selected publications
- Phosphoglycerate kinase is a central leverage point in Parkinson's disease-driven neuronal metabolic deficits. Science advances. 2024 Academic Article GET IT
- Characterization of β-Hydroxybutyrate as a Cell Autonomous Fuel for Active Excitatory and Inhibitory Neurons. 2024 GET IT
- iATPSnFR2: A high-dynamic-range fluorescent sensor for monitoring intracellular ATP. Proceedings of the National Academy of Sciences of the United States of America. 2024 Academic Article GET IT
- A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions. 2024 GET IT
- Isolation and Lipidomic Profiling of Neuronal Lipid Droplets: Unveiling the Lipid Landscape for insights into Neurodegenerative Disorders. 2023 GET IT
- Phosphoglycerate kinase 1 is a central leverage point in Parkinson's disease driven neuronal metabolic deficits. 2023 GET IT
- GABABR silencing of nerve terminals. eLife. 2023 Academic Article GET IT
- Synaptic vesicle pools are a major hidden resting metabolic burden of nerve terminals. Science advances. 2021 Academic Article GET IT
- Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination. The Journal of experimental medicine. 2021 Academic Article GET IT
- Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission. Neuron. 2019 Academic Article GET IT
- Editorial overview: Molecular neuroscience. Current opinion in neurobiology. 2019 Editorial Article GET IT
- SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron. 2019 Academic Article GET IT
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The control of release probability at nerve terminals.
Nature reviews. Neuroscience.
2019
Information Resource
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Times cited: 24 -
Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to CaV2.1 and CaV2.2 in Rat Midbrain Neurons.
eNeuro.
2019
Academic Article
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Times cited: 13 -
Antimicrobial agent triclosan disrupts mitochondrial structure, revealed by super-resolution microscopy, and inhibits mast cell signaling via calcium modulation.
Toxicology and applied pharmacology.
2018
Academic Article
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Times cited: 44 -
Munc13 marks the spot.
Nature neuroscience.
2018
Article
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Times cited: 1 -
INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division.
The Journal of cell biology.
2017
Academic Article
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Times cited: 222 -
Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2017
Academic Article
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Times cited: 101 -
Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages.
Cell.
2017
Academic Article
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Times cited: 255 -
Glucose metabolism in nerve terminals.
Current opinion in neurobiology.
2017
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Times cited: 98 -
Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons.
Neuron.
2017
Academic Article
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Times cited: 132 -
Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder.
The Journal of clinical investigation.
2017
Academic Article
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Times cited: 74 -
Axonal Endoplasmic Reticulum Ca2+ Content Controls Release Probability in CNS Nerve Terminals.
Neuron.
2017
Academic Article
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Times cited: 183 -
Adaptor Protein 2 (AP-2) complex is essential for functional axogenesis in hippocampal neurons.
Scientific reports.
2017
Academic Article
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Times cited: 12 -
GLUT4 Mobilization Supports Energetic Demands of Active Synapses.
Neuron.
2017
Academic Article
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Times cited: 204 -
The Global Challenge in Neuroscience Education and Training: The MBL Perspective.
Neuron.
2016
Article
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Times cited: 4 -
Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis.
The Journal of biological chemistry.
2015
Academic Article
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Times cited: 17 -
Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca2+ influx, not Ca2+-exocytosis coupling.
Proceedings of the National Academy of Sciences of the United States of America.
2015
Academic Article
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Times cited: 73 -
Vesicular glutamate transporter 1 orchestrates recruitment of other synaptic vesicle cargo proteins during synaptic vesicle recycling.
The Journal of biological chemistry.
2015
Academic Article
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Times cited: 37 -
The active-zone protein Munc13 controls the use-dependence of presynaptic voltage-gated calcium channels.
eLife.
2015
Academic Article
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Times cited: 44 -
Synaptic activity regulates the abundance and binding of complexin.
Biophysical journal.
2015
Academic Article
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Times cited: 7 -
Control and plasticity of the presynaptic action potential waveform at small CNS nerve terminals.
Neuron.
2014
Academic Article
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Times cited: 77 -
Activity-driven local ATP synthesis is required for synaptic function.
Cell.
2014
Academic Article
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Times cited: 532 -
Dynamin phosphorylation controls optimization of endocytosis for brief action potential bursts.
eLife.
