Journal of neurochemistry

publication venue for

The human brain acetylome reveals that decreased acetylation of mitochondrial proteins associates with Alzheimer's disease.. 158. 2021
Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human-induced pluripotent stem cells, neural stem cells, and neurons.. 156. 2020
Synaptophysin sustains presynaptic performance by preserving vesicular synaptobrevin-II levels.. 151. 2019
The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A.. 148. 2019
Prohibitin is a positive modulator of mitochondrial function in PC12 cells under oxidative stress.. 146. 2018
Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?. 139. 2016
Differential effects of BDNF and neurotrophin 4 (NT4) on endocytic sorting of TrkB receptors.. 138. 2016
Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines.. 134. 2015
The ratio of acetate-to-glucose oxidation in astrocytes from a single 13C NMR spectrum of cerebral cortex.. 132. 2014
Brain proteomics identifies potential simvastatin targets in acute phase of stroke in a rat embolic model.. 130. 2014
Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.. 128. 2013
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPARγ.. 124. 2013
Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF.. 122. 2012
Up-regulation of the mitochondrial malate dehydrogenase by oxidative stress is mediated by miR-743a.. 118. 2011
Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS.. 113. 2010
The in vivo neuron-to-astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation.. 109 Suppl 1. 2009
The ketogenic diet has no effect on the expression of spike-and-wave discharges and nutrient transporters in genetic absence epilepsy rats from Strasbourg.. 109 Suppl 1. 2009
Enhanced survival and function of neural stem cells-derived dopaminergic neurons under influence of olfactory ensheathing cells in parkinsonian rats.. 109. 2009
Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease.. 109. 2009
Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux.. 108. 2009
The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies.. 107. 2008
Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells.. 106. 2008
Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration.. 106. 2008
Increased levels of gamma-glutamylamines in Huntington disease CSF.. 106. 2008
Enhanced CREB and DARPP-32 phosphorylation in the nucleus accumbens and CREB, ERK, and GluR1 phosphorylation in the dorsal hippocampus is associated with cocaine-conditioned place preference behavior.. 106. 2008
Activation of brain protein phosphatase-1(I) following cardiac arrest and resuscitation involving an interaction with 14-3-3 gamma.. 105. 2008
Regulatory proteins of eukaryotic initiation factor 2-alpha subunit (eIF2 alpha) phosphatase, under ischemic reperfusion and tolerance.. 103. 2007
High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo.. 103. 2007
Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter.. 103. 2007
Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.. 103. 2007
Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia.. 102. 2007
Optical bioluminescence imaging of human ES cell progeny in the rodent CNS.. 102. 2007
Up-regulation of dopamine D(2)L mRNA levels in the ventral tegmental area and dorsal striatum of amphetamine-sensitized C57BL/6 mice: role of Ca(v)1.3 L-type Ca(2+) channels.. 99. 2006
Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia.. 99. 2006
The anxiety-like phenotype of 5-HT receptor null mice is associated with genetic background-specific perturbations in the prefrontal cortex GABA-glutamate system.. 99. 2006
Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis.. 98. 2006
Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice.. 96. 2006
Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss.. 96. 2006
Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.. 95. 2005
Mitochondria are involved in the neurogenic neuroprotection conferred by stimulation of cerebellar fastigial nucleus.. 95. 2005
Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons.. 94. 2005
Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease.. 94. 2005
Proteasome inhibition protects HT22 neuronal cells from oxidative glutamate toxicity.. 92. 2005
