Goldring, Mary Brennan

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Identification of formulation parameters that affect the analgesic efficacy of ProGel-Dex - A thermoresponsive polymeric dexamethasone prodrug for chronic arthritis pain relief. Nanomedicine : nanotechnology, biology, and medicine. 2024 Academic Article GET IT
PTH treatment before cyclic joint loading improves cartilage health and attenuates load-induced osteoarthritis development in mice. Science advances. 2024 Academic Article GET IT
Thermoresponsive Polymeric Hydromorphone Prodrug Provides Sustained Local Analgesia without Apparent Adverse Effects. Molecular pharmaceutics. 2024 Academic Article GET IT
Single dose thermoresponsive dexamethasone prodrug completely mitigates joint pain for 15 weeks in a murine model of osteoarthritis. Nanomedicine : nanotechnology, biology, and medicine. 2024 Academic Article GET IT
Integrin-dependent recruitment of Src to ROS-producing endosomes in osteoarthritic cartilage. Science signaling. 2023 Academic Article GET IT
Macroscopic Synovial Inflammation Correlates with Symptoms and Cartilage Lesions in Patients Undergoing Arthroscopic Partial Meniscectomy: A Clinical Study. Journal of clinical medicine. 2022 Academic Article GET IT
Times cited: 12
Contribution of joint tissue properties to load-induced osteoarthritis. Bone reports. 2022 Academic Article GET IT
Do Synovial Inflammation and Meniscal Degeneration Impact Clinical Outcomes of Patients Undergoing Arthroscopic Partial Meniscectomy? A Histological Study. International journal of molecular sciences. 2022 Academic Article GET IT
Times cited: 9
Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis. Scientific reports. 2021 Academic Article GET IT
Thermoresponsive polymeric dexamethasone prodrug for arthritis pain. Journal of controlled release : official journal of the Controlled Release Society. 2021 Academic Article GET IT
Times cited: 30
Mouse Models of Osteoarthritis: Surgical Model of Post-traumatic Osteoarthritis Induced by Destabilization of the Medial Meniscus. Methods in molecular biology (Clifton, N.J.). 2021 Academic Article GET IT
Times cited: 8
LOXL2 promotes aggrecan and gender-specific anabolic differences to TMJ cartilage. Scientific reports. 2020 Academic Article GET IT
Times cited: 9
The integrative analysis of DNA methylation and mRNA expression profiles confirmed the role of selenocompound metabolism pathway in Kashin-Beck disease. Cell cycle (Georgetown, Tex.). 2020 Academic Article GET IT
Times cited: 5
Response to "Letter to the editor: Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement". Journal of orthopaedic surgery and research. 2020 Letter GET IT
Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement. Journal of orthopaedic surgery and research. 2020 Academic Article GET IT
Times cited: 14
Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice. International journal of molecular sciences. 2019 Academic Article GET IT
Times cited: 13
Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis. Scientific reports. 2019 Academic Article GET IT
Times cited: 16
Bystander effectors of chondrosarcoma cells irradiated at different LET impair proliferation of chondrocytes. Journal of cell communication and signaling. 2019 Academic Article GET IT
Times cited: 16
CITED2 mediates the cross-talk between mechanical loading and IL-4 to promote chondroprotection. Annals of the New York Academy of Sciences. 2019 Academic Article GET IT
Times cited: 20
CITED2 mediates the mechanical loading-induced suppression of adipokines in the infrapatellar fat pad. Annals of the New York Academy of Sciences. 2019 Academic Article GET IT
Times cited: 4
Morphological and ultrastructural analysis of normal, injured and osteoarthritic human knee menisci. European journal of histochemistry : EJH. 2019 Academic Article GET IT
Times cited: 43
Correction to: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model. 2019 GET IT
Times cited: 3
Inflammatory molecules produced by meniscus and synovium in early and end-stage osteoarthritis: a coculture study. Journal of cellular physiology. 2018 Academic Article GET IT
Times cited: 50
Individual and combined toxicity of T-2 toxin and deoxynivalenol on human C-28/I2 and rat primary chondrocytes. Journal of applied toxicology : JAT. 2018 Academic Article GET IT
Times cited: 8
Evaluation of surfactant proteins A, B, C, and D in articular cartilage, synovial membrane and synovial fluid of healthy as well as patients with osteoarthritis and rheumatoid arthritis. PloS one. 2018 Academic Article GET IT
Times cited: 5
Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy. Annals of the New York Academy of Sciences. 2018 Information Resource GET IT
Times cited: 45
Elf3 Contributes to Cartilage Degradation in vivo in a Surgical Model of Post-Traumatic Osteoarthritis. Scientific reports. 2018 Academic Article GET IT
