Xin-Yun Huang   Professor of Physiology and Biophysics

Structural Biology and Translational Cancer Research

1.  Structural Biology of the Mechanisms of Activation of G-proteins by GPCRs

The signaling from G-protein-coupled receptors (GPCRs) to G-proteins is one of the main signaling systems used in biology.  Although we have an outline of this signaling system, the molecular bases for many steps in this signaling cascade are poorly understood.  One of the pressing issues is how GPCRs activate G-proteins.  Currently we use the cryo-electron microscopy (Cryo-EM) technique to investigate this question.

2.  Tumor Metastasis, Cancer Immunotherapy and Drug Development

Tumor metastasis is the major cause of death of cancer patients, responsible for more than 90% of all cancer deaths.  We focus on tumor metastasis, more specifically, on tumor cell migration and invasion.  Our long-term goal of this research program is to reveal the critical proteins for tumor cell migration and invasion, and to use these proteins as targets for drug development to block tumor metastasis.  In addition, we are investigating the roles of dendritic cells and macrophages in cancer immunotherapy.

Publications

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Research

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Funding awarded

  • Molecular Basis of B1-Adrenergic Receptor Function  awarded by National Institute of General Medical Sciences Principal Investigator 2020 - 2024

Background

Contact

full name

  • Xin-Yun Huang

primary email

  • xyhuang@med.cornell.edu

External Relationships

externalRelationships

  • Relationships and collaborations with for-profit and not-for-profit organizations are of vital importance to our faculty because these exchanges of scientific information foster innovation. As experts in their fields, WCM physicians and scientists are sought after by many organizations to consult and educate. WCM and its faculty make this information available to the public, thus creating a transparent environment.

    Advisory/Scientific Board Member refers to a group of individuals who have been selected to advise a business regarding any number of issues (e.g., scientific advisory board member, medical advisory board member)Advisory/Scientific Board Member:
    Novita Pharmaceuticals, Inc.
    Leadership Roles refer to an individual with decision-making responsibility to an outside company (e.g., board of directors, officer, trustee)Leadership Roles:
    Novita Pharmaceuticals, Inc.
    Ownership refers to any financial stake an individual owns in any company (e.g., stock options, equity interest)Ownership:
    Novita Pharmaceuticals, Inc.
    Proprietary Interest refers to ownership of intellectual property rights (e.g., trademarks, patents, royalty income)Proprietary Interest:
    Novita Pharmaceuticals, Inc.