Inhibition of the alpha-ketoglutarate dehydrogenase complex by the myeloperoxidase products, hypochlorous acid and mono-N-chloramine.. 92. 2005
Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.. 91. 2004
The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism.. 90. 2004
3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy.. 89. 2004
Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.. 89. 2004
In vivo efflux of serotonin in the dorsal raphe nucleus of 5-HT1A receptor knockout mice.. 88. 2004
Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity.. 88. 2004
Ischaemic preconditioning in the rat brain: effect on the activity of several initiation factors, Akt and extracellular signal-regulated protein kinase phosphorylation, and GRP78 and GADD34 expression.. 88. 2004
Pharmacologic suppression of neuronal oxidative damage and dendritic degeneration following direct activation of glial innate immunity in mouse cerebrum.. 87. 2003
Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1.. 87. 2003
Role of nitric oxide in rotenone-induced nigro-striatal injury.. 86. 2003
TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation.. 83. 2002
Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma.. 81. 2002
Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients.. 80. 2002
N(epsilon)-(gamma-L-glutamyl)-L-lysine (GGEL) is increased in cerebrospinal fluid of patients with Huntington's disease.. 79. 2001
Parvalbumin overexpression alters immune-mediated increases in intracellular calcium, and delays disease onset in a transgenic model of familial amyotrophic lateral sclerosis.. 79. 2001
Electrical stimulation of cerebellar fastigial nucleus protects rat brain, in vitro, from staurosporine-induced apoptosis.. 79. 2001
Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations.. 77. 2001
Complement anaphylatoxin C5a neuroprotects through mitogen-activated protein kinase-dependent inhibition of caspase 3.. 77. 2001
Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism.. 76. 2001
Frontal lobe dysfunction in progressive supranuclear palsy: evidence for oxidative stress and mitochondrial impairment.. 74. 2000
Metabolic impairment elicits brain cell type-selective changes in oxidative stress and cell death in culture.. 74. 2000
Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury.. 73. 1999
Cell type-specific expression of the Kv3.1 gene is mediated by a negative element in the 5' untranslated region of the Kv3.1 promoter.. 73. 1999
Adaptive changes in postsynaptic dopamine receptors despite unaltered dopamine dynamics in mice lacking monoamine oxidase B.. 73. 1999
Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia.. 72. 1999
Expression of c-fos, c-jun, and c-jun N-terminal kinase (JNK) in a developmental model of induced apoptotic death in neurons of the substantia nigra.. 72. 1999
Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease.. 72. 1999
Kainate-induced apoptosis in cultured murine cerebellar granule cells elevates expression of the cell cycle gene cyclin D1.. 71. 1998
Effects of adrenal steroids on basal ganglia neuropeptide mRNA and tyrosine hydroxylase radioimmunoreactive levels in the adrenalectomized rat.. 71. 1998
Role of potassium channels in amyloid-induced cell death.. 70. 1998
Immunochemical characterization of the deficiency of the alpha-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain.. 70. 1998
In vivo and in vitro characterization of the sequence requirement for oligomer formation of Ca2+/calmodulin-dependent protein kinase IIalpha.. 70. 1998
Beta-amyloid-induced neurotoxicity of a hybrid septal cell line associated with increased tau phosphorylation and expression of beta-amyloid precursor protein.. 69. 1997
Selective changes in cell bodies and growth cones of nerve growth factor-differentiated PC12 cells induced by chemical hypoxia.. 69. 1997
Regional reductions of transketolase in thiamine-deficient rat brain.. 67. 1996
Antisense oligodeoxynucleotides to the cloned delta receptor DOR-1: uptake, stability, and regulation of gene expression.. 65. 1995
beta-Amyloid1-40 increases expression of beta-amyloid precursor protein in neuronal hybrid cells.. 65. 1995
Expression of the choline acetyltransferase gene depends on protein kinase A activity.. 64. 1995
Heterogeneous expression of transketolase in rat brain.. 64. 1995
