selected publications
- TREM2 activation by first-in-class direct small molecule agonists: DEL screening, optimization, biophysical validation, and functional characterization. European journal of medicinal chemistry. 2025 Academic Article GET IT
- Discovery of small molecule CHI3L1 inhibitors by SPR-based high-throughput screening. Bioorganic & medicinal chemistry letters. 2025 Academic Article GET IT
- Surface Plasmon Resonance (SPR)-Based Workflow for High-Throughput Discovery of CD28-Targeted Small Molecules. ACS omega. 2025 Academic Article GET IT
- Revisiting COX-2 inhibitors for Alzheimer's disease as multitargeted ligands: Development of 4-hydrazono-pyrazolidinediones with tuned COX selectivity profile and improved cellular potency. European journal of medicinal chemistry. 2025 Academic Article GET IT
- Affinity Selection-Mass spectrometry coupled with biophysical validation enables proof-of-concept discovery of CHI3L1 binders. Biochemical and biophysical research communications. 2025 Academic Article GET IT
- Temperature-related intensity change (TRIC)-based high throughput screening platform for the discovery of CHI3L1-targeted small molecules. SLAS discovery : advancing life sciences R & D. 2025 Academic Article GET IT
- Design and validation of the first-in-class PROTACs for targeted degradation of the immune checkpoint LAG-3. Bioorganic & medicinal chemistry letters. 2025 Academic Article GET IT
- Discovery of a first-in-class SLIT2 binder disrupting the SLIT2/ROBO1 axis via DNA-encoded library (DEL) screening. RSC medicinal chemistry. 2025 Academic Article GET IT
- Discovery and validation of LAGi-DEL: A nanomolar LAG-3 inhibitor that reverses immune suppression in tumor-immune co-culture models. European journal of medicinal chemistry. 2025 Academic Article GET IT
- Structure-based virtual screening identifies potent CD28 inhibitors that suppress T cell co-stimulation in cellular and mucosal models. European journal of medicinal chemistry. 2025 Academic Article GET IT
- Designing immunity with cytokines: A logic-based framework for programmable CAR therapies. Cytokine & growth factor reviews. 2025 Review GET IT
- AI-Assisted Discovery and Optimization of Small Molecule TREM2 Agonists with Functional Microglial Activity. 2025 GET IT
- As48, a First-in-Class Dual-Function TREM2 Modulator: Receptor Activation and Shedding Inhibition. 2025 GET IT
- Structure-Based Virtual Screening Identifies TREM2-Targeted Small Molecules that Enhance Microglial Phagocytosis. 2025 GET IT
- Discovery of Small Molecule CHI3L1 Inhibitors by SPR-Based High-Throughput Screening. 2025 GET IT
- Phenotypic and targeted drug discovery in immune therapeutics: challenges, opportunities, and future directions. RSC advances. 2025 Review GET IT
- Discovery and Optimization of LAG-3-Targeted Small Molecules via DNA-Encoded Chemical Library (DEL) Screening for Cancer Immunotherapy. Journal of medicinal chemistry. 2025 Academic Article GET IT
- Orthogonal temperature-related intensity change (TRIC) and TR-FRET as a high-throughput screening platform for the discovery of SLIT2 binders: A proof-of-concept approach. SLAS discovery : advancing life sciences R & D. 2025 Academic Article GET IT
- Structure-Guided Discovery of CHI3L1 Inhibitors from Ultralarge Chemical Spaces for Glioblastoma Therapy. 2025 GET IT
- Targeting the CAPON-NOS Axis: A Computational Strategy for Small Molecule Modulator Discovery. 2025 GET IT
-
Temperature-related intensity change (TRIC)-based high-throughput screening enables the discovery of small molecule CD28 binders.
SLAS discovery : advancing life sciences R & D.
