selected publications
- Lupus and inflammatory bowel disease share a common set of microbiome features distinct from other autoimmune disorders. Annals of the rheumatic diseases. 2024 Academic Article GET IT
- Validated, Quantitative, Machine Learning-Generated Neurologic Assessment of Multiple Sclerosis Using a Mobile Application. International journal of MS care. 2024 Academic Article GET IT
- Neuron-binding antibody responses are associated with Black ethnicity in multiple sclerosis during natalizumab treatment. Brain communications. 2023 Academic Article GET IT
- Clostridium perfringens Epsilon Toxin Binds to and Kills Primary Human Lymphocytes. Toxins. 2023 Academic Article GET IT
- Demographics and baseline disease characteristics of Black and Hispanic patients with multiple sclerosis in the open-label, single-arm, multicenter, phase IV CHIMES trial. Multiple sclerosis and related disorders. 2023 Academic Article GET IT
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Understanding humoral immunity and multiple sclerosis severity in Black, and Latinx patients.
Frontiers in immunology.
2023
Review
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Times cited: 7 - Epsilon toxin-producing Clostridium perfringens colonize the MS gut and epsilon toxin overcomes immune privilege. The Journal of clinical investigation. 2023 Academic Article GET IT
- Antigen-presenting innate lymphoid cells orchestrate neuroinflammation. Nature. 2021 Academic Article GET IT
- A Multi-Ligand Imaging Study Exploring GABAergic Receptor Expression and Inflammation in Multiple Sclerosis. Molecular imaging and biology. 2020 Academic Article GET IT
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Impact of Lesion Location on Longitudinal Myelin Water Fraction Change in Chronic Multiple Sclerosis Lesions.
Journal of neuroimaging : official journal of the American Society of Neuroimaging.
2020
Academic Article
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Times cited: 9 -
Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL.
PLoS pathogens.
2019
Academic Article
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Times cited: 25 -
Black African and Latino/a identity correlates with increased plasmablasts in MS.
Neurology(R) neuroimmunology & neuroinflammation.
2019
Academic Article
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Times cited: 15 -
Clostridium perfringens Epsilon Toxin Compromises the Blood-Brain Barrier in a Humanized Zebrafish Model.
iScience.
2019
Academic Article
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Times cited: 13 - A Novel Panel of Rabbit Monoclonal Antibodies and Their Diverse Applications Including Inhibition of Clostridium perfringens Epsilon Toxin Oligomerization. Antibodies (Basel, Switzerland). 2018 Academic Article GET IT
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Induction of disease remission with one cycle of alemtuzumab in relapsing-remitting MS.
Journal of neurology.
2018
Academic Article
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Times cited: 1 -
Thrombocytopenia at the time of alemtuzumab infusion in relapsing-remitting multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England).
2017
Article
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Times cited: 1 -
MRI Analysis of White Matter Myelin Water Content in Multiple Sclerosis: A Novel Approach Applied to Finding Correlates of Cortical Thinning.
Frontiers in neuroscience.
2017
Academic Article
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Times cited: 14 -
Reduction of PK11195 uptake observed in multiple sclerosis lesions after natalizumab initiation.
Multiple sclerosis and related disorders.
2017
Academic Article
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Times cited: 17 -
Immediate transient thrombocytopenia at the time of alemtuzumab infusion in multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England).
2017
Academic Article
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Times cited: 7 -
Oral Multiple Sclerosis Drugs Inhibit the In vitro Growth of Epsilon Toxin Producing Gut Bacterium, Clostridium perfringens.
Frontiers in cellular and infection microbiology.
2017
Academic Article
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Times cited: 54 -
Differential Impact of Multiple Sclerosis on Cortical and Deep Gray Matter Structures in African Americans and Caucasian Americans.
Journal of neuroimaging : official journal of the American Society of Neuroimaging.
2016
Academic Article
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Times cited: 10 -
A study of patients with aggressive multiple sclerosis at disease onset.
Neuropsychiatric disease and treatment.
2016
Academic Article
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Times cited: 10 -
Measuring longitudinal myelin water fraction in new multiple sclerosis lesions.
NeuroImage. Clinical.
2015
Academic Article
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Times cited: 58 -
Relapses in multiple sclerosis: Relationship to disability.
Multiple sclerosis and related disorders.
2015
Review
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Times cited: 29 -
Clostridium perfringens Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination.
mBio.
2015
Academic Article
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Times cited: 72 -
The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin.
PLoS pathogens.
2015
Academic Article
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Times cited: 69 -
Re-evaluating the treatment of acute optic neuritis.
Journal of neurology, neurosurgery, and psychiatry.
2014
Review
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Times cited: 26 -
Isolation of Clostridium perfringens type B in an individual at first clinical presentation of multiple sclerosis provides clues for environmental triggers of the disease.
PloS one.
2013
Academic Article
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Times cited: 177 -
T2 prep three-dimensional spiral imaging with efficient whole brain coverage for myelin water quantification at 1.5 tesla.
Magnetic resonance in medicine.
2012
Academic Article
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Times cited: 46 -
Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling.
Neuron.
2010
Academic Article
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Times cited: 62 -
Carbon monoxide suppresses membrane expression of TLR4 via myeloid differentiation factor-2 in betaTC3 cells.
Journal of immunology (Baltimore, Md. : 1950).
2010
Academic Article
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Times cited: 17 -
Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2.
Proceedings of the National Academy of Sciences of the United States of America.
2010
Academic Article
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Times cited: 299 -
A clear and present danger: endogenous ligands of Toll-like receptors.
Neuromolecular medicine.
2009
Review
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Times cited: 81 -
T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS.
Proceedings of the National Academy of Sciences of the United States of America.
2008
Academic Article
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Times cited: 295 -
More on melanoma with transdifferentiation.
The New England journal of medicine.
2008
Letter
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Times cited: 25 -
Melanoma complicating treatment with natalizumab for multiple sclerosis.
The New England journal of medicine.
2008
Letter
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Times cited: 87 -
Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2007
Academic Article
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Times cited: 189 -
The immunogenicity of disease-modifying therapies for multiple sclerosis: clinical implications for neurologists.
The neurologist.
2007
Review
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Times cited: 20 -
Myosin Va controls oligodendrocyte morphogenesis and myelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2007
Academic Article
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Times cited: 34 -
TLR8: an innate immune receptor in brain, neurons and axons.
Cell cycle (Georgetown, Tex.).
2007
Information Resource
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Times cited: 96 -
Treating multiple sclerosis in the natalizumab era: risks, benefits, clinical decision making, and a comparison between North American and European Union practices.
Reviews in neurological diseases.
2007
Review
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Times cited: 5 -
Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis.
The Journal of cell biology.
2006
Academic Article
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Times cited: 232 -
A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia.
Journal of immunology (Baltimore, Md. : 1950).
2006
Academic Article
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Times cited: 133 -
WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006
Academic Article
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Times cited: 85 -
Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator.
Proceedings of the National Academy of Sciences of the United States of America.
2006
Academic Article
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Times cited: 25 -
High-resolution anatomic, diffusion tensor, and magnetization transfer magnetic resonance imaging of the optic chiasm at 3T.
Journal of magnetic resonance imaging : JMRI.
2005
Academic Article
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Times cited: 24 -
Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes.
Proceedings of the National Academy of Sciences of the United States of America.
2005
Academic Article
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Times cited: 329 -
The ErbB4 neuregulin receptor mediates suppression of oligodendrocyte maturation.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2005
Academic Article
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Times cited: 64 -
Neutralizing antibodies to disease-modifying agents in the treatment of multiple sclerosis.
Neurology.
2004
Review
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Times cited: 26 -
Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination.
The Journal of cell biology.
2003
Academic Article
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Times cited: 136 -
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway.
Proceedings of the National Academy of Sciences of the United States of America.
2003
Academic Article
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Times cited: 901 - An examination of the results of the EVIDENCE, INCOMIN, and phase III studies of interferon beta products in the treatment of multiple sclerosis. Clinical therapeutics. 2003 Review GET IT
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Increased expression of epidermal growth factor receptor induces sequestration of extracellular signal-related kinases and selective attenuation of specific epidermal growth factor-mediated signal transduction pathways.
Molecular cancer research : MCR.
2003
Academic Article
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Times cited: 34 -
Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2002
Academic Article
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Times cited: 341 -
The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2002
Academic Article
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Times cited: 589 -
Sonic hedgehog is required during an early phase of oligodendrocyte development in mammalian brain.
Molecular and cellular neurosciences.
2001
Academic Article
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Times cited: 75 -
The erbB2 gene is required for the development of terminally differentiated spinal cord oligodendrocytes.
The Journal of cell biology.
2001
Academic Article
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Times cited: 90 -
Epidermal growth factor receptor induced apoptosis: potentiation by inhibition of Ras signaling.
FEBS letters.
2001
Academic Article
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Times cited: 34 -
Growth factor control of CNS myelination.
Developmental neuroscience.
2001
Academic Article
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Times cited: 52 -
Neuregulin-induced association of Sos Ras exchange protein with HER2(erbB2)/HER3(erbB3) receptor complexes in Schwann cells through a specific Grb2-HER2(erbB2) interaction.
Developmental neuroscience.
2001
Academic Article
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Times cited: 10 -
Neuregulin: an oligodendrocyte growth factor absent in active multiple sclerosis lesions.
Developmental neuroscience.
2001
Academic Article
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Times cited: 67 -
The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome.
The Journal of biological chemistry.
2000
Academic Article
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Times cited: 107 -
Neuregulin induces the rapid association of focal adhesion kinase with the erbB2-erbB3 receptor complex in schwann cells.
Biochemical and biophysical research communications.
2000
Academic Article
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Times cited: 30 -
Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein.
Nature.
2000
Academic Article
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Times cited: 997 -
Failure of spinal cord oligodendrocyte development in mice lacking neuregulin.
Proceedings of the National Academy of Sciences of the United States of America.
1999
Academic Article
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Times cited: 145 -
Axonal neuregulin signals cells of the oligodendrocyte lineage through activation of HER4 and Schwann cells through HER2 and HER3.
The Journal of cell biology.
1997
Academic Article
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Times cited: 157 -
Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis.
Molecular medicine (Cambridge, Mass.).
1995
Academic Article
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Times cited: 284 -
A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development.
Proceedings of the National Academy of Sciences of the United States of America.
1994
Academic Article
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Times cited: 97 -
Mediation by G proteins of signals that cause collapse of growth cones.
Science (New York, N.Y.).
1993
Academic Article
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Times cited: 169 -
Oligodendrocyte-substratum adhesion activates the synthesis of specific lipid species involved in cell signaling.
Journal of neuroscience research.
1992
Academic Article
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Times cited: 22 -
Phosphorylation of myelin basic protein in intact oligodendrocytes: inhibition by galactosylsphingosine and cyclic AMP.
Glia.
1989
Academic Article
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Times cited: 27 -
Oligodendrocyte substratum adhesion modulates expression of adenylate cyclase-linked receptors.
Proceedings of the National Academy of Sciences of the United States of America.
1988
Academic Article
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Times cited: 52 -
Intracellular messengers. Influence of oligodendrocyte substratum adhesion.
Annals of the New York Academy of Sciences.
1988
Academic Article
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Times cited: 1 -
Oligodendrocyte adhesion activates protein kinase C-mediated phosphorylation of myelin basic protein.
Science (New York, N.Y.).
1986
Academic Article
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Times cited: 101