Developmental biology

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Pronounced early differentiation underlies zebra finch gonadal germ cell development. 2024
Methods for dynamic and whole volume imaging of the zebrafish heart.. 504. 2023
Zinc finger RNA binding protein 2 (ZFR2) is not required for male fertility in the mouse. 2022
miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta.. 449. 2019
Hspb7 is a cardioprotective chaperone facilitating sarcomeric proteostasis.. 435. 2018
Three Tctn proteins are functionally conserved in the regulation of neural tube patterning and Gli3 processing but not ciliogenesis and Hedgehog signaling in the mouse.. 430. 2017
PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant.. 429. 2017
STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development.. 428. 2017
SHH ventralizes the otocyst by maintaining basal PKA activity and regulating GLI3 signaling.. 420. 2016
Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development.. 404. 2015
A requirement for Gch1 and tetrahydrobiopterin in embryonic development.. 399. 2014
Role for endocytosis of a constitutively active GPCR (GPR185) in releasing vertebrate oocyte meiotic arrest.. 395. 2014
Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton.. 392. 2014
Huntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cells.. 391. 2014
Small heat shock proteins Hspb7 and Hspb12 regulate early steps of cardiac morphogenesis.. 381. 2013
Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants.. 379. 2013
Wnt signaling though beta-catenin is required for prostate lineage specification.. 371. 2012
The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development.. 369. 2012
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.. 368. 2012
Intracellular pH regulation by Na⁺/H⁺ exchanger-1 (NHE1) is required for growth factor-induced mammary branching morphogenesis.. 365. 2012
Rex1 (Zfp42) null mice show impaired testicular function, abnormal testis morphology, and aberrant gene expression.. 356. 2011
The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis.. 356. 2011
Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice.. 338. 2009
Gata4 directs development of cardiac-inducing endoderm from ES cells.. 337. 2009
DeltaNp63 antagonizes p53 to regulate mesoderm induction in Xenopus laevis.. 329. 2009
Paraxial mesoderm contributes stromal cells to the developing kidney.. 329. 2009
Transcription factor Lmo4 defines the shape of functional areas in developing cortices and regulates sensorimotor control.. 327. 2008
Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development.. 326. 2008
Notochord-derived BMP antagonists inhibit endothelial cell generation and network formation.. 326. 2008
Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4.. 325. 2008
Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects.. 325. 2008
Internalization of plasma membrane Ca2+-ATPase during Xenopus oocyte maturation.. 324. 2008
The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning.. 321. 2008
Identification of downstream genetic pathways of Tbx1 in the second heart field.. 316. 2008
CYP26A1 knockout embryonic stem cells exhibit reduced differentiation and growth arrest in response to retinoic acid.. 315. 2007
A spatial bias for the origins of interneuron subgroups within the medial ganglionic eminence.. 314. 2007
Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes.. 312. 2007
Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb.. 311. 2007
The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning.. 305. 2007
Identification of interventricular septum precursor cells in the mouse embryo.. 302. 2006
TrkB/BDNF signaling regulates photoreceptor progenitor cell fate decisions.. 299. 2006
Contribution of human embryonic stem cells to mouse blastocysts.. 295. 2006
Calcium signaling differentiation during Xenopus oocyte maturation.. 288. 2005
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli.. 287. 2005
Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins beta1 and beta2.. 283. 2005
Dosage-dependent requirement for mouse Vezf1 in vascular system development.. 283. 2005
Phenotypic analysis of EcR-A mutants suggests that EcR isoforms have unique functions during Drosophila development.. 282. 2005
Increased sensitivity and clustering of elementary Ca2+ release events during oocyte maturation.. 275. 2004
Coordinate regulation of neural tube patterning and proliferation by TGFbeta and WNT activity.. 274. 2004
Sox1 acts through multiple independent pathways to promote neurogenesis.. 269. 2004
Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis.. 268. 2004
T-box binding sites are required for activity of a cardiac GATA-4 enhancer.. 267. 2004
Annexin II-mediated plasmin generation activates TGF-beta3 during epithelial-mesenchymal transformation in the developing avian heart.. 265. 2004
Trk C receptor signaling regulates cardiac myocyte proliferation during early heart development in vivo.. 226. 2000
