Xin-Yun Huang   Professor of Biochemistry and Biophysics

Structural Biochemistry and Translational Cancer Research

1. Structural Basis of Transmembrane Signaling

Our research is dedicated to uncovering the biochemical and structural intricacies of cross-membrane signaling, with a primary focus on 7-transmembrane G-protein-coupled receptors (GPCRs) and single-pass transmembrane receptors. In the realm of GPCRs, we strive to elucidate the activation mechanisms of both GPCRs and G-proteins, which are pivotal in biological signaling. To explore these molecular intricacies, we employ advanced cryo-electron microscopy (Cryo-EM) techniques. Our research also extends to investigating the structural basis of single-pass transmembrane receptors, aiming to provide a comprehensive understanding of transmembrane signaling processes.

2. Tumor Metastasis, Cancer Immunotherapy, and Drug Development

Tumor metastasis, the leading cause of cancer-related deaths, is a primary focus of our research. We delve into the mechanisms underlying tumor cell migration and invasion, identifying key proteins that drive these processes. By targeting these proteins for drug development, we aim to create effective treatments to curb tumor metastasis. Additionally, our research explores the roles of dendritic cells in cancer immunotherapy, contributing to the development of new cancer treatment approaches.

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Contact

full name

  • Xin-Yun Huang

primary email

  • xyhuang@med.cornell.edu

External Relationships

externalRelationships

  • Relationships and collaborations with for-profit and not-for-profit organizations are of vital importance to our faculty because these exchanges of scientific information foster innovation. As experts in their fields, WCM physicians and scientists are sought after by many organizations to consult and educate. WCM and its faculty make this information available to the public, thus creating a transparent environment.

    Advisory/Scientific Board Member refers to a group of individuals who have been selected to advise a business regarding any number of issues (e.g., scientific advisory board member, medical advisory board member)Advisory/Scientific Board Member:
    Novita Pharmaceuticals, Inc.
    Leadership Roles refer to an individual with decision-making responsibility to an outside company (e.g., board of directors, officer, trustee)Leadership Roles:
    Novita Pharmaceuticals, Inc.
    Ownership refers to any financial stake an individual owns in any company (e.g., stock options, equity interest)Ownership:
    Novita Pharmaceuticals, Inc.
    Proprietary Interest refers to ownership of intellectual property rights (e.g., trademarks, patents, royalty income)Proprietary Interest:
    Novita Pharmaceuticals, Inc.