selected publications
- Small molecules from antibody pharmacophores (SMAbPs) as a hit identification workflow for immune checkpoints. Science advances. 2024 Academic Article GET IT
- From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3. ACS medicinal chemistry letters. 2024 Academic Article GET IT
- Design and Biophysical Characterization of Second-Generation cyclic peptide LAG-3 inhibitors for cancer immunotherapy. Bioorganic & medicinal chemistry letters. 2024 Academic Article GET IT
- Discovery of ICOS-targeted small molecules using affinity selection mass spectrometry screening. ChemMedChem. 2024 Academic Article GET IT
- Discovery of ICOS-targeted small molecules using affinity selection mass spectrometry screening. 2024 GET IT
- Structure-Based Rational Design of Constrained Peptides as TIM-3 Inhibitors. ACS medicinal chemistry letters. 2024 Academic Article GET IT
- Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity. European journal of medicinal chemistry. 2024 Academic Article GET IT
- Small Molecule Immunomodulators as Next-Generation Therapeutics for Glioblastoma. Cancers. 2024 Review GET IT
- Lithocholic acid derivatives as potent modulators of the nuclear receptor RORγt. RSC advances. 2024 Academic Article GET IT
- Design of cyclic peptides as novel inhibitors of ICOS/ICOSL interaction. Bioorganic & medicinal chemistry letters. 2024 Academic Article GET IT
- Inhibitors of Immune Checkpoints: Small Molecule- and Peptide-Based Approaches. Journal of personalized medicine. 2024 Review GET IT
- Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer's Disease Therapy. ACS chemical neuroscience. 2023 Academic Article GET IT
- Discovery of ICOS-targeted small molecules using pharmacophore-based screening. ChemMedChem. 2023 Academic Article GET IT
- Discovery of Small-Molecule TIM-3 Inhibitors for Acute Myeloid Leukemia Using Pharmacophore-Based Virtual Screening. Journal of medicinal chemistry. 2023 Academic Article GET IT
- First-in-class small molecule inhibitors of ICOS/ICOSL interaction as a novel class of immunomodulators. RSC medicinal chemistry. 2023 Academic Article GET IT
- Development of a high-throughput TR-FRET screening assay for LAG-3/FGL1 interaction. SLAS discovery : advancing life sciences R & D. 2023 Academic Article GET IT
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Discovery of First-in-Class Small Molecule Inhibitors of Lymphocyte Activation Gene 3 (LAG-3).
ACS medicinal chemistry letters.
2023
Academic Article
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Times cited: 15 - Multicomponent Petasis reaction for the identification of pyrazine based multi-target directed anti-Alzheimer's agents: In-silico design, synthesis, and characterization. European journal of medicinal chemistry. 2023 Academic Article GET IT
- Preclinical Evaluation of a Lead Specific Chelator (PSC) Conjugated to Radiopeptides for 203Pb and 212Pb-Based Theranostics. Pharmaceutics. 2023 Academic Article GET IT
- Gut Microbial-Derived Metabolites as Immune Modulators of T Helper 17 and Regulatory T Cells. International journal of molecular sciences. 2023 Review GET IT
- Prevalence of Chronic Kidney Disease in Nonalcoholic Fatty Liver Disease Patients. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. 2022 Academic Article GET IT
- Discovery of Hydroxybenzothiazole Urea Compounds as Multitargeted Agents Suppressing Major Cytotoxic Mechanisms in Neurodegenerative Diseases. ACS chemical neuroscience. 2021 Academic Article GET IT
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Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects.
European journal of medicinal chemistry.
2021
Academic Article
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Times cited: 1 -
Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer's disease.
Bioorganic chemistry.
2021
Academic Article
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Times cited: 1 -
Mechanism of zinc ejection by disulfiram in nonstructural protein 5A.
Physical chemistry chemical physics : PCCP.
2021
Academic Article
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Times cited: 3 -
Discovery of new phenyl sulfonyl-pyrimidine carboxylate derivatives as the potential multi-target drugs with effective anti-Alzheimer's action: Design, synthesis, crystal structure and in-vitro biological evaluation.
European journal of medicinal chemistry.
2021
Academic Article
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Times cited: 6 -
Discovery and Optimization of Small-Molecule Ligands for V-Domain Ig Suppressor of T-Cell Activation (VISTA).
Journal of the American Chemical Society.
2020
Academic Article
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Times cited: 4 - Discovery of a Histidine-Based Scaffold as an Inhibitor of Gut Microbial Choline Trimethylamine-Lyase. ChemMedChem. 2020 Academic Article GET IT
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A benzoxazole derivative as an inhibitor of anaerobic choline metabolism by human gut microbiota.
RSC medicinal chemistry.
2020
Academic Article
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Times cited: 9 -
First dual binder of microRNA-146a and monomeric tau: a novel approach for multitargeted therapeutics for neurodegenerative diseases.
Chemical communications (Cambridge, England).
2020
Academic Article
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Times cited: 6 -
Quinoline-Pyrazole Scaffold as a Novel Ligand of Galectin-3 and Suppressor of TREM2 Signaling.
ACS medicinal chemistry letters.
2020
Academic Article
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Times cited: 11 -
MicroRNA-Based Multitarget Approach for Alzheimer's Disease: Discovery of the First-In-Class Dual Inhibitor of Acetylcholinesterase and MicroRNA-15b Biogenesis.
Journal of medicinal chemistry.