Increased inositol 1,4,5-trisphosphate accumulation correlates with an up-regulation of bradykinin receptors in Alzheimer's disease.. 64. 1995
Apoptotic cell death of a hybrid motoneuron cell line induced by immunoglobulins from patients with amyotrophic lateral sclerosis.. 63. 1994
Epidermal growth factor and basic fibroblast growth factor have independent actions on mesencephalic dopamine neurons in culture.. 62. 1994
Regulation of NMDA receptor mRNA during visual map formation and after receptor blockade.. 62. 1994
Acute and persistent suppression of preproenkephalin mRNA expression in the striatum following developmental hypoxic-ischemic injury.. 62. 1994
Oxidative stress induces apoptosis in embryonic cortical neurons.. 62. 1994
Fucosyl-GM1 in human sensory nervous tissue is a target antigen in patients with autoimmune neuropathies.. 61. 1993
Isolated bovine spinal motoneurons have specific ganglioside antigens recognized by sera from patients with motor neuron disease and motor neuropathy.. 59. 1992
Increased neopterin levels in brains of patients with human immunodeficiency virus type 1 infection.. 59. 1992
Distribution of protein phosphatase inhibitor-1 in brain and peripheral tissues of various species: comparison with DARPP-32.. 59. 1992
Phosphoethanolamine enhances high-affinity choline uptake and acetylcholine synthesis in dissociated cell cultures of the rat septal nucleus.. 59. 1992
Increase in beta-1,4-galactosyltransferase activity during PC12 cell differentiation induced by forskolin and 2-chloroadenosine.. 57. 1991
Nerve growth factor potentiates bradykinin-induced calcium influx and release in PC12 cells.. 57. 1991
Characterization in mammalian brain of a DARPP-32 serine kinase identical to casein kinase II.. 55. 1990
Nerve growth factor-induced down-regulation of calmodulin-dependent protein kinase III in PC12 cells involves cyclic AMP-dependent protein kinase.. 54. 1990
Purification and characterization of a central cholinergic enhancing factor from rat brain: its identity as phosphoethanolamine.. 53. 1989
Phosphatidylinositol metabolism during in vitro hypoxia.. 52. 1989
DARPP-32 and phosphatase inhibitor-1, two structurally related inhibitors of protein phosphatase-1, are both present in striatonigral neurons.. 50. 1988
Peptide E and its products, BAM 18 and Leu-enkephalin, in bovine adrenal medulla and cultured chromaffin cells: release in response to stimulation.. 49. 1987
Phosphorylation of proteins in normal and regenerating goldfish optic nerve.. 49. 1987
Subcellular localization of sulfated glucuronic acid-containing glycolipids reacting with anti-myelin-associated glycoprotein antibody.. 48. 1987
In vivo phosphorylation of axonal proteins in goldfish optic nerve during regeneration.. 48. 1987
Effect of decreased oxygen on in vitro release of endogenous 3,4-dihydroxyphenylethylamine from mouse striatum.. 47. 1986
Monoamine neurotransmitter metabolism and locomotor activity during chemical hypoxia.. 46. 1986
Subsynaptosomal calcium distribution during hypoxia and 3,4-diaminopyridine treatment.. 45. 1985
Structure of catecholamine secretory vesicles from PC12 cells.. 45. 1985
Nerve growth factor affects cyclic AMP metabolism, but not by directly stimulating adenylate cyclase activity.. 44. 1985
Changes in protein content of goldfish optic nerve during degeneration and regeneration following nerve crush.. 44. 1985
Endogenous inhibitor of ligand binding to the muscarinic acetylcholine receptor.. 44. 1985
Regional acetylcholine metabolism in brain during acute hypoglycemia and recovery.. 44. 1985
Synaptosomal calcium metabolism during hypoxia and 3,4-diaminopyridine treatment.. 42. 1984
Measurement of total opioid peptides in rat brain and pituitary by radioimmunoassay directed at the alpha-N-acetyl derivative.. 40. 1983
Influence of glucose on somatostatin synthesis and secretion in isolated cerebral cortical cells.. 40. 1983
Myelin-associated glycoprotein is the antigen for a monoclonal IgM in polyneuropathy.. 39. 1982
Immunocytochemical and biochemical analysis of carbonic anhydrase in primary astrocyte cultures from rat brain.. 39. 1982
Tyrosine hydroxylase from bovine striatum: catalytic properties of the phosphorylated and nonphosphorylated forms of the purified enzyme.. 39. 1982
Met-enkephalin [Arg6, Phe7] immunoreactivity in bovine caudate and bovine adrenal medulla.. 39. 1982
Studies on the pyruvate dehydrogenase complex in brain with the arylamine acetyltransferase-coupled assay.. 38. 1982
Antibodies specific for alpha-N-acetyl-beta-endorphins: radioimmunoassays and detection of acetylated beta-endorphins in pituitary extracts.. 38. 1982
Measurement of methionine-enkephalin [Arg6,Phe7] in rat brain by specific radioimmunoassay directed at methionine sulphoxide enkephalin[Arg6,Phe7].. 38. 1982
Aging decreases oxidative metabolism and the release and synthesis of acetylcholine.. 37. 1981
Oxygen dependence of glucose and acetylcholine metabolism in slices and synaptosomes from rat brain.. 37. 1981
Acetylcholine synthesis and CO2 production from variously labeled glucose in rat brain slices and synaptosomes.. 37. 1981
Decreases in amino acids and acetylcholine metabolism during hypoxia.. 37. 1981
Alpha-N-acetyl beta-endorphins in the pituitary: immunohistochemical localization using antibodies raised against dynorphin(1-13).. 36. 1981
Thermal denaturation of native striatal tyrosine hydroxylase: increased thermolability of the phosphorylated form of the enzyme.. 36. 1981
Impaired synthesis of acetylcholine by mild hypoxic hypoxia or nitrous oxide.. 36. 1981
Alterations in acetylcholine synthesis and cyclic nucleotides in mild cerebral hypoxia.. 31. 1978
Mass spectrometric identification and selected ion monitoring quantitation of gamma-amino-butyric acid (GABA) in human lumbar cerebrospinal fluid.. 31. 1978
The effects of 5-hydroxytryptophan and 5-hydroxytryptamine on dopamine synthesis and release in rat brain striatal synaptosomes.. 30. 1978
Measurement of acetylcholine turnover with glucose used as precursor: evidence for compartmentation of glucose metabolism in brain.. 30. 1978
Myelin basic protein phosphatase activity in rat brain.. 29. 1977
Cholinergic sites in skeletal muscle: interaction with concanavalin A.. 27. 1976
Impaired synthesis of acetylcholine in brain accompanying mild hypoxia and hypoglycemia.. 27. 1976
Inhibition of acetylcholine synthesis and of carbohydrate utilization by maple-syrup-urine disease metabolites.. 26. 1976
Phosphatidyl inositol turnover in muscle membranes following denervation.. 23. 1974
Effect of actinomycin-D on labelled material in the retina and optic tectum of goldfish after intraocular injection of tritiated RNA precursors.. 23. 1974
Electrophoretic study of 5-hydroxytryptophan decarboxylase from brain and liver in several species.. 23. 1974
Regulation of catecholamine synthesis in rat brain synaptosomes.. 23. 1974
Axonal transport of radioactivity in the goldfish optic system following intraocular injection of labelled RNA precursors.. 20. 1973
The contribution of axoplasmic flow in optic nerve and protein synthesis within the optic tectum to synaptic membrane proteins of the chick optic tectum.. 20. 1973
Biosynthesis of serotonin in Raphé nuclei of rat brain: effect of p-chlorophenylalanine.. 20. 1973
Tyrosine hydroxylase activity in rat brain following "REM" sleep deprivation.. 20. 1973
The effects of electroshock seizures on potassium transport within synaptosomes from rat brain.. 19. 1972
Regional distribution and developmental change of tryptophan hydroxylase activity in rat brain.. 19. 1972
Incorporation of [14C]glucosamine into synaptosomes in vitro.. 18. 1971
Hexose monophosphate pathway in synapses.. 17. 1970
Synthesis de novo of purines in slices of rat brain and liver.. 17. 1970
Pyrimidine synthesis in tissue culture.. 15. 1968
LOCALIZATION OF MELATONIN IN THE NERVOUS SYSTEM.. 11. 1964
Systematic Review - Neuroprotection of ketosis in acute injury of the mammalian central nervous system: A meta-analysis. 2021
STXBP1 encephalopathies: Clinical spectrum, disease mechanisms, and therapeutic strategies. 2020
Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches. 2011
The synaptic vesicle proteome. 2007
The role of mitochondria in inherited neurodegenerative diseases. 2006
Citicoline in pre-clinical animal models of stroke: a meta-analysis shows the optimal neuroprotective profile and the missing steps for jumping into a stroke clinical trial. 2012
Evidence for the efficacy of statins in animal stroke models: a meta-analysis. 2012
Transglutaminases and neurodegeneration. 2009

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