Suthanthiran, Manikkam

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Does the Kidney allograft serve as an in-vivo flow cytometer? The answer, my friend, is flowin' in the urine (with apologies to Bob Dylan). American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2026 Editorial Article GET IT
Single-cell transcriptomics reveals targeted modulation of inflammatory repertoire by SOCE blockers. Human immunology. 2026 Academic Article GET IT
Impact of COVID-19 vaccination on long-Term patient and kidney allograft survival following SARS-CoV-2 infection. 2026 GET IT
Single-cell transcriptomics reveals targeted modulation of inflammatory repertoire by SOCE blockers. 2025 GET IT
Impact of Ultrasound-guided Percutaneous Core Needle Biopsy on Biomarkers of Human Kidney Allograft Status. Transplantation. 2025 Academic Article GET IT
Times cited: 1
Terry B. Strom: not just a pillar but a foundation. Frontiers in transplantation. 2024 Academic Article GET IT
Blockade of store-operated calcium entry by BTP2 preserves anti-inflammatory gene expression in human peripheral blood mononuclear cells. Human immunology. 2024 Academic Article GET IT
A universal urinary cell gene signature of acute rejection in kidney allografts. Journal of immunological methods. 2024 Academic Article GET IT
Times cited: 3
A quantitative comparison of urine centrifugation and filtration for the isolation and analysis of urinary nucleic acid biomarkers. Scientific reports. 2024 Academic Article GET IT
Times cited: 5
RNA-sequencing of Human Kidney Allografts and Delineation of T-Cell Genes, Gene Sets, and Pathways Associated With Acute T Cell-mediated Rejection. Transplantation. 2024 Academic Article GET IT
Times cited: 3
Urinary Cell Gene Signature of Acute Rejection in Kidney Allografts. 2023 GET IT
Transcriptomic signatures of chronic active antibody-mediated rejection deciphered by RNA sequencing of human kidney allografts. Kidney international. 2023 Academic Article GET IT
Times cited: 20
Evaluation of Immunocompetence and Biomarkers of Tolerance in Chimeric and Immunosuppression-free Kidney Allograft Recipients. Transplantation. 2023 Academic Article GET IT
Times cited: 3
Selective modulation of gene expression in activated normal human peripheral blood mononuclear cells by store-operated calcium entry blocker BTP2. 2023 GET IT
Times cited: 535
Urine as liquid gold: the transcriptional landscape of acute rejection defined by urinary cell mRNA profiling of kidney allograft recipients. Current opinion in organ transplantation. 2023 Review GET IT
Urinary cell mRNA profiling of kidney allograft recipients: Development of a portable protocol for noninvasive diagnosis of T cell mediated rejection and BK virus nephropathy. Journal of immunological methods. 2022 Academic Article GET IT
Times cited: 14
The Medawar Prize Acceptance Speech 2022. Transplantation. 2022 Academic Article GET IT
Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications. The Journal of physiology. 2022 Academic Article GET IT
Times cited: 7
Development of a Bak gene based standard curve for absolute quantification of BK virus in real time quantitative PCR assay and noninvasive diagnosis of BK virus nephropathy in kidney allograft recipients. Journal of immunological methods. 2022 Academic Article GET IT
Times cited: 5
A metagenomic DNA sequencing assay that is robust against environmental DNA contamination. Nature communications. 2022 Academic Article GET IT
Times cited: 26
Detection of infiltrating fibroblasts by single-cell transcriptomics in human kidney allografts. PloS one. 2022 Academic Article GET IT
Times cited: 26
Serum MicroRNA Transcriptomics and Acute Rejection or Recurrent Hepatitis C Virus in Human Liver Allograft Recipients: A Pilot Study. Transplantation. 2022 Academic Article GET IT
Times cited: 13
T-Cell-Positive, B-Cell-Negative Flow Cytometry Crossmatch: Frequency, HLA Locus Specificity, and Mechanisms Among 3073 Clinical Flow Cytometry Crossmatch Tests. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 2022 Academic Article GET IT
Times cited: 3
Measurement Biases Distort Cell-Free DNA Fragmentation Profiles and Define the Sensitivity of Metagenomic Cell-Free DNA Sequencing Assays. Clinical chemistry. 2021 Academic Article GET IT
Times cited: 14
A metagenomic DNA sequencing assay that is robust against environmental DNA contamination. 2021 GET IT
Design and Methods of the Validating Injury to the Renal Transplant Using Urinary Signatures (VIRTUUS) Study in Children. Transplantation direct. 2021 Academic Article GET IT
Urinary cell mRNA profiling of kidney allograft recipients: A systematic investigation of a filtration based protocol for the simplification of urine processing. Journal of immunological methods. 2021 Academic Article GET IT
Times cited: 4
Kidney Allograft Function Is a Confounder of Urine Metabolite Profiles in Kidney Allograft Recipients. Metabolites. 2021 Academic Article GET IT
Times cited: 11
FOXP3 mRNA Profile Prognostic of Acute T Cell-mediated Rejection and Human Kidney Allograft Survival. Transplantation. 2021 Academic Article GET IT
Times cited: 16
Urinary Cell mRNA Profiles Predictive of Human Kidney Allograft Status. Clinical journal of the American Society of Nephrology : CJASN. 2021 Review GET IT
Times cited: 29
Deep sequencing of DNA from urine of kidney allograft recipients to estimate donor/recipient-specific DNA fractions. PloS one. 2021 Academic Article GET IT
Validation of a noninvasive prognostic signature for allograft failure following BK virus associated nephropathy. Clinical transplantation. 2021 Academic Article GET IT
Times cited: 4
Characteristics of Acute Kidney Injury in Hospitalized COVID-19 Patients in an Urban Academic Medical Center. Clinical journal of the American Society of Nephrology : CJASN. 2020 Letter GET IT
Times cited: 34