Times cited: 23
E74-Like Factor (ELF3) and Leptin, a Novel Loop Between Obesity and Inflammation Perpetuating a Pro-Catabolic State in Cartilage. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018 Academic Article GET IT
Times cited: 8
Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2017 Academic Article GET IT
Times cited: 22
Collagen XI mutation lowers susceptibility to load-induced cartilage damage in mice. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2017 Academic Article GET IT
Times cited: 11
LOXL2 as a protective in osteoarthritis cartilage. Aging. 2017 Academic Article GET IT
Times cited: 6
Role of subchondral bone properties and changes in development of load-induced osteoarthritis in mice. Osteoarthritis and cartilage. 2017 Academic Article GET IT
Times cited: 43
Is arthroscopic videotape a reliable tool for describing early joint tissue pathology of the knee?. The Knee. 2017 Academic Article GET IT
Times cited: 11
Selenium promotes metabolic conversion of T-2 toxin to HT-2 toxin in cultured human chondrocytes. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2017 Academic Article GET IT
Times cited: 11
DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes. Scientific reports. 2017 Academic Article GET IT
Times cited: 51
Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis. Arthritis research & therapy. 2017 Academic Article GET IT
Times cited: 35
Cellular responses to T-2 toxin and/or deoxynivalenol that induce cartilage damage are not specific to chondrocytes. Scientific reports. 2017 Academic Article GET IT
Times cited: 44
Mitochondrial DNA haplogroups and ageing mechanisms in osteoarthritis. Annals of the rheumatic diseases. 2017 Editorial Article GET IT
Times cited: 9
Osteoarthritis. Nature reviews. Disease primers. 2016 Review GET IT
Times cited: 969
Kinematics of meniscal- and ACL-transected mouse knees during controlled tibial compressive loading captured using roentgen stereophotogrammetry. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2016 Academic Article GET IT
Times cited: 13
Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk. Nature reviews. Rheumatology. 2016 Review GET IT
Times cited: 536
E74-like factor 3 and nuclear factor-κB regulate lipocalin-2 expression in chondrocytes. The Journal of physiology. 2016 Academic Article GET IT
Times cited: 19
ELF3 modulates type II collagen gene (COL2A1) transcription in chondrocytes by inhibiting SOX9-CBP/p300-driven histone acetyltransferase activity. Connective tissue research. 2016 Academic Article GET IT
Times cited: 37
Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2016 Academic Article GET IT
Times cited: 15
Progressive cell-mediated changes in articular cartilage and bone in mice are initiated by a single session of controlled cyclic compressive loading. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2016 Academic Article GET IT
Times cited: 33
CCAAT/enhancer binding protein β (C/EBPβ) regulates the transcription of growth arrest and DNA damage-inducible protein 45 β (GADD45β) in articular chondrocytes. Pathology, research and practice. 2016 Academic Article GET IT
Times cited: 1
Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis. Osteoarthritis and cartilage. 2015 Academic Article GET IT
Times cited: 38
Strain-induced mechanotransduction through primary cilia, extracellular ATP, purinergic calcium signaling, and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes. Osteoarthritis and cartilage. 2015 Academic Article GET IT
Times cited: 53
Laminins and Nidogens in the Pericellular Matrix of Chondrocytes: Their Role in Osteoarthritis and Chondrogenic Differentiation. The American journal of pathology. 2015 Academic Article GET IT
Times cited: 33
Early knee osteoarthritis. RMD open. 2015 Review GET IT
Times cited: 108
Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation. RMD open. 2015 Information Resource GET IT
Times cited: 105
Tribute to Stephen M. Krane. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2015 Academic Article GET IT
Times cited: 1
Emerging targets in osteoarthritis therapy. Current opinion in pharmacology. 2015 Review GET IT
Times cited: 137
Mouse models of osteoarthritis: surgical model of posttraumatic osteoarthritis induced by destabilization of the medial meniscus. Methods in molecular biology (Clifton, N.J.). 2015 Academic Article GET IT
Times cited: 14
PTEN ELEVATION, AUTOPHAGY AND METABOLIC REPROGRAMMING MAY BE INDUCED IN HUMAN CHONDROCYTES DURING STEROIDS OR NUTRIENT DEPLETION AND OSTEOARTHRITIS. Journal of biological regulators and homeostatic agents. 2015 Academic Article GET IT
Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model. Arthritis research & therapy. 2014 Academic Article GET IT
Times cited: 77
Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation. Arthritis & rheumatology (Hoboken, N.J.). 2014 Academic Article GET IT
Times cited: 73
Mechanical forces induce changes in VEGF and VEGFR-1/sFlt-1 expression in human chondrocytes. International journal of molecular sciences. 2014 Academic Article GET IT
Times cited: 40
Identification of α2-macroglobulin as a master inhibitor of cartilage-degrading factors that attenuates the progression of posttraumatic osteoarthritis. Arthritis & rheumatology (Hoboken, N.J.). 2014 Academic Article GET IT
Times cited: 77
A hyaluronic acid-salmon calcitonin conjugate for the local treatment of osteoarthritis: chondro-protective effect in a rabbit model of early OA. Journal of controlled release : official journal of the Controlled Release Society. 2014 Academic Article GET IT
Times cited: 46
Biochemical evidence for gap junctions and Cx43 expression in immortalized human chondrocyte cell line: a potential model in the study of cell communication in human chondrocytes. Osteoarthritis and cartilage. 2014 Academic Article GET IT
Times cited: 15
Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis. Current rheumatology reports. 2013 Review GET IT
Times cited: 265
Lack of ADAM10 in endothelial cells affects osteoclasts at the chondro-osseus junction. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2013 Academic Article GET IT
Times cited: 11
IKKα/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation. PloS one. 2013 Academic Article GET IT
Times cited: 38
Oxidative stress and status of antioxidant enzymes in children with Kashin-Beck disease. Osteoarthritis and cartilage. 2013 Academic Article GET IT
Times cited: 45
ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes. Molecular and cellular biology. 2013 Academic Article GET IT
Times cited: 48
In vivo cyclic compression causes cartilage degeneration and subchondral bone changes in mouse tibiae. Arthritis and rheumatism. 2013 Academic Article GET IT
Times cited: 138
Pulsed electromagnetic fields increased the anti-inflammatory effect of A₂A and A₃ adenosine receptors in human T/C-28a2 chondrocytes and hFOB 1.19 osteoblasts. PloS one. 2013 Academic Article GET IT
Times cited: 117
Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues. Arthritis and rheumatism. 2013 Academic Article GET IT
Times cited: 123
Insight into the function of DIO2, a susceptibility gene in human osteoarthritis, as an inducer of cartilage damage in a rat model: is there a role for chondrocyte hypertrophy?. Osteoarthritis and cartilage. 2013 Editorial Article GET IT
Times cited: 11
Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes. Arthritis and rheumatism. 2013 Academic Article GET IT
Times cited: 88
Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 129
The proinflammatory cytokines interleukin-1α and tumor necrosis factor α promote the expression and secretion of proteolytically active cathepsin S from human chondrocytes. Biological chemistry. 2013 Academic Article GET IT
Times cited: 27
A misplaced lncRNA causes brachydactyly in humans. The Journal of clinical investigation. 2012 Academic Article GET IT
Times cited: 102
Do mouse models reflect the diversity of osteoarthritis in humans?. Arthritis and rheumatism. 2012 Editorial Article GET IT
Times cited: 1
Matrilin-3 induction of IL-1 receptor antagonist is required for up-regulating collagen II and aggrecan and down-regulating ADAMTS-5 gene expression. Arthritis research & therapy. 2012 Academic Article GET IT
Times cited: 34
Association of joint space narrowing with impairment of physical function and work ability in patients with early rheumatoid arthritis: protection beyond disease control by adalimumab plus methotrexate. Annals of the rheumatic diseases. 2012 Academic Article GET IT
Times cited: 55
Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis. Therapeutic advances in musculoskeletal disease. 2012 Academic Article GET IT
Times cited: 342
Dual regulation of metalloproteinase expression in chondrocytes by Wnt-1-inducible signaling pathway protein 3/CCN6. Arthritis and rheumatism. 2012 Academic Article GET IT
Times cited: 29
Osteoarthritis: a disease of the joint as an organ. Arthritis and rheumatism. 2012 Review GET IT
Times cited: 2111
Articular cartilage degradation in osteoarthritis. HSS journal : the musculoskeletal journal of Hospital for Special Surgery. 2012 Academic Article GET IT
Times cited: 110
Human chondrocyte cultures as models of cartilage-specific gene regulation. Methods in molecular biology (Clifton, N.J.). 2012 Academic Article GET IT
Times cited: 30
Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis. Trends in molecular medicine. 2011 Review GET IT
Times cited: 143
E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 66