2025
Academic Article
GET IT
Times cited: 2 - Discovery of CD28-Targeted Small Molecule Inhibitors of T Cell Co-stimulation Using Affinity Selection-Mass Spectrometry (AS-MS) and Ex Vivo Validation. 2025 GET IT
- Virtual Screening-Guided Discovery of Small Molecule CHI3L1 Inhibitors with Functional Activity in Glioblastoma Spheroids. 2025 GET IT
- TREM2 hit discovery using temperature-related intensity change (TRIC) technology: A proof-of-concept high-throughput screening approach. SLAS discovery : advancing life sciences R & D. 2025 Academic Article GET IT
- Discovery of a Small Molecule TREM2 Agonist with Improved In Vitro Pharmacokinetic Profile and Validated Target Engagement. ACS medicinal chemistry letters. 2025 Academic Article GET IT
- HTS-Oracle: A Retrainable AI Platform for High-Confidence Hit Identification Across Difficult-to-Drug Targets. 2025 GET IT
- Small Molecule-Based Blockade of CD28 Suppresses T Cell Costimulation Across Cellular and Mucosal Co-culture Models. 2025 GET IT
- TREM2 and LAG-3 in cancer and Alzheimer's disease immunotherapy. Trends in pharmacological sciences. 2025 Review GET IT
- TRIC Coupled with TR-FRET as a High-Throughput Screening Platform for the Discovery of SLIT2 Binders: A Proof-of-Concept Approach. 2025 GET IT
- CHI3L1-targeted small molecules as glioblastoma therapies: Virtual screening-based discovery, biophysical validation, pharmacokinetic profiling, and evaluation in glioblastoma spheroids. European journal of medicinal chemistry. 2025 Academic Article GET IT
- Lead optimization of a CHI3L1 inhibitor for Glioblastoma: Enhanced target engagement, pharmacokinetics, and efficacy in 3D spheroid models. European journal of medicinal chemistry. 2025 Academic Article GET IT
- Discovery of an Achiral Small Molecule TREM2 Agonist with Improved Pharmacokinetic Profile and Validated Target Engagement. 2025 GET IT
- Discovery of a First-in-Class SLIT2 Binder Disrupting the SLIT2/ROBO1 Axis via DNA-Encoded Library (DEL) Screening. 2025 GET IT
- Surface Plasmon Resonance (SPR)-Based Workflow for High-Throughput Discovery of CD28-Targeted Small Molecules. 2025 GET IT
- CD28 and ICOS in immune regulation: Structural insights and therapeutic targeting. Bioorganic & medicinal chemistry letters. 2025 Review GET IT
- TREM2 Hit Discovery Using TRIC Technology: A Proof-of-Concept High-Throughput Screening Approach. 2025 GET IT
- TRIC-Based High-Throughput Screening Enables the Discovery of Small Molecule CD28 Binders. 2025 GET IT
- TREM2 Activation by First-in-Class Direct Small Molecule Agonists: DEL Screening, Optimization, Biophysical Validation, and Functional Characterization. 2025 GET IT
-
Optimization and development of a high-throughput TR-FRET screening assay for SLIT2/ROBO1 interaction.
SLAS discovery : advancing life sciences R & D.
2025
Academic Article
GET IT
Times cited: 2 - CHI3L1-Targeted Small Molecules as Glioblastoma Therapies: Virtual Screening-Based Discovery, Biophysical Validation, Pharmacokinetic Profiling, and Evaluation in Glioblastoma Spheroids. 2025 GET IT
-
First-in-class dual inhibitors of MASTL and Aurora A kinase: Discovery of selective cyclohexa[b]thiophenes with potent anticancer activity.
European journal of medicinal chemistry.
2025
Academic Article
GET IT
Times cited: 2 -
Computational Design of a Bicyclic Peptide Inhibitor Targeting the ICOS/ICOS-L Protein-Protein Interaction.
Chemical biology & drug design.
2025
Academic Article
GET IT
Times cited: 2 -
Virtual screening: hope, hype, and the fine line in between.
Expert opinion on drug discovery.
2025
Review
GET IT
Times cited: 6 -
Discovery of ICOS-Targeted Small Molecules Using Affinity Selection Mass Spectrometry Screening.
ChemMedChem.
2024
Academic Article
GET IT
Times cited: 7 -
Small molecules from antibody pharmacophores (SMAbPs) as a hit identification workflow for immune checkpoints.
