Kirkman, Laura

Publications

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selected publications

Plasmodium falciparum DNA repair dynamics reveal unique roles for TLS polymerases and PfRad51 in genome diversification. 2025 GET IT
The critical role of PSAC channel in malaria parasite survival is driven home by phenotypic screening under relevant nutrient levels. Cell chemical biology. 2025 Academic Article GET IT
Times cited: 2
Recurrent Plasmodium falciparum Malaria in U.S. Travelers Treated with Artemether-Lumefantrine. 2025 GET IT
Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nature communications. 2023 Academic Article GET IT
Times cited: 15
Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance. Cell chemical biology. 2023 Academic Article GET IT
Times cited: 11
Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II. Journal of medicinal chemistry. 2023 Academic Article GET IT
Times cited: 8
Relapsed Babesia microti Infection Following Allogeneic Hematopoietic Cell Transplantation in a Patient With B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature. 2021 GET IT
Times cited: 7
Telomere length dynamics in response to DNA damage in malaria parasites. iScience. 2021 Academic Article GET IT
Times cited: 9
The contribution of extrachromosomal DNA to genome plasticity in malaria parasites. Molecular microbiology. 2020 Article GET IT
Times cited: 6
Case Report: Mucosal Leishmaniasis in New York City. 2020 GET IT
Times cited: 3
A Histone Methyltransferase Inhibitor Can Reverse Epigenetically Acquired Drug Resistance in the Malaria Parasite Plasmodium falciparum. Antimicrobial agents and chemotherapy. 2020 Academic Article GET IT
Times cited: 14
Vive la Différence: Exploiting the Differences between Rodent and Human Malarias. Trends in parasitology. 2020 Review GET IT
Times cited: 8
Evolution of Host Specificity by Malaria Parasites through Altered Mechanisms Controlling Genome Maintenance. mBio. 2020 Academic Article GET IT
Times cited: 16
Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors. Journal of medicinal chemistry. 2019 Academic Article GET IT
Times cited: 33
Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum. PLoS biology. 2019 Academic Article GET IT
Times cited: 41
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 73
Clinical and Molecular Evidence of Atovaquone and Azithromycin Resistance in Relapsed Babesia microti Infection Associated With Rituximab and Chronic Lymphocytic Leukemia. 2017 GET IT
Times cited: 34
Chromosome End Repair and Genome Stability in Plasmodium falciparum. mBio. 2017 Academic Article GET IT
Times cited: 25
Babesia microti: from Mice to Ticks to an Increasing Number of Highly Susceptible Humans. Journal of clinical microbiology. 2017 Review GET IT
Times cited: 60
Plasmodium falciparum K76T pfcrt Gene Mutations and Parasite Population Structure, Haiti, 2006-2009. Emerging infectious diseases. 2016 Academic Article GET IT
Times cited: 9
Cutaneous Leishmaniasis: Current Treatment Practices in the USA for Returning Travelers. Current treatment options in infectious diseases. 2015 Academic Article GET IT
Recombination and Diversification of the Variant Antigen Encoding Genes in the Malaria Parasite Plasmodium falciparum. Microbiology spectrum. 2014 Review GET IT
Times cited: 12
Origin of robustness in generating drug-resistant malaria parasites. Molecular biology and evolution. 2014 Academic Article GET IT
Times cited: 38
Malaria parasites utilize both homologous recombination and alternative end joining pathways to maintain genome integrity. Nucleic acids research. 2013 Academic Article GET IT
Times cited: 88
Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum. Molecular microbiology. 2013 Academic Article GET IT
Times cited: 49
Antigenic variation and the generation of diversity in malaria parasites. Current opinion in microbiology. 2012 Review GET IT
Times cited: 39
Frequent recombination events generate diversity within the multi-copy variant antigen gene families of Plasmodium falciparum. International journal for parasitology. 2008 Academic Article GET IT
Times cited: 52

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Research

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Co-investigator Network

Funding awarded

missing activity Principal Investigator 2023 - 2025
Role of Translesional Polymerases in Genome Diversification of the Malaria Parasite awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2019 - 2024

Selective Plasmodium proteasome inhibitors as novel multi-stage antimalarials awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2024 - 2029
Hijacking Plasmodium ubiquitin-proteasome system to defeat drug resistance awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2023 - 2028
missing activity Co-Investigator 2019 - 2025
missing activity Co-Investigator 2022 - 2024

Selective Plasmodium proteasome inhibitors as novel multi-stage antimalarials awarded by National Institute of Allergy & Infectious Diseases Co-Principal Investigator 2024 - 2029
Hijacking Plasmodium ubiquitin-proteasome system to defeat drug resistance awarded by National Institute of Allergy & Infectious Diseases Co-Principal Investigator 2023 - 2028

Hijacking Plasmodium ubiquitin-proteasome system to defeat drug resistance awarded by National Institute of Allergy & Infectious Diseases Key Personnel 2024 - 2028

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Background

education and training

M.D., Albert Einstein College of Medicine of Yeshiva University 2001
B.A., Swarthmore College 1993

Contact

full name

Laura Kirkman

primary email

lak9015@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Laura Kirkman Associate Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage