Biochemical pharmacology

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A p38 MAP kinase inhibitor suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss through the inhibition of bone turnover.. 226. 2024
Pterostilbene-isothiocyanate impedes RANK/TRAF6 interaction to inhibit osteoclastogenesis, promoting osteogenesis in vitro and alleviating glucocorticoid induced osteoporosis in rats.. 206. 2022
Pterostilbene-isothiocyanate inhibits breast cancer metastasis by selectively blocking IKK-β/NEMO interaction in cancer cells.. 192. 2021
Hippocampal mitogen-activated protein kinase phosphatase-1 regulates behavioral and systemic effects of chronic corticosterone administration.. 190. 2021
The active second-generation proteasome inhibitor oprozomib reverts the oxaliplatin-induced neuropathy symptoms.. 182. 2020
RGFP966, a histone deacetylase 3 inhibitor, promotes glioma stem cell differentiation by blocking TGF-β signaling via SMAD7.. 180. 2020
Immunoproteasome inhibitor DPLG3 attenuates experimental colitis by restraining NF-κB activation.. 177. 2020
Pyroptotic and apoptotic cell death in iNOS and nNOS overexpressing K562 cells: A mechanistic insight.. 176. 2019
The mTOR inhibitor everolimus overcomes CXCR4-mediated resistance to histone deacetylase inhibitor panobinostat through inhibition of p21 and mitotic regulators.. 168. 2019
Olaparib induces browning of in vitro cultures of human primary white adipocytes.. 167. 2019
Alkylphenol inverse agonists of HCN1 gating: H-bond propensity, ring saturation and adduct geometry differentially determine efficacy and potency.. 163. 2019
Repositioning of anti-cancer drug candidate, AZD7762, to an anti-allergic drug suppressing IgE-mediated mast cells and allergic responses via the inhibition of Lyn and Fyn.. 154. 2018
Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death.. 132. 2017
Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions.. 98. 2015
Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists.. 97. 2015
Somatostatin preserved blood brain barrier against cytokine induced alterations: possible role in multiple sclerosis.. 86. 2013
Identification of novel Sp1 targets involved in proliferation and cancer by functional genomics.. 84. 2012
Lamotrigine is a substrate for OCT1 in brain endothelial cells.. 83. 2011
Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats.. 83. 2011
High density micromass cultures of a human chondrocyte cell line: a reliable assay system to reveal the modulatory functions of pharmacological agents.. 82. 2011
Underexpression of miR-224 in methotrexate resistant human colon cancer cells.. 82. 2011
Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes.. 79. 2009
Retinoid metabolism and ALDH1A2 (RALDH2) expression are altered in the transgenic adenocarcinoma mouse prostate model.. 78. 2009
Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells.. 77. 2008
Homeostasis of retinol in lecithin: retinol acyltransferase gene knockout mice fed a high retinol diet.. 75. 2008
14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy.. 75. 2008
Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells.. 75. 2007
Comparative effects of torasemide and furosemide in rats with heart failure.. 75. 2007
Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA2-COX-PGE2-EP3R pathway.. 73. 2007
8-Chloro-adenosine inhibits growth at least partly by interfering with actin polymerization in cultured human lung cancer cells.. 72. 2006
Mechanism for the inhibition of transglutaminase 2 by cystamine.. 69. 2005
Catalase induces the expression of inducible nitric oxide synthase through activation of NF-kappaB and PI3K signaling pathway in Raw 264.7 cells.. 68. 2004
Leptomycin B-induced apoptosis is mediated through caspase activation and down-regulation of Mcl-1 and XIAP expression, but not through the generation of ROS in U937 leukemia cells.. 68. 2004
Tetrandrine-induced apoptosis is mediated by activation of caspases and PKC-delta in U937 cells.. 67. 2004
Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity.. 66. 2003
Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism.. 62. 2001
The effect of high molecular phospholipase A2 inhibitors on 3T6 fibroblast proliferation.. 61. 2001
Inhibition of select mitochondrial enzymes in PC12 cells exposed to S-(1,1,2,2-tetrafluoroethyl)-L-cysteine.. 58. 1999
Role of leukocyte influx in tissue prostaglandin H synthase-2 overexpression induced by phorbol ester and arachidonic acid in skin.. 58. 1999
