Bradbury, Michelle S.

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Ferroptosis induces heterogeneous death profiles that are controlled by lysosome rupture. Developmental cell. 2026 Academic Article GET IT
An ultrasmall core-shell silica nanoparticle improves antitumour immunity and survival by remodelling suppressive melanoma microenvironments. Nature nanotechnology. 2025 Academic Article GET IT
Engineering bispecific HER2xVEGF designed ankyrin repeat proteins for targeted nanobiotechnology applications. Journal of nanobiotechnology. 2025 Academic Article GET IT
Times cited: 1
A translational framework to DELIVER nanomedicines to the clinic. Nature nanotechnology. 2024 Review GET IT
Times cited: 169
Ultrasmall Folate Receptor Alpha Targeted Enzymatically Cleavable Silica Nanoparticle Drug Conjugates Augment Penetration and Therapeutic Efficacy in Models of Cancer. ACS nano. 2022 Academic Article GET IT
Times cited: 26
Engineered Ultrasmall Nanoparticle Drug-Immune Conjugates with "Hit and Run" Tumor Delivery to Eradicate Gastric Cancer. Advanced therapeutics. 2022 Academic Article GET IT
Ultrasmall Nanoparticle Delivery of Doxorubicin Improves Therapeutic Index for High-Grade Glioma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Academic Article GET IT
Times cited: 16
Detection of cutaneous oxygen saturation using a novel snapshot hyperspectral camera: a feasibility study. Quantitative imaging in medicine and surgery. 2021 Academic Article GET IT
Times cited: 9
Use of Ultrasmall Core-Shell Fluorescent Silica Nanoparticles for Image-Guided Sentinel Lymph Node Biopsy in Head and Neck Melanoma: A Nonrandomized Clinical Trial. JAMA network open. 2021 Academic Article GET IT
Times cited: 99
Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture. Nature cell biology. 2020 Academic Article GET IT
Times cited: 403
Molecular Engineering of Ultrasmall Silica Nanoparticle-Drug Conjugates as Lung Cancer Therapeutics. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Academic Article GET IT
Times cited: 22
Targeted melanoma radiotherapy using ultrasmall ¹⁷⁷Lu-labeled α-melanocyte stimulating hormone-functionalized core-shell silica nanoparticles. Biomaterials. 2020 Academic Article GET IT
Times cited: 56
A Genomic Profile of Local Immunity in the Melanoma Microenvironment Following Treatment with α Particle-Emitting Ultrasmall Silica Nanoparticles. Cancer biotherapy & radiopharmaceuticals. 2020 Academic Article GET IT
Times cited: 20
Molecular phenotyping and image-guided surgical treatment of melanoma using spectrally distinct ultrasmall core-shell silica nanoparticles. Science advances. 2019 Academic Article GET IT
Times cited: 49
Ultrasmall Renally Clearable Silica Nanoparticles Target Prostate Cancer. ACS applied materials & interfaces. 2019 Academic Article GET IT
Times cited: 37
Ultrasmall Core-Shell Silica Nanoparticles for Precision Drug Delivery in a High-Grade Malignant Brain Tumor Model. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Academic Article GET IT
Times cited: 83
Population Dynamics in Cell Death: Mechanisms of Propagation. Trends in cancer. 2019 Review GET IT
Times cited: 69
Acid specific dark quencher QC1 pHLIP for multi-spectral optoacoustic diagnoses of breast cancer. Scientific reports. 2019 Academic Article GET IT
Times cited: 20
Residual Tumor Volume, Cell Volume Fraction, and Tumor Cell Kill During Fractionated Chemoradiation Therapy of Human Glioblastoma using Quantitative Sodium MR Imaging. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Academic Article GET IT
Times cited: 27
Localising functionalised gold-nanoparticles in murine spinal cords by X-ray fluorescence imaging and background-reduction through spatial filtering for human-sized objects. Scientific reports. 2018 Academic Article GET IT
Times cited: 37
Correction to Melanocortin-1 Receptor-Targeting Ultrasmall Silica Nanoparticles for Dual-Modality Human Melanoma Imaging. 2018 GET IT
Times cited: 1
Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer. Nature communications. 2018 Academic Article GET IT
Times cited: 166
Correction: Expanding analytical tools for characterizing ultrasmall silica-based nanoparticles. 2018 GET IT
Melanocortin-1 Receptor-Targeting Ultrasmall Silica Nanoparticles for Dual-Modality Human Melanoma Imaging. ACS applied materials & interfaces. 2018 Academic Article GET IT
Times cited: 44
Nanotechnology Strategies To Advance Outcomes in Clinical Cancer Care. ACS nano. 2017 Review GET IT
Times cited: 252
Cancer-Targeting Ultrasmall Silica Nanoparticles for Clinical Translation: Physicochemical Structure and Biological Property Correlations. Chemistry of materials : a publication of the American Chemical Society. 2017 Academic Article GET IT
Times cited: 67
Target-or-Clear Zirconium-89 Labeled Silica Nanoparticles for Enhanced Cancer-Directed Uptake in Melanoma: A Comparison of Radiolabeling Strategies. Chemistry of materials : a publication of the American Chemical Society. 2017 Academic Article GET IT
Times cited: 67
Expanding Analytical Tools for Characterizing Ultrasmall Silica-based Nanoparticles. RSC advances. 2017 Academic Article GET IT
Times cited: 5
Advances in the clinical translation of nanotechnology. Current opinion in biotechnology. 2017 Review GET IT
Times cited: 33
Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth. Nature nanotechnology. 2016 Academic Article GET IT
Times cited: 562
Intraoperative mapping of sentinel lymph node metastases using a clinically translated ultrasmall silica nanoparticle. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. 2015 Review GET IT
Times cited: 57
Ultrasmall dual-modality silica nanoparticle drug conjugates: Design, synthesis, and characterization. Bioorganic & medicinal chemistry. 2015 Academic Article GET IT
Times cited: 30
Cancer nanomedicines: closing the translational gap. Lancet (London, England). 2014 Academic Article GET IT
Times cited: 66
Ultrasmall integrin-targeted silica nanoparticles modulate signaling events and cellular processes in a concentration-dependent manner. Small (Weinheim an der Bergstrasse, Germany). 2014 Academic Article GET IT
Times cited: 32
Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe. Science translational medicine. 2014 Academic Article GET IT
Times cited: 642
Multicompartment mesoporous silica nanoparticles with branched shapes: an epitaxial growth mechanism. Science (New York, N.Y.). 2013 Academic Article GET IT
Times cited: 161
Clinically-translated silica nanoparticles as dual-modality cancer-targeted probes for image-guided surgery and interventions. Integrative biology : quantitative biosciences from nano to macro. 2013 Academic Article GET IT
Times cited: 159
Fluorine-labeled dasatinib nanoformulations as targeted molecular imaging probes in a PDGFB-driven murine glioblastoma model. Neoplasia (New York, N.Y.). 2012 Academic Article GET IT
Times cited: 43
Serial monitoring of human systemic and xenograft models of leukemia using a novel vascular disrupting agent. Leukemia. 2012 Academic Article GET IT
Times cited: 17
Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma. The Journal of clinical investigation. 2011 Academic Article GET IT
Times cited: 627
Components of a curriculum for molecular imaging scientists. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2011 Academic Article GET IT
Times cited: 2
Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma. PloS one. 2011 Academic Article GET IT
Times cited: 68
Highly aminated mesoporous silica nanoparticles with cubic pore structure. Journal of the American Chemical Society. 2010 Academic Article GET IT
Times cited: 127
The role of the Supplementary Motor Area (SMA) in the execution of primary motor activities in brain tumor patients: functional MRI detection of time-resolved differences in the hemodynamic response. Medical science monitor : international medical journal of experimental and clinical research. 2009 Academic Article GET IT
Times cited: 15
Joint activation of the supplementary motor area and presupplementary motor area during simultaneous motor and language functional MRI. Neuroreport. 2009 Academic Article GET IT
Times cited: 19
Fluorescent silica nanoparticles with efficient urinary excretion for nanomedicine. Nano letters. 2009 Academic Article GET IT
Times cited: 435
Dynamic small-animal PET imaging of tumor proliferation with 3'-deoxy-3'-18F-fluorothymidine in a genetically engineered mouse model of high-grade gliomas. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2008 Academic Article GET IT
Times cited: 34
Long-term impact of radiation on the stem cell and oligodendrocyte precursors in the brain. PloS one. 2007 Academic Article GET IT
Times cited: 167
Optical bioluminescence imaging of human ES cell progeny in the rodent CNS. Journal of neurochemistry. 2007 Academic Article GET IT
Times cited: 25
Derivation of engraftable skeletal myoblasts from human embryonic stem cells. Nature medicine. 2007 Academic Article GET IT
Times cited: 271
Effect of brain tumor neovasculature defined by rCBV on BOLD fMRI activation volume in the primary motor cortex. NeuroImage. 2006 Academic Article GET IT
Times cited: 127
Molecular MR imaging in oncology. Magnetic resonance imaging clinics of North America. 2005 Information Resource GET IT
Times cited: 20
Method for combined FDG-PET and radiographic imaging of primary breast cancers. The breast journal. 2003 Academic Article GET IT
Times cited: 26
Mesenteric venous thrombosis: diagnosis and noninvasive imaging. Radiographics : a review publication of the Radiological Society of North America, Inc. 2002 Review GET IT
Times cited: 181
Noninvasive assessment of portomesenteric venous thrombosis: current concepts and imaging strategies. Journal of computer assisted tomography. 2002 Review GET IT
Times cited: 62