Anti-inflammatory activity of an ethanolic Caesalpinia sappan extract in human chondrocytes and macrophages. Journal of ethnopharmacology. 2011 Academic Article GET IT
Times cited: 73
High density micromass cultures of a human chondrocyte cell line: a reliable assay system to reveal the modulatory functions of pharmacological agents. Biochemical pharmacology. 2011 Academic Article GET IT
Times cited: 51
Inflammation in osteoarthritis. Current opinion in rheumatology. 2011 Information Resource GET IT
Times cited: 1103
Intact pericellular matrix of articular cartilage is required for unactivated discoidin domain receptor 2 in the mouse model. The American journal of pathology. 2011 Academic Article GET IT
Times cited: 45
Caesalpinia sappan extract inhibits IL1β-mediated overexpression of matrix metalloproteinases in human chondrocytes. Genes & nutrition. 2011 Academic Article GET IT
Times cited: 48
Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. European cells & materials. 2011 Academic Article GET IT
Times cited: 384
Senescence of chondrocytes in aging articular cartilage: GADD45β mediates p21 expression in association with C/EBPβ in senescence-accelerated mice. Pathology, research and practice. 2011 Academic Article GET IT
Times cited: 27
Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis. Biochemical and biophysical research communications. 2011 Academic Article GET IT
Times cited: 58
The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes--implications for osteoarthritis. Biochemical and biophysical research communications. 2011 Academic Article GET IT
Times cited: 99
Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis. PloS one. 2010 Academic Article GET IT
Times cited: 39
Lentiviral shRNA knock-down of ADAMTS-5 and -9 restores matrix deposition in 3D chondrocyte culture. Journal of tissue engineering and regenerative medicine. 2010 Academic Article GET IT
Times cited: 10
C-28/I2 and T/C-28a2 chondrocytes as well as human primary articular chondrocytes express sex hormone and insulin receptors--Useful cells in study of cartilage metabolism. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2010 Academic Article GET IT
Times cited: 38
Bone and cartilage in osteoarthritis: is what's best for one good or bad for the other?. Arthritis research & therapy. 2010 Editorial Article GET IT
Times cited: 42
Endoglin differentially regulates TGF-β-induced Smad2/3 and Smad1/5 signalling and its expression correlates with extracellular matrix production and cellular differentiation state in human chondrocytes. Osteoarthritis and cartilage. 2010 Academic Article GET IT
Times cited: 76
Physiological loading of joints prevents cartilage degradation through CITED2. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010 Academic Article GET IT
Times cited: 70
NF-kappaB signaling: multiple angles to target OA. Current drug targets. 2010 Information Resource GET IT
Times cited: 502
Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. Annals of the New York Academy of Sciences. 2010 Review GET IT
Times cited: 632
Trefoil factor 3 is induced during degenerative and inflammatory joint disease, activates matrix metalloproteinases, and enhances apoptosis of articular cartilage chondrocytes. Arthritis and rheumatism. 2010 Academic Article GET IT
Times cited: 40
GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 41
A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;p11.2) and leads to Brachydactyly Type E. Human molecular genetics. 2009 Academic Article GET IT
Times cited: 65
DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes. Arthritis and rheumatism. 2009 Academic Article GET IT
Times cited: 142
Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes. Biochemical pharmacology. 2009 Academic Article GET IT
Times cited: 53
Phenotype-related differential alpha-2,6- or alpha-2,3-sialylation of glycoprotein N-glycans in human chondrocytes. Osteoarthritis and cartilage. 2009 Academic Article GET IT
Times cited: 42
The link between structural damage and pain in a genetic model of osteoarthritis and intervertebral disc degeneration: a joint misadventure. Arthritis and rheumatism. 2009 Editorial Article GET IT
Times cited: 7
Characterization and regulation of ADAMTS-16. Matrix biology : journal of the International Society for Matrix Biology. 2009 Academic Article GET IT
Times cited: 29
Chondrogenesis, joint formation, and articular cartilage regeneration. Journal of cellular biochemistry. 2009 Review GET IT
Times cited: 73
Cartilage homeostasis in health and rheumatic diseases. Arthritis research & therapy. 2009 Review GET IT
Times cited: 586
The effect of paraformaldehyde fixation on the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) measurement. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2009 Academic Article GET IT
Times cited: 5
