The Journal of experimental medicine

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Correction: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity. 2024
Correction: Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques. 2022
Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity.. 221. 2024
SETD1B mutations confer apoptosis resistance and BCL2 independence in B cell lymphoma.. 221. 2024
Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies.. 221. 2024
Transcription of HIV-1 at sites of intact latent provirus integration.. 221. 2024
Sounding the alarm in the lung with TL1A.. 221. 2024
Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation.. 221. 2024
TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance.. 220. 2023
Identifying biomarkers of heterogeneity and transplantation efficacy in retinal pigment epithelial cells.. 220. 2023
Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer.. 220. 2023
Leveraging preclinical study designs to close gaps in vaccine development for perinatal pathogens.. 220. 2023
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs.. 220. 2023
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design.. 220. 2023
Macrophages promote anti-androgen resistance in prostate cancer bone disease.. 220. 2023
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses.. 219. 2022
CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow.. 219. 2022
Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation.. 219. 2022
Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions.. 219. 2022
Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET-rearranged thyroid cancer.. 219. 2022
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion.. 219. 2021
NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy.. 219. 2021
Can repurposing drugs play a role in malaria control?. 218. 2021
Surmounting structural barriers to tackle endemic infectious diseases.. 218. 2021
Reversal of emphysema by restoration of pulmonary endothelial cells.. 218. 2021
Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity.. 218. 2021
GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease.. 218. 2021
Hemolysis-associated phosphatidylserine exposure promotes polyclonal plasmablast differentiation.. 218. 2021
Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination.. 218. 2021
A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies.. 218. 2021
Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis.. 218. 2021
Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells.. 218. 2021
Nuclear receptor LXRβ controls fitness and functionality of activated T cells.. 218. 2021
Retraction: KSHV vFLIP Is Essential for the Survival of Infected Lymphoma Cells.. 218. 2021
T reg cell-intrinsic requirements for ST2 signaling in health and neuroinflammation.. 218. 2021
Type I interferon signaling mediates Mycobacterium tuberculosis-induced macrophage death.. 218. 2021
Transcription cofactor GRIP1 differentially affects myeloid cell-driven neuroinflammation and response to IFN-β therapy.. 218. 2021
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy.. 217. 2020
Cancer cell CCR2 orchestrates suppression of the adaptive immune response.. 217. 2020
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.. 217. 2020
Endothelial mTOR maintains hematopoiesis during aging.. 217. 2020
Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid.. 217. 2020
The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens.. 217. 2020
Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance.. 217. 2020
Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1.. 216. 2019
ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites.. 216. 2019
Selective inhibition of low-affinity memory CD8⁺ T cells by corticosteroids.. 216. 2019
IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus.. 216. 2019
Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription.. 216. 2019
Combination of quadruplex qPCR and next-generation sequencing for qualitative and quantitative analysis of the HIV-1 latent reservoir.. 216. 2019
Embryonic FAP⁺ lymphoid tissue organizer cells generate the reticular network of adult lymph nodes.. 216. 2019
Hes1 attenuates type I IFN responses via VEGF-C and WDFY1.. 216. 2019
Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients.. 216. 2019
Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAF ^V600E mutation.. 216. 2019
Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy.. 216. 2019
Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.. 216. 2019
Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells.. 216. 2019
FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program.. 216. 2019
Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification.. 216. 2018
CD49b defines functionally mature Treg cells that survey skin and vascular tissues.. 215. 2018
Relationship between latent and rebound viruses in a clinical trial of anti-HIV-1 antibody 3BNC117.. 215. 2018
The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses.. 215. 2018
The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination.. 215. 2018
Cholesterol negatively regulates IL-9-producing CD8⁺ T cell differentiation and antitumor activity.. 215. 2018
Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation.. 215. 2018
Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation.. 215. 2018
Functional and clinical relevance of VLA-4 (CD49d/CD29) in ibrutinib-treated chronic lymphocytic leukemia.. 215. 2018
Igβ ubiquitination activates PI3K signals required for endosomal sorting.. 214. 2017
Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors.. 215. 2017
Identification and characterization of T reg-like cells in zebrafish.. 214. 2017
A nonimmune function of T cells in promoting lung tumor progression.. 214. 2017
A multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis.. 214. 2017
Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.. 214. 2017
Annexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases.. 214. 2017
Commensal microbes provide first line defense against Listeria monocytogenes infection.. 214. 2017
Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2.. 214. 2017
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.. 214. 2017
Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity.. 214. 2017
The aryl hydrocarbon receptor controls cell-fate decisions in B cells.. 214. 2016
Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion.. 213. 2016
The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.. 213. 2016
An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.. 213. 2016
Role of neoplastic monocyte-derived fibrocytes in primary myelofibrosis.. 213. 2016
Combined IL-21-primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient.. 213. 2016
Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus.. 213. 2016