Science advances.
2024
Academic Article
GET IT
Times cited: 4 -
From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3.
ACS medicinal chemistry letters.
2024
Academic Article
GET IT
Times cited: 4 -
Design and Biophysical Characterization of Second-Generation cyclic peptide LAG-3 inhibitors for cancer immunotherapy.
Bioorganic & medicinal chemistry letters.
2024
Academic Article
GET IT
Times cited: 1 - Discovery of ICOS-targeted small molecules using affinity selection mass spectrometry screening. 2024 GET IT
-
Structure-Based Rational Design of Constrained Peptides as TIM-3 Inhibitors.
ACS medicinal chemistry letters.
2024
Academic Article
GET IT
Times cited: 5 -
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity.
European journal of medicinal chemistry.
2024
Academic Article
GET IT
Times cited: 14 -
Small Molecule Immunomodulators as Next-Generation Therapeutics for Glioblastoma.
Cancers.
2024
Review
GET IT
Times cited: 5 -
Lithocholic acid derivatives as potent modulators of the nuclear receptor RORγt.
RSC advances.
2024
Academic Article
GET IT
Times cited: 7 -
Design of cyclic peptides as novel inhibitors of ICOS/ICOSL interaction.
Bioorganic & medicinal chemistry letters.
2024
Academic Article
GET IT
Times cited: 8 -
Inhibitors of Immune Checkpoints: Small Molecule- and Peptide-Based Approaches.
Journal of personalized medicine.
2024
Review
GET IT
Times cited: 14 -
Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer's Disease Therapy.
ACS chemical neuroscience.
2023
Academic Article
GET IT
Times cited: 11 -
Discovery of ICOS-Targeted Small Molecules Using Pharmacophore-Based Screening.
ChemMedChem.
2023
Academic Article
GET IT
Times cited: 10 -
Discovery of Small-Molecule TIM-3 Inhibitors for Acute Myeloid Leukemia Using Pharmacophore-Based Virtual Screening.
Journal of medicinal chemistry.
2023
Academic Article
GET IT
Times cited: 19 -
First-in-class small molecule inhibitors of ICOS/ICOSL interaction as a novel class of immunomodulators.
RSC medicinal chemistry.
2023
Academic Article
GET IT
Times cited: 11 -
Development of a high-throughput TR-FRET screening assay for LAG-3/FGL1 interaction.
SLAS discovery : advancing life sciences R & D.
2023
Academic Article
GET IT
Times cited: 19 -
Discovery of First-in-Class Small Molecule Inhibitors of Lymphocyte Activation Gene 3 (LAG-3).
ACS medicinal chemistry letters.
2023
Academic Article
GET IT
Times cited: 26 -
Multicomponent Petasis reaction for the identification of pyrazine based multi-target directed anti-Alzheimer's agents: In-silico design, synthesis, and characterization.
European journal of medicinal chemistry.
2023
Academic Article
GET IT
Times cited: 15 -
Preclinical Evaluation of a Lead Specific Chelator (PSC) Conjugated to Radiopeptides for 203Pb and 212Pb-Based Theranostics.
Pharmaceutics.
2023
Academic Article
GET IT
Times cited: 32 -
Gut Microbial-Derived Metabolites as Immune Modulators of T Helper 17 and Regulatory T Cells.
International journal of molecular sciences.
2023
Review
GET IT
Times cited: 29 -
Emerging small-molecule therapeutic approaches for Alzheimer's disease and Parkinson's disease based on targeting microRNAs.
Neural regeneration research.
2022
Academic Article
GET IT
Times cited: 4 -
Prevalence of Chronic Kidney Disease in Nonalcoholic Fatty Liver Disease Patients.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2022
Academic Article
GET IT
Times cited: 2 -
Discovery of Hydroxybenzothiazole Urea Compounds as Multitargeted Agents Suppressing Major Cytotoxic Mechanisms in Neurodegenerative Diseases.
ACS chemical neuroscience.
2021
Academic Article
GET IT
Times cited: 6 -
Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects.
