Rafii, Shahin

Publications

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selected publications

Restoration of Spermatogenesis is Dependent on Activation of a SPRY4-ERK Checkpoint Following Germline Stem Cell Damage. Biology of reproduction. 2026 Academic Article GET IT
Selective targeting of endothelial and perivascular angiocrine ROCK2 treats liver fibrosis. Cell. 2026 Academic Article GET IT
Times cited: 4
Angiocrine breakdown in metabolically stressed fat. Nature metabolism. 2026 Academic Article GET IT
Vascularization of Human Pancreatic Islets With Adaptive Endothelial Cells for In Vitro Analysis and In Vivo Transplantation. Bio-protocol. 2025 Academic Article GET IT
Corrigendum: Sept4/ARTS is required for stem cell apoptosis and tumor suppression. Genes & development. 2025 Article GET IT
Adenovirus E4ORF1 activates isoform-specific phosphatidylinositol 3-kinase signaling in human endothelial cells. The Journal of biological chemistry. 2025 Academic Article GET IT
A non-canonical aryl hydrocarbon receptor pathway authorizes and safeguards clinical-scale expansion of functional human endothelial cells. Nature cardiovascular research. 2025 Academic Article GET IT
Times cited: 1
Restoration of Spermatogenesis is Dependent on Activation of a SPRY4-ERK Checkpoint Following Germline Stem Cell Damage. bioRxiv : the preprint server for biology. 2025 Article GET IT
Single-cell spatial mapping reveals dynamic bone marrow microarchitectural alterations and enhances clinical diagnostics in MDS. bioRxiv : the preprint server for biology. 2025 Article GET IT
Differentiation latency and dormancy signatures define fetal liver hematopoietic stem cells at single-cell resolution. Cell reports. 2025 Academic Article GET IT
MLKL PARylation in the endothelial niche triggers angiocrine necroptosis to evade cancer immunosurveillance and chemotherapy. Nature cell biology. 2025 Academic Article GET IT
Times cited: 7
Design and Development of a Real-Time Pressure-Driven Monitoring System for In Vitro Microvasculature Formation. Biomimetics (Basel, Switzerland). 2025 Academic Article GET IT
Times cited: 1
Editorial Expression of Concern: Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus. Nature. 2025 Article GET IT
Differentiation latency, cell division symmetry, and dormancy signatures define fetal liver HSCs at single cell resolution. bioRxiv : the preprint server for biology. 2025 Article GET IT
Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature. Cell stem cell. 2025 Academic Article GET IT
Times cited: 28
Transcriptional activation of regenerative hematopoiesis via microenvironmental sensing. Nature immunology. 2025 Academic Article GET IT
Times cited: 1
Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes. Nature communications. 2025 Academic Article GET IT
Times cited: 12
Vascularization of human islets by adaptable endothelium for durable and functional subcutaneous engraftment. Science advances. 2025 Academic Article GET IT
Times cited: 8
Microenvironmental determinants of endothelial cell heterogeneity. Nature reviews. Molecular cell biology. 2025 Information Resource GET IT
Times cited: 25
ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels. Circulation. 2024 Academic Article GET IT
Times cited: 16
A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin. Nature communications. 2024 Academic Article GET IT
Times cited: 8
Bulking up to shed light on leaky transcription in endothelium. Nature cardiovascular research. 2024 Article GET IT
Genetic reprogramming with stem cells regenerates glomerular epithelial podocytes in Alport syndrome. Life science alliance. 2024 Academic Article GET IT
Times cited: 3
SPRY4-dependent ERK negative feedback demarcates functional adult stem cells in the male mouse germline†. Biology of reproduction. 2023 Academic Article GET IT
Times cited: 6
The epicentre of haematopoiesis and osteogenesis. Nature cell biology. 2023 Academic Article GET IT
Times cited: 1
A Notch between vascular morphogenesis and transcriptional identity. Nature cardiovascular research. 2023 Article GET IT
Transcription factor induction of vascular blood stem cell niches in vivo. Developmental cell. 2023 Academic Article GET IT
Times cited: 13
Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response. Nature communications. 2023 Academic Article GET IT
Times cited: 35
Transcriptional Activation of Regenerative Hematopoiesis via Vascular Niche Sensing. bioRxiv : the preprint server for biology. 2023 Article GET IT
Endothelial cell-leukemia interactions remodel drug responses, uncovering T-ALL vulnerabilities. Blood. 2023 Academic Article GET IT
Times cited: 14
Systems Biology Analysis of Temporal Dynamics That Govern Endothelial Response to Cyclic Stretch. Biomolecules. 2022 Information Resource GET IT
Times cited: 3
Akt-Activated Endothelium Increases Cancer Cell Proliferation and Resistance to Treatment in Ovarian Cancer Cell Organoids. International journal of molecular sciences. 2022 Academic Article GET IT
Times cited: 14
Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis. Nature cardiovascular research. 2022 Academic Article GET IT
Times cited: 23
Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells. Cells. 2022 Academic Article GET IT
Times cited: 17
Regenerative medicine: postnatal approaches. The Lancet. Child & adolescent health. 2022 Information Resource GET IT
Times cited: 25
Angiopoietin 2 Is Associated with Vascular Necroptosis Induction in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome. The American journal of pathology. 2022 Academic Article GET IT
Times cited: 21
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction. Cell stem cell. 2022 Academic Article GET IT
Times cited: 57
Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics. Nature communications. 2022 Academic Article GET IT
Times cited: 34
Angiocrine ANGPTL2 executes HSC functions in endothelial niche. Blood. 2022 Editorial Article GET IT
Times cited: 1
Publisher Correction: Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability. Nature cell biology. 2022 Article GET IT
Cardiovascular diseases disrupt the bone-marrow niche. Nature. 2022 Article GET IT
Times cited: 3
Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability. Nature cell biology. 2021 Academic Article GET IT
Times cited: 35
Developmental angiocrine diversification of endothelial cells for organotypic regeneration. Developmental cell. 2021 Information Resource GET IT
Times cited: 39
Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes. Genes & development. 2021 Academic Article GET IT
Times cited: 23
Reversal of emphysema by restoration of pulmonary endothelial cells. The Journal of experimental medicine. 2021 Academic Article GET IT
Times cited: 73
Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice. Communications biology. 2021 Academic Article GET IT
Times cited: 14
Generation of BMEC Lines and in vitro BMEC-HSPC Co-culture Assays. Bio-protocol. 2018 Academic Article GET IT