miR-23∼27∼24 clusters control effector T cell differentiation and function.. 213. 2016
Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.. 213. 2015
Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis.. 212. 2015
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.. 212. 2015
Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity.. 212. 2015
CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts.. 212. 2015
Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.. 212. 2015
BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms.. 212. 2015
Circulating precursors of human CD1c+ and CD141+ dendritic cells.. 212. 2015
Staphylococcus aureus infection induces protein A-mediated immune evasion in humans.. 211. 2014
Sex steroid blockade enhances thymopoiesis by modulating Notch signaling.. 211. 2014
Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections.. 211. 2014
Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.. 211. 2014
Classical Flt3L-dependent dendritic cells control immunity to protein vaccine.. 211. 2014
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.. 211. 2014
Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens.. 211. 2014
CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.. 211. 2014
IKKβ links vascular inflammation to obesity and atherosclerosis.. 211. 2014
Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.. 211. 2014
RNA recognition by human TLR8 can lead to autoimmune inflammation.. 210. 2013
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.. 210. 2013
Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation.. 210. 2013
Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy.. 210. 2013
IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells.. 210. 2013
The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2.. 210. 2013
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.. 210. 2013
Immune history shapes specificity of pandemic H1N1 influenza antibody responses.. 210. 2013
Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4.. 210. 2013
Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.. 210. 2013
IL-2-dependent adaptive control of NK cell homeostasis.. 210. 2013
IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells.. 210. 2013
TGFβ restores hematopoietic homeostasis after myelosuppressive chemotherapy.. 210. 2013
Notch activation inhibits AML growth and survival: a potential therapeutic approach.. 210. 2013
Notch pathway activation targets AML-initiating cell homeostasis and differentiation.. 210. 2013
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.. 210. 2013
Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivity.. 210. 2012
Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease.. 209. 2012
ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation.. 209. 2012
Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.. 209. 2012
Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype.. 209. 2012
Macrophages induce differentiation of plasma cells through CXCL10/IP-10.. 209. 2012
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells.. 209. 2012
The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development.. 209. 2012
Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma.. 209. 2012
Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice.. 209. 2012
Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation.. 209. 2012
Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage.. 209. 2012
Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation.. 209. 2012
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation.. 209. 2012
Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response.. 209. 2012
Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunity.. 209. 2012
Ovarian cancer progression is controlled by phenotypic changes in dendritic cells.. 209. 2012
Self-reactive human CD4 T cell clones form unusual immunological synapses.. 209. 2012
Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition.. 209. 2012
TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J.. 209. 2012
Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection.. 209. 2011
Remembering Ralph Steinman.. 208. 2011
Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans.. 208. 2011
The requirements for natural Th17 cell development are distinct from those of conventional Th17 cells.. 208. 2011
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia.. 208. 2011
Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.. 208. 2011
Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma.. 208. 2011
Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain.. 208. 2011
Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation.. 208. 2011
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection.. 208. 2011
Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9.. 207. 2010
A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota.. 207. 2010
Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway.. 207. 2010
Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function.. 207. 2010
BCL6 is critical for the development of a diverse primary B cell repertoire.. 207. 2010
Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A.. 207. 2010
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells.. 207. 2010
Calcineurin regulates innate antifungal immunity in neutrophils.. 207. 2010
Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin.. 207. 2010
Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts.. 207. 2010
CD8+ T cell concentration determines their efficiency in killing cognate antigen-expressing syngeneic mammalian cells in vitro and in mouse tissues.. 207. 2010
Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice.. 207. 2009
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination.. 206. 2009
XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development.. 206. 2009
Distinction of the memory B cell response to cognate antigen versus bystander inflammatory signals.. 206. 2009
Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8.. 206. 2009
Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging.. 206. 2009
Feedback control of regulatory T cell homeostasis by dendritic cells in vivo.. 206. 2009
Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant.. 206. 2009
Priming of protective T cell responses against virus-induced tumors in mice with human immune system components.. 206. 2009
OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis.. 206. 2009
Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.. 206. 2009
Self-antigen-specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response.. 206. 2009
TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis.. 206. 2009
Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors.. 206. 2008
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection.. 205. 2008
Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection.. 205. 2008
Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine.. 205. 2008
Dicer-dependent microRNA pathway safeguards regulatory T cell function.. 205. 2008
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease.. 205. 2008
Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo.. 205. 2008
Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis.. 205. 2008
ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo.. 205. 2008
PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation.. 205. 2008
Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses.. 204. 2007
Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients.. 204. 2007
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.. 204. 2007
Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade.. 204. 2007
MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival.. 204. 2007
Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis.. 204. 2007
Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells.. 204. 2007
MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection.. 204. 2007
Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen.. 204. 2007
CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance.. 204. 2007
Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease.. 204. 2007
Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers.. 204. 2007
Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model.. 204. 2007
IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung.. 204. 2007
Lack of Foxp3 function and expression in the thymic epithelium.. 204. 2007
Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation.. 204. 2007
Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-gamma-mediated pathways.. 204. 2007
Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice.. 204. 2007
Igkappa allelic inclusion is a consequence of receptor editing.. 204. 2007
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.. 203. 2006
Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts.. 203. 2006
Persistent expression of autoantibodies in SLE patients in remission.. 203. 2006
The plasminogen activator system modulates sympathetic nerve function.. 203. 2006
Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction.. 203. 2006
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation.. 203. 2006
Regulation of lymph node vascular growth by dendritic cells.. 203. 2006
Twist mediates suppression of inflammation by type I IFNs and Axl.. 203. 2006
Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells.. 203. 2006
Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract.. 203. 2006
Live attenuated yellow fever 17D infects human DCs and allows for presentation of endogenous and recombinant T cell epitopes.. 202. 2005
Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase.. 202. 2005
Notch signaling is an important regulator of type 2 immunity.. 202. 2005
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus.. 202. 2005
Developmental regulation of Foxp3 expression during ontogeny.. 202. 2005
Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection.. 202. 2005
Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization.. 202. 2005
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils.. 202. 2005
Tim-2 regulates T helper type 2 responses and autoimmunity.. 202. 2005
Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2.. 201. 2005
Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation.. 201. 2005
Sustained expansion of NKT cells and antigen-specific T cells after injection of alpha-galactosyl-ceramide loaded mature dendritic cells in cancer patients.. 201. 2005
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade.. 201. 2005
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells.. 201. 2005
Defective B cell tolerance checkpoints in systemic lupus erythematosus.. 201. 2005
Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule.. 201. 2005
Yellow fever 17D as a vaccine vector for microbial CTL epitopes: protection in a rodent malaria model.. 201. 2005
Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin.. 200. 2004
A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan.. 200. 2004
Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis.. 200. 2004
Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice.. 200. 2004
Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue.. 199. 2004
KSHV vFLIP is essential for the survival of infected lymphoma cells.. 199. 2004
Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris.. 199. 2004
Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies.. 199. 2003
Activation of transforming growth factor beta by malaria parasite-derived metalloproteinases and a thrombospondin-like molecule.. 198. 2003
Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection.. 198. 2003
Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1.. 198. 2003
MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis.. 198. 2003
Impaired T cell death and lupus-like autoimmunity in T cell-specific adapter protein-deficient mice.. 198. 2003
Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program.. 198. 2003
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment.. 198. 2003
Cross-presentation of disialoganglioside GD3 to natural killer T cells.. 198. 2003
Inhibition of interleukin 10 signaling after Fc receptor ligation and during rheumatoid arthritis.. 197. 2003
Competition between two MHC binding registers in a single peptide processed from myelin basic protein influences tolerance and susceptibility to autoimmunity.. 197. 2003
Interferon and granulopoiesis signatures in systemic lupus erythematosus blood.. 197. 2003
Integrin-dependence of lymphocyte entry into the splenic white pulp.. 197. 2003
Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF-4).. 197. 2003
Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages.. 197. 2003
Critical role of the carboxyl terminus of proline-rich tyrosine kinase (Pyk2) in the activation of human neutrophils by tumor necrosis factor: separation of signals for the respiratory burst and degranulation.. 197. 2003
I-PLA(2) activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation.. 196. 2002
Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands.. 195. 2002
Germinal center B cells regulate their capability to present antigen by modulation of HLA-DO.. 195. 2002
Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling.. 195. 2002
Pharmacological stimulation of the cholinergic antiinflammatory pathway.. 195. 2002
In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.. 195. 2002
Complement C3 activation is required for antiphospholipid antibody-induced fetal loss.. 195. 2002
Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells.. 194. 2001
Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase.. 194. 2001
