Greenblatt, Matthew Blake

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selected publications

A Murine Model of Non-Wear-Particle-Induced Aseptic Loosening. Biomimetics (Basel, Switzerland). 2024 Academic Article GET IT
Itm2a expression marks periosteal skeletal stem cells that contribute to bone fracture healing. The Journal of clinical investigation. 2024 Academic Article GET IT
Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta. Bone research. 2024 Academic Article GET IT
Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion. Nature communications. 2024 Academic Article GET IT
Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor. Nature biomedical engineering. 2024 Academic Article GET IT
A translational murine model of aseptic loosening with osseointegration failure. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2024 Academic Article GET IT
Differential Gene Expression Involved in Bone Turnover of Mice Expressing Constitutively Active TGFβ Receptor Type I. International journal of molecular sciences. 2024 Academic Article GET IT
Schnurri-3 controls osteogenic fate of Adipoq-lineage progenitors in bone marrow. Journal of orthopaedic translation. 2024 Academic Article GET IT
Characterization of the Nucleus Pulposus Progenitor Cells via Spatial Transcriptomics. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024 Academic Article GET IT
Capacity for large language model chatbots to aid in orthopedic management, research, and patient queries. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2024 Academic Article GET IT
Development of Murine Anterior Interbody and Posterolateral Spinal Fusion Techniques. The Journal of bone and joint surgery. American volume. 2024 Academic Article GET IT
Distinct mesenchymal cell states mediate prostate cancer progression. Nature communications. 2024 Academic Article GET IT
The performance of artificial intelligence chatbot large language models to address skeletal biology and bone health queries. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2024 Academic Article GET IT
Lipopolysaccharide Impedes Bone Repair in FcγRIIB-Deficient Mice. International journal of molecular sciences. 2023 Academic Article GET IT
Sfrp4 is required to maintain Ctsk-lineage periosteal stem cell niche function. Proceedings of the National Academy of Sciences of the United States of America. 2023 Academic Article GET IT
Inducing Angiogenesis in the Nucleus Pulposus. Cells. 2023 Academic Article GET IT
A multi-stem cell basis for craniosynostosis and calvarial mineralization. Nature. 2023 Academic Article GET IT
A vertebral skeletal stem cell lineage driving metastasis. Nature. 2023 Academic Article GET IT
Times cited: 4
Accelerated Bone Loss in Transgenic Mice Expressing Constitutively Active TGF-β Receptor Type I. International journal of molecular sciences. 2023 Academic Article GET IT
Times cited: 3
Prevalence of Helicobacter pylori Infection in Bariatric Surgery Patients. Obesity surgery. 2023 Academic Article GET IT
Times cited: 277
An angiogenic approach to osteoanabolic therapy targeting the SHN3-SLIT3 pathway. Bone. 2023 Review GET IT
P-selectin-targeted nanocarriers induce active crossing of the blood-brain barrier via caveolin-1-dependent transcytosis. Nature materials. 2023 Academic Article GET IT
Times cited: 77
Gene Therapy to Treat Osteopenia Associated With Chronic Ethanol Consumption and Aldehyde Dehydrogenase 2 Deficiency. JBMR plus. 2023 Academic Article GET IT
Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass. eLife. 2023 Academic Article GET IT
Skeletal stem cells: origins, definitions, and functions in bone development and disease. Life medicine. 2022 Review GET IT
Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration. Nature communications. 2022 Academic Article GET IT
WNT-modulating gene silencers as a gene therapy for osteoporosis, bone fracture, and critical-sized bone defects. Molecular therapy : the journal of the American Society of Gene Therapy. 2022 Academic Article GET IT
The crosstalk between MYC and mTORC1 during osteoclastogenesis. Frontiers in cell and developmental biology. 2022 Academic Article GET IT
Biphasic regulation of osteoblast development via the ERK MAPK-mTOR pathway. eLife. 2022 Academic Article GET IT
TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis. Nature communications. 2022 Academic Article GET IT
High phosphate intake induces bone loss in nephrectomized thalassemic mice. PloS one. 2022 Academic Article GET IT
Intermittent parathyroid hormone increases stability and improves osseointegration of initially unstable implants. Bone & joint research. 2022 Academic Article GET IT
Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes. Cell death and differentiation. 2022 Academic Article GET IT
The QChip1 knowledgebase and microarray for precision medicine in Qatar. NPJ genomic medicine. 2022 Academic Article GET IT
A Subset of Osteosarcoma Bears Markers of CXCL12-Abundant Reticular Cells. JBMR plus. 2022 Academic Article GET IT
A Potassium-Based Quality-of-Service Metric Reduces Phlebotomy Errors, Resulting in Improved Patient Safety and Decreased Cost. American journal of clinical pathology. 2021 Academic Article GET IT
Identification of candidate regulators of mandibular bone loss in FcγRIIB^-/- Mice. Scientific reports. 2021 Academic Article GET IT
RNA-seq Analysis of Peri-Implant Tissue Shows Differences in Immune, Notch, Wnt, and Angiogenesis Pathways in Aged Versus Young Mice. JBMR plus. 2021 Academic Article GET IT
A stem-cell basis for skeletal ageing. Nature. 2021 Article GET IT
SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts. Nature communications. 2021 Academic Article GET IT
Inhibition of PAD4 mediated neutrophil extracellular traps prevents fibrotic osseointegration failure in a tibial implant murine model : an animal study. The bone & joint journal. 2021 Academic Article GET IT
H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair. Bone research. 2021 Academic Article GET IT
Times cited: 20
Etanercept prevents TNF-α mediated mandibular bone loss in FcγRIIb-/- lupus model. PloS one. 2021 Academic Article GET IT
