Metabolism and the leukemic stem cell. Article uri icon

Overview

abstract

  • Acute leukemias are clonal disorders of hematopoiesis wherein a leukemic stem cell (LSC) acquires mutations that confer the capacity for unlimited self-renewal, impaired hematopoietic differentiation, and enhanced proliferation to the leukemic clone. Many recent advances in understanding the biology of leukemia have come from studies defining specific genetic and epigenetic abnormalities in leukemic cells. Three recent articles, however, further our understanding of leukemia biology by elucidating specific abnormalities in metabolic pathways in leukemic hematopoiesis. These studies potentially converge on the concept that modulation of reactive oxygen species (ROS) abundance may influence the pathogenesis and treatment of acute myeloid leukemia (AML).

publication date

  • April 5, 2010

Research

keywords

  • Hematopoiesis
  • Leukemia
  • Neoplastic Stem Cells
  • Reactive Oxygen Species

Identity

PubMed Central ID

  • PMC2856035

Scopus Document Identifier

  • 77951040369

Digital Object Identifier (DOI)

  • 10.1084/jem.20100523

PubMed ID

  • 20368582

Additional Document Info

volume

  • 207

issue

  • 4