Urinary Cell Transcriptome Profiling and Identification of ITM2A, SLAMF6, and IKZF3 as Biomarkers of Acute Rejection in Human Kidney Allografts. Transplantation direct. 2020 Academic Article GET IT
Times cited: 8
Kidney allograft recipients, immunosuppression, and coronavirus disease-2019: a report of consecutive cases from a New York City transplant center. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2020 Academic Article GET IT
Times cited: 70
Urinary cell transcriptomics and acute rejection in human kidney allografts. JCI insight. 2020 Academic Article GET IT
Times cited: 39
Separating the signal from the noise in metagenomic cell-free DNA sequencing. Microbiome. 2020 Academic Article GET IT
Times cited: 41
Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection. Nature communications. 2019 Academic Article GET IT
Times cited: 188
Gastrointestinal pathogen colonization and the microbiome in asymptomatic kidney transplant recipients. Transplant infectious disease : an official journal of the Transplantation Society. 2019 Academic Article GET IT
Times cited: 19
Butyrate-producing gut bacteria and viral infections in kidney transplant recipients: A pilot study. Transplant infectious disease : an official journal of the Transplantation Society. 2019 Academic Article GET IT
Times cited: 53
A cell-free DNA metagenomic sequencing assay that integrates the host injury response to infection. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 63
Landscape of innate immune system transcriptome and acute T cell-mediated rejection of human kidney allografts. JCI insight. 2019 Academic Article GET IT
Times cited: 45
MicroRNAs and Transplantation. Clinics in laboratory medicine. 2018 Review GET IT
Times cited: 29
Gut microbiota dysbiosis and diarrhea in kidney transplant recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2018 Academic Article GET IT
Times cited: 91
Urinary cell-free DNA is a versatile analyte for monitoring infections of the urinary tract. Nature communications. 2018 Academic Article GET IT
Times cited: 149
Single nucleotide variant counts computed from RNA sequencing and cellular traffic into human kidney allografts. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2018 Academic Article GET IT
Times cited: 11
Intervention using vitamin D for elevated urinary albumin in type 2 diabetes mellitus (IDEAL-2 Study): study protocol for a randomised controlled trial. Trials. 2018 Academic Article GET IT
Times cited: 6
Urine biomarkers informative of human kidney allograft rejection and tolerance. Human immunology. 2018 Review GET IT
Times cited: 10
Kidney allograft failure in the steroid-free immunosuppression era: A matched case-control study. Clinical transplantation. 2017 Academic Article GET IT
Times cited: 10
Sex and Kidney Transplantation: Why Can't a Woman Be More Like a Man?. Journal of the American Society of Nephrology : JASN. 2017 Editorial Article GET IT
Exome Sequencing and Prediction of Long-Term Kidney Allograft Function. PLoS computational biology. 2016 Academic Article GET IT
Times cited: 52
Acute Rejection, Kidney Allograft Function, and Graft Survival in Patients with Circulating Pre-Transplant IgG Antibodies Directed Against Donor HLA-A, -B, or -C Locus Determined Antigens. Clinical transplants. 2016 Academic Article GET IT
Times cited: 2
Design and Implementation of the International Genetics and Translational Research in Transplantation Network. Transplantation. 2015 Academic Article GET IT
Times cited: 63
Urine Metabolite Profiles Predictive of Human Kidney Allograft Status. Journal of the American Society of Nephrology : JASN. 2015 Academic Article GET IT
Times cited: 65
Characteristics of Circulating Donor Human Leukocyte Antigen-specific Immunoglobulin G Antibodies Predictive of Acute Antibody-mediated Rejection and Kidney Allograft Failure. Transplantation. 2015 Academic Article GET IT
Times cited: 56
Urine CXCL10/IP-10 Fingers Ongoing Antibody-Mediated Kidney Graft Rejection. Journal of the American Society of Nephrology : JASN. 2015 Editorial Article GET IT
Times cited: 10
Gut microbiota and tacrolimus dosing in kidney transplantation. PloS one. 2015 Academic Article GET IT
Times cited: 181
Gut microbial community structure and complications after kidney transplantation: a pilot study. Transplantation. 2014 Academic Article GET IT
Times cited: 188
Circulating levels of 25-hydroxyvitamin D and acute cellular rejection in kidney allograft recipients. Transplantation. 2014 Academic Article GET IT
Times cited: 56
Hypertension, kidney disease, HIV and antiretroviral therapy among Tanzanian adults: a cross-sectional study. BMC medicine. 2014 Academic Article GET IT
Times cited: 143
Allograft rejection and tubulointerstitial fibrosis in human kidney allografts: interrogation by urinary cell mRNA profiling. Transplantation reviews (Orlando, Fla.). 2014 Review GET IT
Times cited: 8
Urinary cell mRNA profiles and differential diagnosis of acute kidney graft dysfunction. Journal of the American Society of Nephrology : JASN. 2014 Academic Article GET IT
Times cited: 43
Urinary cell mRNA profiles predictive of human kidney allograft status. Immunological reviews. 2014 Review GET IT
Times cited: 42
Urinary-cell mRNA and acute kidney-transplant rejection. The New England journal of medicine. 2013 Article GET IT
Times cited: 14
Independent risk factors for urinary tract infection and for subsequent bacteremia or acute cellular rejection: a single-center report of 1166 kidney allograft recipients. Transplantation. 2013 Academic Article GET IT
Times cited: 139
On the detection of anti-HLA antibodies using single antigen bead Luminex assay: lot-to-lot variations in MFI. Transplantation. 2013 Letter GET IT
Times cited: 17
Noninvasive prognostication of polyomavirus BK virus-associated nephropathy. Transplantation. 2013 Academic Article GET IT
Times cited: 22