Anterior endoderm is sufficient to rescue foregut apoptosis and heart tube morphogenesis in an embryo lacking retinoic acid.. 219. 2000
A role for GATA-4/5/6 in the regulation of Nkx2.5 expression with implications for patterning of the precardiac field.. 216. 1999
Ectopic expression of the nude gene induces hyperproliferation and defects in differentiation: implications for the self-renewal of cutaneous epithelia.. 212. 1999
Retinoid signaling required for normal heart development regulates GATA-4 in a pathway distinct from cardiomyocyte differentiation.. 206. 1999
Vezf1: A Zn finger transcription factor restricted to endothelial cells and their precursors.. 206. 1999
Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse, and null mutant Drosophila.. 205. 1999
Neural crest-specific and general expression of distinct metalloprotease-disintegrins in early Xenopus laevis development.. 204. 1998
Evidence for distinct serine protease activities with a potential role in processing the sperm protein fertilin.. 191. 1997
Identification of metalloprotease/disintegrins in Xenopus laevis testis with a potential role in fertilization.. 186. 1997
Inhibition of chondrogenesis by Wnt gene expression in vivo and in vitro.. 185. 1997
Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium.. 183. 1997
Neurotrophin and neurotrophin receptors in human fetal kidney.. 179. 1996
A novel chloride channel localizes to Caenorhabditis elegans spermatids and chloride channel blockers induce spermatid differentiation.. 176. 1996
The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis.. 174. 1996
Induction of kidney epithelial morphogenesis by cells expressing Wnt-1.. 166. 1994
Conversion of anterior limb bud cells to ZPA signaling cells in vitro and in vivo.. 164. 1994
Changing patterns of the retinoic acid system in the developing retina.. 158. 1993
Cloning and characterization of a novel Drosophila Wnt gene, Dwnt-5, a putative downstream target of the homeobox gene distal-less.. 154. 1992
Immunocytochemical and biochemical characterization of guanine nucleotide-binding regulatory proteins in mammalian spermatozoa.. 146. 1991
Zona pellucida-mediated acrosomal exocytosis in mouse spermatozoa: characterization of an intermediate stage prior to the completion of the acrosome reaction.. 145. 1991
Polarized release of enveloped viruses in the embryonic chick heart: demonstration of epithelial polarity in the presumptive myocardium.. 141. 1990
Developmental discord among markers for cholinergic differentiation: in vitro time courses for early expression and responses to skeletal muscle extract.. 125. 1988
Immunochemical analysis of protein isoforms in thick myofilaments of regenerating skeletal muscle.. 119. 1987
Myosin heavy chain expression in embryonic cardiac cell cultures.. 115. 1986
Low-molecular-weight peptide stimulates cholinergic development in ventral spinal cord cultures.. 112. 1985
Molecular forms of acetylcholinesterase in Xenopus muscle.. 110. 1985
Molecular cloning of gene sequences transcriptionally regulated by retinoic acid and dibutyryl cyclic AMP in cultured mouse teratocarcinoma cells.. 107. 1985
Butyrate inhibits the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells.. 105. 1984
Coexistence of fast-type and slow-type C-proteins in neonatal chicken breast muscle.. 105. 1984
Immunochemical analysis of C-protein isoform transitions during the development of chicken skeletal muscle.. 101. 1984
Analysis of population cytokinetics of chick myocardial cells in tissue culture.. 97. 1983
Induction of cell attachment and morphological differentiation in a pheochromocytoma cell line and embryonal sensory cells by the extracellular matrix.. 93. 1982
Fibrillary astrocytes proliferate in response to brain injury: a study combining immunoperoxidase technique for glial fibrillary acidic protein and radioautography of tritiated thymidine.. 72. 1979
Control of pattern duplication in the retinotectal system of Xenopus. Suppression of duplication by eye-fragment interactions.. 69. 1979
Muscle development in vitro following X irradiation.. 66. 1978
Mitochondrial development during myogenesis.. 58. 1977
Myosin accumulation in mononucleated cells of chick muscle cultures.. 48. 1976
Scanning electron microscopy of nerve-muscle contacts in embryonic cell culture.. 43. 1975
The correlation of DNA synthesis and DNA polymerase activity in the developing chick heart.. 37. 1974
Scanning electron microscopy of cell aggregation: cardiac and mixed retina-cardiac cell suspensions.. 36. 1974
The in vitro cell fusion of embryonic chick muscle without DNA synthesis.. 36. 1974
Origin of the blastema in regenerating limbs of the newt Triturus viridescens. An autoradiographic study using tritiated thymidine to follow cell proliferation and migration.. 3. 1961

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Developmental biology Journal

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