Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation. Academic Article uri icon

Overview

abstract

  • We used a cloned, TNP-specific, MHC-restricted, human Th cell line, E-11, and an assay of cognate Th-B cell interaction, BLAST-2 antigen expression on the B cell surface, to investigate the functional nature of the Th cell antigen receptor. We observed that E-11 induces BLAST-2 expression by resting B cells in a hapten-dependent, hapten-specific, but MHC nonrestricted manner. The implication of these results for the Th cell receptor are discussed.

publication date

  • November 1, 1986

Research

keywords

  • B-Lymphocytes
  • HLA-D Antigens
  • HLA-DR Antigens
  • Lymphocyte Activation
  • Receptors, Antigen, T-Cell
  • T-Lymphocytes, Helper-Inducer

Identity

PubMed Central ID

  • PMC2188441

Scopus Document Identifier

  • 0022970131

PubMed ID

  • 2945894

Additional Document Info

volume

  • 164

issue

  • 5