Embryonic FAP+ lymphoid tissue organizer cells generate the reticular network of adult lymph nodes. Academic Article uri icon

Overview

abstract

  • The induction of adaptive immunity is dependent on the structural organization of LNs, which is in turn governed by the stromal cells that underpin LN architecture. Using a novel fate-mapping mouse model, we trace the developmental origin of mesenchymal LN stromal cells (mLNSCs) to a previously undescribed embryonic fibroblast activation protein-α (FAP)+ progenitor. FAP+ cells of the LN anlagen express lymphotoxin β receptor (LTβR) and vascular cell adhesion molecule (VCAM), but not intercellular adhesion molecule (ICAM), suggesting they are early mesenchymal lymphoid tissue organizer (mLTo) cells. Clonal labeling shows that FAP+ progenitors locally differentiate into mLNSCs. This process is also coopted in nonlymphoid tissues in response to infection to facilitate the development of tertiary lymphoid structures, thereby mimicking the process of LN ontogeny in response to infection.

publication date

  • July 19, 2019

Research

keywords

  • Embryo, Mammalian
  • Gelatinases
  • Lymph Nodes
  • Membrane Proteins
  • Mesenchymal Stem Cells
  • Models, Immunological
  • Serine Endopeptidases

Identity

PubMed Central ID

  • PMC6780995

Scopus Document Identifier

  • 85072994576

Digital Object Identifier (DOI)

  • 10.1084/jem.20111449

PubMed ID

  • 31324739

Additional Document Info

volume

  • 216

issue

  • 10