Lectin binding patterns reflect the phenotypic status of in vitro chondrocyte models. In vitro cellular & developmental biology. Animal. 2009 Academic Article GET IT
Times cited: 13
Involvement of p38 MAPK in regulation of MMP13 mRNA in chondrocytes in response to surviving stress to endoplasmic reticulum. Archives of oral biology. 2008 Academic Article GET IT
Times cited: 50
Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. Arthritis and rheumatism. 2008 Academic Article GET IT
Times cited: 87
Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. Osteoarthritis and cartilage. 2008 Academic Article GET IT
Times cited: 119
ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes. Journal of cellular physiology. 2008 Academic Article GET IT
Times cited: 50
Dual proline labeling protocol for individual "baseline" and "response" biosynthesis measurements in human articular cartilage. Osteoarthritis and cartilage. 2008 Academic Article GET IT
Times cited: 4
Comparison between chondroprotective effects of glucosamine, curcumin, and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes. Osteoarthritis and cartilage. 2008 Academic Article GET IT
Times cited: 57
The development of anticytokine therapeutics for rheumatic diseases. Arthritis and rheumatism. 2008 Academic Article GET IT
Times cited: 5
Osteoarthritis. Journal of cellular physiology. 2007 Review GET IT
Times cited: 1070
Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis. Arthritis and rheumatism. 2007 Academic Article GET IT
Times cited: 104
Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2007 Academic Article GET IT
Times cited: 35
Evidence for JNK-dependent up-regulation of proteoglycan synthesis and for activation of JNK1 following cyclical mechanical stimulation in a human chondrocyte culture model. Osteoarthritis and cartilage. 2007 Academic Article GET IT
Times cited: 38
Selection of reliable reference genes for qPCR studies on chondroprotective action. BMC molecular biology. 2007 Academic Article GET IT
Times cited: 57
Eating bone or adding it: the Wnt pathway decides. Nature medicine. 2007 Comment GET IT
Times cited: 118
Cells of the synovium in rheumatoid arthritis. Chondrocytes. Arthritis research & therapy. 2007 Information Resource GET IT
Times cited: 100
TLR-2-mediated induction of vascular endothelial growth factor (VEGF) in cartilage in septic joint disease. The Journal of pathology. 2006 Academic Article GET IT
Times cited: 36
Lectin binding studies on C-28/I2 and T/C-28a2 chondrocytes provide a basis for new tissue engineering and drug delivery perspectives in cartilage research. Journal of controlled release : official journal of the Controlled Release Society. 2006 Academic Article GET IT
Times cited: 18
Update on the biology of the chondrocyte and new approaches to treating cartilage diseases. Best practice & research. Clinical rheumatology. 2006 Review GET IT
Times cited: 247
Effects of pleiotrophin, a heparin-binding growth factor, on human primary and immortalized chondrocytes. Osteoarthritis and cartilage. 2006 Academic Article GET IT
Times cited: 33
Expression and regulation of human beta-defensin-2 in osteoarthritic cartilage. The Journal of pathology. 2006 Academic Article GET IT
Times cited: 35
Are bone morphogenetic proteins effective inducers of cartilage repair? Ex vivo transduction of muscle-derived stem cells. Arthritis and rheumatism. 2006 Editorial Article GET IT
Times cited: 14
Clinical aspects, pathology and pathophysiology of osteoarthritis. Journal of musculoskeletal & neuronal interactions. 2006 Review GET IT
Times cited: 150
Polyamine depletion inhibits apoptosis following blocking of survival pathways in human chondrocytes stimulated by tumor necrosis factor-alpha. Journal of cellular physiology. 2006 Academic Article GET IT
Times cited: 33
Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants. Arthritis research & therapy. 2006 Academic Article GET IT
Times cited: 76
The control of chondrogenesis. Journal of cellular biochemistry. 2006 Review GET IT
Times cited: 867
Adeno-associated vector mediated gene transfer of transforming growth factor-beta1 to normal and osteoarthritic human chondrocytes stimulates cartilage anabolism. European cells & materials. 2005 Academic Article GET IT
Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes. Mediators of inflammation. 2005 Academic Article GET IT
Times cited: 55
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 122
A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 90
Polyamine depletion inhibits NF-kappaB binding to DNA and interleukin-8 production in human chondrocytes stimulated by tumor necrosis factor-alpha. Journal of cellular physiology. 2005 Academic Article GET IT
Times cited: 20
Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 120
Divergent stress responses to IL-1beta, nitric oxide, and tunicamycin by chondrocytes. Journal of cellular physiology. 2005 Academic Article GET IT
