Budhu, Sadna

Publications

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selected publications

Preoperative immune checkpoint inhibition and cryoablation in early-stage breast cancer. iScience. 2024 Academic Article GET IT
Phase Ib trial of phenformin in patients with V600-mutated melanoma receiving dabrafenib and trametinib. Cancer research communications. 2023 Academic Article GET IT
APR-246 increases tumor antigenicity independent of p53. Life science alliance. 2023 Academic Article GET IT
Apoptotic contraction drives target cell release by cytotoxic T cells. Nature immunology. 2023 Academic Article GET IT
Cytotoxic T Lymphocytes Control Growth of B16 Tumor Cells in Collagen-Fibrin Gels by Cytolytic and Non-Lytic Mechanisms. Viruses. 2023 Academic Article GET IT
ACTIVATION OF STING IN RESPONSE TO PARTIAL-TUMOR RADIATION EXPOSURE: STING ACTIVATION IN RESPONSE TO RADIATION EXPOSURE. International journal of radiation oncology, biology, physics. 2023 Academic Article GET IT
T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants. Cell. 2023 Academic Article GET IT
Times cited: 1
Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade. The Journal of clinical investigation. 2022 Academic Article GET IT
Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions. The Journal of experimental medicine. 2022 Academic Article GET IT
Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer. Communications biology. 2021 Academic Article GET IT
Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness. JCI insight. 2021 Academic Article GET IT
Tim-4⁺ cavity-resident macrophages impair anti-tumor CD8⁺ T cell immunity. Cancer cell. 2021 Academic Article GET IT
Times cited: 1
Neoadjuvant vascular-targeted photodynamic therapy improves survival and reduces recurrence and progression in a mouse model of urothelial cancer. Scientific reports. 2021 Academic Article GET IT
Times cited: 4
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma. Cell reports. 2021 Academic Article GET IT
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. Nature communications. 2020 Academic Article GET IT
Times cited: 191
In vitro assays for effector T cell functions and activity of immunomodulatory antibodies. Methods in enzymology. 2019 Article GET IT
In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors. The Journal of clinical investigation. 2019 Academic Article GET IT
Times cited: 32
One checkpoint may hide another: inhibiting the TGFβ signaling pathway enhances immune checkpoint blockade. Hepatobiliary surgery and nutrition. 2019 Editorial Article GET IT
Rational design of anti-GITR-based combination immunotherapy. Nature medicine. 2019 Academic Article GET IT
Times cited: 164
An Antitumor Immune Response Is Evoked by Partial-Volume Single-Dose Radiation in 2 Murine Models. International journal of radiation oncology, biology, physics. 2018 Academic Article GET IT
Times cited: 62
Non-conventional Inhibitory CD4⁺Foxp3^-PD-1^hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity. Cancer cell. 2018 Academic Article GET IT
Times cited: 109
Systemic Antitumor Immunity by PD-1/PD-L1 Inhibition Is Potentiated by Vascular-Targeted Photodynamic Therapy of Primary Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017 Academic Article GET IT
Times cited: 78
Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment. Science signaling. 2017 Academic Article GET IT
Times cited: 94
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells. Nature. 2016 Academic Article GET IT
Times cited: 621
Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells. Cancer immunology research. 2016 Academic Article GET IT
Times cited: 126
Clonal Abundance of Tumor-Specific CD4(+) T Cells Potentiates Efficacy and Alters Susceptibility to Exhaustion. Immunity. 2016 Academic Article GET IT
Times cited: 32
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell. 2015 Academic Article GET IT
Times cited: 1173
The New Era of Cancer Immunotherapy: Manipulating T-Cell Activity to Overcome Malignancy. Advances in cancer research. 2015 Article GET IT
Times cited: 31
MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration. Nature communications. 2014 Academic Article GET IT
Times cited: 236
Combination of alphavirus replicon particle-based vaccination with immunomodulatory antibodies: therapeutic activity in the B16 melanoma mouse model and immune correlates. Cancer immunology research. 2014 Academic Article GET IT
Times cited: 35
The importance of animal models in tumor immunity and immunotherapy. Current opinion in genetics & development. 2013 Information Resource GET IT
Times cited: 58
GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability. Cancer immunology research. 2013 Academic Article GET IT
Times cited: 125
Surface acoustic waves enhance neutrophil killing of bacteria. PloS one. 2013 Academic Article GET IT
Times cited: 5
Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype. The Journal of experimental medicine. 2012 Academic Article GET IT
Times cited: 118
CD8+ T cell concentration determines their efficiency in killing cognate antigen-expressing syngeneic mammalian cells in vitro and in mouse tissues. The Journal of experimental medicine. 2010 Academic Article GET IT
Times cited: 97
Different G(i)-coupled chemoattractant receptors signal qualitatively different functions in human neutrophils. Journal of leukocyte biology. 2002 Academic Article GET IT
Times cited: 32
The bacterial peptide N-formyl-Met-Leu-Phe inhibits killing of Staphylococcus epidermidis by human neutrophils in fibrin gels. Journal of immunology (Baltimore, Md. : 1950). 2002 Academic Article GET IT
Times cited: 12
Blockade of alpha 5 beta 1 integrins reverses the inhibitory effect of tenascin on chemotaxis of human monocytes and polymorphonuclear leukocytes through three-dimensional gels of extracellular matrix proteins. Journal of immunology (Baltimore, Md. : 1950). 2001 Academic Article GET IT
Times cited: 45
Differential regulation of beta1 integrins by chemoattractants regulates neutrophil migration through fibrin. The Journal of cell biology. 1999 Academic Article GET IT
Times cited: 61

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Research

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Funding awarded

Enhancing Breast Cancer Therapy by Inhibiting the Adenosine Receptor and Oxygen Consumption awarded by United States Department of Defense Co-Investigator 2023 - 2024

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Background

education and training

Ph.D., Columbia University 2010
M.A., Columbia University 2003
B.A., Wesleyan College 1997

Contact

full name

Sadna Budhu

primary email

sab4028@med.cornell.edu

VIVO Weill Cornell Medical College

Sadna Budhu Assistant Professor of Research in Pharmacology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email