Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity. Academic Article uri icon

Overview

abstract

  • Aggravating aggregation: an N-terminal domain that is in close proximity to the polyQ domain in the huntingtin protein, htt105-138, is shown to be highly aggregation prone. Potential cross-talk between this domain and the polyQ region may play a central role in regulating the aggregation and toxicity of Htt-N-terminal fragments.

publication date

  • November 12, 2012

Research

keywords

  • Huntington Disease
  • Nerve Tissue Proteins

Identity

Scopus Document Identifier

  • 84871946141

Digital Object Identifier (DOI)

  • 10.1002/anie.201206561

PubMed ID

  • 23148019

Additional Document Info

volume

  • 52

issue

  • 2