McGraw, Timothy E.

Publications

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selected publications

Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome. Nature communications. 2024 Academic Article GET IT
Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1⁺ progenitor CD8⁺ T cells to improve immunotherapy. Nature immunology. 2024 Academic Article GET IT
Transferrin receptor-based circulating tumor cell enrichment provides a snapshot of the molecular landscape of solid tumors and correlates with clinical outcomes. 2024 GET IT
A signature of enhanced proliferation associated with response and survival to anti-PD-L1 therapy in early-stage non-small cell lung cancer. Cell reports. Medicine. 2024 Academic Article GET IT
Author Correction: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. 2024 GET IT
Regulated dynamic subcellular GLUT4 localization revealed by proximal proteome mapping in human muscle cells. Journal of cell science. 2023 Academic Article GET IT
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications. 2023 Academic Article GET IT
Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant. Molecular metabolism. 2023 Academic Article GET IT
TIMP1 is an early biomarker for detection and prognosis of lung cancer. Clinical and translational medicine. 2023 Academic Article GET IT
Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve checkpoint blockade. 2023 GET IT
Regulation of PD-L1 Trafficking from Synthesis to Degradation. Cancer immunology research. 2023 Academic Article GET IT
Proximity proteome mapping reveals PD-L1-dependent pathways disrupted by anti-PD-L1 antibody specifically in EGFR-mutant lung cancer cells. Cell communication and signaling : CCS. 2023 Academic Article GET IT
Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer. Nature communications. 2023 Academic Article GET IT
Times cited: 16
Global evolution of the tumor microenvironment associated with progression from preinvasive invasive to invasive human lung adenocarcinoma. Cell reports. 2022 Academic Article GET IT
Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. Science translational medicine. 2022 Academic Article GET IT
Defective insulin-stimulated GLUT4 translocation in brown adipocytes induces systemic glucose homeostasis dysregulation independent of thermogenesis in female mice. Molecular metabolism. 2021 Academic Article GET IT
Neoadjuvant durvalumab with or without stereotactic body radiotherapy in patients with early-stage non-small-cell lung cancer: a single-centre, randomised phase 2 trial. The Lancet. Oncology. 2021 Academic Article GET IT
Times cited: 125
Insulin action in adipocytes, adipose remodeling, and systemic effects. Cell metabolism. 2021 Information Resource GET IT
Times cited: 77
Insulin-promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10. Molecular biology of the cell. 2020 Academic Article GET IT
Thirty sweet years of GLUT4. The Journal of biological chemistry. 2019 Information Resource GET IT
Times cited: 219
The lung microenvironment: an important regulator of tumour growth and metastasis. Nature reviews. Cancer. 2019 Review GET IT
Times cited: 746
Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects. Cell metabolism. 2018 Article GET IT
Times cited: 37
SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy. The Journal of clinical investigation. 2018 Academic Article GET IT
Times cited: 18
Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. Cell reports. 2017 Academic Article GET IT
Times cited: 101
Biochemical and cellular properties of insulin receptor signalling. Nature reviews. Molecular cell biology. 2017 Information Resource GET IT
Times cited: 478
Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake. eLife. 2017 Academic Article GET IT
Times cited: 124
Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin. Cell reports. 2017 Academic Article GET IT
Times cited: 173
Secretion of Adipsin as an Assay to Measure Flux from the Endoplasmic Reticulum (ER). Bio-protocol. 2017 Academic Article GET IT
Adenovirus Protein E4-ORF1 Activation of PI3 Kinase Reveals Differential Regulation of Downstream Effector Pathways in Adipocytes. Cell reports. 2016 Academic Article GET IT
Times cited: 11
Downregulation of a GPCR by β-Arrestin2-Mediated Switch from an Endosomal to a TGN Recycling Pathway. Cell reports. 2016 Academic Article GET IT
Times cited: 40
Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis. The Journal of clinical investigation. 2016 Academic Article GET IT
Times cited: 40
SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes. The Journal of cell biology. 2016 Academic Article GET IT
Times cited: 43
Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise. Cell metabolism. 2016 Academic Article GET IT
Times cited: 294
Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance. Diabetes. 2016 Academic Article GET IT
Times cited: 39
Altered Plasma Profile of Antioxidant Proteins as an Early Correlate of Pancreatic β Cell Dysfunction. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 12
The Microenvironment of Lung Cancer and Therapeutic Implications. Advances in experimental medicine and biology. 2016 Article GET IT
Times cited: 52
A STIM1-dependent 'trafficking trap' mechanism regulates Orai1 plasma membrane residence and Ca²⁺ influx levels. Journal of cell science. 2015 Academic Article GET IT
Times cited: 23
Development of a new model system to dissect isoform specific Akt signalling in adipocytes. The Biochemical journal. 2015 Academic Article GET IT
Times cited: 28
Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 2014 Academic Article GET IT
Times cited: 632
Anorexia and impaired glucose metabolism in mice with hypothalamic ablation of Glut4 neurons. Diabetes. 2014 Academic Article GET IT
Times cited: 27
A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity. Molecular and cellular biology. 2014 Academic Article GET IT
