Ph.D., Columbia University 2004
M.Phil., Columbia University 2004
B.S., Villanova University 1998

Contact

full name

Laura Theresa Donlin

primary email

lad2031@med.cornell.edu

VIVO Weill Cornell Medical College

Laura Theresa Donlin Associate Professor of Immunology in Medicine

Publications

selected publications

Research

keywords

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

keywords

Background

education and training

Contact

full name

primary email