Microdissection testicular sperm extraction in men with Sertoli cell-only testicular histology. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: To study the outcomes of microdissection testicular sperm extraction (microTESE) among men with pure Sertoli cell-only histology on diagnostic testicular biopsy. DESIGN: Retrospective cohort study. SETTING: Tertiary referral center. PATIENT(S): Six hundred forty patients with pure Sertoli cell-only histology on testicular biopsy who underwent microTESE by a single surgeon. INTERVENTION(S): MicroTESE. MAIN OUTCOME MEASURE(S): Sperm retrieval rates. RESULT(S): Overall, 44.5% of patients with Sertoli cell only had sperm retrieved with microTESE. No difference was noted in sperm retrieval rates based on testis volume (≥15 mL vs. <15 mL, 35.3% vs. 46.1%, respectively). Patients with ≥15 mL testicular volume and FSH 10-15 mU/mL had the worst prognosis, with a sperm retrieval rate of 6.7%. CONCLUSION(S): Patients with previous testicular biopsy demonstrating Sertoli cell-only histology can be counseled that they have a reasonable likelihood of sperm retrieval with the contemporary delivery of microTESE. Given this finding, the utility of testicular biopsy before microTESE is further questioned.

publication date

  • October 30, 2014

Research

keywords

  • Azoospermia
  • Cell Separation
  • Microdissection
  • Sertoli Cell-Only Syndrome
  • Sperm Retrieval
  • Spermatozoa
  • Testis

Identity

PubMed Central ID

  • PMC4349348

Scopus Document Identifier

  • 84922032021

Digital Object Identifier (DOI)

  • 10.1016/j.fertnstert.2014.08.007

PubMed ID

  • 25441063

Additional Document Info

volume

  • 102

issue

  • 5