Huang, Xiangao

Publications

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selected publications

Intracellular Activation of Dual-Pharmacophore Artezomib Enhances Selective Cytotoxicity in Hematologic Malignancies. Journal of medicinal chemistry. 2026 Academic Article GET IT
CDK4/6 Inhibition Reverses MEIS2 Suppression of CRL4 ^CRBN to Enhance Immunomodulatory Drug Therapy in Multiple Myeloma. bioRxiv : the preprint server for biology. 2025 Article GET IT
Leveraging BRG1 Driven Ferroptosis Resistance to Overcome Treatment Resistance. bioRxiv : the preprint server for biology. 2025 Article GET IT
Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance. Nature communications. 2023 Academic Article GET IT
Times cited: 20
A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas. The Journal of clinical investigation. 2022 Academic Article GET IT
Times cited: 20
Caspase-8 Regulates the Antimyeloma Activity of Bortezomib and Lenalidomide. The Journal of pharmacology and experimental therapeutics. 2021 Academic Article GET IT
Times cited: 10
Caspase-8 Inhibition Prevents the Cleavage and Degradation of E3 Ligase Substrate Receptor Cereblon and Potentiates Its Biological Function. Frontiers in cell and developmental biology. 2020 Academic Article GET IT
Times cited: 6
Cell Cycle Dysregulation in Mantle Cell Lymphoma: Genomics and Therapy. Hematology/oncology clinics of North America. 2020 Information Resource GET IT
Times cited: 11
Targeting CDK4/6 in mantle cell lymphoma. Annals of lymphoma. 2020 Academic Article GET IT
A phase I trial of palbociclib plus bortezomib in previously treated mantle cell lymphoma. Leukemia & lymphoma. 2019 Academic Article GET IT
Times cited: 23
A phase 1 trial of ibrutinib plus palbociclib in previously treated mantle cell lymphoma. Blood. 2019 Academic Article GET IT
Times cited: 73
A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015 Academic Article GET IT
Times cited: 48
Phase 1/2 study of cyclin-dependent kinase (CDK)4/6 inhibitor palbociclib (PD-0332991) with bortezomib and dexamethasone in relapsed/refractory multiple myeloma. Leukemia & lymphoma. 2015 Academic Article GET IT
Times cited: 61
CDK4/6 Inhibitor PD 0332991 Sensitizes Acute Myeloid Leukemia to Cytarabine-Mediated Cytotoxicity. Cancer research. 2015 Academic Article GET IT
Times cited: 55
Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma. Cancer discovery. 2014 Academic Article GET IT
Times cited: 252
Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling. Cancer discovery. 2014 Academic Article GET IT
Times cited: 164
Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1. Cell cycle (Georgetown, Tex.). 2013 Academic Article GET IT
Times cited: 70
Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4. Blood. 2012 Academic Article GET IT
Times cited: 78
MAGE-A inhibits apoptosis in proliferating myeloma cells through repression of Bax and maintenance of survivin. Clinical cancer research : an official journal of the American Association for Cancer Research. 2011 Academic Article GET IT
Times cited: 93
Noxa mediates p18INK4c cell-cycle control of homeostasis in B cells and plasma cell precursors. Blood. 2010 Academic Article GET IT
Times cited: 23
A novel therapeutic combination using PD 0332991 and bortezomib: study in the 5T33MM myeloma model. Cancer research. 2008 Academic Article GET IT
Times cited: 101
Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G1/S transition in opposition to p18INK4c and p27Kip1. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 52
Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235. Experimental neurology. 2003 Academic Article GET IT
Times cited: 30

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Background

education and training

Ph.D., University of Hong Kong (China) 2002
M.Sc., Guangxi Agricultural College (China) 1992
B.Sc., Guangxi Agricultural College (China) 1989

Contact

full name

Xiangao Huang

primary email

xih2004@med.cornell.edu

VIVO Weill Cornell Medical College

Xiangao Huang Assistant Professor of Research in Pathology and Laboratory Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email