Specimen Preparation for Single-Cell Sequencing Analysis of Skeletal Cells. Methods in molecular biology (Clifton, N.J.). 2021 Article GET IT
Times cited: 1
Def6 regulates endogenous type-I interferon responses in osteoblasts and suppresses osteogenesis. eLife. 2020 Academic Article GET IT
Times cited: 12
MEKK2 mediates aberrant ERK activation in neurofibromatosis type I. Nature communications. 2020 Academic Article GET IT
Times cited: 15
Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing. Science advances. 2020 Academic Article GET IT
Times cited: 20
Alendronate enhances osseointegration in a murine implant model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2020 Academic Article GET IT
Times cited: 3
Osteoblast-Osteoclast Communication and Bone Homeostasis. Cells. 2020 Information Resource GET IT
Times cited: 647
TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization. Biochemical and biophysical research communications. 2020 Academic Article GET IT
Times cited: 20
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation. Nature communications. 2020 Academic Article GET IT
Times cited: 64
Osteoclasts are not a source of SLIT3. Bone research. 2020 Academic Article GET IT
Times cited: 26
Accelerated thrombin times are associated with thrombotic risk. American journal of hematology. 2020 Article GET IT
Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF. Nature communications. 2020 Academic Article GET IT
Times cited: 48
Systemic Adeno-Associated Virus-Mediated Gene Therapy Prevents the Multiorgan Disorders Associated with Aldehyde Dehydrogenase 2 Deficiency and Chronic Ethanol Ingestion. Human gene therapy. 2020 Academic Article GET IT
Times cited: 6
The Unmixing Problem: A Guide to Applying Single-Cell RNA Sequencing to Bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2019 Review GET IT
Times cited: 35
Vascular endothelial growth factor pathway promotes osseointegration and CD31^hiEMCN^hi endothelium expansion in a mouse tibial implant model: an animal study. The bone & joint journal. 2019 Academic Article GET IT
Times cited: 23
The Ca_V1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear. Bone. 2019 Academic Article GET IT
Times cited: 18
The ERK MAPK Pathway Is Essential for Skeletal Development and Homeostasis. International journal of molecular sciences. 2019 Academic Article GET IT
Times cited: 109
Bone protection by inhibition of microRNA-182. Nature communications. 2018 Academic Article GET IT
Times cited: 76
Discovery of a periosteal stem cell mediating intramembranous bone formation. Nature. 2018 Academic Article GET IT
Times cited: 442
Targeting skeletal endothelium to ameliorate bone loss. Nature medicine. 2018 Academic Article GET IT
Times cited: 248
Commentary. Clinical chemistry. 2018 Article GET IT
c-Jun N-Terminal Kinases (JNKs) Are Critical Mediators of Osteoblast Activity In Vivo. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017 Academic Article GET IT
Times cited: 41
SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Nature communications. 2017 Academic Article GET IT
Times cited: 62
Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis. Nature communications. 2016 Academic Article GET IT
Times cited: 41
Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease. Clinical chemistry. 2016 Information Resource GET IT
Times cited: 258
Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics. Arthritis & rheumatology (Hoboken, N.J.). 2016 Academic Article GET IT
Times cited: 35
MEKK2 mediates an alternative β-catenin pathway that promotes bone formation. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 43
CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts. The Journal of experimental medicine. 2015 Academic Article GET IT
Times cited: 55
p38α MAPK is required for tooth morphogenesis and enamel secretion. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 27
Use of potassium concentrations as a quality-of-service metric for phlebotomists detects systematic preanalytical biases and facilitates their correction. Clinical chemistry. 2014 Article GET IT
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. Nature. 2014 Academic Article GET IT
Times cited: 653
S6K1 negatively regulates TAK1 activity in the toll-like receptor signaling pathway. Molecular and cellular biology. 2013 Academic Article GET IT
Times cited: 37
NFATc1 and NFATc2 repress spontaneous osteoarthritis. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 61
Osteoimmunology: a brief introduction. Immune network. 2013 Information Resource GET IT
Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. The Journal of clinical investigation. 2013 Academic Article GET IT
Times cited: 53
The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2. The Journal of experimental medicine. 2013 Academic Article GET IT
Times cited: 51
Mitogen-activated protein kinase pathways in osteoblasts. Annual review of cell and developmental biology. 2013 Information Resource GET IT
Times cited: 155
Graft versus host disease in the bone marrow, liver and thymus humanized mouse model. PloS one. 2012 Academic Article GET IT
Times cited: 123
Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets. The American journal of pathology. 2012 Academic Article GET IT
Times cited: 71
Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice. The Journal of clinical investigation. 2011 Academic Article GET IT
Times cited: 18
MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. The Journal of clinical investigation. 2011 Academic Article GET IT
Times cited: 48
Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Molecular and cellular biology. 2011 Academic Article GET IT
Times cited: 35
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. The Journal of clinical investigation. 2010 Academic Article GET IT
Times cited: 342
Calcineurin regulates innate antifungal immunity in neutrophils. The Journal of experimental medicine. 2010 Academic Article GET IT
Times cited: 128
TAK1 is an essential regulator of BMP signalling in cartilage. The EMBO journal. 2009 Academic Article GET IT
Times cited: 118
A toll-like receptor that prevents infection by uropathogenic bacteria. Science (New York, N.Y.). 2004 Academic Article GET IT
Times cited: 848

