Mittal, Vivek

Publications

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selected publications

Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1⁺ progenitor CD8⁺ T cells to improve immunotherapy. Nature immunology. 2024 Academic Article GET IT
A signature of enhanced proliferation associated with response and survival to anti-PD-L1 therapy in early-stage non-small cell lung cancer. Cell reports. Medicine. 2024 Academic Article GET IT
Author Correction: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. 2024 GET IT
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications. 2023 Academic Article GET IT
Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve checkpoint blockade. 2023 GET IT
A vertebral skeletal stem cell lineage driving metastasis. Nature. 2023 Academic Article GET IT
Times cited: 4
Tumor-targeted non-ablative radiation promotes solid tumor CAR T-cell therapy efficacy. Cancer immunology research. 2023 Academic Article GET IT
Simultaneous quantitative imaging of two PET radiotracers via the detection of positron-electron annihilation and prompt gamma emissions. Nature biomedical engineering. 2023 Academic Article GET IT
Times cited: 22
Epigenetic dysregulation from chromosomal transit in micronuclei. Nature. 2023 Academic Article GET IT
Times cited: 69
Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer. Nature communications. 2023 Academic Article GET IT
Times cited: 16
PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression. Nature communications. 2022 Academic Article GET IT
Global evolution of the tumor microenvironment associated with progression from preinvasive invasive to invasive human lung adenocarcinoma. Cell reports. 2022 Academic Article GET IT
Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. Science translational medicine. 2022 Academic Article GET IT
Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis. Nature communications. 2021 Academic Article GET IT
Times cited: 130
Connecting copper and cancer: from transition metal signalling to metalloplasia. Nature reviews. Cancer. 2021 Review GET IT
The metabolic adaptation evoked by arginine enhances the effect of radiation in brain metastases. Science advances. 2021 Academic Article GET IT
Radiation-activated secretory proteins of Scgb1a1⁺ club cells increase the efficacy of immune checkpoint blockade in lung cancer. Nature cancer. 2021 Academic Article GET IT
Times cited: 32
Tetrathiomolybdate (TM)-associated copper depletion influences collagen remodeling and immune response in the pre-metastatic niche of breast cancer. NPJ breast cancer. 2021 Academic Article GET IT
Times cited: 38
Tim-4⁺ cavity-resident macrophages impair anti-tumor CD8⁺ T cell immunity. Cancer cell. 2021 Academic Article GET IT
Times cited: 112
Correction: Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases. 2020 GET IT
Times cited: 1
Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531. eLife. 2020 Academic Article GET IT
Times cited: 5
Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer. Cell reports. 2020 Academic Article GET IT
Times cited: 14
Thrombospondin in Tumor Microenvironment. Advances in experimental medicine and biology. 2020 Review GET IT
Times cited: 10
Nanoparticle Delivery of miR-708 Mimetic Impairs Breast Cancer Metastasis. Molecular cancer therapeutics. 2019 Academic Article GET IT
Times cited: 58
The lung microenvironment: an important regulator of tumour growth and metastasis. Nature reviews. Cancer. 2019 Review GET IT
Times cited: 739
Metastatic tumor cells - genotypes and phenotypes. Frontiers in biology. 2018 Academic Article GET IT
Times cited: 14
Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival. JCI insight. 2018 Academic Article GET IT
Times cited: 48
Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis. Science translational medicine. 2017 Academic Article GET IT
Times cited: 92
Fischer et al. reply. Nature. 2017 Academic Article GET IT
Times cited: 13
The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein. The Journal of cell biology. 2017 Academic Article GET IT
Times cited: 34
Matrix Metalloproteinase 14 promotes lung cancer by cleavage of Heparin-Binding EGF-like Growth Factor. Neoplasia (New York, N.Y.). 2016 Academic Article GET IT
Times cited: 45
Cancer cell CCL5 mediates bone marrow independent angiogenesis in breast cancer. Oncotarget. 2016 Academic Article GET IT
Times cited: 28
Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases. Clinical cancer research : an official journal of the American Association for Cancer Research. 2016 Academic Article GET IT
Times cited: 132
Expression of the receptor for hyaluronic acid mediated motility (RHAMM) is associated with poor prognosis and metastasis in non-small cell lung carcinoma. Oncotarget. 2016 Academic Article GET IT
Times cited: 45
Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment. Science translational medicine. 2016 Academic Article GET IT
Times cited: 52
In Vivo Visualization and Characterization of Epithelial-Mesenchymal Transition in Breast Tumors. Cancer research. 2016 Academic Article GET IT
Times cited: 66
Epithelial Mesenchymal Transition in Aggressive Lung Cancers. Advances in experimental medicine and biology. 2016 Article GET IT
Times cited: 48
The Microenvironment of Lung Cancer and Therapeutic Implications. Advances in experimental medicine and biology. 2016 Article GET IT
Times cited: 52
Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 166
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance. Nature. 2015 Academic Article GET IT
Times cited: 1471
Identification of Reprogrammed Myeloid Cell Transcriptomes in NSCLC. PloS one. 2015 Academic Article GET IT
Times cited: 17
Transcriptome analysis of individual stromal cell populations identifies stroma-tumor crosstalk in mouse lung cancer model. Cell reports. 2015 Academic Article GET IT
Times cited: 52
Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 91
ID proteins regulate diverse aspects of cancer progression and provide novel therapeutic opportunities. Molecular therapy : the journal of the American Society of Gene Therapy. 2014 Information Resource GET IT
Times cited: 41
Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1. Cancer discovery. 2013 Academic Article GET IT
Times cited: 112
Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse. Annals of oncology : official journal of the European Society for Medical Oncology. 2013 Academic Article GET IT
Times cited: 78
Suppression of miRNA-708 by polycomb group promotes metastases by calcium-induced cell migration. Cancer cell. 2013 Academic Article GET IT
Times cited: 112
Internal hernias through the falciform ligament: a case series and comprehensive literature review of an increasingly common pathology. Hernia : the journal of hernias and abdominal wall surgery. 2012 Information Resource GET IT
Times cited: 16
Microenvironmental regulation of epithelial-mesenchymal transitions in cancer. Cancer research. 2012 Review GET IT
Times cited: 258
MicroRNAs regulate tumor angiogenesis modulated by endothelial progenitor cells. Cancer research. 2012 Academic Article GET IT
Times cited: 100
Tumor microenvironment regulates epithelial-mesenchymal transitions in metastasis. Expert review of anticancer therapy. 2012 Editorial Article GET IT
Times cited: 17
Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition. Cancer research. 2012 Academic Article GET IT
Times cited: 243
Epithelial-mesenchymal transition, cancer stem cells and treatment resistance. Breast cancer research : BCR. 2012 Information Resource GET IT
Times cited: 214
Incremental increase in VEGFR1⁺ hematopoietic progenitor cells and VEGFR2⁺ endothelial progenitor cells predicts relapse and lack of tumor response in breast cancer patients. Breast cancer research and treatment. 2011 Academic Article GET IT
Times cited: 30
Discovery of novel human breast cancer microRNAs from deep sequencing data by analysis of pri-microRNA secondary structures. PloS one. 2011 Academic Article GET IT
Times cited: 35
Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature. 2010 Academic Article GET IT
Times cited: 663
Using the transcription factor inhibitor of DNA binding 1 to selectively target endothelial progenitor cells offers novel strategies to inhibit tumor angiogenesis and growth. Cancer research. 2010 Academic Article GET IT
Times cited: 54
TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 339
Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth. Journal of the National Cancer Institute. 2010 Academic Article GET IT
Times cited: 55
Stem cells: Metabolism regulates differentiation. Nature chemical biology. 2010 Academic Article GET IT
The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression. Trends in molecular medicine. 2009 Academic Article GET IT
Times cited: 79
Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury. Gastroenterology. 2009 Academic Article GET IT
Times cited: 246
Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression. Biochimica et biophysica acta. 2009 Review GET IT
Times cited: 164
Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell stem cell. 2009 Academic Article GET IT
Times cited: 519
Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas. Proceedings of the National Academy of Sciences of the United States of America. 2008 Article GET IT
Times cited: 50
Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science (New York, N.Y.). 2008 Academic Article GET IT
Times cited: 536
Id1 restrains p21 expression to control endothelial progenitor cell formation. PloS one. 2007 Academic Article GET IT
Times cited: 64
ID genes mediate tumor reinitiation during breast cancer lung metastasis. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 220
Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 240
Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. Genes & development. 2007 Academic Article GET IT
Times cited: 364
Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization. PloS one. 2007 Academic Article GET IT
Times cited: 7
Genomics and proteomics approaches in understanding tumor angiogenesis. Expert review of molecular diagnostics. 2007 Information Resource GET IT
Times cited: 14
Biochemical characterization of RGS14: RGS14 activity towards G-protein alpha subunits is independent of its binding to Rap2A. The Biochemical journal. 2006 Academic Article GET IT
Times cited: 19
The RGS14 GoLoco domain discriminates among Galphai isoforms. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 53
Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature. 2004 Academic Article GET IT
Times cited: 441
Role of transposable elements in heterochromatin and epigenetic control. Nature. 2004 Academic Article GET IT
Times cited: 889
Improving the efficiency of RNA interference in mammals. Nature reviews. Genetics. 2004 Information Resource GET IT
Times cited: 234
Inducible, reversible, and stable RNA interference in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 197
Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors. Cancer cell. 2003 Academic Article GET IT
Times cited: 216
High-throughput selection of effective RNAi probes for gene silencing. Genome research. 2003 Academic Article GET IT
Times cited: 154
Nitric oxide activates diverse signaling pathways to regulate gene expression. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 126
Distinct sites on G protein beta gamma subunits regulate different effector functions. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 42
Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America. 2001 Academic Article GET IT
Times cited: 51
SNAP(c): a core promoter factor with a built-in DNA-binding damper that is deactivated by the Oct-1 POU domain. Genes & development. 1999 Academic Article GET IT
Times cited: 60
SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III. Genes & development. 1998 Academic Article GET IT
Times cited: 68
Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins. Somatic cell and molecular genetics. 1998 Academic Article GET IT
Times cited: 223
Role for the amino-terminal region of human TBP in U6 snRNA transcription. Science (New York, N.Y.). 1997 Academic Article GET IT
Times cited: 75
Replication initiates at multiple dispersed sites in the ribosomal DNA plasmid of the protozoan parasite Entamoeba histolytica. Molecular and cellular biology. 1996 Academic Article GET IT
Times cited: 18
The Oct-1 POU-specific domain can stimulate small nuclear RNA gene transcription by stabilizing the basal transcription complex SNAPc. Molecular and cellular biology. 1996 Academic Article GET IT
Times cited: 67
Nucleotide sequence organisation and analysis of the nuclear ribosomal DNA circle of the protozoan parasite Entamoeba histolytica. Molecular and biochemical parasitology. 1994 Academic Article GET IT
Times cited: 53
Isolation and characterization of a species-specific multicopy DNA sequence from Entamoeba histolytica. Parasitology. 1994 Academic Article GET IT
Times cited: 7
Serum sialic acid--an important cancer marker. Indian journal of cancer. 1993 Academic Article GET IT
Times cited: 36
A second short repeat sequence detected downstream of rRNA genes in the Entamoeba histolytica rDNA episome. Molecular and biochemical parasitology. 1992 Academic Article GET IT
Times cited: 12
Sequence analysis of a DNA fragment with yeast autonomously replicating sequence activity from the extrachromosomal ribosomal DNA circle of Entamoeba histolytica. Nucleic acids research. 1991 Academic Article GET IT
Times cited: 10

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Research

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Co-investigator Network

Funding awarded

ER stress-driven IRE1a-XBP1 signaling in lung cancer awarded by National Cancer Institute Principal Investigator 2023 - 2028
Immunoregulatory role of lung-resident club cell factors in lung cancer awarded by National Cancer Institute Principal Investigator 2023 - 2028
Copper-Mediated Metabolic Reprogramming And ECM Alterations In TNBC Metastasis awarded by National Cancer Institute Principal Investigator 2021 - 2026
MSK Spore in Genomic Instability in Breast Cancer awarded by Stand Up To Cancer Principal Investigator 2024 - 2024
missing activity Principal Investigator 2021 - 2024

Discovery of a stem cell driving breast cancer spine metastases awarded by National Cancer Institute Co-Investigator 2024 - 2029
Targeting cytidine deaminase-induced chromosomal instability as a driver of metastasis in bladder cancer awarded by Starr Cancer Consortium Co-Investigator 2023 - 2024

CAP-IT Center for LNP RNA Immunoprevention awarded by National Cancer Institute Co-Principal Investigator 2022 - 2027
Intercepting progression from pre-invasive to invasive lung adenocarcinoma awarded by National Cancer Institute Co-Principal Investigator 2019 - 2025

Elucidating the oncogenic role of EMSY in non-small cell lung cancer awarded by United States Department of Defense Key Personnel 2024 - 2026
Modulation of CD8+ T cell differentiation and anti-tumor immunity by metabolic manipulation awarded by National Center for Advancing Translational Sciences Key Personnel 2024 - 2026
Genetically engineered stem cell like T cells for the treatment of NSCLC awarded by American Association for Thoracic Surgery Key Personnel 2024 - 2026
T cells selected from lymph node acquisition for adoptive cell treatment of solid tumors awarded by Daedalus Fund for Innovation (Weill Cornell) Key Personnel 2024 - 2025
Targeting APOBEC3A-induced chromosomal instability as a driver of metastasis in bladder cancer awarded by United States Department of Defense Key Personnel 2023 - 2025
Characterizing T cell PD-1 response in the tumor draining lymph nodes of early-stage NSCLC patients awarded by International Association for the Study of Lung Cancer Key Personnel 2023 - 2025
To study the EMT contributions in tumor metastasis and chemoresistance by using lineage tracing models awarded by National Cancer Institute Key Personnel 2020 - 2025
Determine Mechanisms by Which Club Cell Factor/s Inhibit Myeloid-derived Suppressor Cells to Increase Efficacy of Immunotherapy in Lung Cancer awarded by PhRMA Foundation Key Personnel 2023 - 2024
Tumor draining lymph node immunomodulation to decrease recurrence in NSCLC awarded by LUNGevity Foundation Key Personnel 2022 - 2024

MSK Spore in Genomic Instability in Breast Cancer awarded by Stand Up To Cancer Principal Investigator Subaward 2024 - 2024

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Background

education and training

Ph.D., Jawaharlal Nehru University (India) 94
M.Sc., Jawaharlal Nehru University (India) 1988
B.Sc., St. Joseph's College (India) 1985

Contact

full name

Vivek Mittal

primary email

vim2010@med.cornell.edu

VIVO Weill Cornell Medical College

Vivek Mittal Professor of Cell and Developmental Biology in Cardiothoracic Surgery

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email