Worgall, Stefan

Publications

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selected publications

Validation of diagnostic coding for children's interstitial lung disease (chILD). Pediatric pulmonology. 2023 Letter GET IT
Sphingolipids in Childhood Asthma and Obesity (SOAP Study): A Protocol of a Cross-Sectional Study. Metabolites. 2023 Academic Article GET IT
Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19. Nature immunology. 2023 Academic Article GET IT
The mast cell exosome-fibroblast connection: A novel pro-fibrotic pathway. Frontiers in medicine. 2023 Academic Article GET IT
Assessment of lung ventilation of premature infants with bronchopulmonary dysplasia at 1.5 Tesla using phase-resolved functional lung magnetic resonance imaging. Pediatric radiology. 2023 Academic Article GET IT
Dietary long-chain omega 3 fatty acids modify sphingolipid metabolism to facilitate airway hyperreactivity. Scientific reports. 2022 Academic Article GET IT
Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation. Nature. 2022 Academic Article GET IT
Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications. The Journal of physiology. 2022 Academic Article GET IT
Asthma 17q21 polymorphism associates with decreased risk of COVID-19 in children. Pediatric pulmonology. 2022 Letter GET IT
Times cited: 2
Perinatal origins of chronic lung disease: mechanisms-prevention-therapy-sphingolipid metabolism and the genetic and perinatal origins of childhood asthma. Molecular and cellular pediatrics. 2021 Review GET IT
Human Rhinovirus Infection of the Respiratory Tract Affects Sphingolipid Synthesis. American journal of respiratory cell and molecular biology. 2021 Academic Article GET IT
ILC3s control airway inflammation by limiting T cell responses to allergens and microbes. Cell reports. 2021 Academic Article GET IT
More Evidence for Inborn Dysregulation of Sphingolipid Metabolism in Children with Asthma?. American journal of respiratory and critical care medicine. 2021 Editorial Article GET IT
Slowing late infantile Batten disease by direct brain parenchymal administration of a rh.10 adeno-associated virus expressing CLN2. Science translational medicine. 2020 Academic Article GET IT
Times cited: 35
Increasing Sphingolipid Synthesis Alleviates Airway Hyperreactivity. American journal of respiratory cell and molecular biology. 2020 Academic Article GET IT
Times cited: 11
Decreased sphingolipid synthesis in children with 17q21 asthma-risk genotypes. The Journal of clinical investigation. 2020 Academic Article GET IT
Times cited: 47
Neonatal Genetic Delivery of Anti-Respiratory Syncytial Virus (RSV) Antibody by Non-Human Primate-Based Adenoviral Vector to Provide Protection against RSV. Vaccines. 2018 Academic Article GET IT
Times cited: 5
Sphingosine 1-Phosphate Receptor 1 Signaling Maintains Endothelial Cell Barrier Function and Protects Against Immune Complex-Induced Vascular Injury. Arthritis & rheumatology (Hoboken, N.J.). 2018 Academic Article GET IT
Times cited: 68
Stranger in a Strange Land: IL-8 in the Mouse Lung?. American journal of respiratory cell and molecular biology. 2018 Editorial Article GET IT
Times cited: 2
Post-exposure immunization by capsid-modified AdC7 vector expressing Pseudomonas aeruginosa OprF clears P. aeruginosa respiratory infection. Vaccine. 2017 Academic Article GET IT
Times cited: 10
Long-term Pulmonary Outcomes in Pediatric Survivors of High-risk Neuroblastoma. Journal of pediatric hematology/oncology. 2017 Academic Article GET IT
Times cited: 9
Distinct Serum Sphingolipid Profiles among School-aged Children with Exercise-induced Wheeze and Asthma Persistence. American journal of respiratory and critical care medicine. 2017 Article GET IT
Times cited: 12
Cost Associated With Pediatric Delirium in the ICU. Critical care medicine. 2016 Academic Article GET IT
Times cited: 118
Regulation of the Coxsackie and adenovirus receptor expression is dependent on cystic fibrosis transmembrane regulator in airway epithelial cells. Cellular microbiology. 2016 Academic Article GET IT
Times cited: 4
The fermentation product 2,3-butanediol alters P. aeruginosa clearance, cytokine response and the lung microbiome. The ISME journal. 2016 Academic Article GET IT
Times cited: 25
Mast cells and exosomes in hyperoxia-induced neonatal lung disease. American journal of physiology. Lung cellular and molecular physiology. 2016 Academic Article GET IT
Times cited: 15
Respiratory Syncytial Virus (RSV) Pulmonary Infection in Humanized Mice Induces Human Anti-RSV Immune Responses and Pathology. Journal of virology. 2016 Academic Article GET IT
Times cited: 23
Airway reactivity and sphingolipids-implications for childhood asthma. Molecular and cellular pediatrics. 2015 Academic Article GET IT
New Developments in Cystic Fibrosis Airway Inflammation. Mediators of inflammation. 2015 Editorial Article GET IT
Times cited: 5
Chronic Infection by Mucoid Pseudomonas aeruginosa Associated with Dysregulation in T-Cell Immunity to Outer Membrane Porin F. American journal of respiratory and critical care medicine. 2015 Academic Article GET IT