2013
Academic Article
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Times cited: 60 -
Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2013
Academic Article
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Times cited: 38 -
Balance of calcineurin Aα and CDK5 activities sets release probability at nerve terminals.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2013
Academic Article
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Times cited: 68 -
Intrinsic variability in Pv, RRP size, Ca(2+) channel repertoire, and presynaptic potentiation in individual synaptic boutons.
Frontiers in synaptic neuroscience.
2013
Academic Article
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Times cited: 38 -
Calbindin controls release probability in ventral tegmental area dopamine neurons.
Nature neuroscience.
2012
Academic Article
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Times cited: 47 -
α2δ expression sets presynaptic calcium channel abundance and release probability.
Nature.
2012
Academic Article
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Times cited: 297 -
New insights into molecular players involved in neurotransmitter release.
Physiology (Bethesda, Md.).
2012
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Times cited: 16 -
A system for performing high throughput assays of synaptic function.
PloS one.
2011
Academic Article
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Times cited: 24 -
Overlapping role of dynamin isoforms in synaptic vesicle endocytosis.
Neuron.
2011
Academic Article
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Times cited: 171 -
Synaptic vesicle retrieval time is a cell-wide rather than individual-synapse property.
Nature neuroscience.
2011
Academic Article
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Times cited: 25 -
CDK5 serves as a major control point in neurotransmitter release.
Neuron.
2010
Academic Article
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Times cited: 222 -
Optical mapping of release properties in synapses.
Frontiers in neural circuits.
2010
Academic Article
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Times cited: 46 -
A distributed set of interactions controls mu2 functionality in the role of AP-2 as a sorting adaptor in synaptic vesicle endocytosis.
The Journal of biological chemistry.
2009
Academic Article
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Times cited: 19 -
Live imaging of synaptic vesicle release and retrieval in dopaminergic neurons.
Frontiers in neural circuits.
2009
Academic Article
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Times cited: 30 -
Synaptic vesicle recycling at CNS snapses without AP-2.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009
Academic Article
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Times cited: 106 -
Molecular circuitry of endocytosis at nerve terminals.
Annual review of cell and developmental biology.
2009
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Times cited: 176 -
A heterogeneous "resting" pool of synaptic vesicles that is dynamically interchanged across boutons in mammalian CNS synapses.
Brain cell biology.
2008
Academic Article
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Times cited: 66 -
Calcium control of endocytic capacity at a CNS synapse.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008
Academic Article
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Times cited: 74 -
The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals.
Neuron.
2007
Academic Article
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Times cited: 157 -
Single-vesicle imaging reveals that synaptic vesicle exocytosis and endocytosis are coupled by a single stochastic mode.
Proceedings of the National Academy of Sciences of the United States of America.
2007
Academic Article
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Times cited: 220 -
A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis.
Science (New York, N.Y.).
2007
Academic Article
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Times cited: 371 -
Synaptic vesicles interchange their membrane proteins with a large surface reservoir during recycling.
Neuron.
2006
Academic Article
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Times cited: 153 -
The efficiency of the synaptic vesicle cycle at central nervous system synapses.
Trends in cell biology.
2006
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Times cited: 56 -
A pre-synaptic to-do list for coupling exocytosis to endocytosis.
Current opinion in cell biology.
2006
Information Resource
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Times cited: 41 -
The synaptic vesicle: cycle of exocytosis and endocytosis.
Current opinion in neurobiology.
2006
Information Resource
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Times cited: 103 -
The kinetics of synaptic vesicle reacidification at hippocampal nerve terminals.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006
Academic Article
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Times cited: 133 -
Neural activity controls the synaptic accumulation of alpha-synuclein.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2005
Academic Article
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Times cited: 237 -
The general anesthetic isoflurane depresses synaptic vesicle exocytosis.
Molecular pharmacology.
2005
Academic Article
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Times cited: 44 -
Highly cooperative control of endocytosis by clathrin.
Molecular biology of the cell.
2005
Academic Article
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Times cited: 39 -
Munc18-dependent regulation of synaptic vesicle exocytosis by syntaxin-1A in hippocampal neurons.
Neuropharmacology.
2005
Academic Article
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Times cited: 17 -
Kinetic efficiency of endocytosis at mammalian CNS synapses requires synaptotagmin I.
Proceedings of the National Academy of Sciences of the United States of America.
2004
Academic Article
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Times cited: 116 -
Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking.
Nature.
2004
Academic Article
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Times cited: 288 -
Syntaxin-1A is excluded from recycling synaptic vesicles at nerve terminals.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2004
Academic Article
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Times cited: 44 -
The kinetics of synaptic vesicle pool depletion at CNS synaptic terminals.
Neuron.
2004
Academic Article
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Times cited: 173 -
Targeted chemical disruption of clathrin function in living cells.
Molecular biology of the cell.
2003
Academic Article
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Times cited: 53 -
Synaptic vesicle mobilization is regulated by distinct synapsin I phosphorylation pathways at different frequencies.
Neuron.
2003
Academic Article
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Times cited: 250 -
Kiss-and-run, fuse-pinch-and-linger, fuse-and-collapse: the life and times of a neurosecretory granule.
Proceedings of the National Academy of Sciences of the United States of America.
2003
Article
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Times cited: 63 -
Actin has a molecular scaffolding, not propulsive, role in presynaptic function.
Nature neuroscience.
2003
Academic Article
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Times cited: 244 -
Regulation of neurotransmitter release by synapsin III.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2002
Academic Article
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Times cited: 130 -
Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons.
The Journal of physiology.
2002
Academic Article
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Times cited: 97 -
Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice.
Neuron.
2002
Academic Article
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Times cited: 184 -
Synapsin dispersion and reclustering during synaptic activity.
Nature neuroscience.
2001
Academic Article
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Times cited: 272 -
Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversion.
Proceedings of the National Academy of Sciences of the United States of America.
2001
Academic Article
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Times cited: 186 -
Presynaptic imaging techniques.
Current opinion in neurobiology.
2001
Information Resource
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Times cited: 79 -
Calcium accelerates endocytosis of vSNAREs at hippocampal synapses.
Nature neuroscience.
2001
Academic Article
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Times cited: 234 -
The use of pHluorins for optical measurements of presynaptic activity.
Biophysical journal.
2000
Academic Article
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Times cited: 462 -
Real-time measurements of vesicle-SNARE recycling in synapses of the central nervous system.
Nature cell biology.
2000
Academic Article
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Times cited: 322 -
Inhibitors of myosin light chain kinase block synaptic vesicle pool mobilization during action potential firing.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1999
Academic Article
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Times cited: 135 -
Optical detection of a quantal presynaptic membrane turnover.
Nature.
1997
Academic Article
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Times cited: 136 -
Endocytosis at nerve terminals: timing is everything.
Neuron.
1996
Information Resource
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Times cited: 23 -
Synaptic vesicle recycling in synapsin I knock-out mice.
The Journal of cell biology.
1996
Academic Article
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Times cited: 146 -
Potentiation of evoked vesicle turnover at individually resolved synaptic boutons.
Neuron.
1996
Academic Article
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Times cited: 97 -
The timing of synaptic vesicle endocytosis.
Proceedings of the National Academy of Sciences of the United States of America.
1996
Academic Article
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Times cited: 207 -
Vesicle pool mobilization during action potential firing at hippocampal synapses.
Neuron.
1995
Academic Article
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Times cited: 241 -
The kinetics of synaptic vesicle recycling measured at single presynaptic boutons.
Neuron.
1993
Academic Article
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Times cited: 450 -
Spatial and temporal dissection of immediate and early events following cadherin-mediated epithelial cell adhesion.
The Journal of cell biology.
1993
Academic Article
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Times cited: 141 -
Imaging [Ca2+]i dynamics during signal transduction.
Cell calcium.
1990
Academic Article
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Times cited: 22 -
Immunoglobulin E receptor cross-linking induces oscillations in intracellular free ionized calcium in individual tumor mast cells.
The Journal of biological chemistry.
1989
Academic Article
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Times cited: 97 - Molecular Interactions on the Cell Surface Revealed by Electrophoresis. The Biological bulletin. 1989 Academic Article GET IT
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Calcium: an important second messenger in mast cells.
Ciba Foundation symposium.
1989
Information Resource
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Times cited: 17 -
Molecular crowding on the cell surface.
Science (New York, N.Y.).
1988
Academic Article
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Times cited: 119