Horner, Philip

Publications

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selected publications

Biomimetic 3D Hydrogels with Aligned Topography for Neural Tissue Engineering. Polymers. 2024 Academic Article GET IT
Scalable networks of wireless bioelectronics using magnetoelectrics. 2024 GET IT
Hemin-Induced Transient Senescence Via DNA Damage Response: A Neuroprotective Mechanism Against Ferroptosis in Intracerebral Hemorrhage. 2024 GET IT
Electrokinetic convection-enhanced delivery for infusion into the brain from a hydrogel reservoir. Communications biology. 2024 Academic Article GET IT
Times cited: 2
A novel minimally invasive and versatile kyphoplasty balloon-based model of porcine spinal cord injury. Frontiers in neurology. 2024 Academic Article GET IT
Times cited: 1
Mapping lumbar efferent and afferent spinal circuitries via paddle array in a porcine model. Journal of neuroscience methods. 2024 Academic Article GET IT
Times cited: 1
iDISCO Tissue Clearing Whole-Brain and Light Sheet Microscopy for High-Throughput Imaging in a Mouse Model of Traumatic Brain Injury. Methods in molecular biology (Clifton, N.J.). 2024 Academic Article GET IT
Assessment of spinal cord injury using ultrasound elastography in a rabbit model in vivo. Scientific reports. 2023 Academic Article GET IT
Times cited: 2
Optogenetic spinal stimulation promotes new axonal growth and skilled forelimb recovery in rats with sub-chronic cervical spinal cord injury. Journal of neural engineering. 2023 Academic Article GET IT
Times cited: 4
Novel TCF4:TCF12 heterodimer inhibits glioblastoma growth. Molecular oncology. 2023 Academic Article GET IT
Times cited: 3
Glial progenitor heterogeneity and key regulators revealed by single-cell RNA sequencing provide insight to regeneration in spinal cord injury. Cell reports. 2023 Academic Article GET IT
Times cited: 12
Cortical stimulation leads to shortened myelin sheaths and increased axonal branching in spared axons after cervical spinal cord injury. Glia. 2023 Academic Article GET IT
Times cited: 3
Magnetic Resonance-Guided Stereotaxy for Infusions to the Pig Brain. Journal of visualized experiments : JoVE. 2023 Academic Article GET IT
Times cited: 1
Rigor and reproducibility in analysis of rodent behavior utilizing the forelimb reaching task following a cervical spinal cord injury. Behavioural brain research. 2022 Academic Article GET IT
Times cited: 1
SARS-CoV-2 and the central nervous system: Emerging insights into hemorrhage-associated neurological consequences and therapeutic considerations. Ageing research reviews. 2022 Review GET IT
Times cited: 14
Stereotaxic Atlas of the Human Lumbar-Sacral Spinal Cord. World neurosurgery. 2022 Academic Article GET IT
Effects of transcutaneous spinal stimulation on spatiotemporal cortical activation patterns: a proof-of-concept EEG study. Journal of neural engineering. 2022 Academic Article GET IT
Times cited: 8
Assessing Gq-GPCR-induced human astrocyte reactivity using bioengineered neural organoids. The Journal of cell biology. 2022 Academic Article GET IT
Times cited: 12
Fully Characterized Mature Human iPS- and NMP-Derived Motor Neurons Thrive Without Neuroprotection in the Spinal Contusion Cavity. Frontiers in cellular neuroscience. 2022 Academic Article GET IT
Times cited: 8
A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage. Annals of clinical and translational neurology. 2021 Review GET IT
Times cited: 6
A wireless spinal stimulation system for ventral activation of the rat cervical spinal cord. Scientific reports. 2021 Academic Article GET IT
Times cited: 14
Transcriptome of rat subcortical white matter and spinal cord after spinal injury and cortical stimulation. Scientific data. 2021 Academic Article GET IT
Times cited: 3
Transplantable human motor networks as a neuron-directed strategy for spinal cord injury. iScience. 2021 Academic Article GET IT
Times cited: 9
Transcutaneous spinal cord stimulation improves postural stability in individuals with multiple sclerosis. Multiple sclerosis and related disorders. 2021 Academic Article GET IT
Times cited: 17
Quantification of Myelinated Nerve Fraction and Degeneration in Spinal Cord Neuropil by SHIFT MRI. Journal of magnetic resonance imaging : JMRI. 2020 Academic Article GET IT
Times cited: 1
Neural Stimulation and Molecular Mechanisms of Plasticity and Regeneration: A Review. Frontiers in cellular neuroscience. 2020 Academic Article GET IT
Times cited: 41
A micro-LED implant and technique for optogenetic stimulation of the rat spinal cord. Experimental neurology. 2020 Academic Article GET IT
Times cited: 18
Fabrication of homotypic neural ribbons as a multiplex platform optimized for spinal cord delivery. Scientific reports. 2020 Academic Article GET IT
Times cited: 12