Times cited: 77
Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs. Molecular biology of the cell. 2013 Academic Article GET IT
Times cited: 59
Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor. Molecular cancer research : MCR. 2013 Academic Article GET IT
Times cited: 77
AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Molecular cell. 2013 Academic Article GET IT
Times cited: 492
TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism. Endocrinology. 2012 Academic Article GET IT
Times cited: 44
Ratio of positron emission tomography uptake to tumor size in surgically resected non-small cell lung cancer. The Annals of thoracic surgery. 2012 Academic Article GET IT
Times cited: 21
Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of phosphatidylinositol 3-kinase. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 46
Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 87
Rosiglitazone, PPARγ, and type 2 diabetes. The New England journal of medicine. 2010 Academic Article GET IT
Times cited: 60
Insulin-regulated aminopeptidase is a key regulator of GLUT4 trafficking by controlling the sorting of GLUT4 from endosomes to specialized insulin-regulated vesicles. Molecular biology of the cell. 2010 Academic Article GET IT
Times cited: 55
Stem cells: Metabolism regulates differentiation. Nature chemical biology. 2010 Academic Article GET IT
GLUT4 is sorted to vesicles whose accumulation beneath and insertion into the plasma membrane are differentially regulated by insulin and selectively affected by insulin resistance. Molecular biology of the cell. 2010 Academic Article GET IT
Times cited: 52
Metabolic surgery: the role of the gastrointestinal tract in diabetes mellitus. Nature reviews. Endocrinology. 2010 Information Resource GET IT
Times cited: 146
The Akt kinases: isoform specificity in metabolism and cancer. Cell cycle (Georgetown, Tex.). 2009 Information Resource GET IT
Times cited: 394
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 152
The CB1 endocannabinoid system modulates adipocyte insulin sensitivity. Obesity (Silver Spring, Md.). 2008 Academic Article GET IT
Times cited: 31
Molecular mechanisms controlling GLUT4 intracellular retention. Molecular biology of the cell. 2008 Academic Article GET IT
Times cited: 71
Insulin regulates leptin secretion from 3T3-L1 adipocytes by a PI 3 kinase independent mechanism. Experimental cell research. 2008 Academic Article GET IT
Times cited: 43
Use of quantitative immunofluorescence microscopy to study intracellular trafficking: studies of the GLUT4 glucose transporter. Methods in molecular biology (Clifton, N.J.). 2008 Academic Article GET IT
Times cited: 19
Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane. Cell metabolism. 2007 Academic Article GET IT
Times cited: 246
GLUT4 is internalized by a cholesterol-dependent nystatin-sensitive mechanism inhibited by insulin. The EMBO journal. 2006 Academic Article GET IT
Times cited: 97
Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane. Molecular biology of the cell. 2006 Academic Article GET IT
Times cited: 165
GLUT4 distribution between the plasma membrane and the intracellular compartments is maintained by an insulin-modulated bipartite dynamic mechanism. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 63
Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein. Cell metabolism. 2005 Academic Article GET IT
Times cited: 240
The transcription factor CCAAT/enhancer-binding protein alpha is required for the intracellular retention of GLUT4. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 11
Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160. Molecular biology of the cell. 2004 Academic Article GET IT
Times cited: 191
Chemical genetic screening identifies sulfonamides that raise organellar pH and interfere with membrane traffic. Traffic (Copenhagen, Denmark). 2004 Academic Article GET IT
Times cited: 28
Endocytic recycling. Nature reviews. Molecular cell biology. 2004 Information Resource GET IT
Times cited: 1397
Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic beta-cells. Molecular biology of the cell. 2004 Academic Article GET IT
Times cited: 57
GLUT4 is retained by an intracellular cycle of vesicle formation and fusion with endosomes. Molecular biology of the cell. 2003 Academic Article GET IT
Times cited: 162
Targeted chemical disruption of clathrin function in living cells. Molecular biology of the cell. 2003 Academic Article GET IT
Times cited: 53
Evidence for the interaction of the hereditary haemochromatosis protein, HFE, with the transferrin receptor in endocytic compartments. The Biochemical journal. 2003 Academic Article GET IT
Times cited: 32
CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl. Traffic (Copenhagen, Denmark). 2003 Academic Article GET IT
Times cited: 105
SARA, a FYVE domain protein, affects Rab5-mediated endocytosis. Journal of cell science. 2002 Academic Article GET IT
Times cited: 53
The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane. Nature cell biology. 2002 Academic Article GET IT
Times cited: 160
GLUT4 retention in adipocytes requires two intracellular insulin-regulated transport steps. Molecular biology of the cell. 2002 Academic Article GET IT
Times cited: 164
Insulin-regulated release from the endosomal recycling compartment is regulated by budding of specialized vesicles. Molecular biology of the cell. 2001 Academic Article GET IT
Times cited: 112
Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 235
Endocytosis: biochemical analyses. Current protocols in cell biology. 2001 Academic Article GET IT
Times cited: 4
A di-leucine sequence and a cluster of acidic amino acids are required for dynamic retention in the endosomal recycling compartment of fibroblasts. Molecular biology of the cell. 2001 Academic Article GET IT
Times cited: 76
Demonstration of insulin-responsive trafficking of GLUT4 and vpTR in fibroblasts. Journal of cell science. 2000 Academic Article GET IT