Induction by interleukin-1beta peptide of prostaglandin E2 formation via enhanced prostaglandin H synthase-2 expression in 3T6 fibroblasts.. 56. 1998
Inhibition of drug-naive and -resistant leukemia cell proliferation by low molecular weight thiols.. 55. 1998
Heme oxygenase induction with attenuation of experimentally induced corneal inflammation.. 53. 1997
Cell cycle-dependent inhibition of the proliferation of human neural tumor cell lines by iron chelators.. 51. 1996
Regulation of interleukin-1-beta-stimulated inducible nitric oxide synthase expression in cultured vascular smooth muscle cells by hemostatic proteins.. 51. 1996
Antiproliferative activity of the topoisomerase I inhibitors topotecan and camptothecin, on sub- and postconfluent tumor cell cultures.. 48. 1994
Differential induction of glutathione S-transferase in rat aorta versus liver.. 47. 1994
Conversion of T-kinin to bradykinin by the rat kidney.. 47. 1994
Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression.. 47. 1994
Early response gene induction following DNA damage in astrocytoma cell lines.. 45. 1993
Evidence for a bioactive clonidine-displacing substance in peripheral tissues and serum.. 44. 1992
CD4(81-92)-based peptide derivatives. Structural requirements for blockade of HIV infection, blockade of HIV-induced syncytium formation, and virostatic activity in vitro.. 43. 1992
Alpha-adrenoceptor activation of polyphosphoinositide hydrolysis in the rat tail artery.. 40. 1990
Actions of orally administered organotin compounds on heme metabolism and cytochrome P-450 content and function in intestinal epithelium.. 38. 1989
Lack of effect by prostaglandin F2 alpha and verapamil on calcium uptake by isolated corpora lutea from pseudopregnant rats.. 38. 1989
Alpha adrenoceptor sites in vascular smooth muscle. Differentiation by selective antagonist binding.. 37. 1988
Changes in cytosolic free calcium with 1,2,3,4-tetrahydro-5-aminoacridine, 4-aminopyridine and 3,4-diaminopyridine.. 37. 1988
Effects of prochlorperazine on the function of integral membrane proteins.. 37. 1988
Hormonal regulation of heme oxygenase induction in avian hepatocyte culture.. 34. 1985
Altered induction response of hepatic cytochrome P-450 to phenobarbital, 3-methylcholanthrene, and beta-naphthoflavone in organotin-treated animals.. 34. 1985
Prostaglandins and cyclic nucleotides. Modulators of arterial cholesterol metabolism.. 34. 1985
Thiamin antagonists and the release of acetylcholine and norepinephrine from brain slices.. 33. 1984
Tyrosine hydroxylase activation. Comparison of in vitro phosphorylation and in vivo administration of haloperidol.. 31. 1982
Decreases in the release of acetylcholine in vitro with low oxygen.. 31. 1982
Synthetic N-dimethyl beta-endorphin, a stabilized opioid peptide.. 30. 1981
Studies on the metabolic pathway of the acetyl group for acetylcholine synthesis.. 29. 1980
Protection by tris(hydroxymethyl)-aminomethane against behavioral and neurochemical effects of hypoxia.. 28. 1979
Proportional inhibition of acetylcholine synthesis accompanying impairment of 3-hydroxybutyrate oxidation in rat brain slices.. 28. 1979
Phospholipid-induced activation of tyrosine hydroxylase from rat brain striatal synaptosomes.. 25. 1976
Microscope immersion oils: effects of skin application on cutaneous and hepatic drug-metabolizing enzymes.. 24. 1975
Psychotomimetics as anticholinergic agents. I. 1-Cyclohexylpiperidine derivatives: anticholinesterase activity and antagonistic activity to acetylcholine.. 23. 1974
BIOCHEMICAL AND BEHAVIOURAL ALTERATIONS FOLLOWING 6-HYDROXYDOPAMINE ADMINISTRATION INTO BRAIN.. 23. 1974
Chlorcyclizine N-demethylase activity in chick embryo hepatic cell culture.. 22. 1973
Spectrophotometric and manometric studies of NADPH and NADH oxidase activities of rat liver microsomes: effects of drugs and adenine nucleotides.. 14. 1965
THE SUBCELLULAR LOCALIZATION OF BRAIN-STEM NOREPINEPHRINE AND 5-HYDROXYTRYPTAMINE IN STRESSED RATS.. 13. 1964
BRAIN AMINES: RESPONSE TO PHYSIOLOGICAL STRESS.. 12. 1963
A Festschrift in honor of David J. Triggle.. 98. 2015
Challenges in the Biomedical Research Enterprise in the 21st century: Antecedents in the writings of David Triggle. 2015
The answer is not 42. 2015
Nicotine signaling and progression of chronic kidney disease in smokers. 2013
A perspective on autophagy and transcription factor EB in Alcohol-Associated Alzheimer's disease. 2023

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Biochemical pharmacology Journal

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