Otero, Miguel

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selected publications

Single dose thermoresponsive dexamethasone prodrug completely mitigates joint pain for 15 weeks in a murine model of osteoarthritis. Nanomedicine : nanotechnology, biology, and medicine. 2024 Academic Article GET IT
Machine learning identification of thresholds to discriminate osteoarthritis and rheumatoid arthritis synovial inflammation. Arthritis research & therapy. 2023 Academic Article GET IT
Adaptive immune responses in patients requiring revision after Total Knee Arthroplasty. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2022 Academic Article GET IT
Association of circulating gene expression signatures with stiffness following total knee arthroplasty for osteoarthritis: a pilot study. Scientific reports. 2022 Academic Article GET IT
Computational pathology for musculoskeletal conditions using machine learning: advances, trends, and challenges. Arthritis research & therapy. 2022 Review GET IT
Identification of biological risk factors for persistent postoperative pain after total knee arthroplasty. Regional anesthesia and pain medicine. 2021 Academic Article GET IT
Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis. Scientific reports. 2021 Academic Article GET IT
Targeted transcriptomic analyses of RNA isolated from formalin-fixed and paraffin-embedded human menisci. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2021 Academic Article GET IT
Early inhibition of subchondral bone remodeling slows load-induced posttraumatic osteoarthritis development in mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2021 Academic Article GET IT
Times cited: 19
Immune and repair responses in joint tissues and lymph nodes after knee arthroplasty surgery in mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2021 Academic Article GET IT
In vitro responses to platelet-rich-plasma are associated with variable clinical outcomes in patients with knee osteoarthritis. Scientific reports. 2021 Academic Article GET IT
Activation of nuclear factor-kappa B by TNF promotes nucleus pulposus mineralization through inhibition of ANKH and ENPP1. Scientific reports. 2021 Academic Article GET IT
Histologic and molecular features in pathologic human menisci from knees with and without osteoarthritis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2021 Academic Article GET IT
Times cited: 1
Mouse Models of Osteoarthritis: Surgical Model of Post-traumatic Osteoarthritis Induced by Destabilization of the Medial Meniscus. Methods in molecular biology (Clifton, N.J.). 2021 Academic Article GET IT
Times cited: 8
Role of iRhoms 1 and 2 in Endochondral Ossification. International journal of molecular sciences. 2020 Academic Article GET IT
Times cited: 6
Changes in DNA methylation accompany changes in gene expression during chondrocyte hypertrophic differentiation in vitro. Annals of the New York Academy of Sciences. 2020 Academic Article GET IT
Times cited: 9
Response to "Letter to the editor: Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement". Journal of orthopaedic surgery and research. 2020 Letter GET IT
Obesity and load-induced posttraumatic osteoarthritis in the absence of fracture or surgical trauma. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2020 Academic Article GET IT
Times cited: 11
Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement. Journal of orthopaedic surgery and research. 2020 Academic Article GET IT
Times cited: 14
Identification of Inflammatory Mediators in Tendinopathy Using a Murine Subacromial Impingement Model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2019 Academic Article GET IT
Times cited: 5
Low-level cyclic tibial compression attenuates early osteoarthritis progression after joint injury in mice. Osteoarthritis and cartilage. 2019 Academic Article GET IT
Times cited: 21
Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis. Scientific reports. 2019 Academic Article GET IT
Times cited: 15
3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Academic Article GET IT
Times cited: 18
Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy. Annals of the New York Academy of Sciences. 2018 Information Resource GET IT
Times cited: 45
Elf3 Contributes to Cartilage Degradation in vivo in a Surgical Model of Post-Traumatic Osteoarthritis. Scientific reports. 2018 Academic Article GET IT
Times cited: 23
FGF8 and FGFR3 are up-regulated in hypertrophic chondrocytes: Association with chondrocyte death in deep zone of Kashin-Beck disease. Biochemical and biophysical research communications. 2018 Academic Article GET IT
Times cited: 10
E74-Like Factor (ELF3) and Leptin, a Novel Loop Between Obesity and Inflammation Perpetuating a Pro-Catabolic State in Cartilage. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018 Academic Article GET IT
Times cited: 8
Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2017 Academic Article GET IT
Times cited: 22
Collagen XI mutation lowers susceptibility to load-induced cartilage damage in mice. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2017 Academic Article GET IT
Times cited: 11
DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes. Scientific reports. 2017 Academic Article GET IT
Times cited: 51
E74-like factor 3 and nuclear factor-κB regulate lipocalin-2 expression in chondrocytes. The Journal of physiology. 2016 Academic Article GET IT
Times cited: 19
