Molecular biology of the cell

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Signaling pathways regulating the extracellular digestion of lipoprotein aggregates by macrophages. 2023
Visualization of the three-dimensional structure of the human centromere in mitotic chromosomes by superresolution microscopy.. 34. 2023
MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles.. 34. 2022
Elevating PI3P drives select downstream membrane trafficking pathways.. 32. 2020
Insulin-promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10.. 32. 2020
β-actin contributes to open chromatin for activation of the adipogenic pioneer factor CEBPA during transcriptional reprograming.. 31. 2020
Roles for a lipid phosphatase in the activation of its opposing lipid kinase.. 31. 2020
ESCRT-III and ER-PM contacts maintain lipid homeostasis.. 31. 2020
Clathrin and clathrin adaptor AP-1 control apical trafficking of megalin in the biosynthetic and recycling routes.. 30. 2019
TOR complex 2-regulated protein kinase Ypk1 controls sterol distribution by inhibiting StARkin domain-containing proteins located at plasma membrane-endoplasmic reticulum contact sites.. 29. 2018
Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation.. 28. 2017
Deubiquitinating enzymes Ubp2 and Ubp15 regulate endocytosis by limiting ubiquitination and degradation of ARTs.. 28. 2017
Role of STARD4 in sterol transport between the endocytic recycling compartment and the plasma membrane.. 28. 2017
Identification of the endocytic sorting signal recognized by the Art1-Rsp5 ubiquitin ligase complex.. 27. 2016
Heterogeneous architecture of vertebrate kinetochores revealed by three-dimensional superresolution fluorescence microscopy.. 27. 2016
Two distinct myosin II populations coordinate ovulatory contraction of the myoepithelial sheath in the Caenorhabditis elegans somatic gonad.. 27. 2016
Phosphatidylserine translocation at the yeast trans-Golgi network regulates protein sorting into exocytic vesicles.. 26. 2015
Signal inhibition by a dynamically regulated pool of monophosphorylated MAPK.. 26. 2015
Basolateral sorting of chloride channel 2 is mediated by interactions between a dileucine motif and the clathrin adaptor AP-1.. 26. 2015
Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs.. 24. 2013
Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes.. 24. 2013
Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity.. 23. 2012
Protein kinase C δ regulates the release of collagen type I from vascular smooth muscle cells via regulation of Cdc42.. 23. 2012
Defining pheromone-receptor signaling in Candida albicans and related asexual Candida species.. 22. 2011
STARD4 abundance regulates sterol transport and sensing.. 22. 2011
Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway.. 22. 2011
Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat.. 22. 2011
Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes.. 22. 2011
Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation.. 22. 2010
Chloride intracellular channel 4 is critical for the epithelial morphogenesis of RPE cells and retinal attachment.. 21. 2010
Insulin-regulated aminopeptidase is a key regulator of GLUT4 trafficking by controlling the sorting of GLUT4 from endosomes to specialized insulin-regulated vesicles.. 21. 2010
GLUT4 is sorted to vesicles whose accumulation beneath and insertion into the plasma membrane are differentially regulated by insulin and selectively affected by insulin resistance.. 21. 2010
Novel role of ATPase subunit C targeting peptides beyond mitochondrial protein import.. 21. 2009
Macrophages create an acidic extracellular hydrolytic compartment to digest aggregated lipoproteins.. 20. 2009
Annexin A2 regulates phagocytosis of photoreceptor outer segments in the mouse retina.. 20. 2009
The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells.. 20. 2009
Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780.. 20. 2009
Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI.. 20. 2009
ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha.. 20. 2009
Nbl1p: a Borealin/Dasra/CSC-1-like protein essential for Aurora/Ipl1 complex function and integrity in Saccharomyces cerevisiae.. 20. 2009
The multiple roles of cohesin in meiotic chromosome morphogenesis and pairing.. 20. 2008
Sterols are mainly in the cytoplasmic leaflet of the plasma membrane and the endocytic recycling compartment in CHO cells.. 20. 2008
Cells lacking the fragile X mental retardation protein (FMRP) have normal RISC activity but exhibit altered stress granule assembly.. 20. 2008
LIM kinase 1 and cofilin regulate actin filament population required for dynamin-dependent apical carrier fission from the trans-Golgi network.. 20. 2008
Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase.. 19. 2008
HDAC4 promotes growth of colon cancer cells via repression of p21.. 19. 2008
Polyubiquitylation of histone H2B.. 19. 2008
Molecular mechanisms controlling GLUT4 intracellular retention.. 19. 2008
Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane.. 19. 2008
Novel Ist1-Did2 complex functions at a late step in multivesicular body sorting.. 19. 2007
Antibody to AP1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes.. 18. 2007
Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate.. 18. 2007
Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells.. 18. 2007
Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment.. 18. 2007
Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils.. 18. 2007
NuMA influences higher order chromatin organization in human mammary epithelium.. 18. 2006
Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx.. 18. 2006
Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2.. 17. 2006
Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane.. 17. 2006
Yeast-to-hyphal transition triggers formin-dependent Golgi localization to the growing tip in Candida albicans.. 17. 2006
The stress-activated mitogen-activated protein kinase signaling cascade promotes exit from mitosis.. 17. 2006
Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres.. 17. 2006
Binding of Src to Na+/K+-ATPase forms a functional signaling complex.. 17. 2005
A novel endocytic recycling signal distinguishes biological responses of Trk neurotrophin receptors.. 16. 2005
Highly cooperative control of endocytosis by clathrin.. 16. 2005
Synthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a Golgi-specific Ypt31/rab-GTPase signaling pathway.. 16. 2004
Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160.. 15. 2004
The basolateral targeting signal of CD147 (EMMPRIN) consists of a single leucine and is not recognized by retinal pigment epithelium.. 15. 2004