Urinary-cell mRNA profile and acute cellular rejection in kidney allografts. The New England journal of medicine. 2013 Academic Article GET IT
Times cited: 316
Multicenter evaluation of a standardized protocol for noninvasive gene expression profiling. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2013 Academic Article GET IT
Times cited: 36
Genomic biomarkers correlate with HLA-identical renal transplant tolerance. Journal of the American Society of Nephrology : JASN. 2013 Academic Article GET IT
Times cited: 57
HIV-infected kidney graft recipients managed with an early corticosteroid withdrawal protocol: clinical outcomes and messenger RNA profiles. Transplantation. 2013 Academic Article GET IT
Times cited: 16
The Nobel Prize-winning work of Ralph Steinman (1943-2011) and its relevance to transplantation. Transplantation. 2013 Editorial Article GET IT
Transplantation: a report of progress. Transplantation. 2013 Editorial Article GET IT
HLA identical non-chimeric and HLA disparate chimeric renal transplant tolerance. Clinical transplants. 2013 Academic Article GET IT
Times cited: 7
MicroRNA sequence profiles of human kidney allografts with or without tubulointerstitial fibrosis. Transplantation. 2012 Academic Article GET IT
Times cited: 106
Early corticosteroid withdrawal in recipients of renal allografts: a single-center report of ethnically diverse recipients and recipients of marginal deceased-donor kidneys. Transplantation. 2012 Academic Article GET IT
Times cited: 10
Concurrent acute cellular rejection is an independent risk factor for renal allograft failure in patients with C4d-positive antibody-mediated rejection. Transplantation. 2012 Academic Article GET IT
Times cited: 40
Discovery and validation of a molecular signature for the noninvasive diagnosis of human renal allograft fibrosis. Transplantation. 2012 Academic Article GET IT
Times cited: 37
Dendritic cells with TGF-β1 and IL-2 differentiate naive CD4+ T cells into alloantigen-specific and allograft protective Foxp3+ regulatory T cells. Transplantation. 2012 Academic Article GET IT
Times cited: 17
Angiogenic factors in superimposed preeclampsia: a longitudinal study of women with chronic hypertension during pregnancy. Hypertension (Dallas, Tex. : 1979). 2012 Academic Article GET IT
Times cited: 114
Excretion of anti-angiogenic proteins in patients with chronic allograft dysfunction. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 Academic Article GET IT
Times cited: 4
Mean arterial blood pressure while awaiting kidney transplantation is associated with the risk of primary nonfunction. Transplantation. 2012 Academic Article GET IT
Times cited: 4
Transplantation: a report of progress. Transplantation. 2010 Editorial Article GET IT
Urinary cell levels of mRNA for OX40, OX40L, PD-1, PD-L1, or PD-L2 and acute rejection of human renal allografts. Transplantation. 2010 Academic Article GET IT
Times cited: 55
Diannexin decreases inflammatory cell infiltration into the islet graft, reduces β-cell apoptosis, and improves early graft function. Transplantation. 2010 Academic Article GET IT
Times cited: 24
MicroRNAs: small RNAs with big effects. Transplantation. 2010 Information Resource GET IT
Times cited: 156
Validation of noninvasive diagnosis of BK virus nephropathy and identification of prognostic biomarkers. Transplantation. 2010 Academic Article GET IT
Times cited: 59
Identification of a B cell signature associated with renal transplant tolerance in humans. The Journal of clinical investigation. 2010 Academic Article GET IT
Times cited: 619
Noninvasive diagnosis of acute rejection of renal allografts. Current opinion in organ transplantation. 2010 Information Resource GET IT
Times cited: 75
Transplantation: Personalizing induction therapy in kidney transplantation. Nature reviews. Nephrology. 2009 Review GET IT
Times cited: 2
MicroRNA expression profiles predictive of human renal allograft status. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 315
Circulating transforming growth factor-beta1 levels and the risk for kidney disease in African Americans. Kidney international. 2009 Academic Article GET IT
Times cited: 51
Post-transplantation malignancy: a cell autonomous mechanism with implications for therapy. Transactions of the American Clinical and Climatological Association. 2009 Academic Article GET IT
Times cited: 20
Transforming growth factor beta and excess burden of renal disease. Transactions of the American Clinical and Climatological Association. 2009 Academic Article GET IT
Times cited: 20
Transplantation: a report of progress. Transplantation. 2008 Editorial Article GET IT
Epidemiology of BK virus in renal allograft recipients: independent risk factors for BK virus replication. Transplantation. 2008 Academic Article GET IT
Times cited: 114
Noninvasive prediction of organ graft rejection and outcome using gene expression patterns. Transplantation. 2008 Information Resource GET IT
Times cited: 88
Should hepatitis C virus infection be a contraindication to renal transplantation?. Nature clinical practice. Nephrology. 2008 Comment GET IT
HLA-mismatched renal transplantation without maintenance immunosuppression. The New England journal of medicine. 2008 Academic Article GET IT
Times cited: 944
Dual transplantation of kidneys from expanded criteria donors: maximizing the use of a scarce resource. Nature clinical practice. Nephrology. 2007 Article GET IT
Hyperexpression of Foxp3 and IDO during acute rejection of islet allografts. Transplantation. 2007 Academic Article GET IT
Times cited: 20
Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 210
Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 313
Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function. Journal of the American Society of Nephrology : JASN. 2006 Academic Article GET IT
Times cited: 80