Selective Antagonism of A1 Adenosinergic Receptors Strengthens the Neuromodulation of the Sensorimotor Network During Epidural Spinal Stimulation. Frontiers in systems neuroscience. 2020 Academic Article GET IT
Times cited: 6
Complications of epidural spinal stimulation: lessons from the past and alternatives for the future. Spinal cord. 2020 Academic Article GET IT
Times cited: 37
Formulation of thrombin-inhibiting hydrogels via self-assembly of ionic peptides with peptide-modified polymers. Soft matter. 2020 Academic Article GET IT
Times cited: 4
Polyplex transfection from intracerebroventricular delivery is not significantly affected by traumatic brain injury. Journal of controlled release : official journal of the Controlled Release Society. 2020 Academic Article GET IT
Times cited: 2
pH-sensitive polymer micelles provide selective and potentiated lytic capacity to venom peptides for effective intracellular delivery. Biomaterials. 2018 Academic Article GET IT
Times cited: 58
Optogenetic surface stimulation of the rat cervical spinal cord. Journal of neurophysiology. 2018 Academic Article GET IT
Times cited: 17
Tunable, Injectable Hydrogels Based on Peptide-Cross-Linked, Cyclized Polymer Nanoparticles for Neural Progenitor Cell Delivery. Biomacromolecules. 2018 Academic Article GET IT
Times cited: 28
Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes. Stem cell reports. 2017 Academic Article GET IT
Times cited: 77
Myelin plasticity, neural activity, and traumatic neural injury. Developmental neurobiology. 2017 Review GET IT
Times cited: 15
3D Printed Vascularized Device for Subcutaneous Transplantation of Human Islets. Biotechnology journal. 2017 Academic Article GET IT
Times cited: 72
Age-related accumulation of phosphorylated mitofusin 2 protein in retinal ganglion cells correlates with glaucoma progression. Experimental neurology. 2017 Academic Article GET IT
Times cited: 15
Fabrication of multipoint side-firing optical fiber by laser micro-ablation. Optics letters. 2017 Academic Article GET IT
Times cited: 13
Development of switchable polymers to address the dilemma of stability and cargo release in polycationic nucleic acid carriers. Biomaterials. 2017 Academic Article GET IT
Times cited: 45
Non-Viral Nucleic Acid Delivery Strategies to the Central Nervous System. Frontiers in molecular neuroscience. 2016 Review GET IT
Times cited: 34
Nano-Sized Sunflower Polycations As Effective Gene Transfer Vehicles. Small (Weinheim an der Bergstrasse, Germany). 2016 Academic Article GET IT
Times cited: 50
Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons. Acta neuropathologica communications. 2016 Academic Article GET IT
Times cited: 46
Targeted axonal import (TAxI) peptide delivers functional proteins into spinal cord motor neurons after peripheral administration. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 30
Microbubbles and ultrasound increase intraventricular polyplex gene transfer to the brain. Journal of controlled release : official journal of the Controlled Release Society. 2016 Academic Article GET IT
Times cited: 43
Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma. Experimental eye research. 2015 Academic Article GET IT
Times cited: 80
A Cervical Hemi-Contusion Spinal Cord Injury Model for the Investigation of Novel Therapeutics Targeting Proximal and Distal Forelimb Functional Recovery. Journal of neurotrauma. 2015 Academic Article GET IT
Times cited: 35
Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity. Stem cells (Dayton, Ohio). 2015 Academic Article GET IT
Times cited: 110
Guanidinylated block copolymers for gene transfer: A comparison with amine-based materials for in vitro and in vivo gene transfer efficiency. Biomaterials. 2015 Academic Article GET IT
Times cited: 21
A functionalized, injectable hydrogel for localized drug delivery with tunable thermosensitivity: synthesis and characterization of physical and toxicological properties. Journal of controlled release : official journal of the Controlled Release Society. 2015 Academic Article GET IT
Times cited: 53
Mitochondrial morphology differences and mitophagy deficit in murine glaucomatous optic nerve. Investigative ophthalmology & visual science. 2015 Academic Article GET IT
Times cited: 106
MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition. Biomaterials science. 2015 Academic Article GET IT
Times cited: 20
Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion. Biomaterials. 2014 Academic Article GET IT
Times cited: 43
Therapeutic intraspinal stimulation to generate activity and promote long-term recovery. Frontiers in neuroscience. 2014 Academic Article GET IT
Times cited: 42
Differential progression of structural and functional alterations in distinct retinal ganglion cell types in a mouse model of glaucoma. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Academic Article GET IT
Times cited: 216
