selected publications
- Preliminary findings from the Dynamics of the Immune Responses to Repeat Influenza Vaccination Exposures (DRIVE I) Study: a Randomized Controlled Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2024 Academic Article GET IT
- Antibody modulation of B cell responses-Incorporating positive and negative feedback. Immunity. 2024 Review GET IT
- A hybrid demultiplexing strategy that improves performance and robustness of cell hashing. Briefings in bioinformatics. 2024 Academic Article GET IT
- Lack of memory recall in human CD4 T cells elicited by the first encounter with SARS-CoV-2. iScience. 2024 Academic Article GET IT
- Preliminary findings from the Dynamics of the Immune Responses to Repeat Influenza Vaccination Exposures (DRIVE I) Study: a Randomized Controlled Trial. 2024 GET IT
- Epitopes recognition of SARS-CoV-2 nucleocapsid RNA binding domain by human monoclonal antibodies. iScience. 2024 Academic Article GET IT
- Germline-encoded specificities and the predictability of the B cell response. PLoS pathogens. 2023 Academic Article GET IT
- IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding. Proceedings of the National Academy of Sciences of the United States of America. 2023 Academic Article GET IT
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Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis.
Nature medicine.
2023
Academic Article
GET IT
Times cited: 8 - Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody to antigenically distinct Omicron subvariants. The Journal of clinical investigation. 2023 Academic Article GET IT
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Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity.
Science advances.
2022
Academic Article
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Times cited: 31 -
IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding.
2022
GET IT
Times cited: 24 - Learning from our differences. Nature immunology. 2022 Academic Article GET IT
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Novel Epitopes of the Influenza Virus N1 Neuraminidase Targeted by Human Monoclonal Antibodies.
Journal of virology.
2022
Academic Article
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Times cited: 8 - Memory B cell diversity: insights for optimized vaccine design. Trends in immunology. 2022 Review GET IT
- Librator: a platform for the optimized analysis, design, and expression of mutable influenza viral antigens. Briefings in bioinformatics. 2022 Academic Article GET IT
- Broadly neutralizing antibodies target a hemagglutinin anchor epitope. Nature. 2021 Academic Article GET IT
- Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn's disease. Nature microbiology. 2021 Academic Article GET IT
- Cross-Neutralization of Emerging SARS-CoV-2 Variants of Concern by Antibodies Targeting Distinct Epitopes on Spike. mBio. 2021 Academic Article GET IT
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Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus.
Nature communications.
2021
Academic Article
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Times cited: 9 -
Human Anti-neuraminidase Antibodies Reduce Airborne Transmission of Clinical Influenza Virus Isolates in the Guinea Pig Model.
Journal of virology.
2021
Academic Article
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Times cited: 11 -
Improved integration of single-cell transcriptome and surface protein expression by LinQ-View.
Cell reports methods.
2021
Academic Article
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Times cited: 8 - Bridging the B Cell Gap: Novel Technologies to Study Antigen-Specific Human B Cell Responses. Vaccines. 2021 Review GET IT
- An Egg-Derived Sulfated N-Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines. mBio. 2021 Academic Article GET IT
- Hemolysis-associated phosphatidylserine exposure promotes polyclonal plasmablast differentiation. The Journal of experimental medicine. 2021 Academic Article GET IT
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First exposure to the pandemic H1N1 virus induced broadly neutralizing antibodies targeting hemagglutinin head epitopes.
Science translational medicine.
2021
Academic Article
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Times cited: 3 -
Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets.
Immunity.
2021
Academic Article
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Times cited: 81 -
Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes.
Proceedings of the National Academy of Sciences of the United States of America.
2021
Academic Article
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Times cited: 7 -
Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model.
mBio.
2021
Academic Article
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Times cited: 20 -
Identification and Characterization of Novel Antibody Epitopes on the N2 Neuraminidase.
mSphere.
2021
Academic Article
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Times cited: 18 - Extrafollicular CD4 T cell-derived IL-10 functions rapidly and transiently to support anti-Plasmodium humoral immunity. PLoS pathogens. 2021 Academic Article GET IT
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SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike.
mBio.
2021
Academic Article
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Times cited: 62 -
Remembering seasonal coronaviruses.
Science (New York, N.Y.).
2020
Article
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Times cited: 9 -
Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans.
Science translational medicine.
2020
Academic Article
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Times cited: 71 -
A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial.
Nature medicine.
2020
Academic Article
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Times cited: 22 -
Machine Learning to Quantify In Situ Humoral Selection in Human Lupus Tubulointerstitial Inflammation.
Frontiers in immunology.
2020
Academic Article
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Times cited: 4 -
Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops.
eLife.