Transforming growth factor beta signaling, vascular remodeling, and hypertension. The New England journal of medicine. 2006 Article GET IT
Times cited: 54
Transcriptional profiling to assess the clinical status of kidney transplants. Nature clinical practice. Nephrology. 2006 Article GET IT
Times cited: 10
Messenger RNA for FOXP3 in the urine of renal-allograft recipients. The New England journal of medicine. 2005 Academic Article GET IT
Times cited: 466
Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations. Transplantation. 2005 Information Resource GET IT
Times cited: 764
Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice. Transplantation. 2005 Academic Article GET IT
Times cited: 67
Measurement of apoptosis of intact human islets by confocal optical sectioning and stereologic analysis of YO-PRO-1-stained islets. Transplantation. 2005 Academic Article GET IT
Times cited: 20
Enhanced granulysin mRNA expression in urinary sediment in early and delayed acute renal allograft rejection. Transplantation. 2004 Academic Article GET IT
Times cited: 94
Noninvasive detection of renal allograft inflammation by measurements of mRNA for IP-10 and CXCR3 in urine. Kidney international. 2004 Academic Article GET IT
Times cited: 155
Correlation between interleukin-15 and granzyme B expression and acute lung allograft rejection. Transplant immunology. 2004 Academic Article GET IT
Times cited: 24
Noninvasive diagnosis of acute rejection of solid organ transplants. Frontiers in bioscience : a journal and virtual library. 2004 Review GET IT
Times cited: 20
Rapamycin inhibits the growth and metastatic progression of non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2004 Academic Article GET IT
Times cited: 86
Optimal modes and targets of gene therapy in transplantation. Immunological reviews. 2003 Information Resource GET IT
Times cited: 9
Transforming growth factor beta and progression of renal disease. Kidney international. Supplement. 2003 Academic Article GET IT
Times cited: 53
Tacrolimus enhances transforming growth factor-beta1 expression and promotes tumor progression. Transplantation. 2003 Academic Article GET IT
Times cited: 184
Optimization of RNA yield, purity and mRNA copy number by treatment of urine cell pellets with RNAlater. Journal of immunological methods. 2003 Academic Article GET IT
Times cited: 37
Noninvasive diagnosis of BK virus nephritis by measurement of messenger RNA for BK VP1 virus in urine. Transplantation. 2003 Article GET IT
Times cited: 12
Molecular signatures of urinary cells distinguish acute rejection of renal allografts from urinary tract infection. Transplantation. 2003 Academic Article GET IT
Times cited: 45
Serine proteinase inhibitor-9, an endogenous blocker of granzyme B/perforin lytic pathway, is hyperexpressed during acute rejection of renal allografts. Transplantation. 2003 Academic Article GET IT
Times cited: 58
CD103 mRNA levels in urinary cells predict acute rejection of renal allografts. Transplantation. 2003 Academic Article GET IT
Times cited: 83
Selective loss of c-Rel compromises dendritic cell activation of T lymphocytes. Cellular immunology. 2003 Academic Article GET IT
Times cited: 30
Rapamycin is an effective inhibitor of human renal cancer metastasis. Kidney international. 2003 Academic Article GET IT
Times cited: 186
Proapoptotic Bax is hyperexpressed in isolated human islets compared with antiapoptotic Bcl-2. Transplantation. 2002 Academic Article GET IT
Times cited: 46
Noninvasive diagnosis of BK virus nephritis by measurement of messenger RNA for BK virus VP1 in urine. Transplantation. 2002 Academic Article GET IT
Times cited: 107
Enforced c-REL deficiency prolongs survival of islet allografts1. Transplantation. 2002 Academic Article GET IT
Times cited: 28
Rapamycin blocks tumor progression: unlinking immunosuppression from antitumor efficacy. Transplantation. 2002 Academic Article GET IT
Times cited: 213
Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine. The New England journal of medicine. 2001 Academic Article GET IT
Times cited: 485
Angiotensin II receptor blockade: a novel strategy to prevent immunosuppressant-associated cancer progression. Transplantation proceedings. 2001 Academic Article GET IT
Times cited: 10
MHC-independent allograft vascular disease: mRNA profile in the MHC congenic rat heterotopic cardiac transplant model. Transplantation proceedings. 2001 Academic Article GET IT
Renal allograft surveillance by mRNA profiling of urinary cells. Transplantation proceedings. 2001 Academic Article GET IT
Times cited: 11
Dendritic cells armed with anti-CD3 mAbs reduce pulmonary metastases, prolong survival, and engender antitumor effector cells demonstrable by adoptive transfer. Annals of surgical oncology. 2000 Academic Article GET IT
Times cited: 2
Immunologic monitoring: implications for treatment of rejection. Transplantation proceedings. 2000 Academic Article GET IT
Times cited: 3
Renal transplantation: reaping the rewards of biomedical research. Current opinion in nephrology and hypertension. 2000 Editorial Article GET IT
T-cell antigen recognition and costimulatory pathways: implications for the induction of transplantation tolerance. Transplantation proceedings. 2000 Academic Article GET IT
Times cited: 2
Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage. Proceedings of the National Academy of Sciences of the United States of America. 2000 Academic Article GET IT
Times cited: 270
Lymphocyte intracellular free calcium concentration is increased in preeclampsia. American journal of obstetrics and gynecology. 1999 Academic Article GET IT
Times cited: 30
Cyclosporine induces cancer progression by a cell-autonomous mechanism. Nature. 1999 Academic Article GET IT
Times cited: 916
TGF-beta1 DNA polymorphisms, protein levels, and blood pressure. Hypertension (Dallas, Tex. : 1979). 1999 Academic Article GET IT
Times cited: 137