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Research

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Funding awarded

Discovery of a stem cell governing vertebral physiology awarded by National Inst of Arthritis & Musculoskeletal & Skin Diseases Principal Investigator 2024 - 2029
Discovery of a stem cell driving breast cancer spine metastases awarded by National Cancer Institute Principal Investigator 2024 - 2029
A skeletal stem cell orchestrating limb regeneration awarded by National Institute of Child Health & Human Development Principal Investigator 2024 - 2029
Discovery of the articular cartilage stem cell awarded by The G. Harold and Leila Y. Mathers Foundation Principal Investigator 2024 - 2027
Skeletal Stem Cell Niche Dysfunction in Marfan Syndrome awarded by National Marfan Foundation Principal Investigator 2024 - 2026
A Bone to Brain Axis Controlling Alzheimer''s Disease Progression awarded by Pershing Square Foundation Principal Investigator 2023 - 2026
New Approaches to Target Vertebral Metastases in Breast Cancer awarded by Mary Kay Foundation, The Principal Investigator 2023 - 2025
Novartis BioPharma Alliance Agreemeent awarded by Novartis Insitutes for BioMedical Research Principal Investigator 2021 - 2025
"Establishing Pathways for Endothelial Support of Bone Formation with SLIT3" awarded by National Inst of Arthritis & Musculoskeletal & Skin Diseases Principal Investigator 2020 - 2025
A novel calvarial stem cell regulating glioblastoma anti-tumor immunity awarded by William Rhodes Center for Glioblastoma - Collaborative Research Initiative Principal Investigator 2023 - 2024
Novel Mechanisms of Bone Formation awarded by Burroughs Wellcome Fund Principal Investigator 2015 - 2023

Next-Gen Oncopathology Program awarded by National Cancer Institute Co-Investigator 2022 - 2027

Biology of cortical bone of long bones and calvarium: Role of Sfrp4 in periosteal bone formation awarded by National Institute of Dental & Craniofacial Research Principal Investigator Subaward 2020 - 2025
missing activity Principal Investigator Subaward 2021 - 2024
Tumor-Selective Delivery Approaches for Medulloblastoma awarded by Stand Up To Cancer Principal Investigator Subaward 2020 - 2024

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Background

education and training

M.D., Harvard Medical School 2012
Ph.D., Harvard Medical School 2010
B.S., M.S., Yale University 2004

Contact

full name

Matthew Blake Greenblatt

primary email

mag3003@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Matthew Blake Greenblatt Associate Professor of Pathology and Laboratory Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage