Chelator-Free Radiolabeling of Nanographene: Breaking the Stereotype of Chelation. Academic Article uri icon

Overview

abstract

  • Macrocyclic chelators have been widely employed in the realm of nanoparticle-based positron emission tomography (PET) imaging, whereas its accuracy remains questionable. Here, we found that 64 Cu can be intrinsically labeled onto nanographene based on interactions between Cu and the π electrons of graphene without the need of chelator conjugation, providing a promising alternative radiolabeling approach that maintains the native in vivo pharmacokinetics of the nanoparticles. Due to abundant π bonds, reduced graphene oxide (RGO) exhibited significantly higher labeling efficiency in comparison with graphene oxide (GO) and exhibited excellent radiostability in vivo. More importantly, nonspecific attachment of 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) on nanographene was observed, which revealed that chelator-mediated nanoparticle-based PET imaging has its inherent drawbacks and can possibly lead to erroneous imaging results in vivo.

publication date

  • February 7, 2017

Research

keywords

  • Breast Neoplasms
  • Chelating Agents
  • Copper Radioisotopes
  • Graphite
  • Nanoparticles
  • Positron-Emission Tomography

Identity

PubMed Central ID

  • PMC5345346

Scopus Document Identifier

  • 85012034056

Digital Object Identifier (DOI)

  • 10.1002/anie.201610649

PubMed ID

  • 28170126

Additional Document Info

volume

  • 56

issue

  • 11