Radiation Oncology Academic Department

Faculty Research Areas

• The main focus of her group is to investigate the key factors impacting the immunogenicity of radiotherapy in brain malignancies. More specifically, the Vanpouille-Box lab aims at exploring the immune-metabolic role of radiation therapy and to define the impact of TGF-beta and activin A in the radiation response of glioblastomas. With a better understanding of the metabolic changes, molecular pathways and cellular responses from the host and/or the tumor that result from radiation therapy, our main goal is to identify new actionable targets for the modulation of anti-tumor immune responses against glioblastomas.
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Affiliation

people

• position

  • Formenti, Silvia Chiara, Professor of Radiation Oncology 2015 -
  • Formenti, Silvia Chiara, Sandra and Edward Meyer Professor of Cancer Research 2015 -

organization within

• Weill Cornell Medical College 

Research

administers grant

• A Digital Twin for rectal cancer to guide adaptive radiotherapy
• A Prospective Comparative Study of Outcomes with Proton and Photon Radiation in Prostate Cancer" ("COMPPARE")
• Biochemical and functional characterization of a novel anti-inflammatory biogenic amine
• CD4 and CD8 T cell epitopes recognized in autoimmune and autoinflammatory diseases
• Cancer Cell Intrinsic Interferon-I pathway Activation by Fractionated Radiation
• Converting HR+ Breast Cancer Into an Individualized Vaccine
• Converting HR+ Breast Cancer Into an Individualized Vaccine
• Creating a 3D TNBC model of PTEN deficiency to discover immunoregulatory tumor epitopes
• Dynamics of Immune Response in Irradiated Rectal Cancer
• Effects of Glycation and Carbonylation on MHC II-restricted immunity
• Extending the survival of HR+ breast cancer patients receiving CDK4/6 inhibitors by targeting IL17-producing gamma delta T cells
• Fatty acid metabolic regulation of anti-tumor immunity against irradiated glioblastoma
• Functional Consequences of Impaired Autophagy in Aging - P01AG031782
• Harnessing Innate Immunity and Radiotherapy for Next-Generation Immuno-Oncology in Metastatic Breast Cancer
• Langerhans cells and lymphatic regulation in immunity
• Lymphatic drainage dysfunction in chronic hypertension
• Lymphatics-Glymphatics in CNS Fluid Homeostasis
• Optimization of immune checkpoint inhibition during radiation-induced vaccination in breast cancer
• Precision use of radiation for in situ cancer immunization
• Role of FAP-positive cells in immune response to irradiated glioblastoma
• Role of oxidative post-translational modifications in generating neoepitopes
• Targeting fatty acid synthesis to restore anti-tumor immunity against irradiated glioblastoma
• Targeting the BCL2 immune checkpoint to enhance the immunostimulatory effects of radiation in breast cancer
• Therapeutic targeting of breast cancer and host immune responses at inflection points in the disease trajectory