Zaninovic, Nikica

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selected publications

Toxic air quality in New York in June 2023 and impact on embryology data: survey of 5 leading infertility centers. Journal of assisted reproduction and genetics. 2025 Editorial Article GET IT
Stability and Reliability of Artificial Intelligence Models in Embryo Selection for In-Vitro Fertilization. Fertility and sterility. 2025 Academic Article GET IT
A foundational model for in vitro fertilization trained on 18 million time-lapse images. Nature communications. 2025 Academic Article GET IT
Dysregulation of the actin cytoskeleton and FMRP causes polar body protrusion defects in human fragile X premutation and aged oocytes. 2025 GET IT
A Combination of Artificial Intelligence with Genetic Algorithms on Static Time-Lapse Images Improves Consistency in Blastocyst Assessment, An Interpretable Tool to Automate Human Embryo Evaluation: A Retrospective Cohort Study. International journal of fertility & sterility. 2024 Academic Article GET IT
Automatic ploidy prediction and quality assessment of human blastocysts using time-lapse imaging. Nature communications. 2024 Academic Article GET IT
Times cited: 13
Day7 and low-quality blastocysts: opt in or opt out? A dilemma with important clinical implications. Fertility and sterility. 2023 Editorial Article GET IT
Times cited: 3
Seeking arrangements: cell contact as a cleavage-stage biomarker. Reproductive biomedicine online. 2023 Academic Article GET IT
Embryo ranking agreement between embryologists and artificial intelligence (AI) algorithms. F&S science. 2023 Academic Article GET IT
Automatic Ploidy Prediction and Quality Assessment of Human Blastocyst Using Time-Lapse Imaging. 2023 GET IT
Successful Cryptozoospermia Management with Multiple Semen Specimen Collection. Fertility and sterility. 2023 Academic Article GET IT
Improving outcomes of assisted reproductive technologies using artificial intelligence for sperm selection. Fertility and sterility. 2023 Review GET IT
Times cited: 12
Human theca arises from ovarian stroma and is comprised of three discrete subtypes. Communications biology. 2023 Academic Article GET IT
Times cited: 20
A non-invasive artificial intelligence approach for the prediction of human blastocyst ploidy: a retrospective model development and validation study. The Lancet. Digital health. 2023 Academic Article GET IT
Times cited: 91
Xenograft model of heterotopic transplantation of human ovarian cortical tissue and its clinical relevance. Reproduction (Cambridge, England). 2022 Academic Article GET IT
Times cited: 7
Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells. Molecular cell. 2022 Academic Article GET IT
Times cited: 15
Reply of the Authors: Testicular sperm characteristics in men with nonobstructive azoospermia and their impact on intracytoplasmic sperm injection outcome. Fertility and sterility. 2022 Letter GET IT
Effects of Chemo- and Radiation Therapy on Microsurgical Testicular Sperm Extraction for Men with Non-obstructive Azoospermia. The Journal of urology. 2022 Academic Article GET IT
Chronic superphysiologic AMH promotes premature luteinization of antral follicles in human ovarian xenografts. Science advances. 2022 Academic Article GET IT
Times cited: 10
Characterization of an artificial intelligence model for ranking static images of blastocyst stage embryos. Fertility and sterility. 2022 Academic Article GET IT
Artificial intelligence in the embryology laboratory: a review. Reproductive biomedicine online. 2021 Review GET IT
Times cited: 84
Testicular sperm characteristics in men with nonobstructive azoospermia and their impact on intracytoplasmic sperm injection outcome. Fertility and sterility. 2021 Academic Article GET IT
Exogenous insulin-like growth factor 1 accelerates growth and maturation of follicles in human cortical xenografts and increases ovarian output in mice. F&S science. 2021 Academic Article GET IT
Times cited: 8
Artificial intelligence in human in vitro fertilization and embryology. Fertility and sterility. 2020 Review GET IT
Times cited: 118
Predictive modeling in reproductive medicine: Where will the future of artificial intelligence research take us?. Fertility and sterility. 2020 Review GET IT
Times cited: 3
Blastocyst score, a blastocyst quality ranking tool, is a predictor of blastocyst ploidy and implantation potential. F&S reports. 2020 Academic Article GET IT
Comparison of Human Antral Follicles of Xenograft versus Ovarian Origin Reveals Disparate Molecular Signatures. Cell reports. 2020 Academic Article GET IT
Times cited: 10
Reply. American journal of obstetrics and gynecology. 2019 Article GET IT
Artificial intelligence: its applications in reproductive medicine and the assisted reproductive technologies. Fertility and sterility. 2019 Editorial Article GET IT
Times cited: 15
Deep learning enables robust assessment and selection of human blastocysts after in vitro fertilization. NPJ digital medicine. 2019 Academic Article GET IT
Times cited: 340
A comparison of morphokinetic markers predicting blastocyst formation and implantation potential from two large clinical data sets. Journal of assisted reproduction and genetics. 2019 Academic Article GET IT
Times cited: 25
Does maternal age at retrieval influence the implantation potential of euploid blastocysts?. American journal of obstetrics and gynecology. 2018 Academic Article GET IT
Times cited: 21
Tripolar chromosome segregation drives the association between maternal genotype at variants spanning PLK4 and aneuploidy in human preimplantation embryos. Human molecular genetics. 2018 Academic Article GET IT
Times cited: 56
Blastocyst development rate influences implantation and live birth rates of similarly graded euploid blastocysts. Fertility and sterility. 2018 Academic Article GET IT
Times cited: 24
Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery. Journal of visualized experiments : JoVE. 2018 Academic Article GET IT
Times cited: 18
A rationale for biopsying embryos reaching the morula stage on Day 6 in women undergoing preimplantation genetic testing for aneuploidy. Human reproduction (Oxford, England). 2018 Academic Article GET IT
Times cited: 9
Time-lapse imaging: clearly useful to both laboratory personnel and patient outcomes versus just because we can doesn't mean we should. Fertility and sterility. 2018 Editorial Article GET IT
Times cited: 13
Assessment of embryo morphology and developmental dynamics by time-lapse microscopy: is there a relation to implantation and ploidy?. Fertility and sterility. 2017 Review GET IT
Times cited: 75
Engineered endothelium provides angiogenic and paracrine stimulus to grafted human ovarian tissue. Scientific reports. 2017 Academic Article GET IT
Times cited: 41
Morphologic grading of euploid blastocysts influences implantation and ongoing pregnancy rates. Fertility and sterility. 2017 Academic Article GET IT
Times cited: 150
Direct Unequal Cleavages: Embryo Developmental Competence, Genetic Constitution and Clinical Outcome. PloS one. 2016 Academic Article GET IT
Times cited: 121
Microdissection testicular sperm extraction in men with Sertoli cell-only testicular histology. Fertility and sterility. 2014 Academic Article GET IT
Times cited: 41
Cis-acting DNA sequence at a replication origin promotes repeat expansion to fragile X full mutation. The Journal of cell biology. 2014 Academic Article GET IT
Times cited: 40
Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome. Science (New York, N.Y.). 2014 Academic Article GET IT
Times cited: 252
Derivation of human embryonic stem cells (hESC). Methods in molecular biology (Clifton, N.J.). 2014 Academic Article GET IT
Times cited: 2
The DNA replication program is altered at the FMR1 locus in fragile X embryonic stem cells. Molecular cell. 2013 Academic Article GET IT
Times cited: 88
Follicular flushing and in vitro fertilization outcomes in the poorest responders: a randomized controlled trial. Human reproduction (Oxford, England). 2013 Academic Article GET IT
Times cited: 22
Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition. Blood. 2012 Academic Article GET IT
Times cited: 65
Fertility preservation using controlled ovarian hyperstimulation and oocyte cryopreservation in a premenarcheal female with myelodysplastic syndrome. 2012 GET IT
Times cited: 38
Role of tissue digestion and extensive sperm search after microdissection testicular sperm extraction. Fertility and sterility. 2011 Academic Article GET IT
Times cited: 35
Lentiviral transduction and clonal selection of hESCs with endothelial-specific transgenic reporters. Current protocols in stem cell biology. 2011 Academic Article GET IT
Times cited: 7
Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent. Nature biotechnology. 2010 Academic Article GET IT
Times cited: 274
Immunohistochemical expression of endometrial L-selectin ligand is higher in donor egg recipients with embryonic implantation. Fertility and sterility. 2006 Academic Article GET IT
Times cited: 27
Cryopreservation of murine embryos, human spermatozoa and embryonic stem cells using a liquid nitrogen-free, controlled rate freezer. Reproductive biomedicine online. 2006 Academic Article GET IT
Times cited: 26
High pregnancy rates can be achieved after freezing and thawing human blastocysts. Fertility and sterility. 2004 Academic Article GET IT
Times cited: 115
Human zona pellucida micromanipulation and monozygotic twinning frequency after IVF. Human reproduction (Oxford, England). 2000 Academic Article GET IT
Times cited: 105
Fertilization and pregnancy outcome with intracytoplasmic sperm injection for azoospermic men. Human reproduction (Oxford, England). 1999 Academic Article GET IT
Times cited: 244
Testicular sperm extraction with intracytoplasmic sperm injection for nonobstructive azoospermia. Urology. 1997 Academic Article GET IT
Times cited: 216
Aggressive sperm immobilization prior to intracytoplasmic sperm injection with immature spermatozoa improves fertilization and pregnancy rates. Human reproduction (Oxford, England). 1996 Academic Article GET IT
Times cited: 126

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Background

education and training

Ph.D., University of Zagreb (Croatia) 2008
M.S., University of Zagreb (Croatia) 1990
B.S., University of Zagreb (Croatia) 1987

Contact

full name

Nikica Zaninovic

VIVO Weill Cornell Medical College

Nikica Zaninovic Associate Professor of Embryology in Clinical Reproductive Medicine

Publications

selected publications

Background

education and training

Contact

full name