Ladjimi, Moncef

Publications

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selected publications

Repurposing Metformin for the Treatment of Atrial Fibrillation: Current Insights. Vascular health and risk management. 2024 Review GET IT
Cyanotoxin accumulation and growth patterns of biocrust communities under variable environmental conditions. Toxicon: X. 2024 Academic Article GET IT
Experimental and computational investigation of the effect of Hsc70 structural variants on inhibiting amylin aggregation. Biophysical chemistry. 2024 Academic Article GET IT
Human islet amyloid polypeptide (hIAPP) aggregation in type 2 diabetes: Correlation between intrinsic physicochemical properties of hIAPP aggregates and their cytotoxicity. International journal of biological macromolecules. 2019 Academic Article GET IT
Times cited: 13
The C-terminal α-helices of mammalian Hsc70 play a critical role in the stabilization of α-synuclein binding and inhibition of aggregation. International journal of biological macromolecules. 2015 Academic Article GET IT
Times cited: 19
Applying chaperones to protein-misfolding disorders: molecular chaperones against α-synuclein in Parkinson's disease. International journal of biological macromolecules. 2013 Information Resource GET IT
Times cited: 31
Surface behavior of α-Synuclein and its interaction with phospholipids using the Langmuir monolayer technique: a comparison between monomeric and fibrillar α-Synuclein. International journal of biological macromolecules. 2013 Academic Article GET IT
Times cited: 15
Identification of proteins related to early changes observed in Human hepatocellular carcinoma cells after treatment with the mycotoxin Zearalenone. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2013 Academic Article GET IT
Times cited: 13
iTRAQ: a method to elucidate cellular responses to mycotoxin zearalenone. Journal of applied toxicology : JAT. 2012 Academic Article GET IT
Times cited: 8
Sequential events of apoptosis induced by zearalenone in cultured hepatocarcinoma cells. Mycotoxin research. 2010 Academic Article GET IT
Times cited: 23
Comparative mechanisms of zearalenone and ochratoxin A toxicities on cultured HepG2 cells: is oxidative stress a common process?. Environmental toxicology. 2009 Academic Article GET IT
Times cited: 28
Toxicities induced in cultured human hepatocarcinoma cells exposed to ochratoxin A: oxidative stress and apoptosis status. Journal of biochemical and molecular toxicology. 2009 Academic Article GET IT
Times cited: 22
3-D structure modelling of the Staphylococcus simulans lipase: conformational changes, substrate specificity and novel structural features. FEMS microbiology letters. 2008 Academic Article GET IT
Times cited: 5
Analysis of monomeric mutants of HSC70: a possible relationship between oligomerization and functional properties. Protein and peptide letters. 2007 Academic Article GET IT
Times cited: 2
The effect of the hexahistidine-tag in the oligomerization of HSC70 constructs. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Academic Article GET IT
Times cited: 40
Induction of Hsp 70 in Vero cells in response to mycotoxins cytoprotection by sub-lethal heat shock and by Vitamin E. Toxicology letters. 2006 Academic Article GET IT
Times cited: 76
Involvement of the interdomain hydrophobic linker and the C-terminal helices in self-association of the molecular chaperone HSC70. Archives de l'Institut Pasteur de Tunis. 2006 Academic Article GET IT
Times cited: 3
Cytotoxicity and Hsp 70 induction in Hep G2 cells in response to zearalenone and cytoprotection by sub-lethal heat shock. Toxicology. 2005 Academic Article GET IT
Times cited: 40
Complementation of an Escherichia coli DnaK defect by Hsc70-DnaK chimeric proteins. Journal of bacteriology. 2004 Academic Article GET IT
Times cited: 13
A three-dimensional tumor cell defect in activating autologous CTLs is associated with inefficient antigen presentation correlated with heat shock protein-70 down-regulation. Cancer research. 2003 Academic Article GET IT
Times cited: 38
The Escherichia coli RecQ helicase functions as a monomer. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 53
Domain structure of the HSC70 cochaperone, HIP. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 18
Quaternary structure of the HSC70 cochaperone HIP. Biochemistry. 2000 Academic Article GET IT
Times cited: 21
Heat-induced oligomerization of the molecular chaperone Hsp90. Inhibition by ATP and geldanamycin and activation by transition metal oxyanions. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 39
Oligomerization of the 17-kDa peptide-binding domain of the molecular chaperone HSC70. European journal of biochemistry. 1999 Academic Article GET IT