The role of recombination activating gene (RAG) reinduction in thymocyte development in vivo.. 194. 2001
A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production.. 194. 2001
p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl).. 194. 2001
A coordinated change in chemokine responsiveness guides plasma cell movements.. 194. 2001
Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells.. 194. 2001
Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands.. 193. 2001
Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells.. 193. 2001
Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice.. 193. 2001
B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta.. 193. 2001
Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6.. 192. 2000
T cell receptor (TCR)-mediated repertoire selection and loss of TCR vbeta diversity during the initiation of a CD4(+) T cell response in vivo.. 192. 2000
Immunoglobulin heavy chain variable region gene replacement As a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes.. 192. 2000
Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response.. 192. 2000
Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis.. 192. 2000
Interferon gamma signaling alters the function of T helper type 1 cells.. 192. 2000
Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling.. 192. 2000
Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells.. 192. 2000
HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function.. 192. 2000
Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2.. 191. 2000
Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes.. 191. 2000
Identification of NY-ESO-1 epitopes presented by human histocompatibility antigen (HLA)-DRB4*0101-0103 and recognized by CD4(+) T lymphocytes of patients with NY-ESO-1-expressing melanoma.. 191. 2000
Induction and suppression of an autoimmune disease by oligomerized T cell epitopes: enhanced in vivo potency of encephalitogenic peptides.. 191. 2000
A single amino acid determines the immunostimulatory activity of interleukin 10.. 191. 2000
Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand.. 191. 2000
Dynamic interactions of macrophages with T cells during antigen presentation.. 190. 1999
Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4.. 190. 1999
Coupling and uncoupling of tumor immunity and autoimmunity.. 190. 1999
Inhibition of interleukin 2 signaling and signal transducer and activator of transcription (STAT)5 activation during T cell receptor-mediated feedback inhibition of T cell expansion.. 190. 1999
Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection.. 190. 1999
Macrophage and retinal pigment epithelium phagocytosis: apoptotic cells and photoreceptors compete for alphavbeta3 and alphavbeta5 integrins, and protein kinase C regulates alphavbeta5 binding and cytoskeletal linkage.. 190. 1999
Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein.. 190. 1999
Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications.. 190. 1999
312-nanometer ultraviolet B light (narrow-band UVB) induces apoptosis of T cells within psoriatic lesions.. 189. 1999
Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani.. 189. 1999
The transcription factor interferon regulatory factor 1 is expressed after cerebral ischemia and contributes to ischemic brain injury.. 189. 1999
Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice.. 188. 1998
Coordinate activation of activator protein 1 and inflammatory cytokines in response to Neisseria gonorrhoeae epithelial cell contact involves stress response kinases.. 188. 1998
Antigen-dependent CD28 signaling selectively enhances survival and proliferation in genetically modified activated human primary T lymphocytes.. 188. 1998
Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation.. 188. 1998
Cerebral ischemia enhances polyamine oxidation: identification of enzymatically formed 3-aminopropanal as an endogenous mediator of neuronal and glial cell death.. 188. 1998
HIV-1 antigen-specific and -nonspecific B cell responses are sensitive to combination antiretroviral therapy.. 188. 1998
Medullary thymic epithelium: a mosaic of epithelial "self"?. 188. 1998
Defective acidification in human breast tumor cells and implications for chemotherapy.. 187. 1998
A survey of the humoral immune response of cancer patients to a panel of human tumor antigens.. 187. 1998
T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells.. 187. 1998
Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock.. 187. 1998
Inhibition of constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor by protein kinases in mammalian cells in culture.. 187. 1998
Inhibition of the B cell by CD22: a requirement for Lyn.. 187. 1998
Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo.. 187. 1998
Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes.. 187. 1998
Identification of a CD36-related thrombospondin 1-binding domain in HIV-1 envelope glycoprotein gp120: relationship to HIV-1-specific inhibitory factors in human saliva.. 187. 1998
Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes.. 187. 1998
A novel antioxidant gene from Mycobacterium tuberculosis.. 186. 1997
Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation.. 186. 1997
Downregulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes.. 186. 1997
Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity.. 186. 1997
Inhibition of virus attachment to CD4+ target cells is a major mechanism of T cell line-adapted HIV-1 neutralization.. 186. 1997
Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding.. 186. 1997
Novel vascular molecule involved in monocyte adhesion to aortic endothelium in models of atherogenesis.. 185. 1997
Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitis.. 185. 1997
Intracellular antimicrobial activity in the absence of interferon-gamma: effect of interleukin-12 in experimental visceral leishmaniasis in interferon-gamma gene-disrupted mice.. 185. 1997
Behavior of visceral Leishmania donovani in an experimentally induced T helper cell 2 (Th2)-associated response model.. 185. 1997
Counterselection against D mu is mediated through immunoglobulin (Ig)alpha-Igbeta.. 184. 1996
Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease.. 184. 1996
Retro-retinoids in regulated cell growth and death.. 184. 1996
A human tumor necrosis factor p75 receptor agonist stimulates in vitro T cell proliferation but does not produce inflammation or shock in the baboon.. 184. 1996
The multidrug resistance phenotype confers immunological resistance.. 183. 1996
Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells.. 183. 1996
Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis.. 183. 1996
Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement.. 183. 1996
Association of mitogen-activated protein kinases with microtubules in mouse macrophages.. 183. 1996
Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production.. 183. 1996
Human Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes home preferentially to and induce selective regressions of autologous EBV-induced B cell lymphoproliferations in xenografted C.B-17 scid/scid mice.. 183. 1996
Neutralizing antibodies to human immunodeficiency virus type-1 gp120 induce envelope glycoprotein subunit dissociation.. 183. 1996
A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors.. 183. 1996
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.. 183. 1996
Regulation of the balance of cytokine production and the signal transducer and activator of transcription (STAT) transcription factor activity by cytokines and inflammatory synovial fluids.. 182. 1995
Successful ultraviolet B treatment of psoriasis is accompanied by a reversal of keratinocyte pathology and by selective depletion of intraepidermal T cells.. 182. 1995
CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway.. 182. 1995
T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates.. 182. 1995
Identification of dendritic cell colony-forming units among normal human CD34+ bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha.. 182. 1995
GD2 oligosaccharide: target for cytotoxic T lymphocytes.. 182. 1995
Human immunodeficiency virus type 1 neutralization is determined by epitope exposure on the gp120 oligomer.. 182. 1995
Fibrin regulates neutrophil migration in response to interleukin 8, leukotriene B4, tumor necrosis factor, and formyl-methionyl-leucyl-phenylalanine.. 181. 1995
Neutrophils from human immunodeficiency virus (HIV)-seronegative donors induce HIV replication from HIV-infected patients' mononuclear cells and cell lines: an in vitro model of HIV transmission facilitated by Chlamydia trachomatis.. 181. 1995
Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells.. 181. 1995
Activation of monocyte effector genes and STAT family transcription factors by inflammatory synovial fluid is independent of interferon gamma.. 181. 1995
Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production.. 181. 1995
Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene.. 181. 1995
Interleukin 12 is effective treatment for an established systemic intracellular infection: experimental visceral leishmaniasis.. 181. 1995
Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.. 181. 1995
Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin.. 180. 1994
Surface expression of a heterologous phosphatase complements CD45 deficiency in a T cell clone.. 180. 1994
Role of interferon regulatory factor 1 in induction of nitric oxide synthase.. 180. 1994
Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.. 180. 1994
Analysis of somatic mutation in five B cell subsets of human tonsil.. 180. 1994
Interleukin 2 receptor gamma chain expression on resting and activated lymphoid cells.. 180. 1994
PUVA bath therapy strongly suppresses immunological and epidermal activation in psoriasis: a possible cellular basis for remittive therapy.. 180. 1994
A human tumor necrosis factor (TNF) alpha mutant that binds exclusively to the p55 TNF receptor produces toxicity in the baboon.. 179. 1994
Impaired interleukin 12 production in human immunodeficiency virus-infected patients.. 179. 1994
Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival.. 179. 1994
Advanced glycosylation endproduct-specific receptors on human and rat T-lymphocytes mediate synthesis of interferon gamma: role in tissue remodeling.. 178. 1993
Growth control or terminal differentiation: endogenous production and differential activities of vitamin A metabolites in HL-60 cells.. 178. 1993
Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes.. 178. 1993
Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment.. 178. 1993
Human interferon-inducible protein 10: expression and purification of recombinant protein demonstrate inhibition of early human hematopoietic progenitors.. 178. 1993
Human keratinocyte growth factor effects in a porcine model of epidermal wound healing.. 178. 1993
Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.. 178. 1993
Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology.. 178. 1993
Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta.. 178. 1993
Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responses.. 178. 1993
Suppression of arthritis by an inhibitor of nitric oxide synthase.. 178. 1993
Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.. 177. 1993
Prolonged immunostimulatory effect of low-dose polyethylene glycol interleukin 2 in patients with human immunodeficiency virus type 1 infection.. 177. 1993
Application of DNA amplification to pneumocystosis: presence of serum Pneumocystis carinii DNA during human and experimentally induced Pneumocystis carinii pneumonia.. 176. 1992
Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection.. 176. 1992
Engineered humanized dimeric forms of IgG are more effective antibodies.. 176. 1992
Calmodulin is a subunit of nitric oxide synthase from macrophages.. 176. 1992
Retinoids are important cofactors in T cell activation.. 176. 1992
Transforming growth factor beta 2 inhibits cerebrovascular changes and brain edema formation in the tumor necrosis factor alpha-independent early phase of experimental pneumococcal meningitis.. 176. 1992
BCL2 oncogene translocation is mediated by a chi-like consensus.. 175. 1992
The insulin-like growth factor I receptor is overexpressed in psoriatic epidermis, but is differentially regulated from the epidermal growth factor receptor.. 175. 1992
Determination of the structural basis for selective binding of Epstein-Barr virus to human complement receptor type 2.. 174. 1991
Macrophage deactivation by interleukin 10.. 174. 1991
Mapping of the C3b-binding site of CR1 and construction of a (CR1)2-F(ab')2 chimeric complement inhibitor.. 174. 1991
Repression of class II major histocompatibility complex genes by cyclic AMP is mediated by conserved promoter elements.. 174. 1991
The genomic structure of human V beta 6 T cell antigen receptor genes.. 174. 1991
Differential regulation of transforming growth factor beta and interleukin 2 genes in human T cells: demonstration by usage of novel competitor DNA constructs in the quantitative polymerase chain reaction.. 174. 1991
Characterization of human T cells reactive with the Mycoplasma arthritidis-derived superantigen (MAM): generation of a monoclonal antibody against V beta 17, the T cell receptor gene product expressed by a large fraction of MAM-reactive human T cells.. 174. 1991
Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.. 174. 1991
Two novel rat liver membrane proteins that bind advanced glycosylation endproducts: relationship to macrophage receptor for glucose-modified proteins.. 174. 1991
Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.. 174. 1991