ELF3 modulates type II collagen gene (COL2A1) transcription in chondrocytes by inhibiting SOX9-CBP/p300-driven histone acetyltransferase activity. Connective tissue research. 2016 Academic Article GET IT
Times cited: 37
Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2016 Academic Article GET IT
Times cited: 15
CCAAT/enhancer binding protein β (C/EBPβ) regulates the transcription of growth arrest and DNA damage-inducible protein 45 β (GADD45β) in articular chondrocytes. Pathology, research and practice. 2016 Academic Article GET IT
Times cited: 1
Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis. Osteoarthritis and cartilage. 2015 Academic Article GET IT
Times cited: 38
Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation. RMD open. 2015 Information Resource GET IT
Times cited: 104
Mouse models of osteoarthritis: surgical model of posttraumatic osteoarthritis induced by destabilization of the medial meniscus. Methods in molecular biology (Clifton, N.J.). 2015 Academic Article GET IT
Times cited: 14
Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation. Arthritis & rheumatology (Hoboken, N.J.). 2014 Academic Article GET IT
Times cited: 74
Fluoroquinolones impair tendon healing in a rat rotator cuff repair model: a preliminary study. The American journal of sports medicine. 2014 Academic Article GET IT
Times cited: 22
Lack of ADAM10 in endothelial cells affects osteoclasts at the chondro-osseus junction. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2013 Academic Article GET IT
Times cited: 11
IKKα/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation. PloS one. 2013 Academic Article GET IT
Times cited: 40
ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes. Molecular and cellular biology. 2013 Academic Article GET IT
Times cited: 48
Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 129
Dual regulation of metalloproteinase expression in chondrocytes by Wnt-1-inducible signaling pathway protein 3/CCN6. Arthritis and rheumatism. 2012 Academic Article GET IT
Times cited: 29
Human chondrocyte cultures as models of cartilage-specific gene regulation. Methods in molecular biology (Clifton, N.J.). 2012 Academic Article GET IT
Times cited: 30
E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 66
Anti-inflammatory activity of an ethanolic Caesalpinia sappan extract in human chondrocytes and macrophages. Journal of ethnopharmacology. 2011 Academic Article GET IT
Times cited: 73
Inflammation in osteoarthritis. Current opinion in rheumatology. 2011 Information Resource GET IT
Times cited: 1107
Caesalpinia sappan extract inhibits IL1β-mediated overexpression of matrix metalloproteinases in human chondrocytes. Genes & nutrition. 2011 Academic Article GET IT
Times cited: 48
Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. European cells & materials. 2011 Academic Article GET IT
Times cited: 387
NF-kappaB signaling: multiple angles to target OA. Current drug targets. 2010 Information Resource GET IT
Times cited: 505
GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 41
A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;p11.2) and leads to Brachydactyly Type E. Human molecular genetics. 2009 Academic Article GET IT
Times cited: 65
Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. Arthritis and rheumatism. 2008 Academic Article GET IT
Times cited: 87
ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes. Journal of cellular physiology. 2008 Academic Article GET IT
Times cited: 50
A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes. Osteoarthritis and cartilage. 2008 Academic Article GET IT
Times cited: 244
Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes. Life sciences. 2007 Academic Article GET IT
Times cited: 48
Cells of the synovium in rheumatoid arthritis. Chondrocytes. Arthritis research & therapy. 2007 Information Resource GET IT
Times cited: 101
Towards a pro-inflammatory and immunomodulatory emerging role of leptin. Rheumatology (Oxford, England). 2006 Review GET IT
Times cited: 212
Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Annals of the rheumatic diseases. 2006 Academic Article GET IT
Times cited: 493
Leptin: a metabolic hormone that functions like a proinflammatory adipokine. Drug news & perspectives. 2006 Review GET IT
Times cited: 81
Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. Arthritis research & therapy. 2005 Academic Article GET IT
Times cited: 172
Leptin, from fat to inflammation: old questions and new insights. FEBS letters. 2005 Review GET IT
Times cited: 348
The endogenous growth hormone secretagogue (ghrelin) is synthesized and secreted by chondrocytes. Endocrinology. 2004 Academic Article GET IT
Times cited: 85
Chronic inflammation modulates ghrelin levels in humans and rats. Rheumatology (Oxford, England). 2003 Academic Article GET IT
Times cited: 74
Ghrelin plasmatic levels in patients with fibromyalgia. Rheumatology international. 2003 Academic Article GET IT
Times cited: 5
Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells. Arthritis and rheumatism. 2003 Academic Article GET IT
Times cited: 137

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Background

education and training

Ph.D., University of Santiago de Compostela (Spain) 2005
B.S., M.S., University of Santiago de Compostela (Spain) 2000

Contact

full name

Miguel Otero

primary email

oterom@hss.edu

VIVO Weill Cornell Medical College

Miguel Otero Assistant Professor of Cell and Developmental Biology in Orthopaedic Surgery

Publications

selected publications

Background

education and training

Contact

full name

primary email