Angewandte Chemie (International ed. in English)
Journal
Overview
publication venue for
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Multi-Targeting Macrocyclic Peptides as Nanomolar Inhibitors of Self- and Cross-Seeded Amyloid Self-Assembly of α-Synuclein.
2025
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Indazole to 2-cyanoindole scaffold progression for mycobacterial lipoamide dehydrogenase inhibitors achieves extended target residence time and improved antibacterial activity.
2024
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Deuteration as a General Strategy to Enhance Azobenzene-Based Photopharmacology.
2024
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Tapcin, an in vivo active dual topoisomerase I/II inhibitor discovered by syn-BNP coupled metagenomics.
2024
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Effective Inhibition of TDP-43 Aggregation by Native State Stabilization..
63.
2023
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Photoswitchable Serotonins for Optical Control of the 5-HT2A Receptor..
61.
2022
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Engineering fluorophore recycling in a fluorogenic RNA aptamer.
2021
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Metagenome-Guided Analogue Synthesis Yields Improved Gram-Negative-Active Albicidin- and Cystobactamid-Type Antibiotics..
60.
2021
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Chemical Evolution of Antivirals Against Enterovirus D68 through Protein-Templated Knoevenagel Reactions..
60.
2021
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Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice..
60.
2021
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Total Synthesis of Malacidin A by β-Hydroxyaspartic Acid Ligation-Mediated Cyclization and Absolute Structure Establishment..
59.
2020
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Fluorophore-Promoted RNA Folding and Photostability Enables Imaging of Single Broccoli-Tagged mRNAs in Live Mammalian Cells..
59.
2020
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Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding..
59.
2020
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3-O-Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake..
59.
2019
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Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding..
58.
2019
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Borazine-CF3- Adducts for Rapid, Room Temperature, and Broad Scope Trifluoromethylation..
57.
2018
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An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy..
56.
2017
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Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6..
56.
2017
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Chelator-Free Radiolabeling of Nanographene: Breaking the Stereotype of Chelation..
56.
2017
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Paper-Based Electrical Respiration Sensor..
55.
2016
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Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons..
55.
2015
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De Novo Fragment Design for Drug Discovery and Chemical Biology..
54.
2015
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Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization..
54.
2015
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Monitoring and targeting the initial dimerization stage of amyloid self-assembly..
54.
2014
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Switching demethylation activities between AlkB family RNA/DNA demethylases through exchange of active-site residues..
53.
2014
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One-pot semisynthesis of exon 1 of the Huntingtin protein: new tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease..
53.
2014
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Genetic incorporation of multiple unnatural amino acids into proteins in mammalian cells..
52.
2013
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Chelator-free synthesis of a dual-modality PET/MRI agent..
52.
2013
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Arimetamycin A: improving clinically relevant families of natural products through sequence-guided screening of soil metagenomes..
52.
2013
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Dual responsive, stabilized nanoparticles for efficient in vivo plasmid delivery..
52.
2013
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Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity..
52.
2012
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Fully integrated thermoplastic genosensor for the highly sensitive detection and identification of multi-drug-resistant tuberculosis..
51.
2012
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Effects of a proximal base on water oxidation and proton reduction catalyzed by geometric isomers of [Ru(tpy)(pynap)(OH2)]2+..
50.
2011
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Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein..
50.
2011
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Cubic mesoporous graphitic carbon(IV) nitride: an all-in-one chemosensor for selective optical sensing of metal ions..
49.
2010
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An environmental DNA-derived type II polyketide biosynthetic pathway encodes the biosynthesis of the pentacyclic polyketide erdacin..
48.
2009
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Cognitive-performance recovery of Alzheimer's disease model mice by modulation of early soluble amyloidal assemblies..
48.
2009
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Highly efficient and chemoselective peptide ubiquitylation..
48.
2009
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Stereocontrolled synthesis of beta-amino alcohols from lithiated aziridines and boronic esters..
48.
2009
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Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept..
46.
2007
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Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA..
44.
2005
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Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom..
44.
2005
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Origins of stereoselectivity in strain-release allylations..
44.
2005
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Design, synthesis, and biological properties of highly potent epothilone B analogues..
42.
2003
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Antibody-catalyzed enantioselective Norrish type II cyclization..
42.
2003
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Total synthesis as a resource in the discovery of potentially valuable antitumor agents: cycloproparadicicol..
42.
2003
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A stereoselective route to guanacastepene A through a surprising epoxidation..
41.
2002
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Synthesis of the functionalized tricyclic skeleton of guanacastepene A: a tandem epoxide-opening beta-elimination/knoevenagel cyclization..
41.
2002
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Stereoselective total synthesis of epothilones by the metathesis approach involving C9-C10 bond formation..
41.
2002
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A Fully Synthetic Globo H Carbohydrate Vaccine Induces a Focused Humoral Response in Prostate Cancer Patients: A Proof of Principle..
38.
1999
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Catalytic Enantioselective Retro-Aldol Reactions: Kinetic Resolution of β-Hydroxyketones with Aldolase Antibodies..
37.
1998
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Amyloidogenic protein-membrane interactions: mechanistic insight from model systems.
2010
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