Times cited: 22
Maternal immunization with chimpanzee adenovirus expressing RSV fusion protein protects against neonatal RSV pulmonary infection. Vaccine. 2014 Academic Article GET IT
Times cited: 16
Annexin A2 mediates secretion of collagen VI, pulmonary elasticity and apoptosis of bronchial epithelial cells. Journal of cell science. 2013 Academic Article GET IT
Times cited: 38
17q21 locus and ORMDL3: an increased risk for childhood asthma. Pediatric research. 2013 Information Resource GET IT
Times cited: 37
RGD capsid modification enhances mucosal protective immunity of a non-human primate adenovirus vector expressing Pseudomonas aeruginosa OprF. Clinical and experimental immunology. 2013 Academic Article GET IT
Times cited: 18
Editorial: RSV, dendritic cells, and allergens--a bad combination. Journal of leukocyte biology. 2013 Editorial Article GET IT
Times cited: 1
Suppression of nicotine-induced pathophysiology by an adenovirus hexon-based antinicotine vaccine. Human gene therapy. 2013 Academic Article GET IT
Times cited: 16
Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity. Science translational medicine. 2013 Academic Article GET IT
Times cited: 64
Mast cells: a pivotal role in pulmonary fibrosis. DNA and cell biology. 2013 Academic Article GET IT
Times cited: 74
Adenovirus-based vaccine with epitopes incorporated in novel fiber sites to induce protective immunity against Pseudomonas aeruginosa. PloS one. 2013 Academic Article GET IT
Times cited: 27
Fungal sensitization in childhood persistent asthma is associated with disease severity. Pediatric pulmonology. 2013 Academic Article GET IT
Times cited: 40
Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity. Human gene therapy. 2012 Academic Article GET IT
Times cited: 21
Low sphingosine-1-phosphate impairs lung dendritic cells in cystic fibrosis. American journal of respiratory cell and molecular biology. 2012 Academic Article GET IT
Times cited: 26
Assessment of disease severity in late infantile neuronal ceroid lipofuscinosis using multiparametric MR imaging. AJNR. American journal of neuroradiology. 2012 Academic Article GET IT
Times cited: 17
AAV-directed persistent expression of a gene encoding anti-nicotine antibody for smoking cessation. Science translational medicine. 2012 Academic Article GET IT
Times cited: 47
AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior. Human gene therapy. 2012 Academic Article GET IT
Times cited: 38
Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell. 2011 Academic Article GET IT
Times cited: 397
Combination therapy with rituximab and cyclophosphamide in the treatment of anti-neutrophil cytoplasmic antibodies (ANCA) positive pulmonary hemorrhage: case report. Pediatric rheumatology online journal. 2011 Academic Article GET IT
Times cited: 4
Recent developments for Pseudomonas vaccines. Human vaccines. 2011 Information Resource GET IT
Times cited: 101
Chemical scaffolds with structural similarities to siderophores of nonribosomal peptide-polyketide origin as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis. Bioorganic & medicinal chemistry letters. 2011 Academic Article GET IT
Times cited: 15
Absence of vaccine-enhanced RSV disease and changes in pulmonary dendritic cells with adenovirus-based RSV vaccine. Virology journal. 2011 Academic Article GET IT
Times cited: 14
Protective anti-Pseudomonas aeruginosa humoral and cellular mucosal immunity by AdC7-mediated expression of the P. aeruginosa protein OprF. Vaccine. 2011 Academic Article GET IT
Times cited: 30
Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Molecular therapy : the journal of the American Society of Gene Therapy. 2011 Academic Article GET IT
Times cited: 56
Delivery of antigens by viral vectors for vaccination. Therapeutic delivery. 2011 Information Resource GET IT
Times cited: 6
Replacing adenoviral vector HVR1 with a malaria B cell epitope improves immunogenicity and circumvents preexisting immunity to adenovirus in mice. The Journal of clinical investigation. 2010 Academic Article GET IT
Times cited: 45
Gene therapy for late infantile neuronal ceroid lipofuscinosis: neurosurgical considerations. Journal of neurosurgery. Pediatrics. 2010 Academic Article GET IT
Times cited: 59
Proinflammatory phenotype and increased caveolin-1 in alveolar macrophages with silenced CFTR mRNA. PloS one. 2010 Academic Article GET IT
Times cited: 41
Overexpression of sonic Hedgehog in the lung mimics the effect of lung injury and compensatory lung growth on pulmonary Sca-1 and CD34 positive cells. Molecular therapy : the journal of the American Society of Gene Therapy. 2009 Academic Article GET IT
Times cited: 13
Expression of B-cell activating factor enhances protective immunity of a vaccine against Pseudomonas aeruginosa. Infection and immunity. 2009 Academic Article GET IT
Times cited: 23
Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells. Respiratory research. 2009 Academic Article GET IT
