Gabr, Moustafa

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Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity. European journal of medicinal chemistry. 2024 Academic Article GET IT
Small Molecule Immunomodulators as Next-Generation Therapeutics for Glioblastoma. Cancers. 2024 Review GET IT
Lithocholic acid derivatives as potent modulators of the nuclear receptor RORγt. RSC advances. 2024 Academic Article GET IT
Design of cyclic peptides as novel inhibitors of ICOS/ICOSL interaction. Bioorganic & medicinal chemistry letters. 2024 Academic Article GET IT
Inhibitors of Immune Checkpoints: Small Molecule- and Peptide-Based Approaches. Journal of personalized medicine. 2024 Review GET IT
Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer's Disease Therapy. ACS chemical neuroscience. 2023 Academic Article GET IT
Discovery of ICOS-targeted small molecules using pharmacophore-based screening. ChemMedChem. 2023 Academic Article GET IT
Discovery of Small-Molecule TIM-3 Inhibitors for Acute Myeloid Leukemia Using Pharmacophore-Based Virtual Screening. Journal of medicinal chemistry. 2023 Academic Article GET IT
First-in-class small molecule inhibitors of ICOS/ICOSL interaction as a novel class of immunomodulators. RSC medicinal chemistry. 2023 Academic Article GET IT
Development of a high-throughput TR-FRET screening assay for LAG-3/FGL1 interaction. SLAS discovery : advancing life sciences R & D. 2023 Academic Article GET IT
Discovery of First-in-Class Small Molecule Inhibitors of Lymphocyte Activation Gene 3 (LAG-3). ACS medicinal chemistry letters. 2023 Academic Article GET IT
Times cited: 6
Multicomponent Petasis reaction for the identification of pyrazine based multi-target directed anti-Alzheimer's agents: In-silico design, synthesis, and characterization. European journal of medicinal chemistry. 2023 Academic Article GET IT
Preclinical Evaluation of a Lead Specific Chelator (PSC) Conjugated to Radiopeptides for ²⁰³Pb and ²¹²Pb-Based Theranostics. Pharmaceutics. 2023 Academic Article GET IT
Gut Microbial-Derived Metabolites as Immune Modulators of T Helper 17 and Regulatory T Cells. International journal of molecular sciences. 2023 Review GET IT
Prevalence of Chronic Kidney Disease in Nonalcoholic Fatty Liver Disease Patients. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. 2022 Academic Article GET IT
Discovery of Hydroxybenzothiazole Urea Compounds as Multitargeted Agents Suppressing Major Cytotoxic Mechanisms in Neurodegenerative Diseases. ACS chemical neuroscience. 2021 Academic Article GET IT
Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects. European journal of medicinal chemistry. 2021 Academic Article GET IT
Times cited: 1
Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer's disease. Bioorganic chemistry. 2021 Academic Article GET IT
Times cited: 1
Mechanism of zinc ejection by disulfiram in nonstructural protein 5A. Physical chemistry chemical physics : PCCP. 2021 Academic Article GET IT
Times cited: 3
Discovery of new phenyl sulfonyl-pyrimidine carboxylate derivatives as the potential multi-target drugs with effective anti-Alzheimer's action: Design, synthesis, crystal structure and in-vitro biological evaluation. European journal of medicinal chemistry. 2021 Academic Article GET IT
Times cited: 6
Discovery and Optimization of Small-Molecule Ligands for V-Domain Ig Suppressor of T-Cell Activation (VISTA). Journal of the American Chemical Society. 2020 Academic Article GET IT
Times cited: 4
Discovery of a Histidine-Based Scaffold as an Inhibitor of Gut Microbial Choline Trimethylamine-Lyase. ChemMedChem. 2020 Academic Article GET IT
A benzoxazole derivative as an inhibitor of anaerobic choline metabolism by human gut microbiota. RSC medicinal chemistry. 2020 Academic Article GET IT
Times cited: 8
First dual binder of microRNA-146a and monomeric tau: a novel approach for multitargeted therapeutics for neurodegenerative diseases. Chemical communications (Cambridge, England). 2020 Academic Article GET IT
Times cited: 6
Quinoline-Pyrazole Scaffold as a Novel Ligand of Galectin-3 and Suppressor of TREM2 Signaling. ACS medicinal chemistry letters. 2020 Academic Article GET IT
Times cited: 10
MicroRNA-Based Multitarget Approach for Alzheimer's Disease: Discovery of the First-In-Class Dual Inhibitor of Acetylcholinesterase and MicroRNA-15b Biogenesis. Journal of medicinal chemistry. 2020 Academic Article GET IT
Times cited: 7
New synthesis of 6″-[¹⁸ F]fluoromaltotriose for positron emission tomography imaging of bacterial infection. Journal of labelled compounds & radiopharmaceuticals. 2020 Academic Article GET IT
Times cited: 1
Discovery of biphenyl pyrazole scaffold for neurodegenerative diseases: A novel class of acetylcholinesterase-centered multitargeted ligands. Bioorganic & medicinal chemistry letters. 2020 Academic Article GET IT
Times cited: 1
High-Throughput Platform for Real-Time Monitoring of ATP-Generating Enzymes in Living Cells Based on a Lanthanide Probe. ACS sensors. 2020 Academic Article GET IT
Multitarget Therapeutic Strategies for Alzheimer's Disease: Review on Emerging Target Combinations. BioMed research international. 2020 Review GET IT
Times cited: 64
