selected publications
- Single dose thermoresponsive dexamethasone prodrug completely mitigates joint pain for 15 weeks in a murine model of osteoarthritis. Nanomedicine : nanotechnology, biology, and medicine. 2024 Academic Article GET IT
- Machine learning identification of thresholds to discriminate osteoarthritis and rheumatoid arthritis synovial inflammation. Arthritis research & therapy. 2023 Academic Article GET IT
- Adaptive immune responses in patients requiring revision after Total Knee Arthroplasty. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2022 Academic Article GET IT
- Association of circulating gene expression signatures with stiffness following total knee arthroplasty for osteoarthritis: a pilot study. Scientific reports. 2022 Academic Article GET IT
- Computational pathology for musculoskeletal conditions using machine learning: advances, trends, and challenges. Arthritis research & therapy. 2022 Review GET IT
- Identification of biological risk factors for persistent postoperative pain after total knee arthroplasty. Regional anesthesia and pain medicine. 2021 Academic Article GET IT
- Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis. Scientific reports. 2021 Academic Article GET IT
- Targeted transcriptomic analyses of RNA isolated from formalin-fixed and paraffin-embedded human menisci. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2021 Academic Article GET IT
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Early inhibition of subchondral bone remodeling slows load-induced posttraumatic osteoarthritis development in mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2021
Academic Article
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Times cited: 19 - Immune and repair responses in joint tissues and lymph nodes after knee arthroplasty surgery in mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2021 Academic Article GET IT
- In vitro responses to platelet-rich-plasma are associated with variable clinical outcomes in patients with knee osteoarthritis. Scientific reports. 2021 Academic Article GET IT
- Activation of nuclear factor-kappa B by TNF promotes nucleus pulposus mineralization through inhibition of ANKH and ENPP1. Scientific reports. 2021 Academic Article GET IT
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Histologic and molecular features in pathologic human menisci from knees with and without osteoarthritis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2021
Academic Article
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Times cited: 1 -
Mouse Models of Osteoarthritis: Surgical Model of Post-traumatic Osteoarthritis Induced by Destabilization of the Medial Meniscus.
Methods in molecular biology (Clifton, N.J.).
2021
Academic Article
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Times cited: 8 -
Role of iRhoms 1 and 2 in Endochondral Ossification.
International journal of molecular sciences.
2020
Academic Article
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Times cited: 6 -
Changes in DNA methylation accompany changes in gene expression during chondrocyte hypertrophic differentiation in vitro.
Annals of the New York Academy of Sciences.
2020
Academic Article
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Times cited: 9 - Response to "Letter to the editor: Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement". Journal of orthopaedic surgery and research. 2020 Letter GET IT
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Obesity and load-induced posttraumatic osteoarthritis in the absence of fracture or surgical trauma.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2020
Academic Article
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Times cited: 11 -
Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement.
Journal of orthopaedic surgery and research.
2020
Academic Article
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Times cited: 14 -
Identification of Inflammatory Mediators in Tendinopathy Using a Murine Subacromial Impingement Model.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2019
Academic Article
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Times cited: 5 -
Low-level cyclic tibial compression attenuates early osteoarthritis progression after joint injury in mice.
Osteoarthritis and cartilage.
2019
Academic Article
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Times cited: 19 -
Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis.
Scientific reports.
2019
Academic Article
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Times cited: 16 -
3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018
Academic Article
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Times cited: 18 -
Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy.
Annals of the New York Academy of Sciences.
2018
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Times cited: 45 -
Elf3 Contributes to Cartilage Degradation in vivo in a Surgical Model of Post-Traumatic Osteoarthritis.
Scientific reports.
2018
Academic Article
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Times cited: 23 -
FGF8 and FGFR3 are up-regulated in hypertrophic chondrocytes: Association with chondrocyte death in deep zone of Kashin-Beck disease.
Biochemical and biophysical research communications.
2018
Academic Article
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Times cited: 10 -
E74-Like Factor (ELF3) and Leptin, a Novel Loop Between Obesity and Inflammation Perpetuating a Pro-Catabolic State in Cartilage.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018
Academic Article
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Times cited: 8 -
Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2017
Academic Article
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Times cited: 22 -
Collagen XI mutation lowers susceptibility to load-induced cartilage damage in mice.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2017
Academic Article
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Times cited: 11 -
DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes.
Scientific reports.
2017
Academic Article
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Times cited: 51 -
E74-like factor 3 and nuclear factor-κB regulate lipocalin-2 expression in chondrocytes.
The Journal of physiology.
2016
Academic Article
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Times cited: 19 -
ELF3 modulates type II collagen gene (COL2A1) transcription in chondrocytes by inhibiting SOX9-CBP/p300-driven histone acetyltransferase activity.
