Leopold, Philip L.

Publications

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selected publications

Predicted deleterious variants in the human genome relevant to gene therapy with adeno-associated virus vectors. Molecular therapy. Methods & clinical development. 2023 Academic Article GET IT
Oral Epithelium Response of Electronic Cigarette Users to Electronic Cigarette. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2022 Academic Article GET IT
Smoking shifts human small airway epithelium club cells toward a lesser differentiated population. NPJ genomic medicine. 2021 Academic Article GET IT
CREB-dependent LPA-induced signaling initiates a pro-fibrotic feedback loop between small airway basal cells and fibroblasts. Respiratory research. 2021 Academic Article GET IT
Times cited: 7
Reply to Sharma and Zeki: Does Vaping Increase Susceptibility to COVID-19?. American journal of respiratory and critical care medicine. 2020 Article GET IT
Dysregulation of club cell biology in idiopathic pulmonary fibrosis. PloS one. 2020 Academic Article GET IT
Times cited: 26
Cell-specific expression of lung disease risk-related genes in the human small airway epithelium. Respiratory research. 2020 Academic Article GET IT
Times cited: 22
Expression of the SARS-CoV-2 ACE2 Receptor in the Human Airway Epithelium. American journal of respiratory and critical care medicine. 2020 Academic Article GET IT
Times cited: 179
Single-Cell Transcriptome Analysis of Mouse Liver Cell-Specific Tropism and Transcriptional Dysregulation Following Intravenous Administration of AAVrh.10 Vectors. Human gene therapy. 2020 Academic Article GET IT
Anti-Phospho-Tau Gene Therapy for Chronic Traumatic Encephalopathy. Human gene therapy. 2019 Academic Article GET IT
Times cited: 4
Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity. Respiratory research. 2019 Academic Article GET IT
Times cited: 34
Role of KRAS in regulating normal human airway basal cell differentiation. Respiratory research. 2019 Academic Article GET IT
Times cited: 4
Ontogeny and Biology of Human Small Airway Epithelial Club Cells. American journal of respiratory and critical care medicine. 2018 Academic Article GET IT
Times cited: 71
Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration. Oncotarget. 2018 Academic Article GET IT
Times cited: 7
Polyene-based cationic lipids as visually traceable siRNA transfer reagents. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2014 Academic Article GET IT
Times cited: 9
Patterned electrospun nanofiber matrices via localized dissolution: potential for guided tissue formation. Advanced materials (Deerfield Beach, Fla.). 2014 Academic Article GET IT
Times cited: 43
Novel cationic polyene glycol phospholipids as DNA transfer reagents--lack of a structure-activity relationship due to uncontrolled self-assembling processes. Chemistry and physics of lipids. 2014 Academic Article GET IT
Times cited: 7
Synthesis, self-assembling and gene delivery potential of a novel highly unsaturated, conjugated cationic phospholipid. Chemistry and physics of lipids. 2013 Academic Article GET IT
Times cited: 6
A comparison of epithelial-to-mesenchymal transition and re-epithelialization. Seminars in cancer biology. 2012 Information Resource GET IT
Times cited: 71
Synthesis and preliminary investigations of the siRNA delivery potential of novel, single-chain rigid cationic carotenoid lipids. Molecules (Basel, Switzerland). 2012 Academic Article GET IT
Times cited: 14
Smoking is associated with shortened airway cilia. PloS one. 2009 Academic Article GET IT
Times cited: 168
A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Nature cell biology. 2009 Academic Article GET IT
Times cited: 570
Sonic hedgehog expands diaphyseal trabecular bone altering bone marrow niche and lymphocyte compartment. Molecular therapy : the journal of the American Society of Gene Therapy. 2009 Academic Article GET IT
Times cited: 11
Functional cystic fibrosis transmembrane conductance regulator expression in cystic fibrosis airway epithelial cells by AAV6.2-mediated segmental trans-splicing. Human gene therapy. 2009 Academic Article GET IT
Times cited: 54
Emphysema mediated by lung overexpression of ADAM10. Clinical and translational science. 2009 Academic Article GET IT
Times cited: 9
Dysfunctional glycogen storage in a mouse model of alpha1-antitrypsin deficiency. American journal of respiratory cell and molecular biology. 2008 Academic Article GET IT
Times cited: 9
Intracellular trafficking of adenovirus: many means to many ends. Advanced drug delivery reviews. 2007 Information Resource GET IT
Times cited: 81
Human embryonic stem cells and gene therapy. Molecular therapy : the journal of the American Society of Gene Therapy. 2007 Information Resource GET IT
Times cited: 45
Responses of the human airway epithelium transcriptome to in vivo injury. Physiological genomics. 2006 Academic Article GET IT
Times cited: 36
Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers. Cancer research. 2006 Academic Article GET IT
Times cited: 62
Modification of gene expression of the small airway epithelium in response to cigarette smoking. Journal of molecular medicine (Berlin, Germany). 2006 Academic Article GET IT
Times cited: 152
Neutralized adenovirus-immune complexes can mediate effective gene transfer via an Fc receptor-dependent infection pathway. Journal of virology. 2006 Academic Article GET IT
Times cited: 32
A common mechanism for cytoplasmic dynein-dependent microtubule binding shared among adeno-associated virus and adenovirus serotypes. Journal of virology. 2006 Academic Article GET IT
Times cited: 49
Viral strategies for intracellular trafficking: motors and microtubules. Traffic (Copenhagen, Denmark). 2006 Information Resource GET IT
Times cited: 70
Correction of a murine model of von Willebrand disease by gene transfer. Blood. 2006 Academic Article GET IT
Times cited: 27
High levels of persistent expression of alpha1-antitrypsin mediated by the nonhuman primate serotype rh.10 adeno-associated virus despite preexisting immunity to common human adeno-associated viruses. Molecular therapy : the journal of the American Society of Gene Therapy. 2005 Academic Article GET IT
Times cited: 98
AAV2-mediated CLN2 gene transfer to rodent and non-human primate brain results in long-term TPP-I expression compatible with therapy for LINCL. Gene therapy. 2005 Academic Article GET IT
Times cited: 58
Enhanced efficacy of cholesterol-minus sonic hedgehog in postnatal skin. Molecular therapy : the journal of the American Society of Gene Therapy. 2005 Academic Article GET IT
Times cited: 7
Intrapleural administration of a serotype 5 adeno-associated virus coding for alpha1-antitrypsin mediates persistent, high lung and serum levels of alpha1-antitrypsin. Molecular therapy : the journal of the American Society of Gene Therapy. 2004 Academic Article GET IT
