Pernis, Alessandra B.

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Serotonin-1A receptor, a psychiatric disease risk factor, influences offspring immunity via sex-dependent genetic nurture. iScience. 2022 Academic Article GET IT
Adaptive immune responses in patients requiring revision after Total Knee Arthroplasty. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2022 Academic Article GET IT
Interleukin-13 Receptor α1-Mediated Signaling Regulates Age-Associated/Autoimmune B Cell Expansion and Lupus Pathogenesis. Arthritis & rheumatology (Hoboken, N.J.). 2022 Academic Article GET IT
Times cited: 8
Molecular mechanisms controlling age-associated B cells in autoimmunity. Immunological reviews. 2022 Review GET IT
Times cited: 24
Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice. Nature communications. 2021 Academic Article GET IT
Times cited: 51
Def6 regulates endogenous type-I interferon responses in osteoblasts and suppresses osteogenesis. eLife. 2020 Academic Article GET IT
Times cited: 12
Selective dysregulation of ROCK2 activity promotes aberrant transcriptional networks in ABC diffuse large B-cell lymphoma. Scientific reports. 2020 Academic Article GET IT
Control of GM-CSF-Dependent Dendritic Cell Differentiation and Maturation by DEF6 and SWAP-70. Journal of immunology (Baltimore, Md. : 1950). 2020 Academic Article GET IT
Times cited: 3
Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis. The Journal of clinical investigation. 2020 Academic Article GET IT
Times cited: 21
'-Omics' shed light on B cells in lupus. Nature immunology. 2019 Article GET IT
Times cited: 4
Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue. Arthritis research & therapy. 2018 Academic Article GET IT
Times cited: 82
Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data. Arthritis & rheumatology (Hoboken, N.J.). 2018 Academic Article GET IT
Times cited: 139
Regulation of age-associated B cells by IRF5 in systemic autoimmunity. Nature immunology. 2018 Academic Article GET IT
Times cited: 104
The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity. Nature communications. 2017 Academic Article GET IT
Times cited: 47
Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption. Journal of immunology (Baltimore, Md. : 1950). 2017 Academic Article GET IT
Times cited: 15
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature. 2017 Academic Article GET IT
Times cited: 758
Targeting the RhoA-ROCK pathway to reverse T-cell dysfunction in SLE. Annals of the rheumatic diseases. 2016 Academic Article GET IT
Times cited: 71
The RhoA-ROCK pathway in the regulation of T and B cell responses. F1000Research. 2016 Information Resource GET IT
SWEF Proteins Distinctly Control Maintenance and Differentiation of Hematopoietic Stem Cells. PloS one. 2016 Academic Article GET IT
Times cited: 9
Regulation of Effector Treg Cells in Murine Lupus. Arthritis & rheumatology (Hoboken, N.J.). 2016 Academic Article GET IT
Times cited: 18
Cigarette smoke inhibits ROCK2 activation in T cells and modulates IL-22 production. Molecular immunology. 2016 Academic Article GET IT
Times cited: 14
IRF4-Dependent and IRF4-Independent Pathways Contribute to DC Dysfunction in Lupus. PloS one. 2015 Academic Article GET IT
Times cited: 16
Increased rho kinase activity in temporal artery biopsies from patients with giant cell arteritis. Rheumatology (Oxford, England). 2014 Academic Article GET IT
Times cited: 15
Epigenetics and the IRFs: a complex interplay in the control of immunity and autoimmunity. Autoimmunity. 2013 Information Resource GET IT
Times cited: 16
Enhanced rho-associated protein kinase activation in patients with systemic lupus erythematosus. Arthritis and rheumatism. 2013 Academic Article GET IT
Times cited: 53
Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunity. The Journal of experimental medicine. 2012 Academic Article GET IT
Times cited: 57
Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice. Lupus. 2012 Academic Article GET IT
Times cited: 34
A murine autoimmune model of rheumatoid arthritis and systemic lupus erythematosus associated with deregulated production of IL-17 and IL-21. Methods in molecular biology (Clifton, N.J.). 2012 Academic Article GET IT
Times cited: 9
Aberrant ROCK activation promotes the development of type I diabetes in NOD mice. Cellular immunology. 2010 Academic Article GET IT
