Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus. Academic Article uri icon

Overview

abstract

  • [structure] The biochemical induction assay (BIA) is a rapid (colorimetric) bacterial assay used to identify compounds that damage DNA or inhibit DNA synthesis and thereby identify potential natural product anticancer agents. Bisanthraquinones based on a 1,3,6, 8-tetrahydroxyanthraquinone-type carbon skeleton were isolated from an endophytic fungus and characterized by NMR and X-ray crystallography. Cytoskyrin A (1) is highly active in the biochemical induction assay, while the closely related cytoskyrin B (2) has no detectable activity in this assay.

publication date

  • December 14, 2000

Research

keywords

  • Anthraquinones
  • Antibiotics, Antineoplastic
  • Mitosporic Fungi

Identity

Scopus Document Identifier

  • 0034649727

Digital Object Identifier (DOI)

  • 10.1021/ol006681k

PubMed ID

  • 11112640

Additional Document Info

volume

  • 2

issue

  • 25