Times cited: 39
Cytoplasmic dynein mediates adenovirus binding to microtubules. Journal of virology. 2004 Academic Article GET IT
Times cited: 119
Cytokine-mediated downregulation of coxsackievirus-adenovirus receptor in endothelial cells. Journal of virology. 2004 Academic Article GET IT
Times cited: 57
Modification to the capsid of the adenovirus vector that enhances dendritic cell infection and transgene-specific cellular immune responses. Journal of virology. 2004 Academic Article GET IT
Times cited: 76
Adenovirus-mediated transfer of a minigene expressing multiple isoforms of VEGF is more effective at inducing angiogenesis than comparable vectors expressing individual VEGF cDNAs. Molecular therapy : the journal of the American Society of Gene Therapy. 2004 Academic Article GET IT
Times cited: 46
Association of adenovirus with the microtubule organizing center. Journal of virology. 2003 Academic Article GET IT
Times cited: 44
Cell physiology as a variable in gene transfer to endothelium. Current atherosclerosis reports. 2003 Information Resource GET IT
Times cited: 7
In vivo enhanced expression of patched dampens the sonic hedgehog pathway. Molecular therapy : the journal of the American Society of Gene Therapy. 2002 Academic Article GET IT
Times cited: 10
Inhibition of HIV-1 replication in alveolar macrophages by adenovirus gene transfer vectors. American journal of respiratory cell and molecular biology. 2002 Academic Article GET IT
Times cited: 2
Analysis of risk factors for local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of comorbid conditions. Human gene therapy. 2002 Academic Article GET IT
Times cited: 71
Effect of adenovirus-mediated expression of Sonic hedgehog gene on hair regrowth in mice with chemotherapy-induced alopecia. Journal of the National Cancer Institute. 2001 Academic Article GET IT
Variation in adenovirus receptor expression and adenovirus vector-mediated transgene expression at defined stages of the cell cycle. Molecular therapy : the journal of the American Society of Gene Therapy. 2001 Academic Article GET IT
Times cited: 81
Adenovirus serotype 7 retention in a late endosomal compartment prior to cytosol escape is modulated by fiber protein. Journal of virology. 2001 Academic Article GET IT
Times cited: 121
Rapid assessment of adenovirus serum neutralizing antibody titer based on quantitative, morphometric evaluation of capsid binding and intracellular trafficking: population analysis of adenovirus capsid association with cells is predictive of adenovirus infectivity. Journal of virology. 2001 Academic Article GET IT
Times cited: 20
Fluorescence methods reveal intracellular trafficking of gene transfer vectors: the light toward the end of the tunnel. Molecular therapy : the journal of the American Society of Gene Therapy. 2000 Article GET IT
Times cited: 2
Dynein- and microtubule-mediated translocation of adenovirus serotype 5 occurs after endosomal lysis. Human gene therapy. 2000 Academic Article GET IT
Times cited: 212
Free cholesterol enhances adenoviral vector gene transfer and expression in CAR-deficient cells. Molecular therapy : the journal of the American Society of Gene Therapy. 2000 Academic Article GET IT
Times cited: 35
Cellular immune responses of healthy individuals to intradermal administration of an E1-E3- adenovirus gene transfer vector. Human gene therapy. 1999 Academic Article GET IT
Times cited: 62
Enhanced liver uptake of opsonized red blood cells after in vivo transfer of FcgammaRIIA cDNA to the liver. Blood. 1999 Academic Article GET IT
Times cited: 3
Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus. The Journal of clinical investigation. 1999 Academic Article GET IT
Times cited: 208
Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog. The Journal of clinical investigation. 1999 Academic Article GET IT
Times cited: 224
Specific binding of the adenovirus capsid to the nuclear envelope. Human gene therapy. 1999 Academic Article GET IT
Times cited: 30
Fiber swap between adenovirus subgroups B and C alters intracellular trafficking of adenovirus gene transfer vectors. Journal of virology. 1999 Academic Article GET IT
Times cited: 135
Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor. American journal of respiratory cell and molecular biology. 1999 Academic Article GET IT
Times cited: 71
Purification and characterization of rat hippocampal CA3-dendritic spines associated with mossy fiber terminals. FEBS letters. 1999 Academic Article GET IT
Times cited: 10
CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts. The Journal of clinical investigation. 1999 Academic Article GET IT
Times cited: 194
Selective expansion of alveolar macrophages in vivo by adenovirus-mediated transfer of the murine granulocyte-macrophage colony-stimulating factor cDNA. Blood. 1999 Academic Article GET IT
Times cited: 37
Adenovirus-mediated expression of melanoma antigen gp75 as immunotherapy for metastatic melanoma. Gene therapy. 1998 Academic Article GET IT
Times cited: 32
Fluorescent virions: dynamic tracking of the pathway of adenoviral gene transfer vectors in living cells. Human gene therapy. 1998 Academic Article GET IT
Times cited: 205
Sphingomyelinase treatment induces ATP-independent endocytosis. The Journal of cell biology. 1998 Academic Article GET IT
Times cited: 177
Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract. Human gene therapy. 1997 Academic Article GET IT
Times cited: 115
Evidence for prolonged cell-surface contact of acetyl-LDL before entry into macrophages. Arteriosclerosis, thrombosis, and vascular biology. 1997 Academic Article GET IT
Times cited: 19
Oligomerized transferrin receptors are selectively retained by a lumenal sorting signal in a long-lived endocytic recycling compartment. The Journal of cell biology. 1995 Academic Article GET IT
Times cited: 133
Activity-Dependent Inhibition of Neurotransmitter Release by Brefeldin A. The Biological bulletin. 1993 Academic Article GET IT
GTP gamma S inhibits organelle transport along axonal microtubules. The Journal of cell biology. 1993 Academic Article GET IT
Times cited: 51
Association of kinesin with characterized membrane-bounded organelles. Cell motility and the cytoskeleton. 1992 Academic Article GET IT
Times cited: 111
Nucleotide specificity for the bidirectional transport of membrane-bounded organelles in isolated axoplasm. Cell motility and the cytoskeleton. 1990 Academic Article GET IT
Times cited: 15
ATP-dependent directional movement of rat synaptic vesicles injected into the presynaptic terminal of squid giant synapse. Proceedings of the National Academy of Sciences of the United States of America. 1989 Academic Article GET IT
Times cited: 37

