Brady, Sean F.

Publications

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selected publications

Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA assisted uptake and ribosomal protein RplL sensitivity. 2024 GET IT
Cinnamosyn, a Cinnamoylated Synthetic-Bioinformatic Natural Product with Cytotoxic Activity. Organic letters. 2024 Academic Article GET IT
DNA glycosylases provide antiviral defence in prokaryotes. Nature. 2024 Academic Article GET IT
Identification of an Optimized Clinical Development Candidate from Cilagicin, an Antibiotic That Evades Resistance by Dual Polyprenyl Phosphate Binding. ACS infectious diseases. 2024 Academic Article GET IT
Tapcin, an in vivo active dual topoisomerase I/II inhibitor discovered by syn-BNP coupled metagenomics. Angewandte Chemie (International ed. in English). 2024 Academic Article GET IT
Author Correction: Bacterial cGAS senses a viral RNA to initiate immunity. 2023 GET IT
Bacterial cGAS senses a viral RNA to initiate immunity. Nature. 2023 Academic Article GET IT
A Family of Antibiotics That Evades Resistance by Binding Polyprenyl Phosphates. ACS infectious diseases. 2023 Academic Article GET IT
Present and future outlooks on environmental DNA-based methods for antibiotic discovery. Current opinion in microbiology. 2023 Review GET IT
Case report: Pneumatosis in a neonate with thrombocytopenia absent radius syndrome. 2023 GET IT
High-throughput retrieval of target sequences from complex clone libraries using CRISPRi. Nature biotechnology. 2022 Academic Article GET IT
Times cited: 3
Multiplexed mobilization and expression of biosynthetic gene clusters. Nature communications. 2022 Academic Article GET IT
Times cited: 10
Automated diagnosis and prognosis of COVID-19 pneumonia from initial ER chest X-rays using deep learning. BMC infectious diseases. 2022 Academic Article GET IT
Times cited: 12
Discovery of Paenibacillaceae Family Gram-Negative-Active Cationic Lipopeptide Antibiotics Using Evolution-Guided Chemical Synthesis. Organic letters. 2022 Academic Article GET IT
Times cited: 8
Unraveling function and diversity of bacterial lectins in the human microbiome. Nature communications. 2022 Academic Article GET IT
Times cited: 4
Bioinformatic prospecting and synthesis of a bifunctional lipopeptide antibiotic that evades resistance. Science (New York, N.Y.). 2022 Academic Article GET IT
Times cited: 24
Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis. Nature communications. 2022 Academic Article GET IT
Times cited: 12
A naturally inspired antibiotic to target multidrug-resistant pathogens. Nature. 2022 Academic Article GET IT
Times cited: 116
Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens. Nature microbiology. 2021 Academic Article GET IT
Times cited: 31
Deep learning model to quantify left atrium volume on routine non-contrast chest CT and predict adverse outcomes. Journal of cardiovascular computed tomography. 2021 Academic Article GET IT
Times cited: 4
Metabolites with SARS-CoV-2 Inhibitory Activity Identified from Human Microbiome Commensals. mSphere. 2021 Academic Article GET IT
Times cited: 17
Synthesis and evaluation of dual-action kanglemycin-fluoroquinolone hybrid antibiotics. Bioorganic & medicinal chemistry letters. 2021 Academic Article GET IT
Times cited: 7
Multiplexed functional metagenomic analysis of the infant microbiome identifies effectors of NF-κB, autophagy, and cellular redox state. Cell reports. 2021 Academic Article GET IT
Times cited: 4
Metagenome-Guided Analogue Synthesis Yields Improved Gram-Negative-Active Albicidin- and Cystobactamid-Type Antibiotics. Angewandte Chemie (International ed. in English). 2021 Academic Article GET IT
Times cited: 13
Adaptive Manufacturing for Healthcare During the COVID-19 Emergency and Beyond. Frontiers in medical technology. 2021 Academic Article GET IT
Times cited: 4
Biosynthetic Interrogation of Soil Metagenomes Reveals Metamarin, an Uncommon Cyclomarin Congener with Activity against Mycobacterium tuberculosis. Journal of natural products. 2021 Academic Article GET IT
Times cited: 18
Refactoring biosynthetic gene clusters for heterologous production of microbial natural products. Current opinion in biotechnology. 2021 Review GET IT