Times cited: 30
Emphysema mediated by lung overexpression of ADAM10. Clinical and translational science. 2009 Academic Article GET IT
Times cited: 9
Genetic delivery of an anti-RSV antibody to protect against pulmonary infection with RSV. Virology. 2008 Academic Article GET IT
Times cited: 44
Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA. Human gene therapy. 2008 Academic Article GET IT
Times cited: 295
Protective immunity to pseudomonas aeruginosa induced with a capsid-modified adenovirus expressing P. aeruginosa OprF. Journal of virology. 2007 Academic Article GET IT
Times cited: 53
Neurological deterioration in late infantile neuronal ceroid lipofuscinosis. Neurology. 2007 Academic Article GET IT
Times cited: 69
Assessing disease severity in late infantile neuronal ceroid lipofuscinosis using quantitative MR diffusion-weighted imaging. AJNR. American journal of neuroradiology. 2007 Academic Article GET IT
Times cited: 25
Interaction of Pneumocystis carinii with dendritic cells and resulting host responses to P. carinii. Journal of immunotherapy (Hagerstown, Md. : 1997). 2007 Academic Article GET IT
Times cited: 9
Epitopes expressed in different adenovirus capsid proteins induce different levels of epitope-specific immunity. Journal of virology. 2006 Academic Article GET IT
Times cited: 62
Gene expression profiling of human alveolar macrophages of phenotypically normal smokers and nonsmokers reveals a previously unrecognized subset of genes modulated by cigarette smoking. Journal of molecular medicine (Berlin, Germany). 2006 Academic Article GET IT
Times cited: 78
Confronting the issues of therapeutic misconception, enrollment decisions, and personal motives in genetic medicine-based clinical research studies for fatal disorders. Human gene therapy. 2005 Review GET IT
Times cited: 27
Similarity of gene expression patterns in human alveolar macrophages in response to Pseudomonas aeruginosa and Burkholderia cepacia. Infection and immunity. 2005 Academic Article GET IT
Times cited: 7
Pseudomonas aeruginosa SoxR does not conform to the archetypal paradigm for SoxR-dependent regulation of the bacterial oxidative stress adaptive response. Infection and immunity. 2005 Academic Article GET IT
Times cited: 101
Protection against P. aeruginosa with an adenovirus vector containing an OprF epitope in the capsid. The Journal of clinical investigation. 2005 Academic Article GET IT
Times cited: 95
A realistic chance for gene therapy in the near future. Pediatric nephrology (Berlin, Germany). 2004 Editorial Article GET IT
Times cited: 19
Clinical protocol. Administration of a replication-deficient adeno-associated virus gene transfer vector expressing the human CLN2 cDNA to the brain of children with late infantile neuronal ceroid lipofuscinosis. Human gene therapy. 2004 Academic Article GET IT
Times cited: 100
Modification to the capsid of the adenovirus vector that enhances dendritic cell infection and transgene-specific cellular immune responses. Journal of virology. 2004 Academic Article GET IT
Times cited: 76
Transcriptome analysis of the response of Pseudomonas aeruginosa to hydrogen peroxide. Journal of bacteriology. 2004 Academic Article GET IT
Times cited: 123
Transcriptome analysis of the Pseudomonas aeruginosa response to iron. Archives of microbiology. 2003 Academic Article GET IT
Times cited: 81
[Cardiologic and diabetologic aspects of therapy with angiotensin receptor blocking agents]. Orvosi hetilap. 2003 Information Resource GET IT
Apoptosis induced by Pseudomonas aeruginosa in antigen presenting cells is diminished by genetic modification with CD40 ligand. Pediatric research. 2002 Academic Article GET IT
Times cited: 19
Inhibition of HIV-1 replication in alveolar macrophages by adenovirus gene transfer vectors. American journal of respiratory cell and molecular biology. 2002 Academic Article GET IT
Times cited: 2
Protection against pulmonary infection with Pseudomonas aeruginosa following immunization with P. aeruginosa-pulsed dendritic cells. Infection and immunity. 2001 Academic Article GET IT
Times cited: 45
Variation in adenovirus receptor expression and adenovirus vector-mediated transgene expression at defined stages of the cell cycle. Molecular therapy : the journal of the American Society of Gene Therapy. 2001 Academic Article GET IT
Times cited: 81
Infection of endothelium with E1(-)E4(+), but not E1(-)E4(-), adenovirus gene transfer vectors enhances leukocyte adhesion and migration by modulation of ICAM-1, VCAM-1, CD34, and chemokine expression. Circulation research. 2001 Academic Article GET IT
Times cited: 27
Dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can initiate antigen-specific humoral immunity independent of CD4+ T cells. Nature medicine. 2000 Academic Article GET IT
Times cited: 73
Downregulation of CXCR4 gene expression in primary human endothelial cells following infection with E1(-)E4(+) adenovirus gene transfer vectors. Molecular therapy : the journal of the American Society of Gene Therapy. 2000 Academic Article GET IT