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Research

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Funding awarded

Ancillary SOURCE Study: Characterization of Small Airway Basal Cell Biology in Early COPD awarded by National Heart, Lung, & Blood Institute Co-Investigator 2023 - 2027

Gene Therapy for Alpha 1-Antitrypsin Deficiency awarded by National Heart, Lung, & Blood Institute Key Personnel 2024 - 2025

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Teaching

teaching activities

Essential Principles of Medicine A Co-Director, Genetics Unit
Essential Principles of Medicine A Lecturer 2020 - 2024
Essential Principles of Medicine A Problem-Based Learning Facilitator 2017 - 2024
Molecules, Genes, and Cells Problem-Based Learning Facilitator 2005 - 2007
Molecules, Genes, and Cells Associate Course Director 2005 - 2007
Molecules, Genes, and Cells Co-Director, Genetics Unit 2005 - 2007
Molecules, Genes, and Cells Lecturer 2005 - 2007
Genetics Associate Course Director 2002 - 2004
Genetics Problem-Based Learning Facilitator 2002 - 2004
Genetics Lecturer 2002 - 2004

VIVO Weill Cornell Medical College

Philip L. Leopold Associate Professor of Research in Genetic Medicine

Publications

selected publications

Research

Funding awarded

Teaching

teaching activities

Background

education and training

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