2020
Academic Article
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Times cited: 23 -
Characterization of Novel Cross-Reactive Influenza B Virus Hemagglutinin Head Specific Antibodies That Lack Hemagglutination Inhibition Activity.
Journal of virology.
2020
Academic Article
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Times cited: 5 -
Proinflammatory IgG Fc structures in patients with severe COVID-19.
Nature immunology.
2020
Academic Article
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Times cited: 209 -
Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses.
Immunity.
2020
Academic Article
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Times cited: 56 -
Distinct B cell subsets give rise to antigen-specific antibody responses against SARS-CoV-2.
2020
GET IT
Times cited: 1033 -
Correctly folded - but not necessarily functional - influenza virus neuraminidase is required to induce protective antibody responses in mice.
Vaccine.
2020
Academic Article
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Times cited: 2 -
Imprinting, immunodominance, and other impediments to generating broad influenza immunity.
Immunological reviews.
2020
Information Resource
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Times cited: 8 -
Characterizing Emerging Canine H3 Influenza Viruses.
PLoS pathogens.
2020
Academic Article
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Times cited: 24 -
High-complexity extracellular barcoding using a viral hemagglutinin.
Proceedings of the National Academy of Sciences of the United States of America.
2020
Academic Article
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Times cited: 1 -
Heterologous viral protein interactions within licensed seasonal influenza virus vaccines.
NPJ vaccines.
2020
Academic Article
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Times cited: 16 -
Identification of Antibodies Targeting the H3N2 Hemagglutinin Receptor Binding Site following Vaccination of Humans.
Cell reports.
2019
Academic Article
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Times cited: 21 -
Aging and influenza vaccine-induced immunity.
Cellular immunology.
2019
Information Resource
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Times cited: 24 -
Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial.
The Lancet. Infectious diseases.
2019
Academic Article
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Times cited: 103 -
Monoclonal Antibody Responses after Recombinant Hemagglutinin Vaccine versus Subunit Inactivated Influenza Virus Vaccine: a Comparative Study.
Journal of virology.
2019
Academic Article
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Times cited: 19 -
Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans.
Cell.
2019
Academic Article
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Times cited: 408 -
Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin.
eLife.
2019
Academic Article
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Times cited: 55 -
The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain.
Nature microbiology.
2019
Academic Article
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Times cited: 51 -
Antigenic Drift of the Influenza A(H1N1)pdm09 Virus Neuraminidase Results in Reduced Effectiveness of A/California/7/2009 (H1N1pdm09)-Specific Antibodies.
mBio.
2019
Academic Article
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Times cited: 43 -
Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery.
Journal of immunology (Baltimore, Md. : 1950).
2019
Academic Article
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Times cited: 24 -
Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals.
Cell host & microbe.
2019
Academic Article
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Times cited: 95 -
Hemagglutinin Stalk-Reactive Antibodies Interfere with Influenza Virus Neuraminidase Activity by Steric Hindrance.
Journal of virology.
2019
Academic Article
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Times cited: 49 -
An Efficient Method to Generate Monoclonal Antibodies from Human B Cells.
Methods in molecular biology (Clifton, N.J.).
2019
Article
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Times cited: 11 -
Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination.
The Journal of clinical investigation.
2018
Academic Article
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Times cited: 30 - Editorial overview: Tough targets. Current opinion in immunology. 2018 Editorial Article GET IT
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Broadly Reactive Human Monoclonal Antibodies Elicited following Pandemic H1N1 Influenza Virus Exposure Protect Mice against Highly Pathogenic H5N1 Challenge.
Journal of virology.
2018
Academic Article
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Times cited: 29 -
Crowd on a Chip: Label-Free Human Monoclonal Antibody Arrays for Serotyping Influenza.
Analytical chemistry.
2018
Academic Article
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Times cited: 18 -
The influenza virus hemagglutinin head evolves faster than the stalk domain.
Scientific reports.
2018
Academic Article
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Times cited: 148 -
Harnessing immune history to combat influenza viruses.
Current opinion in immunology.
2018
Information Resource
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Times cited: 29 -
Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies.
Cell.
2018
Academic Article
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Times cited: 295 -
NAction! How Can Neuraminidase-Based Immunity Contribute to Better Influenza Virus Vaccines?.
mBio.
2018
Information Resource
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Times cited: 194 -
Igβ ubiquitination activates PI3K signals required for endosomal sorting.
The Journal of experimental medicine.
2017
Academic Article
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Times cited: 10 -
Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains.
Proceedings of the National Academy of Sciences of the United States of America.
2017
Academic Article
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Times cited: 417 -
Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice.
Nature communications.