Times cited: 8
Free cholesterol enhances adenoviral vector gene transfer and expression in CAR-deficient cells. Molecular therapy : the journal of the American Society of Gene Therapy. 2000 Academic Article GET IT
Times cited: 35
Induction of endogenous genes following infection of human endothelial cells with an E1(-) E4(+) adenovirus gene transfer vector. Journal of virology. 1999 Academic Article GET IT
Times cited: 28
Cellular immune responses of healthy individuals to intradermal administration of an E1-E3- adenovirus gene transfer vector. Human gene therapy. 1999 Academic Article GET IT
Times cited: 62
Enhanced liver uptake of opsonized red blood cells after in vivo transfer of FcgammaRIIA cDNA to the liver. Blood. 1999 Academic Article GET IT
Times cited: 3
Augmentation of pulmonary host defense against Pseudomonas by FcgammaRIIA cDNA transfer to the respiratory epithelium. The Journal of clinical investigation. 1999 Academic Article GET IT
Times cited: 5
Expression and use of human immunodeficiency virus type 1 coreceptors by human alveolar macrophages. Journal of virology. 1999 Academic Article GET IT
Times cited: 50
Fiber swap between adenovirus subgroups B and C alters intracellular trafficking of adenovirus gene transfer vectors. Journal of virology. 1999 Academic Article GET IT
Times cited: 134
E1(-)E4(+) adenoviral gene transfer vectors function as a "pro-life" signal to promote survival of primary human endothelial cells. Blood. 1999 Academic Article GET IT
Times cited: 32
Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor. American journal of respiratory cell and molecular biology. 1999 Academic Article GET IT
Times cited: 71
Selective expansion of alveolar macrophages in vivo by adenovirus-mediated transfer of the murine granulocyte-macrophage colony-stimulating factor cDNA. Blood. 1999 Academic Article GET IT
Times cited: 37
Hypoglycemic effects of insulin-like growth factor-1 in experimental uremia: can concomitant growth hormone administration prevent this effect?. Hormone research. 1999 Academic Article GET IT
Times cited: 7
Electroporation of nucleic acids into prokaryotic and eukaryotic cells by square wave pulses. Biotechnology Techniques. 1998 Article GET IT
Regional 'pro-drug' gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma. Gene therapy. 1998 Academic Article GET IT
Times cited: 76
Fluorescent virions: dynamic tracking of the pathway of adenoviral gene transfer vectors in living cells. Human gene therapy. 1998 Academic Article GET IT
Times cited: 205
Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract. Human gene therapy. 1997 Academic Article GET IT
Times cited: 115
Monitoring of antisense effects of oligonucleotides targeted to the neuropeptide Y Y1 receptor gene. European journal of pharmacology. 1997 Academic Article GET IT
Times cited: 1
Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ. Journal of virology. 1997 Academic Article GET IT
Times cited: 192
Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration. Human gene therapy. 1997 Academic Article GET IT
Times cited: 413
Urinary excretion of endogenous ouabain-like substance in furosemide-treated neonates: its relation to renal excretory pattern and endocrine factors. Biology of the neonate. 1997 Academic Article GET IT
Times cited: 3
Urinary excretion of endogenous ouabain-like substance is reduced in NaCl supplemented premature infants. Biology of the neonate. 1997 Academic Article GET IT
Times cited: 3
Gene expression of neuropeptide Y and neuropeptide-Y1 receptor in relation to proto-oncogene tyrosine kinase A, nerve-growth-factor low-affinity-receptor and the transcription factor N-myc in human neuroblastomas. International journal of oncology. 1996 Academic Article GET IT
Characterization of ouabain-like immunoreactivity in human urine. Journal of hypertension. 1996 Academic Article GET IT
Times cited: 17
Effect of sodium chloride supplementation on urinary endothelin-1 excretion in premature infants. The Journal of pediatrics. 1994 Academic Article GET IT
Times cited: 4
Renal electrolyte and water handling in normal pregnancy: possible role of endothelin-1. European journal of obstetrics, gynecology, and reproductive biology. 1994 Academic Article GET IT
Times cited: 9
Elevated urinary excretion of endothelin-like immunoreactivity in children with renal disease is related to urine flow rate. Clinical nephrology. 1994 Academic Article GET IT
Times cited: 18
Growth hormone prevents steroid-induced growth depression in health and uremia. Kidney international. 1991 Academic Article GET IT
Times cited: 66
Influence of growth hormone and insulin-like growth factor-I on kidney function and kidney growth. Pediatric nephrology (Berlin, Germany). 1991 Information Resource GET IT
Times cited: 18
Recombinant human growth hormone overcomes the growth-suppressive effect of methylprednisolone in uraemic rats. Pediatric nephrology (Berlin, Germany). 1991 Academic Article GET IT
Times cited: 3

