Mouse models for tumor metastasis. Academic Article uri icon

Overview

abstract

  • Tumor metastasis is the main cause of death of cancer patients. Here we describe two mouse models for investigating tumor metastasis. In the first spontaneous metastasis mouse model, 4T1 mouse breast tumor cells are injected into the mammary gland of host mice and the metastasis of 4T1 tumor cells into the lung are examined with a colonogenic assay. In the second experimental metastasis mouse model, luciferase-labeled MDA-MB-231 human breast tumor cells are injected into the tail vein of NOD-SCID immunodeficient mice and the colonization of MDA-MB-231 tumor cells in the lung are monitored using noninvasive bioluminescence imaging.

publication date

  • January 1, 2012

Research

keywords

  • Mammary Neoplasms, Animal
  • Neoplasm Metastasis

Identity

PubMed Central ID

  • PMC3674868

Scopus Document Identifier

  • 84868550653

Digital Object Identifier (DOI)

  • 10.1007/978-1-62703-008-3_17

PubMed ID

  • 22956145

Additional Document Info

volume

  • 928