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Research

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Funding awarded

Adaptable and hemodynamic Gut-On-VascularNet models to mitigate radiation injury awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2026 - 2031
Molecular Determinants of liver sinusoidal endothelial cells for hepatic regeneration awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2023 - 2028
Adaptable tissue-specific endothelial cells for organ regeneration awarded by National Heart, Lung, & Blood Institute Principal Investigator 2020 - 2027
Sarnoff Cardiovascular Research Foundation 2025-2026 Fellowship Host Institution Agreement awarded by Sarnoff Cardiovascular Research Foundation Principal Investigator 2025 - 2026
Subcutaneous transplantation of Islet-specific endothelial cell vascularized islets to treat diabetes awarded by Daedalus Fund for Innovation (Weill Cornell) Principal Investigator 2024 - 2026
Co-transplantation of adaptive human endothelium and islets within encapsulated angiogenic hydrogels for durable engraftment awarded by JDRF Principal Investigator 2023 - 2026
Engineering islet-like organoids from gastric stem cells for T1D cell replacement therapy awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2022 - 2026
Derivation of pancreatic islet-like organoids from human gastric stem cells awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2022 - 2026
Investigating a master regulator of large intestine stem cells awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2021 - 2026

Controlling the Niche to Control Clonal Hematopoiesis awarded by National Heart, Lung, & Blood Institute Co-Investigator 2025 - 2029

Abnormal Extracellular Vesicles and Particles from Human Islets Impact T1D progression awarded by National Institute of Diabetes & Digestive & Kidney Diseases Co-Principal Investigator 2023 - 2028
In vitro modeling of blood brain barrier dysfunction on a chip to elucidate the pathogenesis of cerebral malaria awarded by National Heart, Lung, & Blood Institute Co-Principal Investigator 2021 - 2026
Negative feedback regulation of growth factor signaling in adult spermatogonial stem cells awarded by National Institute of Child Health & Human Development Co-Principal Investigator 2021 - 2026

Molecular determinants of islet-specific endothelium for regulation of beta-cell homeostasis awarded by National Institute of Diabetes & Digestive & Kidney Diseases Key Personnel 2026 - 2031
Protective role of Endothelial Receptor Interacting Protein Kinase 3 (RIPK3) in acute lung injury awarded by National Heart, Lung, & Blood Institute Key Personnel 2024 - 2029

Human iPSC intestine mimetics with integrated mesenchymal, endothelial and enteric nervous tissue. awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator Subaward 2024 - 2028
Improving pig islet transplant efficacy in a preclinical baboon diabetes model with induced immune tolerance to the xenografts awarded by National Institute on Minority Health & Health Disparities Principal Investigator Subaward 2024 - 2026

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Background

education and training

M.D., Albert Einstein College of Medicine of Yeshiva University 1986
B.A., Cornell University 1982

Contact

full name

Shahin Rafii

primary email

srafii@med.cornell.edu

VIVO Weill Cornell Medical College

Shahin Rafii Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email