Times cited: 33
Aspartate transcarbamylase from the deep-sea hyperthermophilic archaeon Pyrococcus abyssi: genetic organization, structure, and expression in Escherichia coli. Journal of bacteriology. 1997 Academic Article GET IT
Times cited: 33
The COOH-terminal peptide binding domain is essential for self-association of the molecular chaperone HSC70. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 49
Effect of nucleotides, peptides, and unfolded proteins on the self-association of the molecular chaperone HSC70. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 60
Unlike the quaternary structure transition, the tertiary structure change of the 240s loop in allosteric aspartate transcarbamylase requires active site saturation by substrate for completion. Biochemistry. 1995 Academic Article GET IT
Times cited: 12
Self-association of the molecular chaperone HSC70. Biochemistry. 1995 Academic Article GET IT
Times cited: 50
Intramolecular transmission of the ATP regulatory signal in Escherichia coli aspartate transcarbamylase: specific involvement of a clustered set of amino acid interactions at an interface between regulatory and catalytic subunits. Journal of molecular biology. 1995 Academic Article GET IT
Times cited: 27
The activation of Escherichia coli aspartate transcarbamylase by ATP. Specific involvement of helix H2' at the hydrophobic interface between the two domains of the regulatory chains. Journal of molecular biology. 1994 Academic Article GET IT
Times cited: 23
Structural modeling and electrostatic properties of aspartate transcarbamylase from Saccharomyces cerevisiae. Proteins. 1994 Academic Article GET IT
Times cited: 15
Overexpression in Escherichia coli, purification and characterization of the molecular chaperone HSC70. European journal of biochemistry. 1994 Academic Article GET IT
Times cited: 20
The tryptophan residues of aspartate transcarbamylase: site-directed mutagenesis and time-resolved fluorescence spectroscopy. Biochemistry. 1992 Academic Article GET IT
Times cited: 16
Heterotropic interactions in aspartate transcarbamoylase: turning allosteric ATP activation into inhibition as a consequence of a single tyrosine to phenylalanine mutation. Proceedings of the National Academy of Sciences of the United States of America. 1991 Academic Article GET IT
Times cited: 35
Heterotropic interactions in Escherichia coli aspartate transcarbamylase. Subunit interfaces involved in CTP inhibition and ATP activation. Journal of molecular biology. 1991 Academic Article GET IT
Times cited: 28
Co-operative interactions between the catalytic sites in Escherichia coli aspartate transcarbamylase. Role of the C-terminal region of the regulatory chains. Journal of molecular biology. 1990 Academic Article GET IT
Times cited: 16
The catalytic site of Escherichia coli aspartate transcarbamylase: interaction between histidine 134 and the carbonyl group of the substrate carbamyl phosphate. Biochemistry. 1990 Academic Article GET IT
Times cited: 12
Site-directed mutagenesis of a residue located in the regulatory site of Escherichia coli aspartate transcarbamoylase. Involvement of lysine 94 in effector binding and the allosteric mechanism. The Journal of biological chemistry. 1988 Academic Article GET IT
Times cited: 16
A possible model for the concerted allosteric transition in Escherichia coli aspartate transcarbamylase as deduced from site-directed mutagenesis studies. Biochemistry. 1988 Academic Article GET IT
Times cited: 68
Relationship between domain closure and binding, catalysis, and regulation in Escherichia coli aspartate transcarbamylase. Biochemistry. 1988 Academic Article GET IT
Times cited: 57
Catalytic-regulatory subunit interactions and allosteric effects in aspartate transcarbamylase. The Journal of biological chemistry. 1987 Academic Article GET IT
Times cited: 18
Structure-function relationship in allosteric aspartate carbamoyltransferase from Escherichia coli. II. Involvement of the C-terminal region of the regulatory chain in homotropic and heterotropic interactions. Journal of molecular biology. 1985 Academic Article GET IT
Times cited: 37

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Background

education and training

Ph.D., Universite Pierre et Marie Curie Paris VI (France) 1984
Diploma, Pasteur Institute (France) 1981
M.Sc., Universite Pierre et Marie Curie Paris VI (France) 1981
B.Sc., Universite Pierre et Marie Curie Paris VI (France) 1980

Contact

full name

Moncef Ladjimi

primary email

mol2007@qatar-med.cornell.edu

VIVO Weill Cornell Medical College

Moncef Ladjimi Professor of Biochemistry

Publications

selected publications

Background

education and training

Contact

full name

primary email