Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. Academic Article uri icon

Overview

abstract

  • Interleukin (IL)-4 is an immunoregulatory cytokine that exerts distinct biological activities on different cell types. Our studies indicate that interferon regulatory factor (IRF)-4 is both a target and a modulator of the IL-4 signaling cascade. IRF-4 expression is strongly upregulated upon costimulation of B cells with CD40 and IL-4. Furthermore, we find that IRF-4 can interact with signal transducer and activator of transcription (Stat)6 and drive the expression of IL-4-inducible genes. The transactivating ability of IRF-4 is blocked by the repressor factor BCL-6. Since expression of IRF-4 is mostly confined to lymphoid cells, these data provide a potential mechanism by which IL-4-inducible genes can be regulated in a lineage-specific manner.

publication date

  • December 20, 1999

Research

keywords

  • B-Lymphocytes
  • Cell Lineage
  • DNA-Binding Proteins
  • Interleukin-4
  • Proto-Oncogene Proteins
  • Transcription Factors

Identity

PubMed Central ID

  • PMC2195723

Scopus Document Identifier

  • 0033400453

PubMed ID

  • 10601358

Additional Document Info

volume

  • 190

issue

  • 12