Times cited: 51
Human beta-defensin 3 mediates tissue remodeling processes in articular cartilage by increasing levels of metalloproteinases and reducing levels of their endogenous inhibitors. Arthritis and rheumatism. 2005 Academic Article GET IT
Times cited: 70
The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes. The FEBS journal. 2005 Academic Article GET IT
Times cited: 55
Human chondrocyte cultures as models of cartilage-specific gene regulation. Methods in molecular medicine. 2005 Academic Article GET IT
Times cited: 34
The endogenous growth hormone secretagogue (ghrelin) is synthesized and secreted by chondrocytes. Endocrinology. 2004 Academic Article GET IT
Times cited: 85
Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality. Annals of the rheumatic diseases. 2004 Academic Article GET IT
Times cited: 14
Production of endogenous antibiotics in articular cartilage. Arthritis and rheumatism. 2004 Academic Article GET IT
Times cited: 38
Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 158
The regulation of chondrocyte function by proinflammatory mediators: prostaglandins and nitric oxide. Clinical orthopaedics and related research. 2004 Review GET IT
Times cited: 217
The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clinical orthopaedics and related research. 2004 Review GET IT
Times cited: 559
NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 140
Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways. Arthritis and rheumatism. 2004 Academic Article GET IT
Times cited: 121
Endostatin/collagen XVIII--an inhibitor of angiogenesis--is expressed in cartilage and fibrocartilage. Matrix biology : journal of the International Society for Matrix Biology. 2004 Academic Article GET IT
Times cited: 88
VEGF expression in adult permanent thyroid cartilage: implications for lack of cartilage ossification. Bone. 2004 Academic Article GET IT
Times cited: 24
Vascular endothelial growth factor (VEGF) induces matrix metalloproteinase expression in immortalized chondrocytes. The Journal of pathology. 2004 Academic Article GET IT
Times cited: 150
WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes. Arthritis and rheumatism. 2004 Academic Article GET IT
Times cited: 70
ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 53
Culture of immortalized chondrocytes and their use as models of chondrocyte function. Methods in molecular medicine. 2004 Academic Article GET IT
Times cited: 33
Immortalization of human articular chondrocytes for generation of stable, differentiated cell lines. Methods in molecular medicine. 2004 Academic Article GET IT
Times cited: 27
Phenotypic characterization of human chondrocyte cell line C-20/A4: a comparison between monolayer and alginate suspension culture. Cells, tissues, organs. 2004 Academic Article GET IT
Times cited: 23
Impairment of the collagenase-3 endocytotic receptor system in cells from patients with osteoarthritis. Osteoarthritis and cartilage. 2003 Academic Article GET IT
Times cited: 17
Molecular phenotyping of human chondrocyte cell lines T/C-28a2, T/C-28a4, and C-28/I2. Arthritis and rheumatism. 2003 Academic Article GET IT
Times cited: 100
CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 113
Exploring the role of 5' alternative splicing and of the 3'-untranslated region of cathepsin B mRNA. Biological chemistry. 2003 Academic Article GET IT
Times cited: 27
Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1. Arthritis and rheumatism. 2003 Academic Article GET IT
Times cited: 91
Egr-1 mediates transcriptional repression of COL2A1 promoter activity by interleukin-1beta. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 114
Angiopoietin-1 is expressed in the synovium of patients with rheumatoid arthritis and is induced by tumour necrosis factor alpha. Annals of the rheumatic diseases. 2003 Academic Article GET IT
Times cited: 86
Endoglin is expressed on human chondrocytes and forms a heteromeric complex with betaglycan in a ligand and type II TGFbeta receptor independent manner. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2003 Academic Article GET IT
Times cited: 39
The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas. Cancer research. 2003 Academic Article GET IT
Times cited: 41
The TATA-containing core promoter of the type II collagen gene (COL2A1) is the target of interferon-gamma-mediated inhibition in human chondrocytes: requirement for Stat1 alpha, Jak1 and Jak2. The Biochemical journal. 2003 Academic Article GET IT
Times cited: 42
Molecular regulation of the chondrocyte phenotype. Journal of musculoskeletal & neuronal interactions. 2002 Academic Article GET IT
Cathepsin B expression and down-regulation by gene silencing and antisense DNA in human chondrocytes. The Biochemical journal. 2002 Academic Article GET IT
