Arimetamycin A: improving clinically relevant families of natural products through sequence-guided screening of soil metagenomes.
Academic Article
Overview
abstract
Sequence-tag-guided screening of soil environmental DNA libraries can be used to guide the discovery of new compounds with improved properties. In heterologous expression experiments the eDNA-derived arm cluster encodes arimetamycin A, an anthracycline that is more potent than clinically used natural anthracyclines and retains activity against multidrug-resistant (MDR) cancer cells.