Dual Targeting of Monomeric Tau and α-Synuclein Aggregation: A New Multitarget Therapeutic Strategy for Neurodegeneration. ACS chemical neuroscience. 2020 Academic Article GET IT
Times cited: 8
Multitarget Therapeutics for Neurodegenerative Diseases. BioMed research international. 2020 Editorial Article GET IT
Times cited: 5
Expanding the Toolbox for Label-Free Enzyme Assays: A Dinuclear Platinum(II) Complex/DNA Ensemble with Switchable Near-IR Emission. Molecules (Basel, Switzerland). 2019 Academic Article GET IT
Times cited: 3
New series of fused pyrazolopyridines: Synthesis, molecular modeling, antimicrobial, antiquorum-sensing and antitumor activities. Bioorganic chemistry. 2019 Academic Article GET IT
Times cited: 6
Synthesis, molecular modeling and biological evaluation of new pyrazolo[3,4-b]pyridine analogs as potential antimicrobial, antiquorum-sensing and anticancer agents. Bioorganic chemistry. 2019 Academic Article GET IT
Times cited: 16
Multitarget therapeutic strategies for Alzheimer's disease. Neural regeneration research. 2019 Review GET IT
Times cited: 117
Platinum(II) Complexes with Sterically Expansive Tetraarylethylene Ligands as Probes for Mismatched DNA. Inorganic chemistry. 2018 Academic Article GET IT
Times cited: 7
Structure-Based Design and Synthesis of Fluorene Derivatives as Novel RORγt Inverse Agonists. Chemistry & biodiversity. 2018 Academic Article GET IT
Times cited: 3
Structure-based design, synthesis, and evaluation of structurally rigid donepezil analogues as dual AChE and BACE-1 inhibitors. Bioorganic & medicinal chemistry letters. 2018 Academic Article GET IT
Times cited: 9
Rhenium Complexes of Bis(benzothiazole)-Based Tetraarylethylenes as Selective Luminescent Probes for Amyloid Fibrils. Chemistry (Weinheim an der Bergstrasse, Germany). 2018 Academic Article GET IT
Times cited: 19
Design and synthesis of donepezil analogues as dual AChE and BACE-1 inhibitors. Bioorganic chemistry. 2018 Academic Article GET IT
Times cited: 11
Pharmacophore-based tailoring of biphenyl amide derivatives as selective 5-hydroxytryptamine 2B receptor antagonists. MedChemComm. 2018 Academic Article GET IT
Times cited: 4
A fluorescent turn-on probe for cyanide anion detection based on an AIE active cobalt(ii) complex. Dalton transactions (Cambridge, England : 2003). 2018 Academic Article GET IT
Times cited: 29
Rhenium tricarbonyl complexes of AIE active tetraarylethylene ligands: tuning luminescence properties and HSA-specific binding. Dalton transactions (Cambridge, England : 2003). 2017 Academic Article GET IT
Times cited: 21
Microwave-assisted synthesis and antitumor evaluation of a new series of thiazolylcoumarin derivatives. EXCLI journal. 2017 Academic Article GET IT
Times cited: 16
Isatin-β-thiocarbohydrazones: Microwave-assisted synthesis, antitumor activity and structure-activity relationship. European journal of medicinal chemistry. 2017 Academic Article GET IT
Times cited: 33
Synthesis and Evaluation of Tetraarylethylene-based Mono-, Bis-, and Tris(pyridinium) Derivatives for Image-Guided Mitochondria-Specific Targeting and Cytotoxicity of Metastatic Melanoma Cells. Bioconjugate chemistry. 2016 Academic Article GET IT
Times cited: 23
A selective fluorescent sensor for Zn(2+) based on aggregation-induced emission (AIE) activity and metal chelating ability of bis(2-pyridyl)diphenylethylene. Dalton transactions (Cambridge, England : 2003). 2016 Academic Article GET IT
Times cited: 24
Synthesis and in vitro antitumor activity of new series of benzothiazole and pyrimido[2,1-b]benzothiazole derivatives. European journal of medicinal chemistry. 2014 Academic Article GET IT
Times cited: 40
EGFR tyrosine kinase targeted compounds: in vitro antitumor activity and molecular modeling studies of new benzothiazole and pyrimido[2,1-b]benzothiazole derivatives. EXCLI journal. 2014 Academic Article GET IT
Structure-based drug design and biological evaluation of 2-acetamidobenzothiazole derivative as EGFR kinase inhibitor. Journal of enzyme inhibition and medicinal chemistry. 2014 Academic Article GET IT
Times cited: 3

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Research

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Funding awarded

Optimization of small molecule immunomodulators as combination therapy for IBD awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2024 - 2029
Small molecule-mediated inhibition of T cell immunoglobulin and mucin domain 3 (TIM-3) as an immunotherapeutic strategy for Acute Myeloid Leukemia (AML) awarded by American Cancer Society Principal Investigator 2023 - 2024
First-in-class small molecule LAG-3 inhibitors for non-small lung cancer therapy awarded by Elsa U. Pardee Foundation Principal Investigator 2023 - 2024

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Background

education and training

Ph.D., University of Iowa 2019
B.Sc., Mansoura University, Faculty of Medicine (Egypt) 2011
M.Sc., Mansoura University, Faculty of Medicine (Egypt) 2014

Contact

full name

Moustafa Gabr

primary email

mog4005@med.cornell.edu

VIVO Weill Cornell Medical College

Moustafa Gabr Assistant Professor of Chemistry in Radiology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email