Park, Laibaik

Publications

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selected publications

A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury. Nature neuroscience. 2024 Academic Article GET IT
Correction: Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress. 2024 GET IT
tPA supplementation preserves neurovascular and cognitive function in Tg2576 mice. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024 Academic Article GET IT
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension. Nature neuroscience. 2023 Academic Article GET IT
Hippocampal glial inflammatory markers are differentially altered in a novel mouse model of perimenopausal cerebral amyloid angiopathy. Frontiers in aging neuroscience. 2023 Academic Article GET IT
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress. Molecular neurodegeneration. 2023 Academic Article GET IT
Hypoxia Inducible Factor-1α binds and activates γ-secretase for Aβ production under hypoxia and cerebral hypoperfusion. Molecular psychiatry. 2022 Academic Article GET IT
Causes and consequences of baseline cerebral blood flow reductions in Alzheimer's disease. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 Information Resource GET IT
Times cited: 58
tPA Deficiency Underlies Neurovascular Coupling Dysfunction by Amyloid-β. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2020 Academic Article GET IT
Times cited: 34
Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration. Nature neuroscience. 2020 Academic Article GET IT
Times cited: 71
Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models. Nature neuroscience. 2019 Academic Article GET IT
Times cited: 303
Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function. Nature communications. 2018 Academic Article GET IT
Times cited: 106
Brain perivascular macrophages: characterization and functional roles in health and disease. Journal of molecular medicine (Berlin, Germany). 2017 Information Resource GET IT
Times cited: 146
Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides. Circulation research. 2017 Academic Article GET IT
Times cited: 165
Does Checklist Implementation Improve Quantity of Data Transfer: An Observation in Postanesthesia Care Unit (PACU). Open Journal of Anesthesiology. 2017 Academic Article GET IT
Obligatory Role of EP1 Receptors in the Increase in Cerebral Blood Flow Produced by Hypercapnia in the Mice. PloS one. 2016 Academic Article GET IT
Times cited: 6
Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Academic Article GET IT
Times cited: 131
Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations. Cellular and molecular neurobiology. 2015 Information Resource GET IT
Times cited: 91
The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction. Nature communications. 2014 Academic Article GET IT
Times cited: 106
Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy. Stroke. 2014 Academic Article GET IT
Times cited: 93
Prohibitin viral gene transfer protects hippocampal CA1 neurons from ischemia and ameliorates postischemic hippocampal dysfunction. Stroke. 2014 Academic Article GET IT
Times cited: 30
Water deprivation induces neurovascular and cognitive dysfunction through vasopressin-induced oxidative stress. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2014 Academic Article GET IT
Times cited: 47
Innate immunity receptor CD36 promotes cerebral amyloid angiopathy. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 108
Brain and circulating levels of Aβ1-40 differentially contribute to vasomotor dysfunction in the mouse brain. Stroke. 2012 Academic Article GET IT
Times cited: 50
Angiotensin II type 2 receptor-coupled nitric oxide production modulates free radical availability and voltage-gated Ca2+ currents in NTS neurons. American journal of physiology. Regulatory, integrative and comparative physiology. 2012 Academic Article GET IT
Times cited: 24
Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 135
The cerebrovascular dysfunction induced by slow pressor doses of angiotensin II precedes the development of hypertension. American journal of physiology. Heart and circulatory physiology. 2010 Academic Article GET IT
Times cited: 100
Chronic intermittent hypoxia induces NMDA receptor-dependent plasticity and suppresses nitric oxide signaling in the mouse hypothalamic paraventricular nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Academic Article GET IT
Times cited: 61
Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 278
Key role of tissue plasminogen activator in neurovascular coupling. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 82
Neurovascular protection by ischemic tolerance: role of nitric oxide and reactive oxygen species. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 Academic Article GET IT
Times cited: 124
Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2007 Academic Article GET IT
Times cited: 195
Cerebrovascular nitrosative stress mediates neurovascular and endothelial dysfunction induced by angiotensin II. Arteriosclerosis, thrombosis, and vascular biology. 2006 Academic Article GET IT
Times cited: 106
Angiotensin II attenuates endothelium-dependent responses in the cerebral microcirculation through nox-2-derived radicals. Arteriosclerosis, thrombosis, and vascular biology. 2006 Academic Article GET IT
Times cited: 118
Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity. Nature medicine. 2006 Academic Article GET IT
Times cited: 313
The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Academic Article GET IT
Times cited: 187
NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Academic Article GET IT
Times cited: 219
Exogenous NADPH increases cerebral blood flow through NADPH oxidase-dependent and -independent mechanisms. Arteriosclerosis, thrombosis, and vascular biology. 2004 Academic Article GET IT
Times cited: 50
Abeta-induced vascular oxidative stress and attenuation of functional hyperemia in mouse somatosensory cortex. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2004 Academic Article GET IT
Times cited: 109
Phosphoramidon-sensitive endothelin-converting enzymes modulate cerebral blood flow and neural damage of hypoxic rats. Neuroscience letters. 2001 Academic Article GET IT
Times cited: 6
Hypoxic modulation of striatal lesions induced by administration of endothelin-1. Brain research. 2000 Academic Article GET IT
Times cited: 4

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Research

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Funding awarded

tPA and cerebrovascular regulation in a model of ß-amyloid pathology awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2023 - 2028

Alzheimer Pathology and Neurovascular Dysfunction awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2023 - 2027
ApoE4, neurovascular injury and cognitive impairment awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2022 - 2027

missing activity Principal Investigator Subaward 2021 - 2024

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Background

education and training

Ph.D., University of Saskatchewan (Canada) 2002
M.Sc., Chosun University (Korea) 1989
B.Sc., Chosun University (Korea) 1987

Contact

full name

Laibaik Park

primary email

lap2003@med.cornell.edu

VIVO Weill Cornell Medical College

Laibaik Park Associate Professor of Research in Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email