2017
Academic Article
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Times cited: 126 -
Natural polyreactive IgA antibodies coat the intestinal microbiota.
Science (New York, N.Y.).
2017
Academic Article
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Times cited: 322 -
Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivo.
Scientific reports.
2017
Academic Article
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Times cited: 31 -
From Original Antigenic Sin to the Universal Influenza Virus Vaccine.
Trends in immunology.
2017
Information Resource
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Times cited: 182 -
Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies.
Journal of visualized experiments : JoVE.
2017
Academic Article
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Times cited: 6 -
BASIC: BCR assembly from single cells.
Bioinformatics (Oxford, England).
2017
Academic Article
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Times cited: 65 -
Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation.
Science immunology.
2017
Academic Article
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Times cited: 174 -
Single-Cell Genomics: Approaches and Utility in Immunology.
Trends in immunology.
2017
Information Resource
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Times cited: 54 -
Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination.
Nature medicine.
2016
Academic Article
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Times cited: 228 -
Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients.
Acta neuropathologica.
2016
Academic Article
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Times cited: 28 -
Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus.
Proceedings of the National Academy of Sciences of the United States of America.
2016
Academic Article
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Times cited: 152 -
Refined protocol for generating monoclonal antibodies from single human and murine B cells.
Journal of immunological methods.
2016
Academic Article
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Times cited: 51 -
Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.
PLoS pathogens.
2016
Academic Article
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Times cited: 102 -
To B or not to B maintained?.
Blood.
2016
Article
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Times cited: 1 -
Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus.
Proceedings of the National Academy of Sciences of the United States of America.
2016
Academic Article
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Times cited: 456 -
Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection.
Cell host & microbe.
2016
Academic Article
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Times cited: 230 -
Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?.
Current opinion in immunology.
2016
Information Resource
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Times cited: 71 -
B Cell Responses during Secondary Dengue Virus Infection Are Dominated by Highly Cross-Reactive, Memory-Derived Plasmablasts.
Journal of virology.
2016
Academic Article
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Times cited: 94 -
Immune history profoundly affects broadly protective B cell responses to influenza.
Science translational medicine.
2015
Academic Article
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Times cited: 312 - Germinal center selection and the antibody response to influenza. Cell. 2015 Information Resource GET IT
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Restricted, canonical, stereotyped and convergent immunoglobulin responses.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
2015
Information Resource
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Times cited: 40 -
The evolution within us.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
2015
Review
GET IT
Times cited: 29 -
Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.
Immunity.
2015
Academic Article
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Times cited: 418 -
High Affinity Antibodies against Influenza Characterize the Plasmablast Response in SLE Patients After Vaccination.
PloS one.
2015
Academic Article
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Times cited: 27 -
Preexisting human antibodies neutralize recently emerged H7N9 influenza strains.
The Journal of clinical investigation.
2015
Academic Article
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Times cited: 109 -
High preexisting serological antibody levels correlate with diversification of the influenza vaccine response.
Journal of virology.
2015
Academic Article
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Times cited: 99 -
Loss of anergic B cells in prediabetic and new-onset type 1 diabetic patients.
Diabetes.
2014
Academic Article
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Times cited: 74 -
Vimentin is a dominant target of in situ humoral immunity in human lupus tubulointerstitial nephritis.
Arthritis & rheumatology (Hoboken, N.J.).
2014
Academic Article
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Times cited: 82 -
Staphylococcus aureus infection induces protein A-mediated immune evasion in humans.
The Journal of experimental medicine.
2014
Academic Article
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Times cited: 122 -
Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season.
Proceedings of the National Academy of Sciences of the United States of America.
2014
Academic Article
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Times cited: 176 -
Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans.
Proceedings of the National Academy of Sciences of the United States of America.
2014
Academic Article
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Times cited: 181 -
Biogenesis of influenza a virus hemagglutinin cross-protective stem epitopes.
PLoS pathogens.
2014
Academic Article
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Times cited: 7 -
Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells.
Nature communications.
2014
Academic Article
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Times cited: 47 -
Impact of immunosuppression on recall immune responses to influenza vaccination in stable renal transplant recipients.
Transplantation.
2014
Academic Article
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Times cited: 33 -
Divergent H7 immunogens offer protection from H7N9 virus challenge.
Journal of virology.
2014
Academic Article
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Times cited: 50 -
Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses.
Journal of virology.
2013
Academic Article
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Times cited: 173 -
Immune history shapes specificity of pandemic H1N1 influenza antibody responses.
The Journal of experimental medicine.
2013
Academic Article
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Times cited: 142 -
In vitro assessment of the immunological significance of a human monoclonal antibody directed to the influenza a virus nucleoprotein.
