Cell Cycle Dysregulation in Mantle Cell Lymphoma: Genomics and Therapy. Review uri icon

Overview

abstract

  • Cell cycle dysregulation caused by aberrant cyclin D1 and CDK4 expression is a major determinant for proliferation of cancer cells in mantle cell lymphoma (MCL). Inhibition of CDK4/6 induces G1 arrest of MCL cells in patients, appearing to deepen and prolong the clinical response to partner agents. This article reviews aberrations of cell cycle genes in MCL cells and clinical trials of CDK4/6 inhibitors for MCL. Integrative longitudinal functional genomics is discussed as a strategy to discover genomic drivers for resistance in cancer cells and cancer-immune interactions that potentially contribute to the clinical response to palbociclib combination therapy in MCL.

publication date

  • August 1, 2020

Research

keywords

  • Cyclin D1
  • Cyclin-Dependent Kinase 4
  • Cyclin-Dependent Kinase 6
  • G1 Phase Cell Cycle Checkpoints
  • Lymphoma, Mantle-Cell
  • Piperazines
  • Pyridines

Identity

PubMed Central ID

  • PMC7461610

Scopus Document Identifier

  • 85088864983

Digital Object Identifier (DOI)

  • 10.1016/j.hoc.2020.05.003

PubMed ID

  • 32861279

Additional Document Info

volume

  • 34

issue

  • 5