Molecular interactions of complement receptors on B lymphocytes: a CR1/CR2 complex distinct from the CR2/CD19 complex.. 173. 1991
The systemic influence of recombinant interleukin 2 on the manifestations of lepromatous leprosy.. 173. 1991
5' regulatory region of a novel cytokine gene mediates selective activation by interferon gamma.. 173. 1991
Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory.. 173. 1991
Histologic transformation of follicular lymphoma to diffuse lymphoma represents tumor progression by a single malignant B cell.. 173. 1991
Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.. 173. 1991
Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils.. 172. 1990
Endothelins, peptides with potent vasoactive properties, are produced by human macrophages.. 172. 1990
Widespread intradermal accumulation of mononuclear leukocytes in lepromatous leprosy patients treated systemically with recombinant interferon gamma.. 172. 1990
Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding.. 172. 1990
Shedding of tumor necrosis factor receptors by activated human neutrophils.. 172. 1990
Diversity in junctional sequences associated with the common human V gamma 9 and V delta 2 gene segments in normal blood and lung compared with the limited diversity in a granulomatous disease.. 172. 1990
Phagocytosis of tumor cells by human monocytes cultured in recombinant macrophage colony-stimulating factor.. 172. 1990
A novel model for antigen-dependent activation of normal human T cells. Transmembrane signaling by crosslinkage of the CD3/T cell receptor-alpha/beta complex with the cluster determinant 2 antigen.. 171. 1990
Helper T cell-dependent human B cell differentiation mediated by a mycoplasmal superantigen bridge.. 171. 1990
Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors.. 171. 1990
Retinol is essential for growth of activated human B cells.. 171. 1990
Biased accumulation of T lymphocytes with "memory"-type CD45 leukocyte common antigen gene expression on the epithelial surface of the human lung.. 171. 1990
Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells.. 171. 1990
Purification of macrophage deactivating factor.. 171. 1990
A novel addition to the T cell repertory. Cell surface expression of tumor necrosis factor/cachectin by activated normal human T cells.. 171. 1990
Downregulation of tumor necrosis factor receptors on macrophages and endothelial cells by microtubule depolymerizing agents.. 171. 1990
Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2.. 170. 1989
Perforin and serine esterase gene expression in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A.. 170. 1989
Interleukin 6 decreases cell-cell association and increases motility of ductal breast carcinoma cells.. 170. 1989
Antibody-dependent antitumor cytotoxicity by human monocytes cultured with recombinant macrophage colony-stimulating factor. Induction of efficient antibody-mediated antitumor cytotoxicity not detected by isotope release assays.. 170. 1989
Inhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene.. 169. 1989
Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.. 169. 1989
Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.. 169. 1989
Expression of the neutrophil elastase gene during human bone marrow cell differentiation.. 169. 1989
Interferon alpha associated with systemic lupus erythematosus is not intrinsically acid labile.. 169. 1989
Interleukin 1 production during accessory cell-dependent mitogenesis of T lymphocytes.. 169. 1989
Structure of the human CR1 gene. Molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele.. 169. 1989
Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression.. 169. 1989
Isolation of a complementary DNA clone encoding a precursor to human eosinophil major basic protein.. 168. 1988
Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis.. 168. 1988
The dynamics of granuloma formation in experimental visceral leishmaniasis.. 167. 1988
Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1.. 167. 1988
Agonist and antagonist effects of interferon alpha and beta on activation of human macrophages. Two classes of interferon gamma receptors and blockade of the high-affinity sites by interferon alpha or beta.. 167. 1988
Analysis of the nonfunctional respiratory burst in murine Kupffer cells.. 167. 1988
Sn-protoporphyrin blocks the increase in serum bilirubin levels that develops postnatally in homozygous Gunn rats.. 167. 1988
Structure of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and relatedness to other members of the family of C3/C4 binding proteins.. 167. 1988
Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties.. 167. 1988
Aging and arteriosclerosis. The increased proliferation of arterial smooth muscle cells isolated from old rats is associated with increased platelet-derived growth factor-like activity.. 167. 1988
Opsonin-independent ligation of Fc gamma receptors. The 3G8-bearing receptors on neutrophils mediate the phagocytosis of concanavalin A-treated erythrocytes and nonopsonized Escherichia coli.. 166. 1987
Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with interferon gamma.. 166. 1987
The interleukin 2 receptor. Functional consequences of its bimolecular structure.. 166. 1987
Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells.. 166. 1987
Tumor necrosis factor-mediated release of platelet-derived growth factor from cultured endothelial cells.. 166. 1987
High frequency of clonal immunoglobulin or T cell receptor gene rearrangements in acute myelogenous leukemia expressing terminal deoxyribonucleotidyltransferase.. 165. 1987
Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins.. 165. 1987
Proof that Sn-protoporphyrin inhibits the enzymatic catabolism of heme in vivo. Suppression of 14CO generation from radiolabeled endogenous and exogenous heme sources.. 165. 1987
Recombinant human granulocyte colony-stimulating factor. Effects on hematopoiesis in normal and cyclophosphamide-treated primates.. 165. 1987
Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac-1 (complement receptor type 3).. 165. 1987
Histidine-rich glycoprotein inhibits the antiproliferative effect of heparin on smooth muscle cells.. 165. 1987
Identification of the complement decay-accelerating factor (DAF) on epithelium and glandular cells and in body fluids.. 165. 1987
Secretion of pyruvate. An antioxidant defense of mammalian cells.. 165. 1987
Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.. 165. 1987
Multiple monoclonal B cell expansions and c-myc oncogene rearrangements in acquired immune deficiency syndrome-related lymphoproliferative disorders. Implications for lymphomagenesis.. 164. 1986
Analysis of multiple restriction fragment length polymorphisms of the gene for the human complement receptor type I. Duplication of genomic sequences occurs in association with a high molecular mass receptor allotype.. 164. 1986
Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation.. 164. 1986
Direct T helper-B cell interactions induce an early B cell activation antigen.. 164. 1986
Subcellular location and properties of bactericidal factors from human neutrophils.. 164. 1986
Aging and arteriosclerosis. I. Development of myointimal hyperplasia after endothelial injury.. 164. 1986
Macrophage deactivation. Altered kinetic properties of superoxide-producing enzyme after exposure to tumor cell-conditioned medium.. 164. 1986
Blockade of clearance of immune complexes by an anti-Fc gamma receptor monoclonal antibody.. 164. 1986
Identification of a restriction fragment length polymorphism by a CR1 cDNA that correlates with the number of CR1 on erythrocytes.. 164. 1986
Cyclooxygenase blockade elevates leukotriene E4 production during acute anaphylaxis in sheep.. 163. 1986
Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor.. 163. 1986
Regulation of T cell autocrine growth. T4+ cells become refractory to interleukin 2.. 163. 1986
Tissue-specific phosphorylation of complement receptors CR1 and CR2.. 163. 1986
T cell receptor beta chain gene rearrangements in lymphoproliferative disorders of large granular lymphocytes/natural killer cells.. 162. 1985
Self-regulation of procoagulant events on the endothelial cell surface.. 162. 1985
Thymus-leukemia (TL) antigens of the mouse. Analysis of TL mRNA and TL cDNA TL+ and TL- strains.. 162. 1985
Hereditary tyrosinemia. Formation of succinylacetone-amino acid adducts.. 162. 1985
Long-term administration of massive doses of Sn-protoporphyrin in anemic mutant mice (sphha/sphha).. 162. 1985
Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes.. 162. 1985
Liver macrophages in murine listeriosis. Cell-mediated immunity is correlated with an influx of macrophages capable of generating reactive oxygen intermediates.. 161. 1985
Murine Kupffer cells. Mononuclear phagocytes deficient in the generation of reactive oxygen intermediates.. 161. 1985
Interleukin 2 receptors on human B cells. Implications for the role of interleukin 2 in human B cell function.. 161. 1985
Both interleukin 2 and a second T cell-derived factor in EL-4 supernatant have activity as differentiation factors in IgM synthesis.. 160. 1984
Activation of human macrophages. Comparison of other cytokines with interferon-gamma.. 160. 1984
Characterization of soluble factors that induce the cytolytic activity and the expression of T cell growth factor receptors of a T cell hybrid.. 160. 1984
Bacillus Calmette-Guérin-activated murine macrophages kill syngeneic melanoma cells under strict anaerobic conditions.. 160. 1984
Transient expression of interleukin 2 receptors. Consequences for T cell growth.. 158. 1983
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.. 158. 1983
Human platelet activation by C3a and C3a des-arg.. 158. 1983
Lymphokine enhances oxygen-independent activity against intracellular pathogens.. 158. 1983
Impaired fc-mediated mononuclear phagocyte system clearance in HLA-DR2 and MT1-positive healthy young adults.. 157. 1983
Suppression of hyperbilirubinemia in the rat neonate by chromium-protoporphyrin. Interactions of metalloporphyrins with microsomal heme oxygenase of human spleen.. 156. 1982
Suppression of macrophage oxidative metabolism by products of malignant and nonmalignant cells.. 156. 1982
Augmentation of spontaneous macrophage-mediated cytolysis by eosinophil peroxidase.. 155. 1982
Regulation of arachidonic acid metabolism by macrophage activation.. 155. 1982
Antibody-independent complement activation by myelin via the classical complement pathway.. 155. 1982
Antitumor effects of hydrogen peroxide in vivo.. 154. 1981
T cell growth factor receptors. Quantitation, specificity, and biological relevance.. 154. 1981
Thrombin-induced platelet membrane glycoprotein IIb and IIIa complex formation. An electron microscope study.. 154. 1981
Lymphokine-mediated bone resorption requires endogenous prostaglandin synthesis.. 154. 1981
Human megakaryocytes. II. Expression of platelet proteins in early marrow megakaryocytes.. 154. 1981
Interaction of Leishmania with a macrophage cell line. Correlation between intracellular killing and the generation of oxygen intermediates.. 153. 1981
Membrane distribution and adsorptive endocytosis by C3b receptors on human polymorphonuclear leukocytes.. 153. 1981
Susceptibility of Leishmania to oxygen intermediates and killing by normal macrophages.. 153. 1981
Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis.. 153. 1981
Human complement in the arachidonic acid transformation pathway in platelets.. 153. 1981
Potent heme-degrading action of antimony and antimony-containing parasiticidal agents.. 153. 1981
Macrophage oxygen-dependent antimicrobial activity. III. Enhanced oxidative metabolism as an expression of macrophage activation.. 152. 1980
Macrophage oxygen-dependent antimicrobial activity. IV. Role of endogenous scavengers of oxygen intermediates.. 152. 1980
Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte.. 152. 1980
Role of activated macrophages in antibody-dependent lysis of tumor cells.. 152. 1980
Role of oxygen-dependent mechanisms in antibody-induced lysis of tumor cells by activated macrophages.. 152. 1980
The functional relationship of the interleukins.. 151. 1980
Immunological properties of subcellular rat lymphocyte preparations. Primary allogeneic stimulation in vitro by fractions containing Ia (RT1-B), but not RT1-A antigens.. 151. 1980
Synthesis and release of erythroid colony- and burst-potentiating activities by purified populations of murine peritoneal macrophages.. 151. 1980
Generation of a lymphocyte growth factor by treatment of human cells with neuraminidase and galactose oxidase.. 151. 1980
Peripheral blood Ia-positive T cells. Increases in certain diseases and after immunization.. 151. 1980
Surface-associated heparin inhibits zymosan-induced activation of the human alternative complement pathway by augmenting the regulatory action of the control proteins on particle-bound C3b.. 150. 1979
Macrophage oxygen-dependent antimicrobial activity. I. Susceptibility of Toxoplasma gondii to oxygen intermediates.. 150. 1979
Macrophage oxygen-dependent antimicrobial activity. II. The role of oxygen intermediates.. 150. 1979
Human complement in thrombin-mediated platelet function: uptake of the C5b-9 complex.. 150. 1979
Human megakaryocytes. I. Characterization of the membrane and cytoplasmic components of isolated marrow megakaryocytes.. 149. 1979
The influence of steroid hormone metabolites on the in vitro development of erythroid colonies derived from human bone marrow.. 149. 1979
Activation of macrophages in vivo and in vitro. Correlation between hydrogen peroxide release and killing of Trypanosoma cruzi.. 149. 1979
Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide.. 149. 1979
Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity.. 149. 1979
Disease associations of the Ia-like human alloantigens. Contrasting patterns in rheumatoid arthritis and systemic lupus erythematosus.. 148. 1978
Immune suppression in vivo with antigen-modified syngeneic cells. I. T-cell-mediated suppression to the terpolymer poly-(Glu, Lys, Phe)n.. 148. 1978
Identification of lactoferrin as the granulocyte-derived inhibitor of colony-stimulating activity production.. 148. 1978
Inhibition of human erythropoietic colony formation in culture by treatment with Ia antisera.. 148. 1978
Synthesis of fibronectin by cultured human endothelial cells.. 147. 1978
The human complement system in thrombin-mediated platelet function.. 147. 1978
Transplantation of allogeneic bone marrow without graft-versus-host disease using total lymphoid irradiation.. 147. 1978
Prostaglandin E production by human blood monocytes and mouse peritoneal macrophages.. 147. 1978
Modulation of the formation of the amplification convertase of complement, C3b, Bb, by native and commercial heparin.. 147. 1978
Hydrogen peroxide release from mouse peritoneal macrophages: dependence on sequential activation and triggering.. 146. 1977
The separation, long-term cultivation, and maturation of the human monocyte.. 146. 1977
Enzymes of heme metabolism in the kidney: regulation by trace metals which do not form heme complexes.. 146. 1977
Preparative purification of the rat mast cell chymase: characterization and interaction with granule components.. 146. 1977
Activation of the alternative complement pathway with rabbit erythrocytes by circumvention of the regulatory action of endogenous control proteins.. 146. 1977
Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: long-term survival of allogeneic bone marrow and skin grafts.. 146. 1977
On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain.. 145. 1977
Isolation of variants in phagocytosis of a macrophage-like continuous cell line.. 145. 1977
Control of mating preferences in mice by genes in the major histocompatibility complex.. 144. 1976
Synthesis of basement membrane collagen by cultured human endothelial cells.. 144. 1976
Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages.. 142. 1975
Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase.. 142. 1975
Studies in porphyria. IV. Expression of the gene defect of acute intermittent porphyria in cultured human skin fibroblasts and amniotic cells: prenatal diagnosis of the porphyric trait.. 142. 1975
Study of the developmental pattern of heme catabolism in liver and the effects of cobalt on cytochrome P-450 and the rate of heme oxidation during the neonatal period.. 141. 1975
Ultrastructural lesions on the surface of platelets associated with either blood coagulation or with antibody-mediated immune injury.. 141. 1975
Subcellular platelet factor VIII antigen and von Willebrand factor.. 141. 1975
Inhibition of multiplication of Toxoplasma gondii by human monocytes exposed to T-lymphocyte products.. 141. 1975
Properdin factor D. II. Activation to D by properdin.. 140. 1974
Properdin factor D: characterization of its active site and isolation of the precursor form.. 139. 1974
Formation of a hemolytically active cellular intermediate by the interaction between properdin factors B and D and the activated third component of complement.. 138. 1973
Studies in porphyria. II. Evidence for a deficiency of steroid delta-4-5-alpha-reductase activity in acute intermittent porphyria.. 138. 1973
Identification of human B and T lymphocytes by scanning electron microscopy.. 138. 1973
Characterization of a lymphocyte factor which alters macrophage functions.. 137. 1973
Studies in porphyria. I. A defect in the reductive transformation of natural steroid hormones in the hereditary liver disease, acute intermittent porphyria.. 136. 1972
Lead and methyl mercury: effects of acute exposure on cytochrome P-450 and the mixed function oxidase system in the liver.. 135. 1972
Rabbit platelet bactericidal protein.. 134. 1971
The influence of postnatal development on drug-induced hepatic porphyria and the synthesis of cytochrome P-450. A biochemical and morphological study.. 134. 1971
Vasculitis in association with Australia antigen.. 134. 1971
Vasculitis in association with australia antigen.. 134. 1971
Alterations of macrophage functions by mediators from lymphocytes.. 133. 1971
Macrophage plasma membrane. II. Studies on synthesis and turnover of protein constituents.. 133. 1971
Macrophage plasma membranes. I. Isolation and studies on protein components.. 133. 1971
THE APPLICATION OF TISSUE CULTURE TO THE STUDY OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS. II. SERUM FACTORS RESPONSIBLE FOR DEMYELINATION.. 119. 1964
The omentum, a niche for premetastatic ovarian cancer.. 217. 2020
Shared cancer neoantigens: Making private matters public.. 215. 2017
An autoimmune "attack" on melanocytes triggers psoriasis and cellular hyperplasia.. 212. 2015
Self-targeting blocks malaria parasite invasion.. 212. 2015
Immunotherapy and the belly of the beast.. 211. 2014
Retraction. The requirements for natural Th17 cell development are distinct from those of conventional Th17 cells.. 211. 2014
Metabolism and the leukemic stem cell.. 207. 2010
Salim "Slim" Abdool Karim: attacking AIDS in South Africa. Interview by Amy Maxmen.. 206. 2009
Sabine Ehrt: searching for mycobacterial stress points. Interview by Hema Bashyam.. 205. 2008
Viral G protein-coupled receptor and Kaposi's sarcoma: a model of paracrine neoplasia?. 191. 2000
Is IL-6 both a cytokine and a neurotrophic factor?. 183. 1996
Dendritic cells as adjuvants for class I major histocompatibility complex-restricted antitumor immunity.. 183. 1996
Neutrophils and COVID-19: Nots, NETs, and knots. 2020
When pregnancy tames the wolf. 2019
TLR8: No gain, no pain. 2018
Combination immunotherapy for cancer. 2016
In vivo sites and cellular mechanisms of T reg cell-mediated suppression. 2006
The pIV-otal class II transactivator promoter regulates major histocompatibility complex class II expression in the thymus. 2001
New paths in human cancer serology. 1998
Friend turned foe: TREM2 agonist in battles against tau.. 220. 2022
JEM goes viral.. 217. 2020
A time of change.. 214. 2017
Human studies at JEM: Immunology and beyond.. 213. 2016
Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses. 2021
A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection. 2019
Emerging concepts and future challenges in innate lymphoid cell biology. 2016
Aberrant pre-mRNA processing in cancer. 2024
The anatomic basis of leptomeningeal metastasis. 2024
Mycobacterium tuberculosis and the host response. 2005

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