Molecular correlates of human renal allograft rejection. Transplantation proceedings. 1998 Academic Article GET IT
Times cited: 17
Quantitative competitive polymerase chain reaction: design and synthesis of mRNA-specific competitor DNA templates and their clinical usage. Transplantation proceedings. 1998 Academic Article GET IT
Times cited: 3
Transforming growth factor-beta 1 hyperexpression in African American end-stage renal disease patients. Kidney international. 1998 Academic Article GET IT
Times cited: 79
In vivo expression of transforming growth factor-beta1 in humans: stimulation by cyclosporine. Transplantation. 1998 Academic Article GET IT
Times cited: 156
Immunoregulatory drugs: mechanistic basis for use in organ transplantation. Pediatric nephrology (Berlin, Germany). 1997 Information Resource GET IT
Times cited: 11
Immunostimulatory therapy with anti-CD3 monoclonal antibodies and recombinant interleukin-2: heightened in vivo expression of mRNA encoding cytotoxic attack molecules and immunoregulatory cytokines and regression of murine renal cell carcinoma. The Journal of urology. 1997 Academic Article GET IT
Times cited: 7
Clinical application of molecular biology: a study of allograft rejection with polymerase chain reaction. The American journal of the medical sciences. 1997 Academic Article GET IT
Times cited: 45
In vivo hyperexpression of transforming growth factor-beta1 in mice: stimulation by cyclosporine. Transplantation. 1997 Academic Article GET IT
Times cited: 95
Intracellular Ca2+ elevation and cyclosporin A synergistically induce TGF-beta 1-mediated apoptosis in lymphocytes. Journal of immunology (Baltimore, Md. : 1950). 1997 Academic Article GET IT
Times cited: 42
Effect of nifedipine on renal allograft function and survival beyond one year. Clinical nephrology. 1997 Academic Article GET IT
Times cited: 10
In vivo hyperexpression of transforming growth factor-beta 1 in humans: stimulation by cyclosporine. Transplantation proceedings. 1997 Academic Article GET IT
Times cited: 15
Intrarenal display of cytotoxic attack molecules during rejection. Transplantation proceedings. 1997 Academic Article GET IT
Times cited: 1
Molecular executors of cell death--differential intrarenal expression of Fas ligand, Fas, granzyme B, and perforin during acute and/or chronic rejection of human renal allografts. Transplantation. 1996 Academic Article GET IT
Times cited: 124
Immunoregulatory and fibrogenic activities of cyclosporine: a unifying hypothesis based on transforming growth factor-beta expression. Transplantation proceedings. 1996 Review GET IT
Times cited: 24
Immunosuppressants: cellular and molecular mechanisms of action. American journal of kidney diseases : the official journal of the National Kidney Foundation. 1996 Information Resource GET IT
Times cited: 111
CD2 antigen targeting reduces intragraft expression of mRNA-encoding granzyme B and IL-10 and induces tolerance. Transplantation. 1996 Academic Article GET IT
Times cited: 12
Intragraft TGF-beta 1 mRNA: a correlate of interstitial fibrosis and chronic allograft nephropathy. Kidney international. 1996 Academic Article GET IT
Times cited: 169
Regulation of the anti-allograft response by targeting the CD2 antigen: a potential strategy for the creation of transplant tolerance. Surgical technology international. 1996 Academic Article GET IT
Intragraft expression of IL-10 messenger RNA: a novel correlate of renal allograft rejection. Kidney international. 1995 Academic Article GET IT
Times cited: 59
Retrievable, replaceable, macroencapsulated pancreatic islet xenografts. Long-term engraftment without immunosuppression. Transplantation. 1995 Academic Article GET IT
Times cited: 50
Stimulation of transforming growth factor-beta 1 transcription by cyclosporine. FEBS letters. 1995 Academic Article GET IT
Times cited: 95
Consistent long-term allograft survival in murine pancreatic islet transplants without immunosuppression. Transplantation proceedings. 1994 Academic Article GET IT
Times cited: 2
Regulation of transforming growth factor-beta 1 (TGF-beta 1) expression with a novel TGF-beta 1 complementary DNA. Biochemical and biophysical research communications. 1994 Academic Article GET IT
Times cited: 18
Which way for drug-mediated immunosuppression?. Current opinion in immunology. 1994 Review GET IT
Times cited: 35
Immunotherapy with anti-CD3 monoclonal antibodies and recombinant interleukin 2: stimulation of molecular programs of cytotoxic killer cells and induction of tumor regression. Proceedings of the National Academy of Sciences of the United States of America. 1994 Academic Article GET IT
Times cited: 21
Renal transplantation. The New England journal of medicine. 1994 Information Resource GET IT
Times cited: 370
Regulation of new DNA synthesis in mammalian cells by cyclosporine. Demonstration of a transforming growth factor beta-dependent mechanism of inhibition of cell growth. Transplantation. 1994 Academic Article GET IT
Times cited: 123
Modulation of mouse mesangial cell proliferation by thiourea and lipoxygenase inhibitors. Nephron. 1994 Academic Article GET IT
Times cited: 4
Advanced glycosylation endproduct-specific receptors on human and rat T-lymphocytes mediate synthesis of interferon gamma: role in tissue remodeling. The Journal of experimental medicine. 1993 Academic Article GET IT
Times cited: 114
Steroid withdrawal, rejection and the mixed lymphocyte reaction in children after renal transplantation. Kidney international. Supplement. 1993 Academic Article GET IT
Times cited: 40
Excellent outcome with a calcium channel blocker-supplemented immunosuppressive regimen in cadaveric renal transplantation. A potential strategy to avoid antibody induction protocols. Transplantation. 1993 Academic Article GET IT
Times cited: 39
Synergism between the CD3 antigen- and CD2 antigen-derived signals. Exploration at the level of induction of DNA-binding proteins and characterization of the inhibitory activity of cyclosporine. Transplantation. 1993 Academic Article GET IT
