Budhu, Sadna

Publications

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selected publications

Pharmacologic LDH inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models. The Journal of clinical investigation. 2024 Academic Article GET IT
Comparative study of immune response to local tumor destruction modalities in a murine breast cancer model. Frontiers in oncology. 2024 Academic Article GET IT
Intermittent MEK inhibition with GITR co-stimulation rescues T-cell function for increased efficacy with CTLA-4 blockade in solid tumor models. Cancer immunology research. 2024 Academic Article GET IT
Preoperative immune checkpoint inhibition and cryoablation in early-stage breast cancer. iScience. 2024 Academic Article GET IT
Phase Ib trial of phenformin in patients with V600-mutated melanoma receiving dabrafenib and trametinib. Cancer research communications. 2023 Academic Article GET IT
APR-246 increases tumor antigenicity independent of p53. Life science alliance. 2023 Academic Article GET IT
Apoptotic contraction drives target cell release by cytotoxic T cells. Nature immunology. 2023 Academic Article GET IT
Cytotoxic T Lymphocytes Control Growth of B16 Tumor Cells in Collagen-Fibrin Gels by Cytolytic and Non-Lytic Mechanisms. Viruses. 2023 Academic Article GET IT
ACTIVATION OF STING IN RESPONSE TO PARTIAL-TUMOR RADIATION EXPOSURE: STING ACTIVATION IN RESPONSE TO RADIATION EXPOSURE. International journal of radiation oncology, biology, physics. 2023 Academic Article GET IT
T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants. Cell. 2023 Academic Article GET IT
Times cited: 1
Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade. The Journal of clinical investigation. 2022 Academic Article GET IT
Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions. The Journal of experimental medicine. 2022 Academic Article GET IT
Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer. Communications biology. 2021 Academic Article GET IT
Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness. JCI insight. 2021 Academic Article GET IT
Tim-4⁺ cavity-resident macrophages impair anti-tumor CD8⁺ T cell immunity. Cancer cell. 2021 Academic Article GET IT
Times cited: 109
Neoadjuvant vascular-targeted photodynamic therapy improves survival and reduces recurrence and progression in a mouse model of urothelial cancer. Scientific reports. 2021 Academic Article GET IT
Times cited: 4
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma. Cell reports. 2021 Academic Article GET IT
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. Nature communications. 2020 Academic Article GET IT
Times cited: 229
In vitro assays for effector T cell functions and activity of immunomodulatory antibodies. Methods in enzymology. 2019 Article GET IT
In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors. The Journal of clinical investigation. 2019 Academic Article GET IT
Times cited: 34
One checkpoint may hide another: inhibiting the TGFβ signaling pathway enhances immune checkpoint blockade. Hepatobiliary surgery and nutrition. 2019 Editorial Article GET IT
Rational design of anti-GITR-based combination immunotherapy. Nature medicine. 2019 Academic Article GET IT
Times cited: 172
An Antitumor Immune Response Is Evoked by Partial-Volume Single-Dose Radiation in 2 Murine Models. International journal of radiation oncology, biology, physics. 2018 Academic Article GET IT
Times cited: 72
Non-conventional Inhibitory CD4⁺Foxp3^-PD-1^hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity. Cancer cell. 2018 Academic Article GET IT
Times cited: 115
Systemic Antitumor Immunity by PD-1/PD-L1 Inhibition Is Potentiated by Vascular-Targeted Photodynamic Therapy of Primary Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017 Academic Article GET IT
Times cited: 85
Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment. Science signaling. 2017 Academic Article GET IT
Times cited: 103
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells. Nature. 2016 Academic Article GET IT
Times cited: 663
Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells. Cancer immunology research. 2016 Academic Article GET IT
Times cited: 135
Clonal Abundance of Tumor-Specific CD4(+) T Cells Potentiates Efficacy and Alters Susceptibility to Exhaustion. Immunity. 2016 Academic Article GET IT
Times cited: 34
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell. 2015 Academic Article GET IT
Times cited: 1258
The New Era of Cancer Immunotherapy: Manipulating T-Cell Activity to Overcome Malignancy. Advances in cancer research. 2015 Article GET IT
Times cited: 31
MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration. Nature communications. 2014 Academic Article GET IT
Times cited: 253
Combination of alphavirus replicon particle-based vaccination with immunomodulatory antibodies: therapeutic activity in the B16 melanoma mouse model and immune correlates. Cancer immunology research. 2014 Academic Article GET IT
Times cited: 36
The importance of animal models in tumor immunity and immunotherapy. Current opinion in genetics & development. 2013 Information Resource GET IT
Times cited: 59
GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability. Cancer immunology research. 2013 Academic Article GET IT
Times cited: 130
Surface acoustic waves enhance neutrophil killing of bacteria. PloS one. 2013 Academic Article GET IT
Times cited: 6
Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype. The Journal of experimental medicine. 2012 Academic Article GET IT
Times cited: 119
CD8+ T cell concentration determines their efficiency in killing cognate antigen-expressing syngeneic mammalian cells in vitro and in mouse tissues. The Journal of experimental medicine. 2010 Academic Article GET IT
Times cited: 99
Different G(i)-coupled chemoattractant receptors signal qualitatively different functions in human neutrophils. Journal of leukocyte biology. 2002 Academic Article GET IT
Times cited: 32
The bacterial peptide N-formyl-Met-Leu-Phe inhibits killing of Staphylococcus epidermidis by human neutrophils in fibrin gels. Journal of immunology (Baltimore, Md. : 1950). 2002 Academic Article GET IT
Times cited: 12
Blockade of alpha 5 beta 1 integrins reverses the inhibitory effect of tenascin on chemotaxis of human monocytes and polymorphonuclear leukocytes through three-dimensional gels of extracellular matrix proteins. Journal of immunology (Baltimore, Md. : 1950). 2001 Academic Article GET IT
Times cited: 45
Differential regulation of beta1 integrins by chemoattractants regulates neutrophil migration through fibrin. The Journal of cell biology. 1999 Academic Article GET IT
Times cited: 62

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Research

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Funding awarded

Enhancing Breast Cancer Therapy by Inhibiting the Adenosine Receptor and Oxygen Consumption awarded by United States Department of Defense Co-Investigator 2023 - 2025

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Background

education and training

Ph.D., Columbia University 2010
M.A., Columbia University 2003
B.A., Wesleyan College 1997

Contact

full name

Sadna Budhu

primary email

sab4028@med.cornell.edu

VIVO Weill Cornell Medical College

Sadna Budhu Assistant Professor of Research in Pharmacology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email