Essential role for the myotubularin-related phosphatase Ymr1p and the synaptojanin-like phosphatases Sjl2p and Sjl3p in regulation of phosphatidylinositol 3-phosphate in yeast.. 15. 2004
Enteropathogenic Escherichia coli use redundant tyrosine kinases to form actin pedestals.. 15. 2004
Na,K-ATPase beta1-subunit increases the translation efficiency of the alpha1-subunit in MSV-MDCK cells.. 15. 2004
Role of cytoplasmic domain serines in intracellular trafficking of furin.. 15. 2004
Impaired p53 expression, function, and nuclear localization in calreticulin-deficient cells.. 15. 2004
Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack.. 15. 2004
Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic beta-cells.. 15. 2004
Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta.. 15. 2003
Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S.. 15. 2003
Endocytosed cation-independent mannose 6-phosphate receptor traffics via the endocytic recycling compartment en route to the trans-Golgi network and a subpopulation of late endosomes.. 15. 2003
GLUT4 is retained by an intracellular cycle of vesicle formation and fusion with endosomes.. 15. 2003
A novel cytoplasmic tail MXXXL motif mediates the internalization of prostate-specific membrane antigen.. 14. 2003
Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase.. 15. 2003
Targeted chemical disruption of clathrin function in living cells.. 14. 2003
New insights into the bioenergetics of mitochondrial disorders using intracellular ATP reporters.. 14. 2003
MTG1 codes for a conserved protein required for mitochondrial translation.. 14. 2003
IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf.. 14. 2003
Mammalian septins nomenclature.. 13. 2002
Microtubule asymmetry during neutrophil polarization and migration.. 13. 2002
GLUT4 retention in adipocytes requires two intracellular insulin-regulated transport steps.. 13. 2002
PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments.. 13. 2002
Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.. 13. 2002
Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus.. 13. 2002
The yeast synaptojanin-like proteins control the cellular distribution of phosphatidylinositol (4,5)-bisphosphate.. 13. 2002
Export from pericentriolar endocytic recycling compartment to cell surface depends on stable, detyrosinated (glu) microtubules and kinesin.. 13. 2002
Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells.. 13. 2002
Na,K-ATPase activity is required for formation of tight junctions, desmosomes, and induction of polarity in epithelial cells.. 12. 2001
Cytoskeleton-dependent membrane domain segregation during neutrophil polarization.. 12. 2001
Insulin-regulated release from the endosomal recycling compartment is regulated by budding of specialized vesicles.. 12. 2001
Clathrin hub expression affects early endosome distribution with minimal impact on receptor sorting and recycling.. 12. 2001
Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology.. 12. 2001
Distribution and transport of cholesterol in Caenorhabditis elegans.. 12. 2001
Yeast Gga coat proteins function with clathrin in Golgi to endosome transport.. 12. 2001
GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways.. 12. 2001
A di-leucine sequence and a cluster of acidic amino acids are required for dynamic retention in the endosomal recycling compartment of fibroblasts.. 12. 2001
Na,K-ATPase beta-subunit is required for epithelial polarization, suppression of invasion, and cell motility.. 12. 2001
Vps41p function in the alkaline phosphatase pathway requires homo-oligomerization and interaction with AP-3 through two distinct domains.. 12. 2001
Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics.. 11. 2000
Maintenance of human rearranged mitochondrial DNAs in long-term cultured transmitochondrial cell lines.. 11. 2000
Branched chain amino acids induce apoptosis in neural cells without mitochondrial membrane depolarization or cytochrome c release: implications for neurological impairment associated with maple syrup urine disease.. 11. 2000
An endosome-to-plasma membrane pathway involved in trafficking of a mutant plasma membrane ATPase in yeast.. 11. 2000
Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling.. 10. 1999
MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast.. 10. 1999
ARF is required for maintenance of yeast Golgi and endosome structure and function.. 9. 1998
A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole.. 8. 1997
A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor.. 8. 1997
A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast.. 8. 1997
Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant.. 7. 1996
Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast.. 7. 1996
Modulation of myosin filament organization by C-protein family members.. 7. 1996
The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization.. 6. 1995
Insolubility and redistribution of GPI-anchored proteins at the cell surface after detergent treatment.. 6. 1995
Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast.. 6. 1995
TGN38 recycles basolaterally in polarized Madin-Darby canine kidney cells.. 5. 1994
Endosome acidification and receptor trafficking: bafilomycin A1 slows receptor externalization by a mechanism involving the receptor's internalization motif.. 4. 1993
Increased LAMP-2 polylactosamine glycosylation is associated with its slower Golgi transit during establishment of a polarized MDCK epithelial monolayer.. 4. 1993
Evidence for an age-related dysfunction in the antiproliferative response to transforming growth factor-beta in vascular smooth muscle cells.. 4. 1993
Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium.. 3. 1992
A low copy number central sequence with strict symmetry and unusual chromatin structure in fission yeast centromere.. 3. 1992
Amino acid substitutions in the Dictyostelium G alpha subunit G alpha 2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C.. 3. 1992
Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line.. 3. 1992
Alternative pathways for the sorting of soluble vacuolar proteins in yeast: a vps35 null mutant missorts and secretes only a subset of vacuolar hydrolases.. 3. 1992
Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.. 3. 1992
Bone morphogenetic proteins-2 and -4 are involved in the retinoic acid-induced differentiation of embryonal carcinoma cells.. 3. 1992
Caveats on modeling of nuclear biomechanics. 2020

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Molecular biology of the cell Journal

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