Times cited: 22
Transmembrane signaling requirements of T cells. Transplantation proceedings. 1993 Academic Article GET IT
Two-signal model for T-cell activation: molecular mechanisms. Transplantation proceedings. 1993 Academic Article GET IT
Times cited: 3
Inhibition of interleukin 2 receptor expression in normal human T cells by cyclosporine. Demonstration at the mRNA, protein, and functional levels. Transplantation. 1992 Academic Article GET IT
Times cited: 19
Differential regulation of transforming growth factor beta and interleukin 2 genes in human T cells: demonstration by usage of novel competitor DNA constructs in the quantitative polymerase chain reaction. The Journal of experimental medicine. 1991 Academic Article GET IT
Times cited: 198
Two novel rat liver membrane proteins that bind advanced glycosylation endproducts: relationship to macrophage receptor for glucose-modified proteins. The Journal of experimental medicine. 1991 Academic Article GET IT
Times cited: 180
The role of interleukin-6 in mitogenic T-cell activation: detection of interleukin-2 heteronuclear RNA by polymerase chain reaction. Cellular immunology. 1991 Academic Article GET IT
Times cited: 5
Ferro-mitogens: iron-containing compounds with lymphocyte-stimulatory properties. Cellular immunology. 1991 Academic Article GET IT
Times cited: 19
Minimal sensitization and excellent renal allograft outcome following donor-specific blood transfusion with a short course of cyclosporine. Transplantation. 1991 Academic Article GET IT
Times cited: 29
The molecular basis for the synergism between the CD3/alpha beta T cell receptor and the CD2 antigen-derived signals in promoting T-cell proliferation. Transplantation. 1991 Academic Article GET IT
Times cited: 8
A randomized controlled trial of low-dose prednisone and ciclosporin versus high-dose prednisone in nephrotic syndrome of children. Nephron. 1991 Academic Article GET IT
Times cited: 45
A novel model for antigen-dependent activation of normal human T cells. Transmembrane signaling by crosslinkage of the CD3/T cell receptor-alpha/beta complex with the cluster determinant 2 antigen. The Journal of experimental medicine. 1990 Academic Article GET IT
Times cited: 41
Physiologic signaling in normal human T-cells: mRNA phenotyping by northern blot analysis and reverse transcription-polymerase chain reaction. Cellular immunology. 1990 Academic Article GET IT
Times cited: 9
Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens. Proceedings of the National Academy of Sciences of the United States of America. 1990 Academic Article GET IT
Times cited: 368
A novel addition to the T cell repertory. Cell surface expression of tumor necrosis factor/cachectin by activated normal human T cells. The Journal of experimental medicine. 1990 Academic Article GET IT
Times cited: 141
Possible association of the immunosuppressive and B cell lymphoma-promoting properties of cyclosporine. Transplantation. 1990 Academic Article GET IT
Times cited: 45
Immune stimulatory properties of metalloporphyrins. Journal of immunology (Baltimore, Md. : 1950). 1989 Academic Article GET IT
Times cited: 51
A phase II clinical trial of adoptive immunotherapy for advanced renal cell carcinoma using mitogen-activated autologous leukocytes and continuous infusion interleukin-2. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1989 Academic Article GET IT
Times cited: 27
OKT3-associated adverse reactions: mechanistic basis and therapeutic options. American journal of kidney diseases : the official journal of the National Kidney Foundation. 1989 Academic Article GET IT
Times cited: 32
Demonstration of a direct inhibitory effect of cyclosporine on normal human T-cells with two novel models of T-cell activation as probes. Cellular immunology. 1989 Academic Article GET IT
Times cited: 8
Analysis of spontaneous blastogenesis profiles in recipients of renal allografts. Transplantation proceedings. 1989 Academic Article GET IT
Signaling via the T-cell antigen receptor heterodimer and the CD2 antigen: a novel, synergistic pathway for activation of T-cells. Transplantation proceedings. 1989 Academic Article GET IT
Times cited: 2
Transmembrane signalling via the T cell antigen receptor heterodimer and the CD2 antigen. A synergistic pathway for activation of T cells. Transplantation. 1989 Academic Article GET IT
Times cited: 8
Activation of human T cells with the physiological regulator of protein kinase C. Cellular immunology. 1988 Academic Article GET IT
Times cited: 13
Human memory T cell activation. Effects of monoclonal antibodies directed at interleukin-2, receptors for interleukin-2, or interferon-gamma. Transplantation. 1988 Academic Article GET IT
Times cited: 2
Oxidative mitogenesis: participation of CD2 antigen in the generation and/or transduction of obligatory accessory signals. Cellular immunology. 1988 Academic Article GET IT
Times cited: 7
Altered nucleic acid contents of mononuclear cells in blood of renal allograft recipients. Cytometry. 1988 Academic Article GET IT
Times cited: 1
Cyclosporine A induced remission of relapsing nephrotic syndrome in children. Kidney international. 1988 Academic Article GET IT
Times cited: 146
In vivo effects of high-dose steroids on nucleic acid content of immunocompetent cells of renal allograft recipients. Transplantation. 1988 Academic Article GET IT
Times cited: 1
T-cell differentiation antigen cluster 2 (CD2) is a receptor for accessory cells and can generate and/or transduce accessory signals. Cellular immunology. 1988 Academic Article GET IT
Times cited: 21
Periodate and recombinant interleukin-2-activated autologous leukocytes can induce regression of metastases of renal cancer. Cancer detection and prevention. 1988 Academic Article GET IT