Connective tissue research.
2016
Academic Article
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Times cited: 37 -
Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2016
Academic Article
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Times cited: 15 -
CCAAT/enhancer binding protein β (C/EBPβ) regulates the transcription of growth arrest and DNA damage-inducible protein 45 β (GADD45β) in articular chondrocytes.
Pathology, research and practice.
2016
Academic Article
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Times cited: 1 -
Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis.
Osteoarthritis and cartilage.
2015
Academic Article
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Times cited: 38 -
Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation.
RMD open.
2015
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Times cited: 105 -
Mouse models of osteoarthritis: surgical model of posttraumatic osteoarthritis induced by destabilization of the medial meniscus.
Methods in molecular biology (Clifton, N.J.).
2015
Academic Article
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Times cited: 14 -
Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation.
Arthritis & rheumatology (Hoboken, N.J.).
2014
Academic Article
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Times cited: 73 -
Fluoroquinolones impair tendon healing in a rat rotator cuff repair model: a preliminary study.
The American journal of sports medicine.
2014
Academic Article
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Times cited: 22 -
Lack of ADAM10 in endothelial cells affects osteoclasts at the chondro-osseus junction.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2013
Academic Article
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Times cited: 11 -
IKKα/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation.
PloS one.
2013
Academic Article
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Times cited: 38 -
ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes.
Molecular and cellular biology.
2013
Academic Article
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Times cited: 48 -
Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites.
The Journal of biological chemistry.
2013
Academic Article
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Times cited: 129 -
Dual regulation of metalloproteinase expression in chondrocytes by Wnt-1-inducible signaling pathway protein 3/CCN6.
Arthritis and rheumatism.
2012
Academic Article
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Times cited: 29 -
Human chondrocyte cultures as models of cartilage-specific gene regulation.
Methods in molecular biology (Clifton, N.J.).
2012
Academic Article
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Times cited: 30 -
E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress.
The Journal of biological chemistry.
2011
Academic Article
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Times cited: 66 -
Anti-inflammatory activity of an ethanolic Caesalpinia sappan extract in human chondrocytes and macrophages.
Journal of ethnopharmacology.
2011
Academic Article
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Times cited: 73 -
Inflammation in osteoarthritis.
Current opinion in rheumatology.
2011
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Times cited: 1103 -
Caesalpinia sappan extract inhibits IL1β-mediated overexpression of matrix metalloproteinases in human chondrocytes.
Genes & nutrition.
2011
Academic Article
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Times cited: 48 -
Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis.
European cells & materials.
2011
Academic Article
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Times cited: 384 -
NF-kappaB signaling: multiple angles to target OA.
Current drug targets.
2010
Information Resource
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Times cited: 502 -
GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes.
The Journal of biological chemistry.
2010
Academic Article
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Times cited: 41 -
A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;p11.2) and leads to Brachydactyly Type E.
Human molecular genetics.
2009
Academic Article
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Times cited: 65 -
Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes.
Arthritis and rheumatism.
2008
Academic Article
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Times cited: 87 -
ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes.
Journal of cellular physiology.
2008
Academic Article
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Times cited: 50 -
A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes.
Osteoarthritis and cartilage.
2008
Academic Article
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Times cited: 244 -
Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes.
Life sciences.
2007
Academic Article
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Times cited: 48 -
Cells of the synovium in rheumatoid arthritis. Chondrocytes.
Arthritis research & therapy.
2007
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Times cited: 100 -
Towards a pro-inflammatory and immunomodulatory emerging role of leptin.
Rheumatology (Oxford, England).
2006
Review
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Times cited: 212 -
Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis.
Annals of the rheumatic diseases.
2006
Academic Article
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Times cited: 492 -
Leptin: a metabolic hormone that functions like a proinflammatory adipokine.
Drug news & perspectives.
2006
Review
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Times cited: 81 -
Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1.
Arthritis research & therapy.
2005
Academic Article
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Times cited: 172 -
Leptin, from fat to inflammation: old questions and new insights.
FEBS letters.
2005
Review
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Times cited: 348 -
The endogenous growth hormone secretagogue (ghrelin) is synthesized and secreted by chondrocytes.
Endocrinology.
2004
Academic Article
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Times cited: 85 -
Chronic inflammation modulates ghrelin levels in humans and rats.
Rheumatology (Oxford, England).
2003
Academic Article
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Times cited: 74 -
Ghrelin plasmatic levels in patients with fibromyalgia.
Rheumatology international.
2003
Academic Article
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Times cited: 5 -
Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells.
Arthritis and rheumatism.
2003
Academic Article
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Times cited: 137