Times cited: 29
T cell-specific expression of the murine CD3delta promoter. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 22
Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes. Arthritis and rheumatism. 2002 Academic Article GET IT
Times cited: 34
Production of interleukin-1 receptor antagonist by human articular chondrocytes. Arthritis research. 2002 Academic Article GET IT
Times cited: 43
Differentiation regulates interleukin-1beta-induced cyclo-oxygenase-2 in human articular chondrocytes: role of p38 mitogen-activated protein kinase. The Biochemical journal. 2002 Academic Article GET IT
Times cited: 71
The effects of pressure on chondrocyte tumour necrosis factor receptor expression. Biorheology. 2002 Academic Article GET IT
Times cited: 15
Anticytokine therapy for osteoarthritis. Expert opinion on biological therapy. 2001 Review GET IT
Times cited: 125
YY1 is a positive regulator of transcription of the Col1a1 gene. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 38
Expression of frizzled genes in mouse costochondral chondrocytes. Matrix biology : journal of the International Society for Matrix Biology. 2001 Academic Article GET IT
Times cited: 9
Reversal of autocrine and paracrine effects of interleukin 1 (IL-1) in human arthritis by type II IL-1 decoy receptor. Potential for pharmacological intervention. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 112
Osteoarthritis and cartilage: the role of cytokines. Current rheumatology reports. 2000 Review GET IT
Times cited: 385
Proteoglycan production by immortalized human chondrocyte cell lines cultured under conditions that promote expression of the differentiated phenotype. Archives of biochemistry and biophysics. 2000 Academic Article GET IT
Times cited: 51
Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-1beta. Arthritis and rheumatism. 2000 Academic Article GET IT
Times cited: 108
The role of the chondrocyte in osteoarthritis. Arthritis and rheumatism. 2000 Review GET IT
Times cited: 645
Suppression of type I collagen gene expression by prostaglandins in fibroblasts is mediated at the transcriptional level. Molecular medicine (Cambridge, Mass.). 2000 Academic Article GET IT
Times cited: 48
Differential effects of IGF-binding proteins, IGFBP-3 and IGFBP-5, on IGF-I action and binding to cell membranes of immortalized human chondrocytes. The Journal of endocrinology. 2000 Academic Article GET IT
Times cited: 30
Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2000 Academic Article GET IT
Times cited: 80
Integrin expression by primary and immortalized human chondrocytes: evidence of a differential role for alpha1beta1 and alpha2beta1 integrins in mediating chondrocyte adhesion to types II and VI collagen. Osteoarthritis and cartilage. 2000 Academic Article GET IT
Times cited: 163
Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes. Arthritis and rheumatism. 1999 Academic Article GET IT
Times cited: 111
Human chondrocyte culture models for studying cyclooxygenase expression and prostaglandin regulation of collagen gene expression. Osteoarthritis and cartilage. 1999 Academic Article GET IT
Times cited: 43
The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator. Oncogene. 1999 Academic Article GET IT
Times cited: 81
Preparation of immortalized human chondrocyte cell lines. Methods in molecular medicine. 1999 Academic Article GET IT
The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models. Connective tissue research. 1999 Review GET IT
Times cited: 265
Parathyroid hormone-related proteins is abundant in osteoarthritic cartilage, and the parathyroid hormone-related protein 1-173 isoform is selectively induced by transforming growth factor beta in articular chondrocytes and suppresses generation of extracellular inorganic pyrophosphate. Arthritis and rheumatism. 1998 Academic Article GET IT
Times cited: 64
The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint. Arthritis and rheumatism. 1998 Academic Article GET IT
Times cited: 179
Artificial cavitation nuclei significantly enhance acoustically induced cell transfection. Ultrasound in medicine & biology. 1998 Academic Article GET IT
Times cited: 330
Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation. Proceedings of the National Academy of Sciences of the United States of America. 1998 Academic Article GET IT
Times cited: 146
NADPH oxidase of chondrocytes contains an isoform of the gp91phox subunit. The Biochemical journal. 1998 Academic Article GET IT
Times cited: 42
Human chondrocyte expression of growth-arrest-specific gene 6 and the tyrosine kinase receptor axl: potential role in autocrine signaling in cartilage. Arthritis and rheumatism. 1997 Academic Article GET IT
Times cited: 67
Detection of protein and mRNA of various components of the NADPH oxidase complex in an immortalized human chondrocyte line. British journal of rheumatology. 1997 Academic Article GET IT