Adoptive immunotherapy for stage IV renal cell carcinoma: a novel protocol utilizing periodate and interleukin-2-activated autologous leukocytes and continuous infusions of low-dose interleukin-2. The American journal of medicine. 1987 Academic Article GET IT
Times cited: 33
Cyclosporine-induced remission of relapsing nephrotic syndrome in children. The Journal of pediatrics. 1987 Academic Article GET IT
Times cited: 45
Inhibitory activity of cyclosporine is dependent on the activating signal(s) provided to T cells. The Journal of pediatrics. 1987 Academic Article GET IT
Times cited: 5
Effect of immunosuppressants on OKT3 associated T cell activation: clinical implications. Kidney international. 1987 Academic Article GET IT
Times cited: 12
Cell cycle analysis of activated mononuclear blood cells of renal allograft recipients. Transplantation proceedings. 1987 Academic Article GET IT
Human T cell activation: participation of Tll antigen (CD2, T,gp.50) in T cell-accessory cell interactions. Transplantation proceedings. 1987 Academic Article GET IT
Times cited: 4
Optimization of donor specific blood transfusion in kidney transplantation. Transplantation proceedings. 1987 Academic Article GET IT
Anti-tumor properties of lymphocytes activated by the oxidizing mitogens. Journal of immunology (Baltimore, Md. : 1950). 1986 Academic Article GET IT
Times cited: 2
Human B lymphoblastoid cell lines provide an interleukin 1-like signal for mitogen-treated T lymphocytes via direct cell contact. Journal of immunology (Baltimore, Md. : 1950). 1985 Academic Article GET IT
Times cited: 14
Cellular and humoral mechanisms in the pathogenesis of tubulointerstitial nephritis. Uremia investigation. 1985 Academic Article GET IT
Induction of donor-specific immune modulation and successful renal transplantation with a simplified method of donor-specific blood transfusion. Uremia investigation. 1985 Academic Article GET IT
Times cited: 3
A reappraisal of the effects of monoclonal antibodies directed at T cell differentiation antigens. Transplantation. 1984 Academic Article GET IT
Times cited: 2
Induction of cytolytic activity by anti-T3 monoclonal antibody. Activation of alloimmune memory cells and natural killer cells from normal and immunodeficient individuals. The Journal of clinical investigation. 1984 Academic Article GET IT
Induction of immune alterations and successful renal transplantation with a simplified method of donor-specific blood transfusion. Transplantation. 1984 Academic Article GET IT
Times cited: 13
Activation of T cells via cell-cell interaction: role of growth factors and accessory cells. Uremia investigation. 1984 Academic Article GET IT
Evolution of immunosuppressive treatment modalities for renal transplant recipients. Uremia investigation. 1984 Academic Article GET IT
Hydroxyl radical scavengers inhibit human natural killer cell activity. Nature. 1984 Academic Article GET IT
Times cited: 86
Presumed assault or accommodative reactions involved in human renal transplantation. Uremia investigation. 1984 Academic Article GET IT
Immunologic monitoring of the renal transplant recipient. The Urologic clinics of North America. 1983 Information Resource GET IT
Times cited: 17
Long-term renal allograft survival in rats preimmunized with donor strain RT1.B antigens. Transplantation. 1983 Academic Article GET IT
Times cited: 5
Maternal-fetal immunity: presence of specific cellular hyporesponsiveness and humoral suppressor activity in normal pregnancy and their absence in preeclampsia. Clinical and experimental hypertension. Part B, Hypertension in pregnancy. 1983 Academic Article GET IT
Times cited: 12
Natural history of cadaveric kidney transplants in the absence of early acute rejection. Nephron. 1983 Academic Article GET IT
Times cited: 3
The advantage of measurement of intact PTH in the prediction of clinical response and calcium metabolism after subtotal parathyroidectomy for renal osteodystrophy. Transactions - American Society for Artificial Internal Organs. 1983 Academic Article GET IT
Times cited: 3
Abrogation of proliferation and generation of cytotoxic T cells in human mixed lymphocyte culture reactions by modification of the cell surface with mitogenic oxidizing agents. Transplantation. 1982 Academic Article GET IT
Times cited: 1
Enhanced kidney graft survival with retroplacental source gamma-globulin. Results of a 5-year prospective study at a single center. Transplantation. 1982 Academic Article GET IT
Times cited: 6
Immunosuppressive properties of polar organic compounds that induce cellular differentiation in Friend erythroleukemia cells. Transplantation. 1982 Academic Article GET IT
Times cited: 13
Role of HLA DR in renal transplantation. New York state journal of medicine. 1982 Academic Article GET IT
Expression of Fc mu receptors by human T lymphocytes: effects of enzymes, metabolic inhibitors, and X-irradiation. Journal of immunology (Baltimore, Md. : 1950). 1981 Academic Article GET IT
Times cited: 14
Detection of alloimmune memory cells by chemical modification of the cell surface with mitogenic oxidizing agents. Transplantation proceedings. 1981 Academic Article GET IT
Declining transplantability of prospective kidney transplant recipients. JAMA. 1981 Academic Article GET IT
Times cited: 21
Biological effects of activation of human peripheral blood mononuclear cells by mitogenic oxidizing agents. I Alloantigen-independent activation of alloimmune memory cells. Cellular immunology. 1981 Academic Article GET IT
Times cited: 8
Alloantigen-independent activation of alloimmune memory cells by soluble factors from mitogen-primed cells. Transplantation proceedings. 1981 Academic Article GET IT
Times cited: 1
Plasmapheresis in the prevention and treatment of rapidly progressive renal disease. Clinical and experimental dialysis and apheresis. 1981 Information Resource GET IT