Caudalized human iPSC-derived neural progenitor cells produce neurons and glia but fail to restore function in an early chronic spinal cord injury model. Experimental neurology. 2013 Academic Article GET IT
Times cited: 81
The impact of age on oncogenic potential: tumor-initiating cells and the brain microenvironment. Aging cell. 2013 Review GET IT
Times cited: 22
α-Lipoic acid antioxidant treatment limits glaucoma-related retinal ganglion cell death and dysfunction. PloS one. 2013 Academic Article GET IT
Times cited: 116
Therapeutic intraspinal microstimulation improves forelimb function after cervical contusion injury. Journal of neural engineering. 2013 Academic Article GET IT
Times cited: 62
Dual responsive, stabilized nanoparticles for efficient in vivo plasmid delivery. Angewandte Chemie (International ed. in English). 2013 Academic Article GET IT
Times cited: 114
FMR1 transcript isoforms: association with polyribosomes; regional and developmental expression in mouse brain. PloS one. 2013 Academic Article GET IT
Times cited: 45
Remyelination reporter reveals prolonged refinement of spontaneously regenerated myelin. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 92
Melittin-grafted HPMA-oligolysine based copolymers for gene delivery. Biomaterials. 2012 Academic Article GET IT
Times cited: 61
Geropotency: increased malignant potential of aging neural progenitors. Aging. 2012 Editorial Article GET IT
Increased age of transformed mouse neural progenitor/stem cells recapitulates age-dependent clinical features of human glioma malignancy. Aging cell. 2012 Academic Article GET IT
Times cited: 11
Stem cell-based therapy for spinal cord injury. Cell transplantation. 2012 Review GET IT
Times cited: 51
Early reduction of microglia activation by irradiation in a model of chronic glaucoma. PloS one. 2012 Academic Article GET IT
Times cited: 122
The cell and molecular biology of glaucoma: axonopathy and the brain. Investigative ophthalmology & visual science. 2012 Academic Article GET IT
Times cited: 85
Axonal thinning and extensive remyelination without chronic demyelination in spinal injured rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 70
Chondroitinase ABC combined with neurotrophin NT-3 secretion and NR2D expression promotes axonal plasticity and functional recovery in rats with lateral hemisection of the spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Academic Article GET IT
Times cited: 90
Increased re-entry into cell cycle mitigates age-related neurogenic decline in the murine subventricular zone. Stem cells (Dayton, Ohio). 2011 Academic Article GET IT
Times cited: 24
Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord. The European journal of neuroscience. 2011 Academic Article GET IT
Times cited: 55
Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 62
TWIST1 promotes invasion through mesenchymal change in human glioblastoma. Molecular cancer. 2010 Academic Article GET IT
Times cited: 239
Metabolic vulnerability disposes retinal ganglion cell axons to dysfunction in a model of glaucomatous degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Academic Article GET IT
Times cited: 130
Distal axonopathy with structural persistence in glaucomatous neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 294
Beta-catenin signaling increases in proliferating NG2+ progenitors and astrocytes during post-traumatic gliogenesis in the adult brain. Stem cells (Dayton, Ohio). 2010 Academic Article GET IT
Times cited: 66
Reply to: age as a predictive factor in glioblastomas: population-based study. Neuroepidemiology. 2010 Letter GET IT
Targeted nonviral delivery vehicles to neural progenitor cells in the mouse subventricular zone. Biomaterials. 2009 Academic Article GET IT
Times cited: 70
A syngeneic glioma model to assess the impact of neural progenitor target cell age on tumor malignancy. Aging cell. 2009 Academic Article GET IT
Times cited: 16
Postinjury niches induce temporal shifts in progenitor fates to direct lesion repair after spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Academic Article GET IT
Times cited: 112
Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons. Experimental neurology. 2009 Academic Article GET IT
Times cited: 83
Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2. The American journal of pathology. 2009 Academic Article GET IT
Times cited: 34
Age-related myelin dynamics revealed by increased oligodendrogenesis and short internodes. Aging cell. 2009 Academic Article GET IT
Times cited: 90
Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas: implications for glioma histogenesis and biology. Glia. 2009 Academic Article GET IT
Times cited: 42
Manganese-enhanced MRI of the DBA/2J mouse model of hereditary glaucoma. Investigative ophthalmology & visual science. 2008 Academic Article GET IT
Times cited: 51
No evidence for chronic demyelination in spared axons after spinal cord injury in a mouse. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Academic Article GET IT