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Research

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Funding awarded

Targeting Inflammatory Pathways in Breast Cancer Brain Metastases for the Treatment of Edema and Radiation Necrosis Using Anti-VEGF Ultrasmall Particle Therapy awarded by Breast Cancer Research Foundation, Inc. Principal Investigator 2025 - 2027
Targeting Inflammatory Pathways in Breast Cancer Brain Metastases for the Treatment of Edema and Radiation Necrosis Using Anti-VEGF Ultrasmall Particle Therapy awarded by United States Department of Defense Principal Investigator 2025 - 2027
Ultrasmall PSMA-Targeted Particle Radiotherapy for Regulating the Immunosuppressive Prostate Cancer Tumor Microenvironment and Enhancing Treatment Efficacy awarded by United States Department of Defense Principal Investigator 2023 - 2026
Ultrasmall particle-based solutions for inducing ferroptosis and improving anti-tumor immune responses in cancer awarded by National Cancer Institute Principal Investigator 2023 - 2026
Molecular Phenotyping and Image-Guidance for Surgical Treatment of High-Risk Prostate Cancer Using Ultrasmall Silica Nanoparticles Principal Investigator 2023 - 2026

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Background

education and training

M.D., George Washington University School of Medicine and Health Sciences 1997
Ph.D., Massachusetts Institute of Technology 1993
M.S., University of Maryland 1986
B.A., University of Pennsylvania 1982

Contact

full name

Michelle S. Bradbury

primary email

msb2006@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Michelle S. Bradbury Professor of Radiology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage