Reed-Sternberg cells in Hodgkin's disease contain fibronectin. Academic Article uri icon

Overview

abstract

  • Reed-Sternberg cells in the lymph nodes from five patients with Hodgkin's disease were studied. Indirect immunofluorescence on fixed sections with a monospecific anti-serum to fibronectin revealed abundant cytoplasmic fibronectin in approximately 90% of the Reed-Sternberg cells. In addition, the cells were shown by immunofluorescence to contain polyclonal IgG; however, factor VIII antigen, albumin, fibrinogen, alpha-2-macroglobulin, anti-thrombin III, and ceruloplasmin were not present. The abundant cytoplasmic fibronectin suggests that Reed-Sternberg cells are derived from tissue macrophages.

publication date

  • February 1, 1981

Research

keywords

  • Fibronectins
  • Hodgkin Disease
  • Lymph Nodes

Identity

Scopus Document Identifier

  • 0019365354

PubMed ID

  • 7004537

Additional Document Info

volume

  • 57

issue

  • 2