Times cited: 12
Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. The Journal of clinical investigation. 2010 Academic Article GET IT
Times cited: 193
IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?. Immunological reviews. 2010 Information Resource GET IT
Times cited: 67
Regulation of TLR4-mediated signaling by IBP/Def6, a novel activator of Rho GTPases. Journal of leukocyte biology. 2008 Academic Article GET IT
Times cited: 23
IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor. Immunity. 2008 Academic Article GET IT
Times cited: 165
Rho GTPase-mediated pathways in mature CD4+ T cells. Autoimmunity reviews. 2008 Information Resource GET IT
Times cited: 24
A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma. Cancer cell. 2007 Academic Article GET IT
Times cited: 273
Estrogen and CD4+ T cells. Current opinion in rheumatology. 2007 Information Resource GET IT
Times cited: 86
Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity. The Journal of clinical investigation. 2006 Academic Article GET IT
Times cited: 84
Enhancer-mediated control of macrophage-specific arginase I expression. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 169
T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 65
CD95 rapidly clusters in cells of diverse origins. Cancer biology & therapy. 2003 Academic Article GET IT
Times cited: 49
Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system. Human immunology. 2003 Academic Article GET IT
Times cited: 66
Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF-4). The Journal of experimental medicine. 2003 Academic Article GET IT
Times cited: 26
Modulation of T cell cytokine production by interferon regulatory factor-4. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 84
JAK-STAT signaling in asthma. The Journal of clinical investigation. 2002 Information Resource GET IT
Times cited: 170
The role of IRF-4 in B and T cell activation and differentiation. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2002 Information Resource GET IT
Times cited: 54
Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins. Journal of immunology (Baltimore, Md. : 1950). 2001 Academic Article GET IT
Times cited: 40
Interferon gamma signaling alters the function of T helper type 1 cells. The Journal of experimental medicine. 2000 Academic Article GET IT
Times cited: 62
Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. The Journal of experimental medicine. 1999 Academic Article GET IT
Times cited: 109
IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells. Journal of immunology (Baltimore, Md. : 1950). 1999 Academic Article GET IT
Times cited: 68
Signaling pathways mediated by the TNF- and cytokine-receptor families target a common cis-element of the IFN regulatory factor 1 promoter. Journal of immunology (Baltimore, Md. : 1950). 1998 Academic Article GET IT
Times cited: 23
Jak-STAT signaling induced by the v-abl oncogene. Science (New York, N.Y.). 1995 Academic Article GET IT
Times cited: 313
Interleukin 4 signals through two related pathways. Proceedings of the National Academy of Sciences of the United States of America. 1995 Academic Article GET IT
Times cited: 82
Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells. Science (New York, N.Y.). 1995 Academic Article GET IT
Times cited: 274
Gamma chain-associated cytokine receptors signal through distinct transducing factors. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 30
Intravenous pulse cyclophosphamide treatment of severe lupus nephritis: a prospective five-year study. Clinical nephrology. 1994 Academic Article GET IT
Times cited: 99
STF-IL-4: a novel IL-4-induced signal transducing factor. The EMBO journal. 1994 Academic Article GET IT
Times cited: 185
T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell death. Journal of immunology (Baltimore, Md. : 1950). 1994 Academic Article GET IT
Times cited: 106

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Background

education and training

M.D., Columbia University College of Physicians and Surgeons 1986
B.A., Barnard College - Columbia University 1981

Contact

full name

Alessandra B. Pernis

primary email

pernisa@med.cornell.edu

VIVO Weill Cornell Medical College

Alessandra B. Pernis Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email