Wu, Zhuhao

Publications

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selected publications

Brain-wide neuronal circuit connectome of human glioblastoma. Nature. 2025 Academic Article GET IT
Neuronal diversity and stereotypy at multiple scales through whole brain morphometry. Nature communications. 2024 Academic Article GET IT
Characteristics of blood-brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells. Nature neuroscience. 2024 Academic Article GET IT
Massively parallel in vivo Perturb-seq reveals cell-type-specific transcriptional networks in cortical development. Cell. 2024 Academic Article GET IT
Functional sensory circuits built from neurons of two species. Cell. 2024 Academic Article GET IT
Times cited: 1
Fine-tuning TrailMap: The utility of transfer learning to improve the performance of deep learning in axon segmentation of light-sheet microscopy images. PloS one. 2024 Academic Article GET IT
Regulation of Axon Degeneration after Injury and in Development by the Endogenous Calpain Inhibitor Calpastatin. 2023 GET IT
Fine-tuning TrailMap: The utility of transfer learning to improve the performance of deep learning in axon segmentation of light-sheet microscopy images. 2023 GET IT
A suite of engineered mice for interrogating psychedelic drug actions. 2023 GET IT
Cortical Brain Injury Causes Retrograde Degeneration of Afferent Basal Forebrain Cholinergic Neurons via the p75NTR. eNeuro. 2023 Academic Article GET IT
Full-Spectrum Neuronal Diversity and Stereotypy through Whole Brain Morphometry. 2023 GET IT
Activation of MAP2K signaling by genetic engineering or HF-rTMS promotes corticospinal axon sprouting and functional regeneration. Science translational medicine. 2023 Academic Article GET IT
Ex situ perfusion fixation for brain banking: a technical report. Free neuropathology. 2022 Academic Article GET IT
Times cited: 5
Delayed Infiltration of Peripheral Monocyte Contributes to Phagocytosis and Transneuronal Degeneration in Chronic Stroke. Stroke. 2022 Academic Article GET IT
Times cited: 17
An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling. Cell stem cell. 2022 Academic Article GET IT
Times cited: 41
Cross-modal coherent registration of whole mouse brains. Nature methods. 2021 Academic Article GET IT
Times cited: 10
Optical Clearing and 3D Analysis Optimized for Mouse and Human Pancreata. Bio-protocol. 2021 Academic Article GET IT
Times cited: 3
Topographical organization of mammillary neurogenesis and efferent projections in the mouse brain. Cell reports. 2021 Academic Article GET IT
Times cited: 2
A 3D atlas of the dynamic and regional variation of pancreatic innervation in diabetes. Science advances. 2020 Academic Article GET IT
Times cited: 41
Sustained Increases in Immune Transcripts and Immune Cell Trafficking During the Recovery of Experimental Brain Ischemia. Stroke. 2020 Academic Article GET IT
Times cited: 18
Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cell number and organ growth. eLife. 2019 Academic Article GET IT
Times cited: 27
Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain. Cell. 2019 Academic Article GET IT
Times cited: 269
Regulation of Energy Expenditure by Brainstem GABA Neurons. Cell. 2019 Academic Article GET IT
Times cited: 69
Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration. eLife. 2019 Academic Article GET IT
Times cited: 39
Long-Range Guidance of Spinal Commissural Axons by Netrin1 and Sonic Hedgehog from Midline Floor Plate Cells. Neuron. 2019 Academic Article GET IT
Times cited: 36
Genetic access to neurons in the accessory optic system reveals a role for Sema6A in midbrain circuitry mediating motion perception. The Journal of comparative neurology. 2018 Academic Article GET IT
Times cited: 17
Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue. Journal of visualized experiments : JoVE. 2018 Academic Article GET IT
Times cited: 55
Cdc42 Regulates Neuronal Polarity during Cerebellar Axon Formation and Glial-Guided Migration. iScience. 2018 Academic Article GET IT
Times cited: 35
Netrin-1 Confines Rhombic Lip-Derived Neurons to the CNS. Cell reports. 2018 Academic Article GET IT
Times cited: 20
Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density. Cell metabolism. 2018 Academic Article GET IT
Times cited: 129
Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells. Nature biotechnology. 2017 Academic Article GET IT
Times cited: 169
GLUT4 Mobilization Supports Energetic Demands of Active Synapses. Neuron. 2017 Academic Article GET IT
Times cited: 208
Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes. Cell. 2016 Academic Article GET IT
Times cited: 543
Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 120
Floor plate-derived neuropilin-2 functions as a secreted semaphorin sink to facilitate commissural axon midline crossing. Genes & development. 2015 Academic Article GET IT
Times cited: 19
Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell. 2015 Academic Article GET IT
Times cited: 240
Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution. Neuron. 2014 Academic Article GET IT
Times cited: 52
iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging. Cell. 2014 Academic Article GET IT
Times cited: 1035
Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. Science (New York, N.Y.). 2014 Academic Article GET IT
Times cited: 138
Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of β-secretase. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Academic Article GET IT
Times cited: 46
Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin. Neuron. 2013 Academic Article GET IT
Times cited: 132
The coordinate regulation of sensory afferent CNS targeting and CNS longitudinal tract organization in Drosophila during neural development. Journal of the peripheral nervous system : JPNS. 2012 Review GET IT
Times cited: 3
Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting. Neuron. 2011 Academic Article GET IT
Times cited: 59
A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS. Neuron. 2011 Academic Article GET IT
Times cited: 69
A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning. Nature neuroscience. 2009 Academic Article GET IT
Times cited: 115

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Research

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Funding awarded

Investigating the Neurobiology of Early Cognitive Impairment awarded by Pershing Square Sohn Cancer Research Alliance, The Principal Investigator Subaward 2024 - 2029
Mechanisms of anosmia and brain infection in a mouse model of COVID-19 awarded by Pershing Square Sohn Cancer Research Alliance, The Principal Investigator Subaward 2023 - 2028
BRAIN CONNECTS: The Center for Large-scale Imaging of Neural Circuits (LINC) awarded by National Institute of Neurological Disorders & Stroke Principal Investigator Subaward 2023 - 2028
Global mapping of altered neural circuits in a mouse model of DDX3X mutations awarded by Pershing Square Sohn Cancer Research Alliance, The Principal Investigator Subaward 2023 - 2028
In vivo Perturb-map: scalable genetic screens with single-cell and spatial resolution in intact tissues awarded by National Human Genome Research Institute Principal Investigator Subaward 2023 - 2027
Genetic circuitry governing heart growth and repair awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2022 - 2027
A clear view of encephalitis: a single cell approach to determine the basis of flaviviral pathogenesis in the central nervous system awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2023 - 2026
Molecular control of cardiac regenerative potential awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2023 - 2026
Cell type atlasing of whole human brains using HOLiS: an optimized pipeline for staining, clearing, imaging, and analysis awarded by National Institute of Child Health & Human Development Principal Investigator Subaward 2022 - 2025
missing activity Principal Investigator Subaward 2023 - 2024
missing activity Principal Investigator Subaward 2022 - 2024

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Background

education and training

Ph.D., The Johns Hopkins University School of Medicine 2011
B.S., Tsinghua University (China) 2003

Contact

full name

Zhuhao Wu

primary email

zhw4007@med.cornell.edu

VIVO Weill Cornell Medical College

Zhuhao Wu Assistant Professor of Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email