Detection of alloimmune memory cells by chemical modification of the cell surface with mitogenic oxidizing agents. Transplantation. 1980 Academic Article GET IT
Kidney transplantation; use of gamma globulin as an immunosuppressive agent. New York state journal of medicine. 1980 Academic Article GET IT
Times cited: 2
Role of humoral presenitization in human renal transplant rejection. Kidney international. 1980 Academic Article GET IT
Times cited: 17
Immunological properties of subcellular rat lymphocyte preparations. Primary allogeneic stimulation in vitro by fractions containing Ia (RT1-B), but not RT1-A antigens. The Journal of experimental medicine. 1980 Academic Article GET IT
Augmentation of proliferation and generation of specific cytotoxic cells in human mixed lymphocyte culture reactions by colchicine. Cellular immunology. 1980 Academic Article GET IT
Times cited: 19
Generation of a lymphocyte growth factor by treatment of human cells with neuraminidase and galactose oxidase. The Journal of experimental medicine. 1980 Academic Article GET IT
Activation of alloimmune memory cells by soluble factors: a model for elicitation of specific allograft responses by immunologically nonspecific signals. Proceedings of the Clinical Dialysis and Transplant Forum. 1980 Academic Article GET IT
Generation of specific secondary cytotoxic T cells by treatment of long-term primary MLC cells with sodium periodate. Transplantation proceedings. 1979 Academic Article GET IT
Times cited: 1
Differential antibody responses to Ag-B (A region) and Ia (B region) antigens during enhancement of rat renal allografts. Transplantation. 1979 Academic Article GET IT
Times cited: 11
Adverse presensitization: detection by utilization of B lymphoblastoid cell panels. Transplantation proceedings. 1979 Academic Article GET IT
Times cited: 1
Immunosuppressive properties of placental-source gamma globulin: results of a 5-year clinical investigative study in a cadaver kidney transplant program. Transplantation proceedings. 1979 Academic Article GET IT
Times cited: 3
Adverse presensitization to renal transplants. Detection by utilization of a D locus antigen-defined lymphoblastoid cell panel as targets in antibody-dependent cell-mediated cytotoxicity assays. Transplantation. 1979 Academic Article GET IT
Times cited: 4
Detection of memory cells by chemical modification of the lymphocyte cell surface. Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association. 1979 Academic Article GET IT
Human gamma globulin enhances the survival of renal allografts. Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association. 1979 Academic Article GET IT
Times cited: 1
HLA-D activity in lymphocyte subcellular fractions. Transplantation proceedings. 1978 Academic Article GET IT
Regulation of human mixed lymphocyte culture reactions: augmentation of proliferation and generation of cytotoxic cells. Transplantation proceedings. 1978 Academic Article GET IT
Times cited: 2
D lucus antigen defined lymphoblastoid cell panel allows detection of hitherto undetected adverse presensitization. Proceedings of the Clinical Dialysis and Transplant Forum. 1978 Academic Article GET IT
Times cited: 1
Anti-Ia antibody eluted from rejected human renal allografts. Transplantation proceedings. 1978 Academic Article GET IT
Times cited: 9
Detection of anti-donor "Ia" antibodies: a strong correlate of rejection. Transplantation proceedings. 1978 Academic Article GET IT
Times cited: 7
Posttransplant immunologic monitoring of the renal allograft recipient. Transplantation proceedings. 1978 Academic Article GET IT
Times cited: 9
Accelerated graft loss: association with presensitization to donor B-cell (Ia) antigens. Transplantation proceedings. 1978 Academic Article GET IT
Times cited: 7
Intragraft immune events causing vascularized organ graft rejection. Transplantation proceedings. 1978 Academic Article GET IT
Times cited: 4
Evidence for close association between B-cell Fc receptors and Ia antigens, and independence from HLA-A,B locus-determined antigens. Transplantation proceedings. 1977 Academic Article GET IT
Times cited: 5
Immunologic monitoring in the diagnosis of renal allograft rejection. Transplantation proceedings. 1977 Academic Article GET IT
Times cited: 9
Presensitization to donor B-cell ("Ia") antigens is associated with early allograft failures. Transplantation proceedings. 1977 Academic Article GET IT
Times cited: 14
Pretransplant assays of alloimmunity in predicting renal graft outcome. Proceedings of the Clinical Dialysis and Transplant Forum. 1977 Academic Article GET IT
Times cited: 1

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Funding awarded

Optimization of UroMap awarded by CareDx, Inc. Principal Investigator 2023 - 2028
Multianalyte Profiling of Kidney Allograft Recipients (Biopharma) awarded by CareDx, Inc. Principal Investigator 2020 - 2026
missing activity Principal Investigator 2020 - 2024

6/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center awarded by National Institute of Diabetes & Digestive & Kidney Diseases Co-Investigator 2023 - 2028
Metagenomic profiling of urinary cell-free DNA to monitor urinary tract infection after kidney transplantation awarded by NovaSterilis INC Co-Investigator 2020 - 2026
missing activity Co-Investigator 2017 - 2023
missing activity Co-Investigator 2017 - 2022
missing activity Co-Investigator 2017 - 2022

missing activity Principal Investigator Subaward 2017 - 2024

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Background

education and training

M.B.,B.S., Kilpauk Medical College, Madras University (India) 1970

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full name

Manikkam Suthanthiran

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Clinical Profile

VIVO Weill Cornell Medical College

Manikkam Suthanthiran Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

webpage