Clinical and vaccine immunology : CVI.
2013
Academic Article
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Times cited: 38 -
Transglutaminase 2-specific autoantibodies in celiac disease target clustered, N-terminal epitopes not displayed on the surface of cells.
Journal of immunology (Baltimore, Md. : 1950).
2013
Academic Article
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Times cited: 67 -
Lineage structure of the human antibody repertoire in response to influenza vaccination.
Science translational medicine.
2013
Academic Article
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Times cited: 276 -
High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire.
Nature biotechnology.
2013
Academic Article
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Times cited: 346 -
Most influenza a virions fail to express at least one essential viral protein.
Journal of virology.
2013
Academic Article
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Times cited: 102 -
Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivity.
The Journal of experimental medicine.
2012
Academic Article
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Times cited: 19 -
Tools to therapeutically harness the human antibody response.
Nature reviews. Immunology.
2012
Information Resource
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Times cited: 110 -
Fully human monoclonal antibodies from antibody secreting cells after vaccination with Pneumovax®23 are serotype specific and facilitate opsonophagocytosis.
Immunobiology.
2012
Academic Article
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Times cited: 23 -
Immunodominance of antigenic site B over site A of hemagglutinin of recent H3N2 influenza viruses.
PloS one.
2012
Academic Article
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Times cited: 86 -
Antibody pressure by a human monoclonal antibody targeting the 2009 pandemic H1N1 virus hemagglutinin drives the emergence of a virus with increased virulence in mice.
mBio.
2012
Academic Article
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Times cited: 65 -
Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells.
Proceedings of the National Academy of Sciences of the United States of America.
2012
Academic Article
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Times cited: 349 -
High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions.
Nature medicine.
2012
Academic Article
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Times cited: 177 -
Rapid and massive virus-specific plasmablast responses during acute dengue virus infection in humans.
Journal of virology.
2012
Academic Article
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Times cited: 199 -
Complement-dependent lysis of influenza a virus-infected cells by broadly cross-reactive human monoclonal antibodies.
Journal of virology.
2011
Academic Article
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Times cited: 91 -
Targeting B cell responses in universal influenza vaccine design.
Trends in immunology.
2011
Information Resource
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Times cited: 47 -
Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies.
The Journal of clinical investigation.
2011
Academic Article
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Times cited: 249 -
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection.
The Journal of experimental medicine.
2011
Academic Article
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Times cited: 683 -
Rapid generation of rotavirus-specific human monoclonal antibodies from small-intestinal mucosa.
Journal of immunology (Baltimore, Md. : 1950).
2010
Academic Article
GET IT
Times cited: 63 -
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation.
Nature.
2010
Academic Article
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Times cited: 354 -
The anergic B cell.
Blood.
2010
Article
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Times cited: 21 -
Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen.
Nature protocols.
2009
Academic Article
GET IT
Times cited: 394 -
Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors.
The Journal of experimental medicine.
2008
Academic Article
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Times cited: 198 -
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus.
Nature.
2008
Academic Article
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Times cited: 855 -
Human B cell subsets.
Advances in immunology.
2008
Information Resource
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Times cited: 58 -
Cutting edge: Transitional T3 B cells do not give rise to mature B cells, have undergone selection, and are reduced in murine lupus.
Journal of immunology (Baltimore, Md. : 1950).
2007
Academic Article
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Times cited: 43 -
Mature B cells class switched to IgD are autoreactive in healthy individuals.
The Journal of clinical investigation.
2007
Academic Article
GET IT
Times cited: 115 -
Igkappa allelic inclusion is a consequence of receptor editing.
The Journal of experimental medicine.
2007
Academic Article
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Times cited: 69 -
Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation.
The Journal of experimental medicine.
2005
Academic Article
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Times cited: 56 -
Programmed cell death of peripheral blood B cells determined by laser scanning cytometry in Sjögren's syndrome with a special emphasis on BAFF.
Journal of clinical immunology.
2004
Academic Article
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Times cited: 34 -
Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells.
The Journal of clinical investigation.
2004
Academic Article
GET IT
Times cited: 81 -
Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies.
The Journal of experimental medicine.
2003
Academic Article
GET IT
Times cited: 115 -
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching.
Nature.
2001
Academic Article
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Times cited: 443 -
The role of recombination activating gene (RAG) reinduction in thymocyte development in vivo.
The Journal of experimental medicine.
2001
Academic Article
GET IT
Times cited: 63 -
Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes.
The Journal of experimental medicine.
2000
Academic Article
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Times cited: 138 -
Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes.
The Journal of experimental medicine.
1998
Academic Article
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Times cited: 223