Nachman, Ralph L

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selected publications

Endothelium: from cellophane to orchestral maestro. The Journal of clinical investigation. 2012 Article GET IT
Times cited: 4
Flexner redux. Perspectives in biology and medicine. 2011 Academic Article GET IT
Times cited: 3
Military medical ethics. The New England journal of medicine. 2008 Article GET IT
Times cited: 1
Platelets, petechiae, and preservation of the vascular wall. The New England journal of medicine. 2008 Information Resource GET IT
Times cited: 229
Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1. The Journal of clinical investigation. 2001 Academic Article GET IT
Times cited: 97
The Jeremiah Metzger Lecture. Hypercoagulable states: challenges and opportunities. Transactions of the American Clinical and Climatological Association. 2001 Conference Paper GET IT
Times cited: 1
Angiogenesis and atherosclerosis. The mandate broadens. Circulation. 1999 Editorial Article GET IT
Times cited: 20
Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation. The Journal of experimental medicine. 1998 Academic Article GET IT
Times cited: 220
Identification of a CD36-related thrombospondin 1-binding domain in HIV-1 envelope glycoprotein gp120: relationship to HIV-1-specific inhibitory factors in human saliva. The Journal of experimental medicine. 1998 Academic Article GET IT
Times cited: 80
Lipoprotein(a): molecular mischief in the microvasculature. Circulation. 1997 Editorial Article GET IT
Times cited: 12
Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proceedings of the National Academy of Sciences of the United States of America. 1997 Academic Article GET IT
Times cited: 654
Transendothelial migration of CD34+ and mature hematopoietic cells: an in vitro study using a human bone marrow endothelial cell line. Blood. 1997 Academic Article GET IT
Times cited: 112
Effector cell protease receptor-1 is a vascular receptor for coagulation factor Xa. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 74
BMEC-1: a human bone marrow microvascular endothelial cell line with primary cell characteristics. Microvascular research. 1996 Academic Article GET IT
Times cited: 60
The role of lipoprotein(a) in atherogenesis and thrombosis. Annual review of medicine. 1996 Information Resource GET IT
Times cited: 96
Characterization of hematopoietic cells arising on the textured surface of left ventricular assist devices. The Annals of thoracic surgery. 1995 Academic Article GET IT
Times cited: 94
Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors. Blood. 1995 Academic Article GET IT
Times cited: 234
Isolation and characterization of human bone marrow microvascular endothelial cells: hematopoietic progenitor cell adhesion. Blood. 1994 Academic Article GET IT
Times cited: 229
Hypercoagulability after hip and knee replacement. Annals of internal medicine. 1994 Article GET IT
Hypercoagulable states. Annals of internal medicine. 1993 Information Resource GET IT
Times cited: 184
Cancer and clotting--Trousseau's warning. The New England journal of medicine. 1992 Editorial Article GET IT
Times cited: 48
Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding. Biochemical and biophysical research communications. 1992 Academic Article GET IT
Times cited: 160
Lipoprotein (a) regulates plasminogen activator inhibitor-1 expression in endothelial cells. A potential mechanism in thrombogenesis. The Journal of biological chemistry. 1991 Academic Article GET IT
Times cited: 268
Cellular attachment to thrombospondin. Cooperative interactions between receptor systems. The Journal of biological chemistry. 1991 Academic Article GET IT
Times cited: 77
Lipoprotein(a) in diet-induced atherosclerosis in nonhuman primates. Arteriosclerosis and thrombosis : a journal of vascular biology. 1991 Academic Article GET IT
Times cited: 26
Cytokine-enhanced expression of glycoprotein Ib alpha in human endothelium. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 39
Thrombospondin forms complexes with single-chain and two-chain forms of urokinase. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 37
A human 88-kD membrane glycoprotein (CD36) functions in vitro as a receptor for a cytoadherence ligand on Plasmodium falciparum-infected erythrocytes. The Journal of clinical investigation. 1989 Academic Article GET IT
Times cited: 328
Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion. The Journal of clinical investigation. 1989 Academic Article GET IT
Times cited: 172
Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis. Nature. 1989 Academic Article GET IT
Times cited: 563
Platelet histidine-rich glycoprotein. Methods in enzymology. 1989 Academic Article GET IT
Times cited: 6
Thrombospondin: phenomenology to function. Progress in hemostasis and thrombosis. 1989 Information Resource GET IT
Times cited: 23
Binding of Lys-plasminogen to monocytes/macrophages. The Journal of clinical investigation. 1988 Academic Article GET IT
Times cited: 48
Endothelial cell-mediated conversion of Glu-plasminogen to Lys-plasminogen. Further evidence for assembly of the fibrinolytic system on the endothelial cell surface. The Journal of clinical investigation. 1988 Academic Article GET IT
Times cited: 94
Case 11-1988. The New England journal of medicine. 1988 Article GET IT
Times cited: 1
Matrix plasminogen activator inhibitor. Modulation of the extracellular proteolytic environment. The Journal of biological chemistry. 1988 Academic Article GET IT
Times cited: 32
Maintenance treatment of adults with chronic refractory immune thrombocytopenic purpura using repeated intravenous infusions of gammaglobulin. Blood. 1988 Academic Article GET IT
Times cited: 84
Identification and isolation of a platelet GPIb-like protein in human umbilical vein endothelial cells and bovine aortic smooth muscle cells. The Journal of clinical investigation. 1988 Academic Article GET IT
Times cited: 41
Binding of tissue plasminogen activator to cultured human endothelial cells. The Journal of clinical investigation. 1987 Academic Article GET IT
Times cited: 173
Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells. The Journal of clinical investigation. 1987 Academic Article GET IT
Times cited: 136
Thrombospondin-plasminogen interactions: modulation of plasmin generation. Seminars in thrombosis and hemostasis. 1987 Academic Article GET IT
Times cited: 12
Tumor necrosis factor-mediated release of platelet-derived growth factor from cultured endothelial cells. The Journal of experimental medicine. 1987 Academic Article GET IT
Times cited: 155
Isolation of the thrombospondin membrane receptor. The Journal of clinical investigation. 1987 Academic Article GET IT
Times cited: 432
Histidine-rich glycoprotein inhibits the antiproliferative effect of heparin on smooth muscle cells. The Journal of experimental medicine. 1987 Academic Article GET IT
Times cited: 9
Thrombospondin binds to monocytes-macrophages and mediates platelet-monocyte adhesion. The Journal of clinical investigation. 1987 Academic Article GET IT
Times cited: 105
Binding of plasminogen to cultured human endothelial cells. The Journal of biological chemistry. 1986 Academic Article GET IT
Times cited: 218
Binding of plasminogen to extracellular matrix. The Journal of biological chemistry. 1986 Academic Article GET IT
Times cited: 129
Blockade of clearance of immune complexes by an anti-Fc gamma receptor monoclonal antibody. The Journal of experimental medicine. 1986 Academic Article GET IT
Times cited: 147
Tissue plasminogen activator and urokinase enhance the binding of plasminogen to thrombospondin. The Journal of biological chemistry. 1986 Academic Article GET IT
Times cited: 28
Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor. The Journal of experimental medicine. 1986 Academic Article GET IT
Times cited: 254
Human brain glial cells synthesize thrombospondin. Proceedings of the National Academy of Sciences of the United States of America. 1986 Academic Article GET IT
Times cited: 102
Thrombospondin: a versatile multifunctional glycoprotein. Arteriosclerosis (Dallas, Tex.). 1986 Information Resource GET IT
Times cited: 40
Molecular mechanisms of platelet aggregation. Annual review of medicine. 1986 Information Resource GET IT
Times cited: 64
Platelet membrane topography: colocalization of thrombospondin and fibrinogen with the glycoprotein IIb-IIIa complex. Blood. 1985 Academic Article GET IT
Times cited: 38
Activation of immobilized plasminogen by tissue activator. Multimolecular complex formation. The Journal of biological chemistry. 1985 Academic Article GET IT
Times cited: 77
Platelet thrombospondin forms a trimolecular complex with plasminogen and histidine-rich glycoprotein. The Journal of clinical investigation. 1985 Academic Article GET IT
Times cited: 85
Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator. The Journal of clinical investigation. 1984 Academic Article GET IT
Times cited: 123
Complex formation of platelet membrane glycoproteins IIb and IIIa with the fibrinogen D domain. The Journal of biological chemistry. 1984 Academic Article GET IT
Times cited: 26
Human megakaryocytes. III. Characterization in myeloproliferative disorders. Blood. 1984 Academic Article GET IT
Times cited: 40
Plasma and platelet fibrinogen differ in gamma chain content. Thrombosis and haemostasis. 1984 Academic Article GET IT
Times cited: 18
Complex formation of platelet thrombospondin with histidine-rich glycoprotein. The Journal of clinical investigation. 1984 Academic Article GET IT
Times cited: 98
Histidine-rich glycoprotein is present in human platelets and is released following thrombin stimulation. Blood. 1983 Academic Article GET IT
Times cited: 90
Human platelet activation by C3a and C3a des-arg. The Journal of experimental medicine. 1983 Academic Article GET IT
Times cited: 165
Purification of human platelet calcium-activated protease. Effect on platelet and endothelial function. The Journal of biological chemistry. 1983 Academic Article GET IT
Times cited: 60
Complex formation of platelet membrane glycoproteins IIb and IIIa: a model of platelet activation. Bibliotheca haematologica. 1983 Academic Article GET IT
Times cited: 1
Cyclic AMP-binding proteins in human blood platelets detected by photoaffinity labelling. Biochimica et biophysica acta. 1982 Academic Article GET IT
Times cited: 3
Complex formation of platelet thrombospondin with fibrinogen. The Journal of clinical investigation. 1982 Academic Article GET IT
Times cited: 111
Complex formation of platelet membrane glycoproteins IIb and IIIa with fibrinogen. The Journal of clinical investigation. 1982 Academic Article GET IT
Times cited: 199
Thrombospondin is the endogenous lectin of human platelets. Nature. 1982 Academic Article GET IT
Times cited: 97
alpha-Actinin and membrane glycoprotein IIIa are different proteins in human blood platelets. Proceedings of the National Academy of Sciences of the United States of America. 1982 Academic Article GET IT
Times cited: 11
Thrombin-induced platelet membrane glycoprotein IIb and IIIa complex formation. An electron microscope study. The Journal of experimental medicine. 1981 Academic Article GET IT
Times cited: 55
Cryoglobulinemia. Disease-a-month : DM. 1981 Academic Article GET IT
Times cited: 11
Human megakaryocytes. II. Expression of platelet proteins in early marrow megakaryocytes. The Journal of experimental medicine. 1981 Academic Article GET IT
Times cited: 128
Human megakaryocyte stimulation of proliferation of bone marrow fibroblasts. Blood. 1981 Academic Article GET IT
Times cited: 214
Platelet Fc receptor. Increased expression in myeloproliferative disease. The Journal of clinical investigation. 1981 Academic Article GET IT
Times cited: 48
Isolation, purification, and partial characterization of platelet membrane glycoproteins IIb and IIIa. The Journal of biological chemistry. 1981 Academic Article GET IT
Times cited: 35
Human complement in the arachidonic acid transformation pathway in platelets. The Journal of experimental medicine. 1981 Academic Article GET IT
Times cited: 37
Platelet FcIgG receptor: increased expression in female platelets. Thrombosis research. 1981 Academic Article GET IT
Times cited: 5
Reed-Sternberg cells in Hodgkin's disease contain fibronectin. Blood. 1981 Academic Article GET IT
Times cited: 18
Structural analysis of factor VIII antigen in von Willebrand disease. Proceedings of the National Academy of Sciences of the United States of America. 1980 Academic Article GET IT
Times cited: 9
Peptide map analysis of normal plasma and platelet factor VIII antigen. Biochemical and biophysical research communications. 1980 Academic Article GET IT
Times cited: 6
Selective binding of the factor VIII/von Willebrand factor protein to human platelets. Blood. 1980 Academic Article GET IT
Times cited: 35
Human complement in thrombin-mediated platelet function: uptake of the C5b-9 complex. The Journal of experimental medicine. 1979 Academic Article GET IT
Times cited: 64
Isolation of human platelet plasma membranes with polylysine beads. The Journal of cell biology. 1979 Academic Article GET IT
Times cited: 27
Human megakaryocytes. I. Characterization of the membrane and cytoplasmic components of isolated marrow megakaryocytes. The Journal of experimental medicine. 1979 Academic Article GET IT