European journal of medicinal chemistry.
2021
Academic Article
GET IT
Times cited: 22 -
Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer's disease.
Bioorganic chemistry.
2021
Academic Article
GET IT
Times cited: 25 -
Mechanism of zinc ejection by disulfiram in nonstructural protein 5A.
Physical chemistry chemical physics : PCCP.
2021
Academic Article
GET IT
Times cited: 32 -
Discovery of new phenyl sulfonyl-pyrimidine carboxylate derivatives as the potential multi-target drugs with effective anti-Alzheimer's action: Design, synthesis, crystal structure and in-vitro biological evaluation.
European journal of medicinal chemistry.
2021
Academic Article
GET IT
Times cited: 58 -
Discovery and Optimization of Small-Molecule Ligands for V-Domain Ig Suppressor of T-Cell Activation (VISTA).
Journal of the American Chemical Society.
2020
Academic Article
GET IT
Times cited: 37 -
Discovery of a Histidine-Based Scaffold as an Inhibitor of Gut Microbial Choline Trimethylamine-Lyase.
ChemMedChem.
2020
Academic Article
GET IT
Times cited: 11 -
A benzoxazole derivative as an inhibitor of anaerobic choline metabolism by human gut microbiota.
RSC medicinal chemistry.
2020
Academic Article
GET IT
Times cited: 11 -
First dual binder of microRNA-146a and monomeric tau: a novel approach for multitargeted therapeutics for neurodegenerative diseases.
Chemical communications (Cambridge, England).
2020
Academic Article
GET IT
Times cited: 8 -
Peptidomimetic-based approach toward inhibitors of microbial trimethylamine lyases.
Chemical biology & drug design.
2020
Letter
GET IT
Times cited: 7 -
Quinoline-Pyrazole Scaffold as a Novel Ligand of Galectin-3 and Suppressor of TREM2 Signaling.
ACS medicinal chemistry letters.
2020
Academic Article
GET IT
Times cited: 17 -
MicroRNA-Based Multitarget Approach for Alzheimer's Disease: Discovery of the First-In-Class Dual Inhibitor of Acetylcholinesterase and MicroRNA-15b Biogenesis.
Journal of medicinal chemistry.
2020
Academic Article
GET IT
Times cited: 24 -
New synthesis of 6″-[18 F]fluoromaltotriose for positron emission tomography imaging of bacterial infection.
Journal of labelled compounds & radiopharmaceuticals.
2020
Academic Article
GET IT
Times cited: 8 -
Discovery of biphenyl pyrazole scaffold for neurodegenerative diseases: A novel class of acetylcholinesterase-centered multitargeted ligands.
Bioorganic & medicinal chemistry letters.
2020
Academic Article
GET IT
Times cited: 5 -
High-Throughput Platform for Real-Time Monitoring of ATP-Generating Enzymes in Living Cells Based on a Lanthanide Probe.
ACS sensors.
2020
Academic Article
GET IT
Times cited: 4 -
Multitarget Therapeutic Strategies for Alzheimer's Disease: Review on Emerging Target Combinations.
BioMed research international.
2020
Review
GET IT
Times cited: 93 -
Dual Targeting of Monomeric Tau and α-Synuclein Aggregation: A New Multitarget Therapeutic Strategy for Neurodegeneration.
ACS chemical neuroscience.
2020
Academic Article
GET IT
Times cited: 19 -
Molecular Imaging of Infective Endocarditis With 6''-[18F]Fluoromaltotriose Positron Emission Tomography-Computed Tomography.
Circulation.
2020
Letter
GET IT
Times cited: 13 -
Multitarget Therapeutics for Neurodegenerative Diseases.
BioMed research international.
2020
Editorial Article
GET IT
Times cited: 8 -
Expanding the Toolbox for Label-Free Enzyme Assays: A Dinuclear Platinum(II) Complex/DNA Ensemble with Switchable Near-IR Emission.
Molecules (Basel, Switzerland).
2019
Academic Article
GET IT
Times cited: 6 -
New series of fused pyrazolopyridines: Synthesis, molecular modeling, antimicrobial, antiquorum-sensing and antitumor activities.