2020
Academic Article
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Times cited: 7 -
New synthesis of 6″-[18 F]fluoromaltotriose for positron emission tomography imaging of bacterial infection.
Journal of labelled compounds & radiopharmaceuticals.
2020
Academic Article
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Times cited: 1 -
Discovery of biphenyl pyrazole scaffold for neurodegenerative diseases: A novel class of acetylcholinesterase-centered multitargeted ligands.
Bioorganic & medicinal chemistry letters.
2020
Academic Article
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Times cited: 1 - High-Throughput Platform for Real-Time Monitoring of ATP-Generating Enzymes in Living Cells Based on a Lanthanide Probe. ACS sensors. 2020 Academic Article GET IT
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Multitarget Therapeutic Strategies for Alzheimer's Disease: Review on Emerging Target Combinations.
BioMed research international.
2020
Review
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Times cited: 75 -
Dual Targeting of Monomeric Tau and α-Synuclein Aggregation: A New Multitarget Therapeutic Strategy for Neurodegeneration.
ACS chemical neuroscience.
2020
Academic Article
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Times cited: 8 -
Multitarget Therapeutics for Neurodegenerative Diseases.
BioMed research international.
2020
Editorial Article
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Times cited: 5 -
Expanding the Toolbox for Label-Free Enzyme Assays: A Dinuclear Platinum(II) Complex/DNA Ensemble with Switchable Near-IR Emission.
Molecules (Basel, Switzerland).
2019
Academic Article
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Times cited: 3 -
New series of fused pyrazolopyridines: Synthesis, molecular modeling, antimicrobial, antiquorum-sensing and antitumor activities.
Bioorganic chemistry.
2019
Academic Article
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Times cited: 6 -
Synthesis, molecular modeling and biological evaluation of new pyrazolo[3,4-b]pyridine analogs as potential antimicrobial, antiquorum-sensing and anticancer agents.
Bioorganic chemistry.
2019
Academic Article
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Times cited: 16 -
Multitarget therapeutic strategies for Alzheimer's disease.
Neural regeneration research.
2019
Review
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Times cited: 134 -
Platinum(II) Complexes with Sterically Expansive Tetraarylethylene Ligands as Probes for Mismatched DNA.
Inorganic chemistry.
2018
Academic Article
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Times cited: 7 -
Structure-Based Design and Synthesis of Fluorene Derivatives as Novel RORγt Inverse Agonists.
Chemistry & biodiversity.
2018
Academic Article
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Times cited: 3 -
Structure-based design, synthesis, and evaluation of structurally rigid donepezil analogues as dual AChE and BACE-1 inhibitors.
Bioorganic & medicinal chemistry letters.
2018
Academic Article
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Times cited: 9 -
Rhenium Complexes of Bis(benzothiazole)-Based Tetraarylethylenes as Selective Luminescent Probes for Amyloid Fibrils.
Chemistry (Weinheim an der Bergstrasse, Germany).
2018
Academic Article
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Times cited: 19 -
Design and synthesis of donepezil analogues as dual AChE and BACE-1 inhibitors.
Bioorganic chemistry.
2018
Academic Article
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Times cited: 11 -
Pharmacophore-based tailoring of biphenyl amide derivatives as selective 5-hydroxytryptamine 2B receptor antagonists.
MedChemComm.
2018
Academic Article
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Times cited: 5 -
A fluorescent turn-on probe for cyanide anion detection based on an AIE active cobalt(ii) complex.
Dalton transactions (Cambridge, England : 2003).
2018
Academic Article
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Times cited: 29 -
Rhenium tricarbonyl complexes of AIE active tetraarylethylene ligands: tuning luminescence properties and HSA-specific binding.
Dalton transactions (Cambridge, England : 2003).
2017
Academic Article
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Times cited: 21 -
Microwave-assisted synthesis and antitumor evaluation of a new series of thiazolylcoumarin derivatives.
EXCLI journal.
2017
Academic Article
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Times cited: 18 -
Isatin-β-thiocarbohydrazones: Microwave-assisted synthesis, antitumor activity and structure-activity relationship.
European journal of medicinal chemistry.
2017
Academic Article
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Times cited: 33 -
Synthesis and Evaluation of Tetraarylethylene-based Mono-, Bis-, and Tris(pyridinium) Derivatives for Image-Guided Mitochondria-Specific Targeting and Cytotoxicity of Metastatic Melanoma Cells.
Bioconjugate chemistry.
2016
Academic Article
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Times cited: 25 -
A selective fluorescent sensor for Zn(2+) based on aggregation-induced emission (AIE) activity and metal chelating ability of bis(2-pyridyl)diphenylethylene.
Dalton transactions (Cambridge, England : 2003).
2016
Academic Article
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Times cited: 24 -
Synthesis and in vitro antitumor activity of new series of benzothiazole and pyrimido[2,1-b]benzothiazole derivatives.
European journal of medicinal chemistry.
2014
Academic Article
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Times cited: 40 - EGFR tyrosine kinase targeted compounds: in vitro antitumor activity and molecular modeling studies of new benzothiazole and pyrimido[2,1-b]benzothiazole derivatives. EXCLI journal. 2014 Academic Article GET IT
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Structure-based drug design and biological evaluation of 2-acetamidobenzothiazole derivative as EGFR kinase inhibitor.
Journal of enzyme inhibition and medicinal chemistry.
2014
Academic Article
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Times cited: 3