Times cited: 105
Structural analysis of human platelet membrane glycoprotein I complex. Proceedings of the National Academy of Sciences of the United States of America. 1979 Academic Article GET IT
Times cited: 15
Interaction of platelet membrane receptors with von Willebrand factor, ristocetin, and the Fc region of immunoglobulin G. The Journal of clinical investigation. 1978 Academic Article GET IT
Times cited: 41
Synthesis of actin by cultured guinea pig megakaryocytes. Complex formation with fibrin. Biochimica et biophysica acta. 1978 Academic Article GET IT
Times cited: 12
The human complement system in thrombin-mediated platelet function. The Journal of experimental medicine. 1978 Academic Article GET IT
Times cited: 78
The thrombotic process in atherogenesis. Summary of workshop a: endothelium. Advances in experimental medicine and biology. 1978 Academic Article GET IT
Times cited: 1
Wheat germ agglutinin affinity chromatography of human platelet membrane glycoproteins. Thrombosis research. 1978 Academic Article GET IT
Times cited: 26
Synthesis of factor VIII antigen by cultured guinea pig megakaryocytes. The Journal of clinical investigation. 1977 Academic Article GET IT
Times cited: 251
Von Willebrand's disease and the molecular pathology of hemostasis. The New England journal of medicine. 1977 Editorial Article GET IT
Times cited: 2
Electron microscopic techniques in the study of cultured vascular cells. Advances in experimental medicine and biology. 1977 Academic Article GET IT
Immunoinhibition of ristocetin-induced platelet aggregation. The Journal of clinical investigation. 1977 Academic Article GET IT
Times cited: 43
Myosin in cultured human endothelial cells. British journal of haematology. 1977 Academic Article GET IT
Times cited: 7
A clinical study of the lupus anticoagulant. Blood. 1976 Academic Article GET IT
Times cited: 404
Platelet alpha2-macroglobulin and alpha1-antitrypsin. The Journal of biological chemistry. 1976 Academic Article GET IT
Times cited: 30
Synthesis of basement membrane collagen by cultured human endothelial cells. The Journal of experimental medicine. 1976 Academic Article GET IT
Times cited: 145
The platelet-endothelial cell--VIII axis. Thrombosis and haemostasis. 1976 Academic Article GET IT
Times cited: 9
The interaction of platelets and concanavalin A. Thrombosis research. 1975 Academic Article GET IT
Times cited: 5
Subunit structure of factor VIII antigen synthesized by cultured human endothelial cells. The Journal of clinical investigation. 1975 Academic Article GET IT
Times cited: 46
Ultrastructural lesions on the surface of platelets associated with either blood coagulation or with antibody-mediated immune injury. The Journal of experimental medicine. 1975 Academic Article GET IT
Times cited: 10
Subcellular platelet factor VIII antigen and von Willebrand factor. The Journal of experimental medicine. 1975 Academic Article GET IT
Times cited: 99
Gold-associated thrombocytopenia. Report six cases. Archives of internal medicine. 1974 Academic Article GET IT
Times cited: 26
The effect of platelet membrane antibodies on aggregation and release. British journal of haematology. 1974 Academic Article GET IT
Times cited: 16
Synthesis of von Willebrand factor by cultured human endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 1974 Academic Article GET IT
Times cited: 364
Binding of adenosine diphosphate by isolated membranes from human platelets. The Journal of biological chemistry. 1974 Academic Article GET IT
Times cited: 55
Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. The Journal of clinical investigation. 1973 Academic Article GET IT
Times cited: 6305
Synthesis of antihemophilic factor antigen by cultured human endothelial cells. The Journal of clinical investigation. 1973 Academic Article GET IT
Times cited: 955
Thrombotic thrombocytopenic purpura--coagulation parameters in twelve patients. Blood. 1973 Academic Article GET IT
Times cited: 74
Iodination of the human platelet membrane. Studies of the major surface glycoprotein. The Journal of biological chemistry. 1973 Academic Article GET IT
Times cited: 89
Contractile proteins of endothelial cells, platelets and smooth muscle. The American journal of pathology. 1973 Information Resource GET IT
Times cited: 109
The platelet as an inflammatory cell. Annals of the New York Academy of Sciences. 1972 Academic Article GET IT