Bioorganic chemistry.
2019
Academic Article
GET IT
Times cited: 17 -
Synthesis, molecular modeling and biological evaluation of new pyrazolo[3,4-b]pyridine analogs as potential antimicrobial, antiquorum-sensing and anticancer agents.
Bioorganic chemistry.
2019
Academic Article
GET IT
Times cited: 41 -
Multitarget therapeutic strategies for Alzheimer's disease.
Neural regeneration research.
2019
Review
GET IT
Times cited: 152 -
Platinum(II) Complexes with Sterically Expansive Tetraarylethylene Ligands as Probes for Mismatched DNA.
Inorganic chemistry.
2018
Academic Article
GET IT
Times cited: 14 -
Structure-Based Design and Synthesis of Fluorene Derivatives as Novel RORγt Inverse Agonists.
Chemistry & biodiversity.
2018
Academic Article
GET IT
Times cited: 3 -
Structure-based design, synthesis, and evaluation of structurally rigid donepezil analogues as dual AChE and BACE-1 inhibitors.
Bioorganic & medicinal chemistry letters.
2018
Academic Article
GET IT
Times cited: 21 -
Rhenium Complexes of Bis(benzothiazole)-Based Tetraarylethylenes as Selective Luminescent Probes for Amyloid Fibrils.
Chemistry (Weinheim an der Bergstrasse, Germany).
2018
Academic Article
GET IT
Times cited: 29 -
Design and synthesis of donepezil analogues as dual AChE and BACE-1 inhibitors.
Bioorganic chemistry.
2018
Academic Article
GET IT
Times cited: 55 -
Pharmacophore-based tailoring of biphenyl amide derivatives as selective 5-hydroxytryptamine 2B receptor antagonists.
MedChemComm.
2018
Academic Article
GET IT
Times cited: 5 -
A fluorescent turn-on probe for cyanide anion detection based on an AIE active cobalt(ii) complex.
Dalton transactions (Cambridge, England : 2003).
2018
Academic Article
GET IT
Times cited: 42 -
Rhenium tricarbonyl complexes of AIE active tetraarylethylene ligands: tuning luminescence properties and HSA-specific binding.
Dalton transactions (Cambridge, England : 2003).
2017
Academic Article
GET IT
Times cited: 33 -
Microwave-assisted synthesis and antitumor evaluation of a new series of thiazolylcoumarin derivatives.
EXCLI journal.
2017
Academic Article
GET IT
Times cited: 19 -
Isatin-β-thiocarbohydrazones: Microwave-assisted synthesis, antitumor activity and structure-activity relationship.
European journal of medicinal chemistry.
2017
Academic Article
GET IT
Times cited: 49 -
Synthesis and Evaluation of Tetraarylethylene-based Mono-, Bis-, and Tris(pyridinium) Derivatives for Image-Guided Mitochondria-Specific Targeting and Cytotoxicity of Metastatic Melanoma Cells.
Bioconjugate chemistry.
2016
Academic Article
GET IT
Times cited: 26 -
A selective fluorescent sensor for Zn(2+) based on aggregation-induced emission (AIE) activity and metal chelating ability of bis(2-pyridyl)diphenylethylene.
Dalton transactions (Cambridge, England : 2003).
2016
Academic Article
GET IT
Times cited: 37 -
Synthesis and in vitro antitumor activity of new series of benzothiazole and pyrimido[2,1-b]benzothiazole derivatives.
European journal of medicinal chemistry.
2014
Academic Article
GET IT
Times cited: 63 - EGFR tyrosine kinase targeted compounds: in vitro antitumor activity and molecular modeling studies of new benzothiazole and pyrimido[2,1-b]benzothiazole derivatives. EXCLI journal. 2014 Academic Article GET IT
-
Structure-based drug design and biological evaluation of 2-acetamidobenzothiazole derivative as EGFR kinase inhibitor.
Journal of enzyme inhibition and medicinal chemistry.
2014
Academic Article
GET IT
Times cited: 5