Times cited: 49
[Regulation of collagen from the cartilage by interleukin-1]. La Revue du praticien. 1996 Review GET IT
Times cited: 1
Cytokines and skeletal physiology. Clinical orthopaedics and related research. 1996 Review GET IT
Times cited: 50
Human chondrocyte cultures as models of cartilage-specific gene regulation. Methods in molecular medicine. 1996 Academic Article GET IT
Regulation of Collagen Gene Expression by Prostaglandins and Interleukin-1beta in Cultured Chondrocytes and Fibroblasts. American journal of therapeutics. 1996 Academic Article GET IT
Times cited: 55
Autosomal dominant and recessive osteochondrodysplasias associated with the COL11A2 locus. Cell. 1995 Academic Article GET IT
Times cited: 317
Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes. The Journal of clinical investigation. 1994 Academic Article GET IT
Times cited: 400
Transcriptional suppression by interleukin-1 and interferon-gamma of type II collagen gene expression in human chondrocytes. Journal of cellular biochemistry. 1994 Academic Article GET IT
Times cited: 149
Susceptibility of type I collagen containing mutated alpha 1(1) chains to cleavage by human neutrophil collagenase. Matrix (Stuttgart, Germany). 1993 Academic Article GET IT
Times cited: 17
Alternatively spliced type II procollagen mRNAs define distinct populations of cells during vertebral development: differential expression of the amino-propeptide. The Journal of cell biology. 1991 Academic Article GET IT
Times cited: 316
Cytokines and cell growth control. Critical reviews in eukaryotic gene expression. 1991 Review GET IT
Times cited: 86
Skeletal tissue response to cytokines. Clinical orthopaedics and related research. 1990 Review GET IT
Times cited: 154
Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene. Proceedings of the National Academy of Sciences of the United States of America. 1990 Academic Article GET IT
Times cited: 104
Clinical implications of cartilage metabolism in arthritis. European journal of rheumatology and inflammation. 1990 Review GET IT
Times cited: 6
Etodolac preserves cartilage-specific phenotype in human chondrocytes: effects on type II collagen synthesis and associated mRNA levels. European journal of rheumatology and inflammation. 1990 Academic Article GET IT
Times cited: 22
Mechanisms of matrix degradation in rheumatoid arthritis. Annals of the New York Academy of Sciences. 1990 Review GET IT
Times cited: 127
Molecular cloning of rat and human type IX collagen cDNA and localization of the alpha 1(IX) gene on the human chromosome 6. European journal of biochemistry. 1989 Academic Article GET IT
Times cited: 75
Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes. The Journal of clinical investigation. 1988 Academic Article GET IT
Times cited: 371
Cytokines. Ciba Foundation symposium. 1988 Review GET IT
Times cited: 12
Potential role for interleukin-1 in fibrosis associated with chronic ambulatory peritoneal dialysis. Blood purification. 1988 Review GET IT
Times cited: 19
Modulation by recombinant interleukin 1 of synthesis of types I and III collagens and associated procollagen mRNA levels in cultured human cells. The Journal of biological chemistry. 1987 Academic Article GET IT
Times cited: 162
Human articular chondrocytes acquire 1,25-(OH)2 vitamin D-3 receptors in culture. Biochimica et biophysica acta. 1987 Academic Article GET IT
Times cited: 16
Control of collagen synthesis in human chondrocyte cultures by immune interferon and interleukin-1. The Journal of rheumatology. 1987 Academic Article GET IT
Times cited: 25
Stimulation of procollagenase synthesis parallels increases in cellular procollagenase mRNA in human articular chondrocytes exposed to recombinant interleukin 1 beta or phorbol ester. Biochemical and biophysical research communications. 1987 Academic Article GET IT
Times cited: 79
Immune interferon suppresses levels of procollagen mRNA and type II collagen synthesis in cultured human articular and costal chondrocytes. The Journal of biological chemistry. 1986 Academic Article GET IT
Times cited: 141
The four biochemically distinct species of human interleukin 1 all exhibit similar biologic activities. Journal of immunology (Baltimore, Md. : 1950). 1985 Academic Article GET IT
Times cited: 72

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Background

education and training

Ph.D., University of Sheffield (United Kingdom) 1982
B.S., University of Oregon 1969

Contact

full name

Mary Brennan Goldring

primary email

mbg2001@med.cornell.edu

VIVO Weill Cornell Medical College

Mary Brennan Goldring Professor Emerita of Cell and Developmental Biology

Publications

selected publications

Background

education and training

Contact

full name

primary email