Times cited: 31
Elucidating the Diversity and Potential Function of Nonribosomal Peptide and Polyketide Biosynthetic Gene Clusters in the Root Microbiome. mSystems. 2020 Academic Article GET IT
Times cited: 16
The Current State of Biologic Therapies for Treatment of Refractory Asthma. Clinical reviews in allergy & immunology. 2020 Review GET IT
Times cited: 22
Total Synthesis of Malacidin A by β-Hydroxyaspartic Acid Ligation-Mediated Cyclization and Absolute Structure Establishment. Angewandte Chemie (International ed. in English). 2020 Academic Article GET IT
Times cited: 27
A Semisynthetic Kanglemycin Shows In Vivo Efficacy against High-Burden Rifampicin Resistant Pathogens. ACS infectious diseases. 2020 Academic Article GET IT
Times cited: 16
Synthetic-Bioinformatic Natural Product Antibiotics with Diverse Modes of Action. Journal of the American Chemical Society. 2020 Academic Article GET IT
Times cited: 37
Functional Multigenomic Screening of Human-Associated Bacteria for NF-κB-Inducing Bioactive Effectors. mBio. 2019 Academic Article GET IT
Times cited: 8
Bioactive Synthetic-Bioinformatic Natural Product Cyclic Peptides Inspired by Nonribosomal Peptide Synthetase Gene Clusters from the Human Microbiome. Journal of the American Chemical Society. 2019 Academic Article GET IT
Times cited: 29
Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis of targeted sequences. Nature communications. 2019 Academic Article GET IT
Times cited: 45
Mapping Interactions of Microbial Metabolites with Human G-Protein-Coupled Receptors. Cell host & microbe. 2019 Academic Article GET IT
Times cited: 124
Cadasides, Calcium-Dependent Acidic Lipopeptides from the Soil Metagenome That Are Active against Multidrug-Resistant Bacteria. Journal of the American Chemical Society. 2019 Academic Article GET IT
Times cited: 62
Atolypenes, Tricyclic Bacterial Sesterterpenes Discovered Using a Multiplexed In Vitro Cas9-TAR Gene Cluster Refactoring Approach. ACS synthetic biology. 2018 Academic Article GET IT
Times cited: 40
Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nature communications. 2018 Academic Article GET IT
Times cited: 55
Accessing Bioactive Natural Products from the Human Microbiome. Cell host & microbe. 2018 Review GET IT
Times cited: 93
Corrigendum: Commensal bacteria make GPCR ligands that mimic human signalling molecules. 2018 GET IT
Times cited: 3
Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens. Nature microbiology. 2018 Letter GET IT
Times cited: 310
An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant Acinetobacter baumannii-Infected Wounds. mSphere. 2018 Academic Article GET IT
Times cited: 20
A non-linear data mining parameter selection algorithm for continuous variables. PloS one. 2017 Academic Article GET IT
Times cited: 10
Bacterial natural product biosynthetic domain composition in soil correlates with changes in latitude on a continent-wide scale. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 41
Human Microbiome Inspired Antibiotics with Improved β-Lactam Synergy against MDR Staphylococcus aureus. ACS infectious diseases. 2017 Letter GET IT
Times cited: 27
Identification of biosynthetic gene clusters from metagenomic libraries using PPTase complementation in a Streptomyces host. FEMS microbiology letters. 2017 Academic Article GET IT
Times cited: 19
Commensal bacteria make GPCR ligands that mimic human signalling molecules. Nature. 2017 Academic Article GET IT
Times cited: 349
Identification of the Colicin V Bacteriocin Gene Cluster by Functional Screening of a Human Microbiome Metagenomic Library. ACS infectious diseases. 2017 Letter GET IT
Times cited: 20
Antimicrobials Inspired by Nonribosomal Peptide Synthetase Gene Clusters. Journal of the American Chemical Society. 2017 Academic Article GET IT
Times cited: 38
Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 75
Comprehensive Analysis of a Novel Ketoreductase for Pentangular Polyphenol Biosynthesis. ACS chemical biology. 2016 Academic Article GET IT
Times cited: 8
Biotechnological potential of Actinobacteria from Canadian and Azorean volcanic caves. Applied microbiology and biotechnology. 2016 Academic Article GET IT
Times cited: 33
Discovery of MRSA active antibiotics using primary sequence from the human microbiome. Nature chemical biology. 2016 Academic Article GET IT
Times cited: 136
HEMATOLOGY AND PLASMA BIOCHEMISTRY INTERVALS FOR CAPTIVE-BORN CALIFORNIA TIGER SALAMANDERS (AMBYSTOMA CALIFORNIENSE). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2016 Academic Article GET IT
Times cited: 6
Natural Product Discovery through Improved Functional Metagenomics in Streptomyces. Journal of the American Chemical Society. 2016 Academic Article GET IT
Times cited: 60
Multiplexed CRISPR/Cas9- and TAR-Mediated Promoter Engineering of Natural Product Biosynthetic Gene Clusters in Yeast. ACS synthetic biology. 2016 Academic Article GET IT
Times cited: 81
Culture-independent discovery of natural products from soil metagenomes. Journal of industrial microbiology & biotechnology. 2015 Review GET IT
Times cited: 93
Minimum Information about a Biosynthetic Gene cluster. Nature chemical biology. 2015 Academic Article GET IT
Times cited: 623
Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 147
Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 87
Targeted metagenomics: finding rare tryptophan dimer natural products in the environment. Journal of the American Chemical Society. 2015 Academic Article GET IT
Times cited: 48
phylogeo: an R package for geographic analysis and visualization of microbiome data. Bioinformatics (Oxford, England). 2015 Academic Article GET IT
Times cited: 18
Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 85
Global biogeographic sampling of bacterial secondary metabolism. eLife. 2015 Academic Article GET IT
Times cited: 103
Mining soil metagenomes to better understand the evolution of natural product structural diversity: pentangular polyphenols as a case study. Journal of the American Chemical Society. 2014 Academic Article GET IT
Times cited: 51
Mutations in the proteolipid subunits of the vacuolar H+-ATPase provide resistance to indolotryptoline natural products. Biochemistry. 2014 Academic Article GET IT
Times cited: 7
Mining the metabiome: identifying novel natural products from microbial communities. Chemistry & biology. 2014 Review GET IT
Times cited: 143
eSNaPD: a versatile, web-based bioinformatics platform for surveying and mining natural product biosynthetic diversity from metagenomes. Chemistry & biology. 2014 Academic Article GET IT
Times cited: 79
Metagenomic small molecule discovery methods. Current opinion in microbiology. 2014 Academic Article GET IT
Times cited: 70
The chemical arsenal of Burkholderia pseudomallei is essential for pathogenicity. Journal of the American Chemical Society. 2014 Academic Article GET IT
Times cited: 49
Arixanthomycins A-C: Phylogeny-guided discovery of biologically active eDNA-derived pentangular polyphenols. ACS chemical biology. 2014 Academic Article GET IT
Times cited: 58
Antibacterial enzymes from the functional screening of metagenomic libraries hosted in Ralstonia metallidurans. FEMS microbiology letters. 2014 Academic Article GET IT
Times cited: 36
Characterization of an environmental DNA-derived gene cluster that encodes the bisindolylmaleimide methylarcyriarubin. Chembiochem : a European journal of chemical biology. 2014 Academic Article GET IT
Times cited: 21
Chemical-biogeographic survey of secondary metabolism in soil. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 115
Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment. Journal of the American Chemical Society. 2013 Academic Article GET IT
Times cited: 40
Arimetamycin A: improving clinically relevant families of natural products through sequence-guided screening of soil metagenomes. Angewandte Chemie (International ed. in English). 2013 Academic Article GET IT
Times cited: 55
Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 112
The pvc operon regulates the expression of the Pseudomonas aeruginosa fimbrial chaperone/usher pathway (cup) genes. PloS one. 2013 Academic Article GET IT
Times cited: 18
Meeting report: 1st international functional metagenomics workshop may 7-8, 2012, st. Jacobs, ontario, Canada. Standards in genomic sciences. 2013 Academic Article GET IT
Times cited: 2
Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 92
Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters. Journal of the American Chemical Society. 2012 Academic Article GET IT
Times cited: 81
Selective enrichment of environmental DNA libraries for genes encoding nonribosomal peptides and polyketides by phosphopantetheine transferase-dependent complementation of siderophore biosynthesis. ACS chemical biology. 2012 Letter GET IT
Times cited: 17
Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens. Journal of the American Chemical Society. 2012 Academic Article GET IT
Times cited: 101
Biocatalysts and small molecule products from metagenomic studies. Current opinion in chemical biology. 2012 Review GET IT
Times cited: 58
Natural product biosynthetic gene diversity in geographically distinct soil microbiomes. Applied and environmental microbiology. 2012 Academic Article GET IT
Times cited: 77
Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis. Journal of the American Chemical Society. 2012 Academic Article GET IT
Times cited: 83
Reassembly of functionally intact environmental DNA-derived biosynthetic gene clusters. Methods in enzymology. 2012 Academic Article GET IT
Times cited: 20
Long-chain N-acyl amino acid synthases are linked to the putative PEP-CTERM/exosortase protein-sorting system in Gram-negative bacteria. Journal of bacteriology. 2011 Academic Article GET IT
Times cited: 27
Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 118
Discovery of a metagenome-derived enzyme that produces branched-chain acyl-(acyl-carrier-protein)s from branched-chain α-keto acids. Chembiochem : a European journal of chemical biology. 2011 Academic Article GET IT
Times cited: 8
Cloning and characterization of an environmental DNA-derived gene cluster that encodes the biosynthesis of the antitumor substance BE-54017. Journal of the American Chemical Society. 2011 Academic Article GET IT
Times cited: 71
Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis. Organic letters. 2011 Academic Article GET IT
Times cited: 87
Metabolites from the induced expression of cryptic single operons found in the genome of Burkholderia pseudomallei. Journal of the American Chemical Society. 2011 Academic Article GET IT
Times cited: 62
The 2.7 Å resolution structure of the glycopeptide sulfotransferase Teg14. Acta crystallographica. Section D, Biological crystallography. 2010 Academic Article GET IT
Times cited: 5
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products. Journal of the American Chemical Society. 2010 Academic Article GET IT
Times cited: 46
Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules. Current opinion in microbiology. 2010 Review GET IT
Times cited: 109
Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR. Biopolymers. 2010 Academic Article GET IT
Times cited: 106
Fluostatins produced by the heterologous expression of a TAR reassembled environmental DNA derived type II PKS gene cluster. Journal of the American Chemical Society. 2010 Academic Article GET IT
Times cited: 88
Utahmycins a and B, azaquinones produced by an environmental DNA clone. Journal of natural products. 2010 Academic Article GET IT
Times cited: 41
Crystal structures of the glycopeptide sulfotransferase Teg12 in a complex with the teicoplanin aglycone. Biochemistry. 2010 Academic Article GET IT
Times cited: 15
Expanding small-molecule functional metagenomics through parallel screening of broad-host-range cosmid environmental DNA libraries in diverse proteobacteria. Applied and environmental microbiology. 2010 Academic Article GET IT
Times cited: 160
Metagenomic approaches to natural products from free-living and symbiotic organisms. Natural product reports. 2009 Review GET IT
Times cited: 100
An environmental DNA-derived type II polyketide biosynthetic pathway encodes the biosynthesis of the pentacyclic polyketide erdacin. Angewandte Chemie (International ed. in English). 2009 Academic Article GET IT
Times cited: 42
Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 95
Paerucumarin, a new metabolite produced by the pvc gene cluster from Pseudomonas aeruginosa. Journal of bacteriology. 2008 Academic Article GET IT
Times cited: 46
Natural products from isnA-containing biosynthetic gene clusters recovered from the genomes of cultured and uncultured bacteria. Journal of the American Chemical Society. 2007 Academic Article GET IT
Times cited: 39
Cytoskyrins and cytosporones produced by Cytospora sp. CR200: taxonomy, fermentation and biological activities. Marine drugs. 2007 Academic Article GET IT
Times cited: 41
Cyclic AMP directly activates NasP, an N-acyl amino acid antibiotic biosynthetic enzyme cloned from an uncultured beta-proteobacterium. Journal of bacteriology. 2007 Academic Article GET IT
Times cited: 16
Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules. Nature protocols. 2007 Academic Article GET IT
Times cited: 170
The history of early bee diversification based on five genes plus morphology. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 212
Phaeosphaeride A, an inhibitor of STAT3-dependent signaling isolated from an endophytic fungus. Organic letters. 2006 Academic Article GET IT
Times cited: 64
Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA. Angewandte Chemie (International ed. in English). 2005 Academic Article GET IT
Times cited: 89
Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom. Angewandte Chemie (International ed. in English). 2005 Academic Article GET IT
Times cited: 41
N-acyl derivatives of arginine and tryptophan isolated from environmental DNA expressed in Escherichia coli. Organic letters. 2005 Academic Article GET IT
Times cited: 48
Bacterial printing press that regenerates its ink: contact-printing bacteria using hydrogel stamps. Langmuir : the ACS journal of surfaces and colloids. 2005 Academic Article GET IT
Times cited: 110
Long-chain N-acyltyrosine synthases from environmental DNA. Applied and environmental microbiology. 2004 Academic Article GET IT
Times cited: 90
Palmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water. Journal of natural products. 2004 Academic Article GET IT
Times cited: 67
Synthesis of long-chain fatty acid enol esters isolated from an environmental DNA clone. Organic letters. 2003 Academic Article GET IT
Times cited: 25
Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA. Applied and environmental microbiology. 2002 Academic Article GET IT
Times cited: 409
New natural product families from an environmental DNA (eDNA) gene cluster. Journal of the American Chemical Society. 2002 Academic Article GET IT
Times cited: 134
The guanacastepenes: a highly diverse family of secondary metabolites produced by an endophytic fungus. Journal of the American Chemical Society. 2001 Academic Article GET IT
Times cited: 160
Cloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA. Organic letters. 2001 Academic Article GET IT
Times cited: 187
Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus. Organic letters. 2000 Academic Article GET IT
Times cited: 55
The cytosporones, new octaketide antibiotics isolated from an endophytic fungus. Organic letters. 2000 Academic Article GET IT
Times cited: 173
CR377, a new pentaketide antifungal agent isolated from an endophytic fungus. Journal of natural products. 2000 Academic Article GET IT
Times cited: 73
Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms. Applied and environmental microbiology. 2000 Academic Article GET IT
Times cited: 964
Biological activity of guanacastepene, a novel diterpenoid antibiotic produced by an unidentified fungus CR115. The Journal of antibiotics. 2000 Academic Article GET IT
Times cited: 117
ZmaR, a novel and widespread antibiotic resistance determinant that acetylates zwittermicin A. Journal of bacteriology. 1999 Academic Article GET IT
Times cited: 18

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Background

education and training

Ph.D., Cornell University 2002
M.S., Cornell University 1999
B.A., Pomona College 1993

Contact

full name

Sean F. Brady

primary email

sfb2004@med.cornell.edu

VIVO Weill Cornell Medical College

Sean F. Brady Tri-Institutional Professor

Publications

selected publications

Background

education and training

Contact

full name

primary email