Times cited: 46
Studies on the proteins of human platelet membranes. The Journal of biological chemistry. 1972 Academic Article GET IT
Times cited: 58
Studies on isolated membranes of azurophil and specific granules from rabbit polymorphonuclear leukocytes. The Journal of cell biology. 1972 Academic Article GET IT
Times cited: 23
Nature of the defect in congenital factor V deficiency: study in a patient with an acquired circulating anticoagulant. Blood. 1972 Academic Article GET IT
Times cited: 24
Characterization of human platelet vascular permeability-enhancing activity. The Journal of clinical investigation. 1972 Academic Article GET IT
Times cited: 86
Inhibition of fibrin monomer polymerization by lambda myeloma globulins. Blood. 1972 Academic Article GET IT
Times cited: 72
Rabbit platelet bactericidal protein. The Journal of experimental medicine. 1971 Academic Article GET IT
Times cited: 59
Macrophage plasma membrane. II. Studies on synthesis and turnover of protein constituents. The Journal of experimental medicine. 1971 Academic Article GET IT
Times cited: 18
Macrophage plasma membranes. I. Isolation and studies on protein components. The Journal of experimental medicine. 1971 Academic Article GET IT
Times cited: 32
Increased vascular permeability produced by human platelet granule cationic extract. The Journal of clinical investigation. 1970 Academic Article GET IT
Times cited: 56
Human platelet membrane protein. Biochemistry. 1970 Academic Article GET IT
Times cited: 13
Studies on human platelet protease activity. The Journal of clinical investigation. 1969 Academic Article GET IT
Times cited: 31
Immunological studies of proteins associated with the subcellular fractions of thrombasthenic and afibrinogenaemic platelets. British journal of haematology. 1968 Academic Article GET IT
Times cited: 31
Intramural small intestinal hematoma. A review and a report of a new cause: uremia. Archives of internal medicine. 1968 Academic Article GET IT
Times cited: 5
Ultrastructure of thrombosthenin, the contractile protein of human blood platelets. Science (New York, N.Y.). 1967 Academic Article GET IT
Times cited: 30
Immunologic studies of proteins associated with subcellular fractions of normal human platelets. The Journal of laboratory and clinical medicine. 1967 Academic Article GET IT
Times cited: 32
Thrombocytopenia due to digitoxin. Demonstration of antibody and mechanisms of action. The American journal of medicine. 1966 Academic Article GET IT
Times cited: 20
Correlation of immunologic and structural heterogeneity of Bence Jones proteins. Journal of immunology (Baltimore, Md. : 1950). 1966 Academic Article GET IT
Times cited: 2
Platelet amino acid levels in essential thrombocytosis. Blood. 1966 Academic Article GET IT
Times cited: 2
Thrombasthenia: immunologic evidence of a platelet protein abnormality. The Journal of laboratory and clinical medicine. 1966 Academic Article GET IT
Times cited: 5
Two Bence Jones proteins of different immunologic types in the same patient with multiple myeloma. Blood. 1966 Academic Article GET IT
Times cited: 8
Subtypes of Bence-Jones proteins. Journal of immunology (Baltimore, Md. : 1950). 1965 Academic Article GET IT
Times cited: 9
Amino acid generation following platelet-antibody interaction. Vox sanguinis. 1965 Academic Article GET IT
IMMUNOLOGIC STUDIES OF PLATELET PROTEIN. Blood. 1965 Academic Article GET IT
Times cited: 30
GAMMA GLOBULIN: UNMASKING OF HIDDEN ANTIGENIC SITES ON LIGHT CHAINS. Science (New York, N.Y.). 1964 Academic Article GET IT
Times cited: 3
HYPOFIBRINOGENEMIC HEMORRHAGE IN ACUTE MYELOGENOUS LEUKEMIA TREATED WITH HEPARIN. WITH AUTOPSY FINDINGS OF WIDESPREAD INTRAVASCULAR CLOTTING. Annals of internal medicine. 1964 Academic Article GET IT
Times cited: 51
INDIVIDUAL AND SUB-GROUP ANTIGENIC SPECIFICITY OF BENCE-JONES PROTEIN. Nature. 1963 Academic Article GET IT
Times cited: 5
Streptomycin-induced hemolytic anemia. Archives of internal medicine. 1962 Academic Article GET IT
Times cited: 11

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Background

education and training

M.D., Vanderbilt University School of Medicine 1956
A.B., Vanderbilt University 1953

Contact

full name

Ralph L Nachman

primary email

rlnachm@med.cornell.edu

VIVO Weill Cornell Medical College

Ralph L Nachman Professor Emeritus of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email