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Research

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Funding awarded

Impact of SARS-CoV-2 infection on respiratory viral immune responses in children with and without asthma awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2023 - 2028
Respiratory Sphingolipid Synthesis Involved in Airway Hyperreactivity and Viral-Triggered Asthma awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2023 - 2028
Enhancing protective immunity against RSV by inhibitors of sphingolipid synthesis awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2022 - 2024

Physiologic phenotyping of chronic lung disease of prematurity using MRI awarded by National Heart, Lung, & Blood Institute Co-Investigator 2023 - 2027
Innate immune regulation of lung inflammation through mitochondrial dynamics awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2023 - 2027
PANDEMIC RESPONSE REPOSITORY – MICROBIAL AND IMMUNE SURVEILLANCE AND EPIDEMIOLOGY (PREMISE): ENTEROVIRUS D68 (EV-D68) PILOT STUDY - Option Period Three awarded by National Cancer Institute Co-Investigator 2024 - 2025
PANDEMIC RESPONSE REPOSITORY – MICROBIAL AND IMMUNE SURVEILLANCE AND EPIDEMIOLOGY (PREMISE): ENTEROVIRUS D68 (EV-D68) PILOT STUDY - Option Period Two awarded by National Cancer Institute Co-Investigator 2023 - 2024

missing activity Principal Investigator Subaward 2019 - 2023

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Background

education and training

M.D., University of Heidelberg, Faculty of Medicine (Germany) 91
Ph.D., University of Heidelberg (Germany) 1992

Contact

full name

Stefan Worgall

primary email

stw2006@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Stefan Worgall Professor of Pediatrics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage