Overlapping role of dynamin isoforms in synaptic vesicle endocytosis. Academic Article uri icon

Overview

abstract

  • The existence of neuron-specific endocytic protein isoforms raises questions about their importance for specialized neuronal functions. Dynamin, a GTPase implicated in the fission reaction of endocytosis, is encoded by three genes, two of which, dynamin 1 and 3, are highly expressed in neurons. We show that dynamin 3, thought to play a predominantly postsynaptic role, has a major presynaptic function. Although lack of dynamin 3 does not produce an overt phenotype in mice, it worsens the dynamin 1 KO phenotype, leading to perinatal lethality and a more severe defect in activity-dependent synaptic vesicle endocytosis. Thus, dynamin 1 and 3, which together account for the overwhelming majority of brain dynamin, cooperate in supporting optimal rates of synaptic vesicle endocytosis. Persistence of synaptic transmission in their absence indicates that if dynamin plays essential functions in neurons, such functions can be achieved by the very low levels of dynamin 2.

publication date

  • June 23, 2011

Research

keywords

  • Dynamin I
  • Dynamin III
  • Endocytosis
  • Neurons
  • Synaptic Vesicles

Identity

PubMed Central ID

  • PMC3190241

Scopus Document Identifier

  • 79959316429

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2011.04.031

PubMed ID

  • 21689597

Additional Document Info

volume

  • 70

issue

  • 6