Times cited: 86
Characterization of the insulin-regulated endocytic recycling mechanism in 3T3-L1 adipocytes using a novel reporter molecule. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 71
Acute cholesterol depletion inhibits clathrin-coated pit budding. Proceedings of the National Academy of Sciences of the United States of America. 1999 Academic Article GET IT
Times cited: 498
An endocytosed TGN38 chimeric protein is delivered to the TGN after trafficking through the endocytic recycling compartment in CHO cells. The Journal of cell biology. 1998 Academic Article GET IT
Times cited: 214
Identification of an insulin-responsive, slow endocytic recycling mechanism in Chinese hamster ovary cells. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 48
The transferrin receptor cytoplasmic domain determines its rate of transport through the biosynthetic pathway and its susceptibility to cleavage early in the pathway. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 12
Overexpression of MAP4 inhibits organelle motility and trafficking in vivo. Journal of cell science. 1997 Academic Article GET IT
Times cited: 66
Bafilomycin A1 treatment retards transferrin receptor recycling more than bulk membrane recycling. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 133
Transferrin receptor containing the SDYQRL motif of TGN38 causes a reorganization of the recycling compartment but is not targeted to the TGN. The Journal of cell biology. 1996 Academic Article GET IT
Times cited: 32
The carboxyl terminus of GLUT4 contains a serine-leucine-leucine sequence that functions as a potent internalization motif in Chinese hamster ovary cells. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 52
Wortmannin-sensitive trafficking pathways in Chinese hamster ovary cells. Differential effects on endocytosis and lysosomal sorting. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 117
Studies of transferrin recycling reconstituted in streptolysin O permeabilized Chinese hamster ovary cells. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 32
An internalization motif is created in the cytoplasmic domain of the transferrin receptor by substitution of a tyrosine at the first position of a predicted tight turn. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 24
The amino terminus of GLUT4 functions as an internalization motif but not an intracellular retention signal when substituted for the transferrin receptor cytoplasmic domain. The Journal of cell biology. 1994 Academic Article GET IT
Times cited: 75
Regulation of endocytic trafficking and acidification are independent of the cystic fibrosis transmembrane regulator. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 49
Slowed receptor trafficking in mutant CHO lines of the End1 and End2 complementation groups. Journal of cellular physiology. 1994 Academic Article GET IT
Times cited: 14
Endosome acidification and receptor trafficking: bafilomycin A1 slows receptor externalization by a mechanism involving the receptor's internalization motif. Molecular biology of the cell. 1993 Academic Article GET IT
Times cited: 183
The End2 mutation in CHO cells slows the exit of transferrin receptors from the recycling compartment but bulk membrane recycling is unaffected. The Journal of cell biology. 1993 Academic Article GET IT
Times cited: 75
Isolation of a temperature-sensitive variant Chinese hamster ovary cell line with a morphologically altered endocytic recycling compartment. Journal of cellular physiology. 1993 Academic Article GET IT
Times cited: 62
Mutagenesis of the human transferrin receptor: two cytoplasmic phenylalanines are required for efficient internalization and a second-site mutation is capable of reverting an internalization-defective phenotype. The Journal of cell biology. 1991 Academic Article GET IT
Times cited: 50
Human transferrin receptor internalization is partially dependent upon an aromatic amino acid on the cytoplasmic domain. Cell regulation. 1990 Academic Article GET IT
Times cited: 126
Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosome. The Journal of cell biology. 1989 Academic Article GET IT
Times cited: 292
Phorbol ester treatment increases the exocytic rate of the transferrin receptor recycling pathway independent of serine-24 phosphorylation. The Journal of cell biology. 1988 Academic Article GET IT
Times cited: 47
Functional expression of the human transferrin receptor cDNA in Chinese hamster ovary cells deficient in endogenous transferrin receptor. The Journal of cell biology. 1987 Academic Article GET IT
Times cited: 179

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Research

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Funding awarded

Insulin control of GLUT4 traffic to the plasma membrane of adipocytes awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2020 - 2025

Immunoregulatory role of lung-resident club cell factors in lung cancer awarded by National Cancer Institute Co-Investigator 2023 - 2028
missing activity Co-Investigator 2021 - 2024

CAP-IT Center for LNP RNA Immunoprevention awarded by National Cancer Institute Co-Principal Investigator 2022 - 2027
Intercepting progression from pre-invasive to invasive lung adenocarcinoma awarded by National Cancer Institute Co-Principal Investigator 2019 - 2025

Research Training in Endocrinology and Metabolism awarded by National Institute of Diabetes & Digestive & Kidney Diseases Key Personnel 2023 - 2028

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Background

education and training

M.A., New York University 83
Ph.D., New York University 1985
B.A., University of Chicago 1978

Contact

full name

Timothy E. McGraw

primary email

temcgraw@med.cornell.edu

VIVO Weill Cornell Medical College

Timothy E. McGraw Professor of Biochemistry

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email