Times cited: 114
Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma. Investigative ophthalmology & visual science. 2008 Academic Article GET IT
Times cited: 283
Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Academic Article GET IT
Times cited: 358
Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Academic Article GET IT
Times cited: 251
Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 34
Nonviral approaches for neuronal delivery of nucleic acids. Pharmaceutical research. 2007 Review GET IT
Times cited: 112
Neuron-specific delivery of nucleic acids mediated by Tet1-modified poly(ethylenimine). The journal of gene medicine. 2007 Academic Article GET IT
Times cited: 90
Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma. Glia. 2007 Academic Article GET IT
Times cited: 173
Fate of endogenous stem/progenitor cells following spinal cord injury. The Journal of comparative neurology. 2006 Academic Article GET IT
Times cited: 226
Microarray analysis of retinal gene expression in the DBA/2J model of glaucoma. Investigative ophthalmology & visual science. 2006 Academic Article GET IT
Times cited: 188
Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma. Investigative ophthalmology & visual science. 2006 Academic Article GET IT
Times cited: 116
Instructive niches: environmental instructions that confound NG2 proteoglycan expression and the fate-restriction of CNS progenitors. Journal of anatomy. 2005 Review GET IT
Times cited: 20
Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat. Experimental neurology. 2005 Academic Article GET IT
Times cited: 31
Environmental enrichment increases progenitor cell survival in the dentate gyrus following lateral fluid percussion injury. Brain research. Molecular brain research. 2005 Academic Article GET IT
Times cited: 54
Pharmacologic suppression of neuronal oxidative damage and dendritic degeneration following direct activation of glial innate immunity in mouse cerebrum. Journal of neurochemistry. 2003 Academic Article GET IT
Times cited: 91
New roles for astrocytes: the nightlife of an 'astrocyte'. La vida loca!. Trends in neurosciences. 2003 Review GET IT
Times cited: 102
Chronic neurotrophin-3 strengthens synaptic connections to motoneurons in the neonatal rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Academic Article GET IT
Times cited: 38
A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Academic Article GET IT
Times cited: 171
Regeneration in the adult and aging brain. Archives of neurology. 2002 Editorial Article GET IT
Times cited: 31
Expression of IL-17B in neurons and evaluation of its possible role in the chromosome 5q-linked form of Charcot-Marie-Tooth disease. Neuromuscular disorders : NMD. 2002 Academic Article GET IT
Times cited: 50
Defining the NG2-expressing cell of the adult CNS. Journal of neurocytology. 2002 Review GET IT
Times cited: 118
Potent possibilities: endogenous stem cells in the adult spinal cord. Progress in brain research. 2002 Review GET IT
Times cited: 8
Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Academic Article GET IT
Times cited: 605
Regenerating the damaged central nervous system. Nature. 2000 Academic Article GET IT
Times cited: 726
Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Academic Article GET IT
Times cited: 707
Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1998 Academic Article GET IT
Times cited: 525
A quantitative spatial analysis of the blood-spinal cord barrier. I. Permeability changes after experimental spinal contusion injury. Experimental neurology. 1996 Academic Article GET IT
Times cited: 236
A quantitative spatial analysis of the blood-spinal cord barrier. II. Permeability after intraspinal fetal transplantation. Experimental neurology. 1996 Academic Article GET IT
Times cited: 14
Quantitative analysis of vascularization and cytochrome oxidase following fetal transplantation in the contused rat spinal cord. The Journal of comparative neurology. 1996 Academic Article GET IT
Times cited: 20
Fetal transplantation following spinal contusion injury results in chronic alterations in CNS glucose metabolism. Experimental neurology. 1995 Academic Article GET IT
Times cited: 12
N-acetyl-GRP(20-26)-O-CH3 reverses intracisternal bombesin-induced inhibition of gastric acid secretion in rats. Peptides. 1991 Academic Article GET IT
Times cited: 10

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Background

education and training

Ph.D., Ohio State University 1995
M.S., Ohio State University 1992
B.S., University of Nevada 1988

Contact

full name

Philip Horner

primary email

pjh2008@med.cornell.edu

VIVO Weill Cornell Medical College

Philip Horner Professor of Physiology in Neurological Surgery

Publications

selected publications

Background

education and training

Contact

full name

primary email